AutismKB 2.0

Annotation Detail for RPL3


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Basic Information Top
Gene Symbol:RPL3 ( MGC104284,TARBP-B )
Gene Full Name: ribosomal protein L3
Band: 22q13.1
Quick LinksEntrez ID:6122; OMIM: 604163; Uniprot ID:RL3_HUMAN; ENSEMBL ID: ENSG00000100316; HGNC ID: 10332
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RPL3 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of RPL3 mRNAaffects expression 19483382
C006632 arsenic trioxide arsenic trioxide results in increased expression of RPL3 mRNAincreases expression 20458559
D001553 Benzbromarone Benzbromarone affects the expression of RPL3 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RPL3 mRNAdecreases expression 20106945
D002994 Clofibrate Clofibrate affects the expression of RPL3 mRNAaffects expression 19483382
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPL3 mRNAaffects cotreatment|affects expression 17602206
D003976 Diazinon Diazinon affects the expression of RPL3 mRNAaffects expression 17474016
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPL3 mRNAaffects cotreatment|affects expression 17602206
D005001 Ethionine Ethionine affects the expression of RPL3 mRNAaffects expression 19483382
D005472 Fluorouracil Fluorouracil results in decreased expression of RPL3 proteindecreases expression 16803524
15585135
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPL3 protein]affects binding|increases reaction 17220478
D009853 Omeprazole Omeprazole affects the expression of RPL3 mRNAaffects expression 19483382
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of RPL3 mRNAdecreases expression 17616710
C006253 pirinixic acid pirinixic acid affects the expression of RPL3 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of RPL3 mRNAaffects expression 19483382
D013853 Thioacetamide Thioacetamide affects the expression of RPL3 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 7.0811798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0820464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 7.0817638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.596695378
MESH:D000236 Adenoma Diethylnitrosamine 6.596695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.0717162532 19061943 17620307 16434500 19052882 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.3316487989
MESH:D000740 Anemia Fluorouracil 3.6917963324 15504547 16511603
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7818057881 18218290 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 3.8919698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 58.3319483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 58.3316206674
MESH:D001778 Blood Coagulation Disorders Benzbromarone 58.3319483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 58.3319483382
MESH:D001778 Blood Coagulation Disorders Ethionine 58.3319483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 58.3319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 58.3319483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 58.3319483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 58.3319483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9017474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9017474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.9015136595 16110121 19217205 16595493 16557594 18357371 18608205
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3111589617
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6716051944
MESH:D002277 Carcinoma Fluorouracil 3.5517121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.373084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.3715073043 11135700 15553829 14691202 16217749
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 11.371701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.3720084675 18210153 18494052 19822196 16935385 17173139 16698587 18393292 19335982 11831363 19383236 19701751 18785209 17978847 19919837 18506893 17162532 19539802 20214788 19208518 19519916 16878318 16681979 20514400 17055752 17761372 10737359 20727157 16540662 19171122 19418558 20524982 18056438 16807293 10672840 17138121 20935162 3084413 17428255 20007298 19394651 16288022 20512989 18788625 20101231 16779866 19107877 19052882 18978308 16502159 20432363 21159647 18665156 16328049 16830150 18691550 18971187 3581430 16569478
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.3716799960 18930000 17971768 16332177 17088986 17045692
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 11.3717997003
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8719014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0118695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6220419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.6216757204 17066447 16280240 18986760
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8819225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0818974383
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 6.921399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.9221159647 17174075 2727394 7505956
MESH:D002637 Chest Pain Omeprazole 5.1115447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.6819052882
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.6818291259
MESH:D002779 Cholestasis pirinixic acid 2.8119176532
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6420423518
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2315001691 17016597 17169374 17287894 17725105 18772588 16340194 17018589 16510598 17172411
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5420501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5414970324 16282729 17454858 15289873 18509181 17695437 17094418 18949393 16303861 17016601 20501625 16391804 15148649 18288408 18802399 18448328 16331619 17594712 17255274 18383874 16524972 17401013
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D007644 Darier Disease Fluorouracil 4.7816733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0815213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1820387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.9716081117 10663392 12153990 16227642 16781746 12392966 11461765 10774834 15968718 19370779 16177239 17562736 19416960 19420014 18071297 19164858 19739265 16485898 12705907 11834606 19085960 12594235 10915739 11421492 14725611 15619225 11287661 17522070 18713872 12540782 17906064 19923254 14550746 11743745 12958197 2444490 11739529 16109766 16393943 11529661 14986274
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.9715265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.9719107877
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.9712963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004381 Duodenal Ulcer Omeprazole 4.3117151854 21218061 15991576 16613094
MESH:D050171 Dyslipidemias Clofibrate 4.0516707586
MESH:D004417 Dyspnea Diazinon 4.8016487989
MESH:D004487 Edema pirinixic acid 2.4612083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.2312903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.2315173087 16337965 16785472 16481741 17638652
MESH:D005218 Fat Necrosis Thioacetamide 5.7216456712
MESH:D005234 Fatty Liver Amiodarone 24.4914986274
MESH:D005234 Fatty Liver arsenic trioxide 24.4915073043
MESH:D005234 Fatty Liver Clofibrate 24.4919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 24.4920387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 24.4919236843 20131406
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2416904648
