AutismKB 2.0

Annotation Detail for RPE65


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Basic Information Top
Gene Symbol:RPE65 ( LCA2,RP20,mRPE65,rd12,sRPE65 )
Gene Full Name: retinal pigment epithelium-specific protein 65kDa
Band: 1p31.3
Quick LinksEntrez ID:6121; OMIM: 180069; Uniprot ID:RPE65_HUMAN; ENSEMBL ID: ENSG00000116745; HGNC ID: 10294
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
No data
Pathway IDPathway Name
200139Visual signal transduction: Rods
200078Visual signal transduction: Cones
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1705Retinitis pigmentosa
2178Retinal disease
2234Amaurosis congenita of leber I
No data
No data
Desease Name
Leber congenital amaurosis 2
Retinitis pigmentosa-20
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C025205 1,10-phenanthroline 1,10-phenanthroline inhibits the reaction [RPE65 protein affects the metabolism of Vitamin A]affects metabolic processing|decreases reaction 16319067
C025205 1,10-phenanthroline ferric sulfate inhibits the reaction [1,10-phenanthroline inhibits the reaction [RPE65 protein affects the metabolism of Vitamin A]]affects metabolic processing|decreases reaction 16319067
C509503 13,17,21-trimethyldocosa-12,16,20-trien-11-one 13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 proteinaffects binding|decreases activity 16411761
C509503 13,17,21-trimethyldocosa-12,16,20-trien-11-one [13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of A2E compoundaffects binding|decreases abundance|decreases activity 16411761
C509503 13,17,21-trimethyldocosa-12,16,20-trien-11-one [13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
C509503 13,17,21-trimethyldocosa-12,16,20-trien-11-one [13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
C509502 3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide 3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 proteinaffects binding|decreases activity 16411761
C509502 3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of A2E compoundaffects binding|decreases abundance|decreases activity 16411761
C509502 3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
C509502 3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
C450832 A2E compound [13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of A2E compoundaffects binding|decreases abundance|decreases activity 16411761
C450832 A2E compound [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of A2E compoundaffects binding|decreases abundance|decreases activity 16411761
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPE65 mRNAaffects expression 16483693
D015082 2,2'-Dipyridyl 2,2'-Dipyridyl inhibits the reaction [RPE65 protein affects the metabolism of Vitamin A]affects metabolic processing|decreases reaction 16319067
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RPE65 mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of RPE65 mRNAaffects cotreatment|decreases expression 20360939
C024823 ferric sulfate ferric sulfate inhibits the reaction [1,10-phenanthroline inhibits the reaction [RPE65 protein affects the metabolism of Vitamin A]]affects metabolic processing|decreases reaction 16319067
D007501 Iron Iron binds to RPE65 proteinaffects binding 16319067
D007501 Iron Iron binds to and affects the activity of RPE65 proteinaffects activity|affects binding 16968212
D012172 Retinaldehyde RPE65 protein results in increased chemical synthesis of Retinaldehydeincreases chemical synthesis 16828753
D012172 Retinaldehyde [13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
D012172 Retinaldehyde [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
D012172 Retinaldehyde [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
D012172 Retinaldehyde RPE65 protein results in increased chemical synthesis of Retinaldehydeincreases chemical synthesis 16026160
D012172 Retinaldehyde RPE65 protein results in increased metabolism of Retinaldehydeincreases metabolic processing 17251447
D012172 Retinaldehyde [13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
D012172 Retinaldehyde [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
D012172 Retinaldehyde [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
D015474 Isotretinoin [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
D015474 Isotretinoin [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehydeaffects binding|decreases abundance|decreases activity 16411761
C014794 retinol palmitate retinol palmitate binds to RPE65 proteinaffects binding 16262246
D014212 Tretinoin Tretinoin results in decreased expression of RPE65 mRNAdecreases expression 12910240
