AutismKB 2.0

Annotation Detail for HCN2


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Basic Information Top
Gene Symbol:HCN2 ( BCNG-2,BCNG2,HAC-1 )
Gene Full Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Band: 19p13.3
Quick LinksEntrez ID:610; OMIM: 602781; Uniprot ID:HCN2_HUMAN; ENSEMBL ID: ENSG00000099822; HGNC ID: 4846
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Seizures, Febrile
NEUROLOGICAL
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HCN2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of HCN2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HCN2 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in decreased expression of HCN2 mRNAdecreases expression 17711693
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HCN2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HCN2 mRNAdecreases expression 20106945
C121718 dicyclanil dicyclanil results in increased expression of HCN2 mRNAincreases expression 15664270
C025299 polyphenols polyphenols results in decreased expression of HCN2 mRNAdecreases expression 16293270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.287525203
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell dicyclanil 5.4317162532
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0318057881 18218290 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 4.0819698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.1419483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.863084413
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 4.8617162532
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9619225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4218974383
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.8514694615
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3715095906
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.7121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.7121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.7111287661 12153990 11834606 17906064 16227642 19420014 19416960 14550746 19739265 2444490 18071297 10663392 11461765 12540782 14986274 16393943 12705907 19923254 15968718 18713872 17522070 19370779 14725611 10774834 11421492 16485898 16781746 17562736 10915739 11529661 16109766 12594235 12958197 15619225 19085960 11743745 16081117 19164858 16177239 11739529 12392966
MESH:D056486 Drug-Induced Liver Injury Amiodarone 12.7115265979 18218290
MESH:D056486 Drug-Induced Liver Injury polyphenols 12.7119370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Amiodarone 3.7614986274
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006529 Hepatomegaly Amiodarone 4.0515265979
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.128137927 9751232
MESH:D007037 Hypothyroidism Amiodarone 4.8218020914 17991464
MESH:D007249 Inflammation polyphenols 3.1716366677
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1816705839
MESH:D008064 Lipidoses Amiodarone 3.6815342952 17567588
MESH:D008107 Liver Diseases Acetaminophen 4.3319014921 19784758 12969438 11587558 19460945 16611625 16610002 12587719
MESH:D008107 Liver Diseases polyphenols 4.3316698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.057678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0521137059 20195826
MESH:D008113 Liver Neoplasms dicyclanil 8.0520118626
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.686135515 2876784 2876786
MESH:D008133 Long QT Syndrome Amiodarone 3.7611989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.5312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8518516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618569708 18520028 18816296 20064080 20464547 17053015 6695378 20869020 20135361
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009181 Mycoses Amiodarone 5.2812754197 17974566
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9016049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.9014694615
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9311597910 12490602 12832656
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4218724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4610029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Amiodarone 3.5518087811
MESH:D013610 Tachycardia Amiodarone 4.5711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4719225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.6317997062
MESH:D013959 Thyroid Diseases Amiodarone 5.1319731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.1718020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5311989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA78
    • No data
    No data
    Releated drug ID Related drug Name
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02315 - Cyclic Guanosine Monophosphate
    DB02527 - Cyclic Adenosine Monophosphate
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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