AutismKB 2.0

Annotation Detail for CCDC90B


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Basic Information Top
Gene Symbol:CCDC90B ( MDS011,MDS025,MGC104239 )
Gene Full Name: coiled-coil domain containing 90B
Band: 11q14.1
Quick LinksEntrez ID:60492; OMIM: NA; Uniprot ID:CC90B_HUMAN; ENSEMBL ID: ENSG00000137500; HGNC ID: 28108
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of CCDC90B mRNAincreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CCDC90B mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of CCDC90B mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CCDC90B proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CCDC90B mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CCDC90B mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of CCDC90B mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.093712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.096695378
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.857296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.853084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8521507988 12619106 12907637
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.566135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 17.567505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.5620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.5612371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.569022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.5619486331
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1518759878 8156756 2524372 11906362 14531868 12868966 8970840 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.579328219 16192314 6679447 7440962 18692083 9022650 18648102 8291058 9653073 11289319 18289764 1440618 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5710774834 11461765 12392966 18071297 15619225 16227642 16393943 11834606 17562736 19416960 15968718 14986274 11421492 12958197 17522070 16177239 16485898 12705907 19370779 16109766 11739529 19085960 19739265 16781746 12540782 14725611 10915739 16081117 2444490 12594235 19923254 19164858 11529661 11743745 11287661 12153990 17906064 18713872 14550746 19420014 10663392
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.533581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5316530937
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis Cyclosporine 3.5012639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.288314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.7616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.766582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.7612371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6812969438 12587719 19014921 16610002 19460945 16611625 11587558 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.967678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.9615890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9621137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.812876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.816587162 1399818 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.818603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4814755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4820464547 18520028 18816296 20064080 18569708 20869020 17053015 20135361 6695378
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.267678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.786482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4810029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.093712494 6587162 1399818 6582329 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.818074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8117053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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