AutismKB 2.0

Annotation Detail for RORB


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Basic Information Top
Gene Symbol:RORB ( NR1F2,ROR-BETA,RZR-BETA,RZRB,bA133M9.1 )
Gene Full Name: RAR-related orphan receptor B
Band: 9q21.13
Quick LinksEntrez ID:6096; OMIM: 601972; Uniprot ID:RORB_HUMAN; ENSEMBL ID: ENSG00000198963; HGNC ID: 10259
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
Pathway IDPathway Name
Gene Expression
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RORB proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RORB mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of RORB mRNAincreases expression 12832660
D003024 Clozapine Clozapine results in decreased expression of RORB mRNAdecreases expression 11564422
D006220 Haloperidol Haloperidol results in decreased expression of RORB mRNAdecreases expression 11564422
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RORB mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone Progesterone results in increased expression of RORB mRNAincreases expression 17404688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RORB mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000380 Agranulocytosis Clozapine 5.3612649775 14617031 16160616
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001321 Autistic Disorder Haloperidol 2.7219368416 18080171
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615665606 15380490 15845082
MESH:D001943 Breast Neoplasms Progesterone 2.0317614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0818705752 16192424 16227642 10355542 15721981 16050911 15673190 15700767 3786805 16124888 16011737 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1512619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1518788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002375 Catalepsy Haloperidol 5.251977408 15215559
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 8697196 15668235 15340226 12621046
MESH:D003072 Cognition Disorders Clozapine 5.2717123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.1020210726
MESH:D003704 Dementia Haloperidol 4.8211575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.6716402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6717107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.9315331141
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9216227642 16177239 21278145 15027814 7179309 3732212 2869522 19336974 6884620 9327722 10915739 19085960 4309450 15998439 17522070 10092053 15968718 3786805 7440962 7120509 11566570 6623471
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D050171 Dyslipidemias Clozapine 4.3516402076
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0617692515
MESH:D004715 Endometriosis Progesterone 9.7016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.7010568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.4912795759 17595544 12631006 19224547 16239168 16045604 61145 15959796
MESH:D005234 Fatty Liver pirinixic acid 8.4920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 18606429 15340226 16354765 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006948 Hyperkinesis Clozapine 5.2516046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007249 Inflammation Progesterone 5.3515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3512878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D008064 Lipidoses Clozapine 4.1317567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9221278145 11903743 16239168 16943688 16221502 11408273 17334410 17174718 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5112958196 17525996 12632512 16638106 12609069 17698563 18166357 18156304 15052691 12667390 15959796 18279442 18395095 17761835 14724832 18472094 15893842 17823541 16033810 18339082 15057751 15818738 15123356 12389079 12741479 16136751 15996030 13678700 18472332 18395914 20821823 15876570 11481614 18210741 16097048 17708605 18420326 17557913 16116963 18429990 18481824 17721639 15650968 12666154 12586293 15362042 17976157 12898905 16192424 17481882 18317297 15338365 14716833 12445418 17944888 12445421 14748882 10355542 17631135 15931870 16011737 16027843 18705752 14716496 18263696 15370692 17565644 15730626 18277467 15673190 17900296 17805973 16015684 17640975 18054572 14512876 17714472 12649538 17766677 18376398 12546737 18251166 18412020 12632514 16248980 18205269 18187930 18418968 18006644 14620537 17869086 15925388 17922224
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1315830285 16246199 15720792 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9216899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.342125692 18177683 15890375 9163691
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.3419294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.3415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.648603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.6412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6412151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3514755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3519555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.0117203775 11408345
MESH:D001523 Mental Disorders Clozapine 9.5116856516
MESH:D001523 Mental Disorders Haloperidol 9.5116856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.6119142101
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009765 Obesity Clozapine 4.8718515891 19142110
MESH:D009765 Obesity pirinixic acid 4.8720558911
MESH:D010051 Ovarian Neoplasms Progesterone 2.5816525653 17393432
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311222880 11399792 11896295 11118676
MESH:D011595 Psychomotor Agitation Haloperidol 5.2611575062
MESH:D011618 Psychotic Disorders Clozapine 9.7215331141
MESH:D011618 Psychotic Disorders Haloperidol 9.7211575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
MESH:D012559 Schizophrenia Clozapine 4.2020580759 20452607 20521320 20521326 17667964 19369910 18806925 18855531 11151749 17123785 20168265 20107430 16141801 11763009 17726453
MESH:D012559 Schizophrenia Haloperidol 4.2020107430 19369910 18513383 1830565
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.6216503802 15862959
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.9920210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Clozapine 4.6817502770 20564506 20521320 16402076 20107430 16141801
MESH:D015431 Weight Loss Clozapine 5.4117933447
Pathway ID Pathway Name
KEGG:04710 Circadian rhythm - mammal
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01065 agonist Plenovit Melatonina Antioxidants;Free Radical Scavengers;Anticonvulsants;Adjuvants, Immunologic;Central Nervous System Depressants
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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