AutismKB 2.0

Annotation Detail for ALX4


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Basic Information Top
Gene Symbol:ALX4 ( FND2,KIAA1788 )
Gene Full Name: ALX homeobox 4
Band: 11p11.2
Quick LinksEntrez ID:60529; OMIM: 605420; Uniprot ID:ALX4_HUMAN; ENSEMBL ID: ENSG00000052850; HGNC ID: 450
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
diabetes, type 2
No data
Desease Name
Parietal foramina 2
Frontonasal dysplasia 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ALX4 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of ALX4 mRNAincreases expression 20458559
D009151 Mustard Gas Mustard Gas results in increased expression of ALX4 mRNAincreases expression 15674843
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3619825857 11798837
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001249 Asthma Mustard Gas 2.8110378619
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001768 Blister Mustard Gas 5.9019167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1516206674
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.9015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.8417687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.8611589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.043084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0415073043 14691202 11135700 16217749 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.7419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5712490120
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8720501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.7712609071
MESH:D019465 Craniofacial Abnormalities marker/mechanism 9847249
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.6315213294
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6819416960 12392966 17906064 16393943 14725611 11739529 11461765 19370779 12705907 17562736 12153990 14550746 18071297 10663392 16781746 16485898 18713872 12540782 12958197 10774834 15619225 11529661 17522070 11743745 16081117 16109766 16177239 10915739 19085960 11287661 14986274 11834606 2444490 12594235 19420014 19739265 11421492 15968718 19164858 16227642 19923254
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004487 Edema Mustard Gas 3.789260866 11402378 11428631 11428647
MESH:D004890 Erythema Mustard Gas 5.909357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3912903497
MESH:D005234 Fatty Liver arsenic trioxide 3.7715073043
OMIM:613451 FRONTONASAL DYSPLASIA 2 marker/mechanism
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.8516904648
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D007249 Inflammation Mustard Gas 2.988975870 9260866 9357497 16001271 17524151 11428647 11428631 11402378 11428620
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D007938 Leukemia arsenic trioxide 3.0115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 5.0516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.2419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1917050201 20471514 16968895 16467208 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4816330433 12018890 11161223 12712474 15336539 19035177 12679006 17712046 15748426 9834237 16331271 16112521 19225113 19642359 16966277 17649720 17869043 11468182 15622746 17217047 19075265 16891316 16823087 15213294 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.9416882451
MESH:D008107 Liver Diseases Acetaminophen 1.7119784758 16611625 11587558 12969438 19460945 12587719 19014921 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6817185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4714682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9820377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6915213294
MESH:D008171 Lung Diseases Mustard Gas 3.7318702808 18161513
MESH:D008175 Lung Neoplasms arsenic trioxide 2.7319825857 11798837
MESH:D008175 Lung Neoplasms Mustard Gas 2.733148597 8781369
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.4115949261 19417148 14977855 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3616105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.5416624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3810525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009503 Neutropenia Mustard Gas 4.507688884 16761898
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5112452020 19769630 16624393
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6415580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6919927285
OMIM:168500 PARIETAL FORAMINA marker/mechanism 11137991
OMIM:609597 PARIETAL FORAMINA 2 marker/mechanism
MESH:D011041 Poisoning Mustard Gas 4.3215727166
MESH:D017689 Polydactyly marker/mechanism 9847249
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2019131511
MESH:D011537 Pruritus Mustard Gas 4.8318058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0617266442 17894541 17720292 10334151 17620002
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.5416646077
MESH:D012871 Skin Diseases Mustard Gas 2.8012880345 15451306 16961503
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.4319014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.7015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6112845720 20435036 11780464 12973940
MESH:D014581 Urticaria Acetaminophen 3.5010982225
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24755
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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