AutismKB 2.0

Annotation Detail for ROCK1


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Basic Information Top
Gene Symbol:ROCK1 ( MGC131603,MGC43611,P160ROCK,PRO0435 )
Gene Full Name: Rho-associated, coiled-coil containing protein kinase 1
Band: 18q11.1
Quick LinksEntrez ID:6093; OMIM: 601702; Uniprot ID:ROCK1_HUMAN; ENSEMBL ID: ENSG00000067900; HGNC ID: 10251
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04270Vascular smooth muscle contraction
hsa04360Axon guidance
hsa04310Wnt signaling pathway
hsa05131Shigellosis
hsa05130Pathogenic Escherichia coli infection
hsa04350TGF-beta signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Axon guidance
Apoptosis
Pathway IDPathway Name
200006Signaling events mediated by PRL
200007RhoA signaling pathway
200155Stabilization and expansion of the E-cadherin adherens junction
200016Noncanonical Wnt signaling pathway
200121EPHA forward signaling
200069Thromboxane A2 receptor signaling
200180N-cadherin signaling events
200161Signaling events mediated by VEGFR1 and VEGFR2
200041EPHB forward signaling
200109Integrins in angiogenesis
200108amb2 Integrin signaling
Pathway IDPathway Name
P00016Cytoskeletal regulation by Rho GTPase
P00031Inflammation mediated by chemokine and cytokine signaling pathway
Pathway IDPathway Name
500270Apoptotic cleavage of cellular proteins
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1758Common cold
1818Systemic scleroderma
1848Embryoma
1859Ovarian cancer
1878Ischemia
1944Breast cancer
1954Stroke
2022Liver cancer
2040Hyperglycemia
2053Colon cancer
2106Pancreas cancer
2145Subarachnoid hemorrhage
2157Scleroderma
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of ROCK1 mRNAdecreases expression 20406850
D000496 Alloxan Alloxan results in increased expression of ROCK1 mRNAincreases expression 12605241
D000496 Alloxan Alloxan results in increased expression of ROCK1 proteinincreases expression 12605241
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ROCK1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ROCK1 mRNAdecreases expression 19150397
D002101 Cacodylic Acid Cacodylic Acid results in decreased expression of ROCK1 mRNAdecreases expression 17720352
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ROCK1 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ROCK1 mRNAaffects cotreatment|affects expression 17602206
D004642 Emodin Emodin results in decreased expression of ROCK1 mRNAdecreases expression 16045814
D004967 Estrogens Estrogens results in decreased expression of ROCK1 mRNAdecreases expression 20970835
D006820 Hyaluronic Acid Hyaluronic Acid results in increased phosphorylation of ROCK1 proteinincreases phosphorylation 16864594
C108255 levormeloxifene levormeloxifene results in decreased expression of ROCK1 mRNAdecreases expression 20970835
D052638 Particulate Matter Particulate Matter results in increased expression of ROCK1 mRNAincreases expression 18599801
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of ROCK1 mRNAdecreases expression 17616710
D010634 Phenobarbital Phenobarbital results in decreased expression of ROCK1 mRNAdecreases expression 19363144
C045950 propiconazole propiconazole results in decreased expression of ROCK1 mRNAdecreases expression 19363144
D011794 Quercetin Quercetin results in increased expression of ROCK1 proteinincreases expression 15221776
D020849 Raloxifene Raloxifene results in decreased expression of ROCK1 mRNAdecreases expression 20970835
D018038 Sodium Selenite Sodium Selenite results in increased expression of ROCK1 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of ROCK1 mRNAaffects expression 18691609
C402769 tipifarnib tipifarnib results in increased expression of ROCK1 mRNAincreases expression 16403772
D002762 Cholecalciferol Cholecalciferol results in increased expression of ROCK1 mRNAincreases expression 17170073
C108830 Y 27632 Y 27632 results in decreased activity of ROCK1 proteindecreases activity 10686302
C108830 Y 27632 ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein]affects cleavage|affects reaction 14615541
C108830 Y 27632 Y 27632 results in decreased activity of ROCK1 proteindecreases activity 14615541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.866195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8615322242 11752688 14514962
MESH:D055371 Acute Lung Injury Particulate Matter 5.0812396868
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 6.386695378
MESH:D000236 Adenoma Diethylnitrosamine 6.3810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.5916434500 17620307 19052882 18056438 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.5917620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.5916835633
MESH:D000419 Albuminuria Raloxifene 4.4717308373 17451421
MESH:D000544 Alzheimer Disease Particulate Matter 4.7615513908
MESH:D000544 Alzheimer Disease Raloxifene 4.7615800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1217084956
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8515336622
MESH:D001327 Autoimmune Diseases Cholecalciferol 10.6316142846
MESH:D001327 Autoimmune Diseases Quercetin 10.6319761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001930 Brain Injuries Raloxifene 4.3416580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9020146248 17474063
MESH:D001943 Breast Neoplasms Cacodylic Acid 2.9017474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9017474063
MESH:D001943 Breast Neoplasms Quercetin 2.9018628248
MESH:D001943 Breast Neoplasms Raloxifene 2.9017440819 15758505 17952589 16912660 16837676 17242785 17049068 15572757 17261762 17595753 17893378 15775269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9020435547