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005910 Glioma Fluorouracil 2.8616145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3715162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6420471113
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5517276928 15929193 18665440
MESH:D006505 Hepatitis Diazinon 9.7916487989
MESH:D006505 Hepatitis Thioacetamide 9.7916456712
MESH:D006529 Hepatomegaly Amiodarone 8.5315265979
MESH:D006529 Hepatomegaly pirinixic acid 8.5318467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.858137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D007037 Hypothyroidism Amiodarone 11.5718020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.578137927 18031379
MESH:D007248 Infertility, Male Diazinon 3.8112948887 16466525
MESH:D007249 Inflammation Diethylnitrosamine 2.3718785209
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.1912587719 15629191
MESH:D007680 Kidney Neoplasms Fluorouracil 3.2916985049
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0819248655
MESH:D007938 Leukemia arsenic trioxide 2.8215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1317050201 16467208 20471514 16968895 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2015213294 16112521 16823087 19225113 17649720 19035177 16891316 17217047 19075265 12712474 15622746 15336539 17712046 11468182 9834237 17107899 16330433 17869043 16966277 19642359 15748426 16331271 11161223 12679006 12018890
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3416882451
MESH:D008064 Lipidoses Amiodarone 3.4915342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8119638242 18522880 18665156 20032147 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5417292413 16098781 11682029 12085344 12679928 18380797 16343077 18615449 15078482 15288473 15158331 16097051 18295389 16248980 15095483 12891558 18395095 18458672 11172339 18031379 17355460 12531686 18263696 15075984 17629604 15334695 15474484 12557150 18032466 14739098 15288472 15362042 15316131 15465738 16126171 16489207 17127702 18606216 17050028 11481614 12175628 10677585 15716488 16511523 18416461
MESH:D008107 Liver Diseases Acetaminophen 6.5312969438 19784758 16611625 16610002 12587719 11587558 19014921 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5317034775
MESH:D008107 Liver Diseases Thioacetamide 6.5316337175 18374380 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5817185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 9.5812479984 15313186 15633222 17276928
MESH:D008113 Liver Neoplasms arsenic trioxide 17.9014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.9020195826 21137059
MESH:D008113 Liver Neoplasms Clofibric Acid 17.9017602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.9019073162 19551842 20101389 19850985 18648771 21071580 21047994 19090486 20452335 10737359 19812893 21167192 19690152 20118626 21278145 18977376 19638242 19996281 15175105 2422723 19254457 15885732 18644402 18978307 16942905 19833225 12112319 19642983 20137499 20434301 19499222 19255062 19426721 9163691 19427195 20492335 19294768 20583210 18754104 2862719 12771043 20501860 20405173 19256749
MESH:D008113 Liver Neoplasms Fluorouracil 17.9017045692 16603448 15113037 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 17.9015890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.9520377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.9519004024 19009564 17854601 19126423 21159647 3124819 19519916 18079962 17942915 18253720 16842330 18544905 18308698 19539802 18093689 18775883 18282651 18164116 9362446 16267830 2563599 17174075
MESH:D008133 Long QT Syndrome Amiodarone 8.1417391786 11989578 15350150
MESH:D008133 Long QT Syndrome arsenic trioxide 8.1415213294
MESH:D008171 Lung Diseases Amiodarone 3.3612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4818516814
MESH:D008175 Lung Neoplasms arsenic trioxide 4.8411798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8417053015 20064080 18520028 20135361 6695378 18816296 20464547 18569708 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8420512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 4.8415246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7815086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.4716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.4716757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0919417148 19549372 15949261 11468182 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009181 Mycoses Amiodarone 4.9017974566 12754197
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1316882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9416624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.563581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 8.1611141357
MESH:D009369 Neoplasms Fluorouracil 8.1618600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 8.1617405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1010525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4216436463
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.929802331
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4012452020 19769630 16624393
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.6015580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.6016540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.6016500647 16929163 19003803 15113037
MESH:D010235 Paraganglioma arsenic trioxide 4.1419927285
MESH:D011041 Poisoning Diazinon 4.3317603234
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.532563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5718626508 19082440
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8411597910 12832656 12490602
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9916160472 18722050 15538739 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9416646077
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0818724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3619755658 10029692
MESH:D013272 Stomach Diseases Omeprazole 4.6018545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.7017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.7020155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.7018456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.7019084572 17172411 16951190 16424979 19015929 17522103 18567086 17498489 15786421 18396642
MESH:D013276 Stomach Ulcer Amiodarone 7.5118087811
MESH:D013276 Stomach Ulcer Omeprazole 7.5110750652 15991576 16755016 11906479 18237397 17977527
MESH:D013610 Tachycardia Amiodarone 4.2711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1719225199
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.9315864552
MESH:D013959 Thyroid Diseases Amiodarone 4.7619731979
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.9719014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.977505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 11.9715710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.8519584973 18020914
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9716280240
MESH:D016171 Torsades de Pointes Amiodarone 10.2311989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 10.2315213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.0111780464 12845720 12973940 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0117053015
MESH:D014570 Urologic Diseases Diazinon 5.2816487989
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8616803524
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02494 - Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 - ANISOMYCIN
DB08437 - PUROMYCIN
DB08769 - N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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