AutismKB 2.0

Annotation Detail for BCL7A


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Basic Information Top
Gene Symbol:BCL7A ( BCL7 )
Gene Full Name: B-cell CLL/lymphoma 7A
Band: 12q24.31
Quick LinksEntrez ID:605; OMIM: 601406; Uniprot ID:BCL7A_HUMAN; ENSEMBL ID: ENSG00000110987; HGNC ID: 1004
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
B-cell non-Hodgkin lymphoma, high-grade
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of BCL7A mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of BCL7A mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BCL7A mRNAdecreases expression 20382639
C051890 irinotecan irinotecan metabolite results in increased expression of BCL7A mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of BCL7A mRNAincreases expression 15956246
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of BCL7A mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 14514962 11752688
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3511798837 19825857
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.2316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.2312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7311589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.023084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0211135700 14691202 15073043 15553829 16217749
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4712490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9620889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2215668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms irinotecan 2.6417287894 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7420501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.7418509181 16303861 17454858 17159606 18259882 15273666 16391804
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5510525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5510048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5015213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.832444490 12153990 19085960 19416960 16177239 11287661 16485898 10663392 16109766 17906064 12958197 17522070 19370779 12705907 19923254 11461765 17562736 11421492 16081117 14986274 15968718 10915739 16393943 16227642 11739529 19739265 11743745 16781746 19420014 11834606 18713872 18071297 19164858 14725611 15619225 12540782 11529661 14550746 12594235 12392966 10774834
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7012903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver arsenic trioxide 3.6615073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7016904648
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4911294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6616354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007938 Leukemia arsenic trioxide 2.9815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1820471514 16968895 16467208 17050201 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4317217047 16331271 12679006 12018890 16330433 17712046 15622746 12712474 17869043 9834237 11468182 17107899 19035177 15748426 15213294 15336539 19642359 17649720 16112521 19225113 19075265 11161223 16966277 16823087 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7916882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 16610002 19460945 11587558 19014921 12587719 19784758 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8114682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.4920377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6215213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3711798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3719555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D052016 Mucositis irinotecan 5.5517159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3511468182 19417148 15949261 14977855 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3216882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4016624393
MESH:D009362 Neoplasm Metastasis irinotecan 3.2818259882
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3310525206
MESH:D009447 Neuroblastoma irinotecan 3.648761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D017599 Neuroectodermal Tumors irinotecan 5.278761367
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4919769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6215580305
MESH:D010235 Paraganglioma arsenic trioxide 4.5719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4016646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7317007042
MESH:D013274 Stomach Neoplasms irinotecan 2.7315723263
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3619014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5920435036 11780464 12845720 12973940
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25314
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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