AutismKB 2.0

Annotation Detail for RORC


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RORC ( MGC129539,NR1F3,RORG,RZR-GAMMA,RZRG,TOR )
Gene Full Name: RAR-related orphan receptor C
Band: 1q21
Quick LinksEntrez ID:6097; OMIM: 602943; Uniprot ID:RORG_HUMAN; ENSEMBL ID: ENSG00000143365; HGNC ID: 10260
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
Pathway IDPathway Name
Gene Expression
No data
Pathway IDPathway Name
P00030Hypoxia response via HIF activation
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of RORC mRNAincreases expression 16014739
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RORC mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RORC mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RORC proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RORC mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in decreased expression of RORC mRNAdecreases expression 14967926
D016572 Cyclosporine Cyclosporine results in decreased expression of RORC mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of RORC mRNAdecreases expression 20106945
C116926 rofecoxib rofecoxib results in decreased expression of RORC mRNAdecreases expression 17070997
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RORC mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 14514962 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4111473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.913712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.916695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001169 Arthritis, Experimental rofecoxib 4.4416690336
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001862 Bone Resorption bisphenol A 4.0311985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9520146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 1.9517123778
MESH:D001943 Breast Neoplasms Estradiol 1.9518497071 17289903 17261762 16675129 17018787 12948864 19861407 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.753581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.753084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7512907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7516924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.2317123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.827505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.8218566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.309022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.3019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 16354765 15340226 15668235 12621046
MESH:D003110 Colonic Neoplasms rofecoxib 3.3212902858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.012524372 8970840 11906362 18759878 14531868 8156756 12868966 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.388291058 6679447 9022650 6482804 18289764 11289319 18692083 16192314 1440618 9653073 7440962 18648102 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3819370779 16177239 2444490 15968718 17562736 18071297 11529661 11287661 17522070 16109766 16393943 11461765 16227642 16781746 16485898 12540782 12392966 19085960 11834606 19739265 19420014 19416960 16081117 17906064 12958197 11743745 14986274 10915739 10663392 11739529 11421492 14550746 12594235 14725611 18713872 12705907 10774834 15619225 12153990 19164858 19923254
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.0911473722 18566989 19148513
MESH:D004715 Endometriosis rofecoxib 9.8715652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.8710568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.493581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 3.0319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Cyclosporine 9.2112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.8016393666
MESH:D007333 Insulin Resistance Estradiol 7.8016627594 16393666
MESH:D007410 Intestinal Diseases rofecoxib 5.2515831440
MESH:D007417 Intestinal Polyps rofecoxib 5.5511245490
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 10.5212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.528314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.5215618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.226582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 13.2215610895
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.7114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 3.7117565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 12587719 19784758 12969438 19460945 11587558 16610002 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.729163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7221137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7216984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.40598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.408603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4012151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4518569708 20135361 20464547 20064080 18816296 20869020 18520028 17053015 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4519555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6611807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4116810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 17.5616427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 17.5611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.5614600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.586482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010003 Osteoarthritis rofecoxib 4.4716690336
MESH:D010049 Ovarian Diseases bisphenol A 5.2311985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.2619401270
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010149 Pain, Postoperative rofecoxib 5.6516678543 18165598
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.3110548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.3111118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.1320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.1320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5117292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5116740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.5116740699
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011629 Puberty, Precocious bisphenol A 5.0210548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7210029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019966 Substance-Related Disorders bisphenol A 4.2216045194 16684133
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.011399818 6587162 3712494 6582329 7505956
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.178074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1717053015
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014591 Uterine Diseases bisphenol A 5.2714652134
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:04710 Circadian rhythm - mammal
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved