AutismKB 2.0

Annotation Detail for ROS1


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Basic Information Top
Gene Symbol:ROS1 ( MCF3,ROS,c-ros-1 )
Gene Full Name: c-ros oncogene 1 , receptor tyrosine kinase
Band: 6q22.1
Quick LinksEntrez ID:6098; OMIM: 165020; Uniprot ID:ROS_HUMAN; ENSEMBL ID: ENSG00000047936; HGNC ID: 10261
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1954Stroke
2091Hypertension
2191Meningioma
Desease Name
CARDIOVASCULAR
myocardial infarct
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C021296 2-ethoxyethanol 2-ethoxyethanol results in increased expression of ROS1 mRNAincreases expression 19643169
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ROS1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ROS1 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of ROS1 mRNAdecreases expression 20106945
D003609 Dactinomycin Dactinomycin results in increased expression of ROS1 mRNAincreases expression 16001973
C014347 decitabine decitabine results in decreased methylation of ROS1 promoterdecreases methylation 19276365
C014347 decitabine decitabine results in increased expression of ROS1 mRNAincreases expression 19276365
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of ROS1 mRNAincreases expression 17187413
D019833 Genistein Genistein results in decreased expression of ROS1 mRNAdecreases expression 17341692
C005219 methyl cellosolve methyl cellosolve results in increased expression of ROS1 mRNAincreases expression 19643169
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of ROS1 mRNAincreases expression 15120970
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ROS1 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-ethoxyethanol 15.716499812 6499823 7151721 6499820 6499796
MESH:D000014 Abnormalities, Drug-Induced methyl cellosolve 15.713652986 6499812 6474471
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 15.7114514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5320127859 20464547
MESH:D000230 Adenocarcinoma Genistein 4.5311473722
MESH:D000236 Adenoma 2-Acetylaminofluorene 7.2210737359
MESH:D000236 Adenoma Benzo(a)pyrene 7.226695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.236705139
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000748 Anemia, Macrocytic methyl cellosolve 6.573699323
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D053627 Asthenozoospermia 2-ethoxyethanol 13.266499807 10689203 6499823
MESH:D053627 Asthenozoospermia methyl cellosolve 13.263987992
MESH:D001259 Ataxia 2-ethoxyethanol 5.607151721
MESH:D001284 Atrophy 2-ethoxyethanol 11.966499799 15850284
MESH:D001284 Atrophy methyl cellosolve 11.966705890 3699323 2626667
MESH:D053713 Azoospermia 2-ethoxyethanol 5.756492198 6499807
MESH:D001724 Birth Weight 2-ethoxyethanol 6.732884743 6499823
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes 2-ethoxyethanol 12.776499796 7151721
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 12.7715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.7514601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9720146248 17474063
MESH:D001943 Breast Neoplasms decitabine 1.9719208741 18320071
MESH:D001943 Breast Neoplasms Genistein 1.9716541309 17200150 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 3.523084413 3581430 17761372 6705139 10737359
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.5216924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8020419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8019215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.4016332659
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3412371664
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 7.342727394
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002764 Cholecystitis 2-ethoxyethanol 14.396499794
MESH:D002764 Cholecystitis methyl cellosolve 14.396499794
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 16354765 15340226 8697196 15668235
MESH:D003110 Colonic Neoplasms decitabine 3.9617616700
MESH:D003110 Colonic Neoplasms Genistein 3.9617182828
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities methyl cellosolve 9.8512530607 6499821
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.8517141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003643 Death 2-ethoxyethanol 6.186499796
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4317107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D020964 Embryo Loss 2-ethoxyethanol 6.736499796
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3319294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.7816402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4511473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 2.9919224547
MESH:D005313 Fetal Death 2-ethoxyethanol 11.442884743 6499823 7151721 7198755 6499820
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 11.4411858732
MESH:D005317 Fetal Growth Retardation 2-ethoxyethanol 5.576499796
MESH:D005327 Fetal Resorption 2-ethoxyethanol 13.416499820 6499812
MESH:D005327 Fetal Resorption methyl cellosolve 13.416499821 3987992 6474471 6499812
MESH:D020567 Fetal Weight 2-ethoxyethanol 14.396499820 2884743 7151721
MESH:D020567 Fetal Weight methyl cellosolve 14.396499812 6474471 6499821