D014212 Tretinoin Tretinoin results in decreased expression of RPE65 proteindecreases expression 12910240
D014801 Vitamin A 1,10-phenanthroline inhibits the reaction [RPE65 protein affects the metabolism of Vitamin A]affects metabolic processing|decreases reaction 16319067
D014801 Vitamin A 2,2'-Dipyridyl inhibits the reaction [RPE65 protein affects the metabolism of Vitamin A]affects metabolic processing|decreases reaction 16319067
D014801 Vitamin A ferric sulfate inhibits the reaction [1,10-phenanthroline inhibits the reaction [RPE65 protein affects the metabolism of Vitamin A]]affects metabolic processing|decreases reaction 16319067
D014801 Vitamin A RPE65 protein affects the metabolism of Vitamin Aaffects metabolic processing 16319067
D014801 Vitamin A RPE65 protein results in increased chemical synthesis of Vitamin Aincreases chemical synthesis 16150724
D014801 Vitamin A RPE65 protein results in increased metabolism of Vitamin Aincreases metabolic processing 16828753
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 4.5918769834
MESH:D000015 Abnormalities, Multiple Isotretinoin 10.8618769834
MESH:D000015 Abnormalities, Multiple Vitamin A 10.8610992263
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D017486 Acneiform Eruptions Isotretinoin 6.3516232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.5416185265 18769834
MESH:D000236 Adenoma Diethylnitrosamine 2.876695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.9518056438 19061943 17162532 17620307 16434500 19052882
MESH:D000505 Alopecia Tretinoin 3.6415955085
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.7016640825
MESH:D000544 Alzheimer Disease Iron 3.0116640825 16563566
MESH:D000740 Anemia Iron 9.5916566752 16434484
MESH:D000740 Anemia Vitamin A 9.5916960172
MESH:D018798 Anemia, Iron-Deficiency Iron 10.5316569441 17375513 17162259 17163184 17147795
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 10.5316960172
MESH:D000756 Anemia, Sideroblastic Iron 4.8416910769
MESH:D001145 Arrhythmias, Cardiac Iron 4.4016604332
MESH:D001169 Arthritis, Experimental Tretinoin 3.0916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 5.2416456186
MESH:D001249 Asthma Vitamin A 5.2416732791
MESH:D001260 Ataxia Telangiectasia Iron 5.5015336622
MESH:D050197 Atherosclerosis Iron 3.7216640825 16632123
MESH:D001321 Autistic Disorder Iron 2.7917352947
MESH:D001424 Bacterial Infections Iron 5.2416640825
MESH:D001471 Barrett Esophagus Tretinoin 4.4416935849
MESH:D001766 Blindness marker/mechanism|therapeutic 16150724 16226919
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.6416197459 16206674
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1817474063
MESH:D001943 Breast Neoplasms Tretinoin 2.1816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 13.1916813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 13.1917426644 17377406
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2216168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.053084413 19701751 19418558 18494052 20514400 18978308 17055752 19519916 18788625 16807293 18971187 3581430 18056438 19335982 19208518 19171122 16935385 19394651 16502159 17138121 16328049 20084675 20214788 20512989 19052882 18506893 10672840 17162532 16878318 20101231 10737359 16830150 18210153 17173139 16569478 18785209 19919837 19822196 18393292 11831363 16681979 17428255 18665156 17761372 20432363 20007298 20727157 16698587 18691550 16779866 20935162 20524982 19107877 19383236 17978847 16288022 16540662 19539802 21159647
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.051917145
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 8.0111237771
MESH:D002294 Carcinoma, Squamous Cell retinol palmitate 8.0115984520
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.0116051514 16096774
MESH:D009202 Cardiomyopathies Iron 4.0616640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.4716604332
MESH:D002386 Cataract Tretinoin 3.1117460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.8717174075 2727394 21159647 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6416129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.5416153327
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7119052882
MESH:D002779 Cholestasis Vitamin A 4.3216175620
MESH:D002822 Choriocarcinoma Tretinoin 5.2216461808
MESH:D002972 Cleft Palate Tretinoin 6.389407595
MESH:D002972 Cleft Palate Vitamin A 6.3816054864
MESH:D003092 Colitis Tretinoin 3.7517035595
MESH:D003110 Colonic Neoplasms Iron 4.3916640825
MESH:D003110 Colonic Neoplasms Vitamin A 4.3917219422 16267017