MESH:D002105 Cadmium Poisoning Quercetin 5.4216962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.6816705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.6816288022 17428255 19919837 18788625 19539802 16830150 19394651 18494052 10672840 20512989 16328049 19418558 17138121 20514400 3581430 18056438 17761372 18785209 19171122 10737359 21159647 18971187 20524982 17162532 18506893 19383236 16569478 16540662 17055752 18691550 16502159 18978308 19822196 16681979 20007298 20432363 18210153 20084675 11831363 20101231 16935385 20935162 20214788 19107877 19052882 16807293 19519916 16878318 19335982 20727157 19701751 18665156 17173139 16698587 18393292 17978847 3084413 16779866 19208518
MESH:D006528 Carcinoma, Hepatocellular Estrogens 8.6815341023
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.681701930 20007298 6705139 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.6812508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8217234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0120419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.9617572228
MESH:D006332 Cardiomegaly Quercetin 6.5619794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5618670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Particulate Matter 7.7012396868
MESH:D002318 Cardiovascular Diseases Raloxifene 7.7015775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.666135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.6620889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.662727394 21159647 7505956 17174075
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.124080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.9519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9516835633
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.058697196 16354765 15340226 15668235 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.4915800139
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6020423518
MESH:D003110 Colonic Neoplasms Quercetin 2.4017148506 16640504 19440933 19056647 11134977 15741050 17191121
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9514669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D016638 Critical Illness Estrogens 5.8116670151
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8918551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0517474826
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6616285004
MESH:D003921 Diabetes Mellitus, Experimental Alloxan 8.9517034923
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.9519496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 3.8217451421 15920148 17308373
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.6518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.6519107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 8.6515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.6520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:D004421 Dystonia Phenobarbital 3.881851702
MESH:D004487 Edema Raloxifene 6.4615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 3.8715845917
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.983659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.7411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8220417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.436401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.127750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.893659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver Diethylnitrosamine 7.6020387270 21071580
MESH:D005234 Fatty Liver Raloxifene 7.6017473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005355 Fibrosis Emodin 14.2419474275
MESH:D005355 Fibrosis Quercetin 14.2419474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2420067830
MESH:D005909 Glioblastoma Quercetin 3.3119804834
MESH:D005910 Glioma Quercetin 3.0017643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2210048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.4411110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006529 Hepatomegaly Phenobarbital 13.8416109766
MESH:D006529 Hepatomegaly propiconazole 13.8417178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.8416120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9216354765 15340226 16959395 8697196 18606429
MESH:D006943 Hyperglycemia Quercetin 3.9218262572 11834736
MESH:D006973 Hypertension Quercetin 8.3918356687
MESH:D006973 Hypertension Raloxifene 8.3917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3918850075 18670907
MESH:D007249 Inflammation Diethylnitrosamine 4.6718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6712878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.3816624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.1914714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007627 Keloid Quercetin 4.8217086741
MESH:D007674 Kidney Diseases Quercetin 3.0216962696
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 2.8716705839
MESH:D007889 Leiomyoma Raloxifene 4.3716973256
MESH:D007938 Leukemia Quercetin 3.0917468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 4.9017077332
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4020032147 18407596 18522880 19638242 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 6.4021047994
MESH:D008106 Liver Cirrhosis, Experimental Emodin 5.0115288473
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.0112741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0112878042
MESH:D008106 Liver Cirrhosis, Experimental Y 27632 5.0113678700
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5017034775
MESH:D008107 Liver Diseases Phenobarbital 6.5019363144
MESH:D008107 Liver Diseases propiconazole 6.5019363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 25.137678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 25.1321137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 25.1317602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 25.1319427195 20118626 18644402 21167192 12112319 19850985 20492335 18978307 15175105 19551842 19499222 19996281 12771043 15885732 19812893 19294768 21278145 21047994 20452335 19256749 18648771 9163691 20101389 20434301 19073162 2422723 18977376 19833225 20137499 19090486 16942905 21071580 19638242 20501860 18754104 20583210 10737359 19642983 19254457 2862719 19690152 19255062 19426721 20405173