MESH:D005355 Fibrosis Cyclosporine 9.0712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005532 Foot Deformities, Congenital methyl cellosolve 5.643652986
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Genistein 3.3416598420
MESH:D005910 Glioma marker/mechanism 19276365
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5819215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006345 Heart Septal Defects, Ventricular methyl cellosolve 5.976499821
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.536705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.546705139
MESH:D006402 Hematologic Diseases 2-ethoxyethanol 5.5420172899 10514026
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006461 Hemolysis 2-ethoxyethanol 13.0817874071 19051582
MESH:D006461 Hemolysis methyl cellosolve 13.0817874071
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0712621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 18606429 16959395 16354765 15340226
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018850075 18670907
MESH:D007247 Infertility, Female 2-ethoxyethanol 5.386499823
MESH:D007248 Infertility, Male 2-ethoxyethanol 12.156499823
MESH:D007248 Infertility, Male decitabine 12.1517581917
MESH:D007248 Infertility, Male methyl cellosolve 12.153987992
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D007938 Leukemia decitabine 6.7419235587 18980019
MESH:D007938 Leukemia Genistein 6.7418980019 17468513
MESH:D007951 Leukemia, Myeloid decitabine 4.1419117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4018704418 19010910 18206229 18460780 19387464 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6818055864
MESH:D017880 Limb Deformities, Congenital methyl cellosolve 4.596499821
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.4417823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4412878042
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 7.7714678523 10737359 11376686 10672840 18001218 16273603
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7721137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7716984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 6.376150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3712151625
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 3.5411376686
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5418816296 20869020 20464547 6695378 18569708 20135361 18520028 17053015 20064080
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5419555203 11884234
MESH:D008223 Lymphoma decitabine 3.5219470736
MESH:D008231 Lymphopenia methyl cellosolve 5.973699323
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0214578162 12929590
MESH:D008545 Melanoma decitabine 2.2616505122 17785578
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 6.0817671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma decitabine 3.4418172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4619010910 18608210 19157545 16882708
MESH:D009203 Myocardial Infarction Genistein 2.9117141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7717141266
MESH:D009336 Necrosis 2-ethoxyethanol 5.5420172899
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3111141357
MESH:D009369 Neoplasms decitabine 5.3117925555 19116145 19470736
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Genistein 10.1516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.1514600291
MESH:D009845 Oligospermia 2-ethoxyethanol 12.0420172899
MESH:D009845 Oligospermia methyl cellosolve 12.043987992
MESH:D010024 Osteoporosis Genistein 3.3319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2316169203
MESH:D010051 Ovarian Neoplasms decitabine 5.1919331143 19259094
MESH:D010051 Ovarian Neoplasms Genistein 5.1919005980
MESH:D010190 Pancreatic Neoplasms decitabine 2.8119294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects 2-ethoxyethanol 17.746499817 2884743 7198755
MESH:D011297 Prenatal Exposure Delayed Effects methyl cellosolve 17.746499817 7974496 12530607
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.7411896295 11399792 11118676 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.9017616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2117292933
MESH:D011471 Prostatic Neoplasms Genistein 3.2115378649 15256057 16925846
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5519155313
MESH:D012512 Sarcoma, Ewing's Dactinomycin 5.2414601052
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6710029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4920155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 2.4919037991
MESH:D013276 Stomach Ulcer 2-ethoxyethanol 4.526499799
MESH:D013733 Testicular Diseases 2-ethoxyethanol 11.7210048760 10514026 6499806
MESH:D013733 Testicular Diseases methyl cellosolve 11.726499806
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4317967635
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 8.7515289314 15867355 1399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7517053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.7517616700 19087683
MESH:D014604 Uveal Neoplasms decitabine 5.1317785578
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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