AutismKB 2.0

Annotation Detail for MIIP


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Basic Information Top
Gene Symbol:MIIP ( FLJ12438,FLJ38609,IIP45 )
Gene Full Name: migration and invasion inhibitory protein
Band: 1p36.22
Quick LinksEntrez ID:60672; OMIM: 608772; Uniprot ID:MIIP_HUMAN; ENSEMBL ID: ENSG00000116691; HGNC ID: 25715
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
1934Cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of MIIP mRNAdecreases expression 16788091
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MIIP mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in increased expression of MIIP mRNAincreases expression 19244175
D013467 Sulindac Sulindac results in increased expression of MIIP mRNAincreases expression 11906190
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 6.2214745880
MESH:D058186 Acute Kidney Injury Sulindac 4.747897758
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Sulindac 3.1811910360
MESH:D000236 Adenoma Sulindac 3.9810223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.9911874996 15623613 11535846 16460482 12394442 19003578 17611924
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D001913 Bowen's Disease Sulindac 6.0811207687
MESH:D001943 Breast Neoplasms Sulindac 3.1216642371
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003092 Colitis Selenium 4.3417936198
MESH:D003110 Colonic Neoplasms Sulindac 2.9712902858 12458338
MESH:D015179 Colorectal Neoplasms Sulindac 2.6911197048 11076880 18059344 10666051
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003930 Diabetic Retinopathy Sulindac 5.6917621415 12861449
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2615131321
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004715 Endometriosis Sulindac 4.8715652904
MESH:D004938 Esophageal Neoplasms Sulindac 3.2112235107
MESH:D005234 Fatty Liver pirinixic acid 3.1919236843 20131406
MESH:D018221 Fibromatosis, Abdominal Sulindac 6.1114745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.7619069698
MESH:D005764 Gastroesophageal Reflux Sulindac 5.5211910360
MESH:D006333 Heart Failure pirinixic acid 7.7020558911
MESH:D006333 Heart Failure Selenium 7.7017162251
MESH:D006529 Hepatomegaly pirinixic acid 3.5518467677 16221962 19176532 19772884
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D007249 Inflammation Sulindac 3.483291741
MESH:D007251 Influenza, Human Selenium 4.9216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007414 Intestinal Neoplasms Sulindac 5.0312584176 10223192 12628509 12351151 12663524 10213222
MESH:D007417 Intestinal Polyps Sulindac 5.4511245490 12394442
MESH:D007676 Kidney Failure, Chronic Selenium 4.3116518626
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.4512468960
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Sulindac 3.1016867024 14986274
MESH:D008113 Liver Neoplasms pirinixic acid 1.9316377806 20007298 15890375
MESH:D008175 Lung Neoplasms Sulindac 2.6919359593 15713900
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9915318939
MESH:D008545 Melanoma Sulindac 2.8716642371
MESH:D008654 Mesothelioma Selenium 2.9215107826
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D019636 Neurodegenerative Diseases Sulindac 4.6117266991 16850258
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010146 Pain Sulindac 4.133291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4611504793 16820089
MESH:D010954 Plasmacytoma Selenium 5.6115087411
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D014594 Uterine Neoplasms Sulindac 5.1018645019
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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