MESH:D008113 Liver Neoplasms Phenobarbital 25.1315975961 19482888 8742319 19812893 19073162 21047994
MESH:D008113 Liver Neoplasms propiconazole 25.1319028983
MESH:D008113 Liver Neoplasms Quercetin 25.1318980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 25.1316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.322876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.3216267830 18079962 19004024 18544905 9362446 18253720 17854601 18164116 2563599 17942915 18282651 19126423 18308698 18775883 19009564 3124819 17174075 16842330 21159647 19519916 19539802 18093689
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 22.322563599 17172636 18308698 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental propiconazole 22.3217178689
MESH:D008114 Liver Neoplasms, Experimental Quercetin 22.3219519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.3212151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4417053015 20464547 18520028 18816296 20064080 18569708 20869020 20135361 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.4420970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Quercetin 6.4416280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4419555203 11884234
MESH:D008175 Lung Neoplasms tipifarnib 6.4416885199
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9314737004
MESH:D008325 Mammary Neoplasms, Experimental tipifarnib 4.2516648579
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.4315863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D009101 Multiple Myeloma Raloxifene 3.3516497877
MESH:D009203 Myocardial Infarction Quercetin 2.9419595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.6919207477
MESH:D009205 Myocarditis Particulate Matter 5.8312563109
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3417484760
MESH:D009232 Myxoma Raloxifene 5.4316343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7318551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.523581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9211141357
MESH:D009369 Neoplasms Quercetin 4.9215185748
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0914600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2320387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.2417929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3216049721
MESH:D010018 Osteomalacia Phenobarbital 4.2317016548
MESH:D010024 Osteoporosis Raloxifene 3.3117882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.7819495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.7815579764 17823083 15758505 17893378
MESH:D010051 Ovarian Neoplasms Quercetin 2.6919005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.3916540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.3916965848
MESH:D010190 Pancreatic Neoplasms Quercetin 8.3916965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.722563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.722563599
MESH:D011230 Precancerous Conditions Quercetin 14.7219056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 1.9017024972
MESH:D011471 Prostatic Neoplasms Hyaluronic Acid 1.9016864594
MESH:D011471 Prostatic Neoplasms Quercetin 1.9017292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9016220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.9018760546
MESH:D019310 Pseudolymphoma Phenobarbital 4.3712752131
MESH:D011658 Pulmonary Fibrosis Particulate Matter 4.1412475806
MESH:D011693 Purpura Raloxifene 5.4315770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012554 Schistosomiasis japonica Quercetin 5.4216862918
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6318551238
MESH:D012640 Seizures Phenobarbital 5.633137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.696407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.2719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2716192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.302093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3018456281
MESH:D020521 Stroke Raloxifene 3.7216837676
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.8115864552
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.857505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.851399818
MESH:D013978 Tibial Fractures Raloxifene 5.0819048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.2916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.2917053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 15.2915537745
MESH:D001749 Urinary Bladder Neoplasms Quercetin 15.2916720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.2917572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1910091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.4316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D014947 Wounds and Injuries Estrogens 4.6311172683
Pathway ID Pathway Name
REACT:578 Apoptosis
KEGG:04360 Axon guidance
REACT:18266 Axon guidance
KEGG:04062 Chemokine signaling pathway
KEGG:04510 Focal adhesion
KEGG:04670 Leukocyte transendothelial migration
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05131 Shigellosis
REACT:14797 Signaling by GPCR
KEGG:04350 TGF-beta signaling pathway
KEGG:04270 Vascular smooth muscle contraction
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34623
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04707 inhibitor HYDROXYFASUDIL
    DB07876 - (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
    DB08162 - 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE
    DB08756 - (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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