AutismKB 2.0

Annotation Detail for ROBO2


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Basic Information Top
Gene Symbol:ROBO2 ( KIAA1568,SAX3 )
Gene Full Name: roundabout, axon guidance receptor, homolog 2 (Drosophila)
Band: 3p12.3
Quick LinksEntrez ID:6092; OMIM: 602431; Uniprot ID:ROBO2_HUMAN; ENSEMBL ID: ENSG00000185008; HGNC ID: 10250
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04360Axon guidance
Pathway IDPathway Name
Axon guidance
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1955Urogenital abnormalities
2032Kidney disease
Desease Name
PSYCH
Brain imaging in schizophrenia (interaction)
Desease Name
Brain imaging in schizophrenia (interaction)
Desease Name
Vesicoureteral reflux 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ROBO2 mRNAincreases expression 18648102
C041524 aluminum sulfate aluminum sulfate results in decreased expression of ROBO2 mRNAdecreases expression 15961160
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ROBO2 mRNAdecreases expression 20382639
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ROBO2 mRNAaffects cotreatment|decreases expression 18606552
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ROBO2 mRNAaffects cotreatment|decreases expression 18606552
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of ROBO2 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of ROBO2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001321 Autistic Disorder marker/mechanism 18270976
MESH:D001321 Autistic Disorder Valproic Acid 1.9917157402 18558336 19460635 19232924 17688650 20603192 18940202 18316065 18396377 18775368 16609825 18177632 18985861 15238991 17507914
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.773581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D009202 Cardiomyopathies Zalcitabine 4.8810591146
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.267505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.359022650 19486331
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1511298694 8156756 14531868 18759878 8970840 2524372 11906362 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.1518289764 9328219 11289319 6679447 6482804 7440962 18692083 8291058 9022650 9653073 1440618 18648102 16192314
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.1519641884 1733752
MESH:D004362 Drug Toxicity Zalcitabine 5.057515130
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.513659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.363922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5820426865
MESH:D005234 Fatty Liver Valproic Acid 9.4119224547 14986274
MESH:D005234 Fatty Liver Zalcitabine 9.4118299183
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D015658 HIV Infections Zalcitabine 4.4617457083
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9816612254
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.691399818 3712494 598648 6587162
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008223 Lymphoma Zalcitabine 4.839205081 17941976 11980663 9488045 8764131 8840982 18798262
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009374 Neoplasms, Experimental Zalcitabine 5.469205081 9488045 8764131
MESH:D009437 Neuralgia Zalcitabine 6.7117292584
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.826679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.8216359493 8888407
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 12.0518606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 12.0518606552
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.9812752131 11422049
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9116876388 11738929 14763951 15475178 11044598 1511512 3137016 17978042
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096582329 6587162 3712494 1399818 7505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.368074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014718 Vesico-Ureteral Reflux marker/mechanism
Pathway ID Pathway Name
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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