MESH:D019465 Craniofacial Abnormalities Isotretinoin 4.1318769834 9879862
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.1310589399 9664655 9125849 9211117 17551590 9142499 14991402 16925845 9224671 8800419
MESH:D019465 Craniofacial Abnormalities Vitamin A 4.1310992263
MESH:D003920 Diabetes Mellitus Iron 4.4816640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 Iron 6.1016506275
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 6.1016506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.7620387270
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.7616506275
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.0619107877
MESH:D015352 Dry Eye Syndromes Vitamin A 5.8516146918
MESH:C538011 Eales disease Vitamin A 5.689068938
MESH:D004480 Ectromelia Vitamin A 5.8816054864
MESH:D004489 Edema, Cardiac Tretinoin 4.5318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1216569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D005124 Eye Abnormalities Tretinoin 3.609664655 16938888
MESH:D015785 Eye Diseases, Hereditary therapeutic 16968212
MESH:D005234 Fatty Liver Diethylnitrosamine 8.2621071580 20387270
MESH:D005234 Fatty Liver Iron 8.2616640825
MESH:D005327 Fetal Resorption Vitamin A 5.4316054864
MESH:D005355 Fibrosis Tretinoin 3.5517994277
MESH:D005621 Friedreich Ataxia Iron 5.4716604332 16640825
MESH:D005909 Glioblastoma Tretinoin 3.0217312396
MESH:D006258 Head and Neck Neoplasms retinol palmitate 8.5415984520
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.5416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 7.1614991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 7.1610992263 16080930
MESH:D006432 Hemochromatosis Iron 4.5116604332 16574947 17053826 17255318 17236123 16640825
MESH:D006486 Hemosiderosis Iron 5.2816604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.5316640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.9817182432
MESH:D006529 Hepatomegaly Iron 4.3616890145
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.6317436238 16877224 15707848 16863852 16490937 16292552
MESH:D015658 HIV Infections Iron 7.1916597321
MESH:D015658 HIV Infections Vitamin A 7.1916960176
MESH:D006679 HIV Seropositivity Vitamin A 5.6517209195
MESH:D006930 Hyperalgesia Tretinoin 3.2316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6116778211
MESH:D006986 Hypervitaminosis A Vitamin A 6.2316054864
MESH:D007006 Hypogonadism Iron 4.4216640825
MESH:D007037 Hypothyroidism Iron 5.1216640825
MESH:D007249 Inflammation Diethylnitrosamine 2.3918785209
MESH:D007410 Intestinal Diseases Tretinoin 3.8117994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6110783313
MESH:D019586 Intracranial Hypertension Vitamin A 5.8815955940
MESH:D019189 Iron Metabolism Disorders Iron 5.0717163184
MESH:D007569 Jaw Abnormalities Tretinoin 3.9315992940 17551590
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.5615369732
MESH:D057130 Leber Congenital Amaurosis marker/mechanism
MESH:D007938 Leukemia Tretinoin 2.7817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7319285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0819850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.9816766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.9817294898 12679006 17368321 17301526 17649720 16140955 19075265 16935935 17339181 17506722 16766008 17217047 17712046 16891316 9834237 17361223 15748426 19225113 16788101 19029980 19642359 16823087 17107899 19035177 16331271
MESH:D020961 Lewy Body Disease Iron 5.4716563566
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.579224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 8.5716054864
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.3618522880 18665156 19638242 20032147 18407596
MESH:D008103 Liver Cirrhosis Iron 11.3616640825
MESH:D008103 Liver Cirrhosis Vitamin A 11.3616256175
MESH:D008106 Liver Cirrhosis, Experimental Retinaldehyde 3.9416248980
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.9418397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 3.9416248980
MESH:D008107 Liver Diseases Diethylnitrosamine 4.4917034775
MESH:D008107 Liver Diseases Vitamin A 4.4916175620
MESH:D008108 Liver Diseases, Alcoholic Iron 11.8216737972 17207112
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 11.8216762690
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.9619551842 16942905 20501860 19499222 18754104 12771043 19090486 2862719 19294768 20492335 19254457 19426721 18644402 10737359 20452335 20405173 19812893 15885732 20118626 19690152 18977376 12112319 2422723 21047994 20101389 19642983 18648771 19255062 15175105 19996281 18978307 20434301 20137499 19833225 21167192 9163691 20583210 19427195 21071580 19256749 21278145 19638242 19850985 19073162
MESH:D008113 Liver Neoplasms Iron 4.9616640825 20302851
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.4019519916 18093689 17174075 9362446 18544905 17942915 16267830 3124819 18079962 16842330 18775883 18253720 19539802 17854601 19009564 18308698 19004024 18164116 2563599 18282651 19126423 21159647
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 6.4017113696
MESH:D008171 Lung Diseases Vitamin A 4.1116863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.7421163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Iron 3.7416640825
MESH:D008175 Lung Neoplasms Isotretinoin 3.7415899809
MESH:D008268 Macular Degeneration 13,17,21-trimethyldocosa-12,16,20-trien-11-one 13.5916411761
MESH:D008268 Macular Degeneration 3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide 13.5916411761
MESH:D008268 Macular Degeneration Iron 13.5916640825
MESH:D008527 Medulloblastoma Tretinoin 2.7917453147
MESH:D008545 Melanoma Isotretinoin 3.7417237267
MESH:D008545 Melanoma Tretinoin 3.7416752155
MESH:D008591 Meningomyelocele Tretinoin 4.4716940565
MESH:D009101 Multiple Myeloma Vitamin A 4.0716374440
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.7317086897
MESH:D009181 Mycoses Iron 5.5316640825
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0917596541
MESH:D017202 Myocardial Ischemia Iron 4.4616604332
MESH:D015428 Myocardial Reperfusion Injury Iron 4.2916604332
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.583581430 9029167
MESH:D009369 Neoplasms Tretinoin 2.4216946489 16594593
MESH:D009404 Nephrotic Syndrome Iron 4.5417178036
MESH:D009421 Nervous System Malformations Tretinoin 3.819125849
MESH:D009436 Neural Tube Defects Tretinoin 7.719142499
MESH:D009436 Neural Tube Defects Vitamin A 7.7117400914
MESH:D009447 Neuroblastoma Isotretinoin 4.0617368321
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D019636 Neurodegenerative Diseases Iron 8.7617296847 16604332
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D029242 Optic Atrophy, Hereditary, Leber marker/mechanism 17011878 16828753
MESH:D010003 Osteoarthritis Iron 3.9816640825
MESH:D010024 Osteoporosis Iron 3.8716648989 16640825
MESH:D010033 Otitis Media retinol palmitate 6.9217303254
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3516936753
MESH:D010146 Pain Tretinoin 2.9216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2816540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2815976015
MESH:D010212 Papilloma Iron 4.5212065085
MESH:D020447 Parasomnias Iron 6.0817352947
MESH:D010300 Parkinson Disease Iron 3.3316640825 16563566
MESH:D010900 Pituitary Diseases Iron 5.7316604332
MESH:D011041 Poisoning Iron 4.3216604332
MESH:D017119 Porphyria Cutanea Tarda Iron 5.0216640825
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.582563599
MESH:D011225 Pre-Eclampsia Iron 4.4416640825
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 4.9318769834
MESH:D011507 Proteinuria Tretinoin 3.6416636307
MESH:D011528 Protozoan Infections Iron 6.0816640825
MESH:D011596 Psychomotor Disorders Isotretinoin 5.9718769834
MESH:D011625 Pterygium Tretinoin 4.8416723453
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.8516877224
MESH:D012148 Restless Legs Syndrome Iron 4.5716930377
MESH:D012174 Retinitis Pigmentosa marker/mechanism 16272259 16968212
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1316283617 16116481
MESH:D012871 Skin Diseases Vitamin A 3.3618709164
MESH:D012878 Skin Neoplasms Iron 6.1312065085
MESH:D012878 Skin Neoplasms Tretinoin 6.1316467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4218456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4217261132
MESH:D013398 Sudden Infant Death Iron 5.5016640825
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.247505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.2416026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8116051514
MESH:D014376 Tuberculosis Iron 8.2316597321
MESH:D014376 Tuberculosis Tretinoin 8.2316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6716752155
MESH:D014802 Vitamin A Deficiency Vitamin A 5.3116175781 16960172 16146918
MESH:D014820 Vitiligo Tretinoin 4.0916761959
MESH:D009396 Wilms Tumor Tretinoin 3.9916287080
Pathway ID Pathway Name
KEGG:00830 Retinol metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34655
    • No data
    No data
    Releated drug ID Related drug Name
    PA450191lecithin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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