AutismKB 2.0

Annotation Detail for RPL4


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Basic Information Top
Gene Symbol:RPL4 ( - )
Gene Full Name: ribosomal protein L4
Band: 15q22.31
Quick LinksEntrez ID:6124; OMIM: 180479; Uniprot ID:RL4_HUMAN; ENSEMBL ID: ENSG00000174444; HGNC ID: 10353
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RPL4 mRNAincreases expression 18648102
D000638 Amiodarone Amiodarone affects the expression of RPL4 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPL4 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of RPL4 mRNAaffects expression 19483382
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RPL4 mRNAaffects expression 15963342
D002994 Clofibrate Clofibrate affects the expression of RPL4 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in increased expression of RPL4 mRNAincreases expression 20106945
C014347 decitabine decitabine affects the methylation of RPL4 geneaffects methylation 17630775
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPL4 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RPL4 mRNAdecreases expression 17557909
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RPL4 mRNAincreases expression 17108234
D005001 Ethionine Ethionine affects the expression of RPL4 mRNAaffects expression 19483382
D005419 Flavonoids Flavonoids results in decreased expression of RPL4 mRNAdecreases expression 18035473
D018684 Glycine Agents Glycine Agents results in decreased expression of RPL4 mRNAdecreases expression 16532367
C051890 irinotecan irinotecan analog results in decreased expression of RPL4 mRNAdecreases expression 18927307
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPL4 protein]affects binding|increases reaction 17220478
D009532 Nickel MT1 affects the reaction [Nickel affects the expression of RPL4 mRNA]affects expression|affects reaction 16166738
D009532 Nickel MT2 affects the reaction [Nickel affects the expression of RPL4 mRNA]affects expression|affects reaction 16166738
D009853 Omeprazole Omeprazole affects the expression of RPL4 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of RPL4 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of RPL4 mRNAaffects expression 19483382
D018038 Sodium Selenite Sodium Selenite results in increased expression of RPL4 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPL4 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPL4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RPL4 mRNAincreases expression 18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RPL4 proteindecreases expression 16548065
D013853 Thioacetamide Thioacetamide affects the expression of RPL4 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D055371 Acute Lung Injury Nickel 8.9016166738
MESH:D055371 Acute Lung Injury pirinixic acid 8.9018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7914692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.693712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.5416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7018218290 18057881 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6015885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.8218651412 19698954
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9111289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 56.5019483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 56.5019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 56.5019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 56.5019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 56.5019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 56.5019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 56.5019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 56.5012125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 56.5019483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D001943 Breast Neoplasms decitabine 2.0219208741 18320071
MESH:D001943 Breast Neoplasms Nickel 2.0215986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6716192424 15700767 16011737 15673190 3786805 16227642 18705752 15721981 16050911 10355542 16124888 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.503581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 6.501701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.5018788625
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 6.5017997003
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5619215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8619225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9818974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.807505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 10.801399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.8012371664
MESH:D002637 Chest Pain Omeprazole 5.0015447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2316835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.2318291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.549022650 19486331
MESH:D002779 Cholestasis Cyclosporine 18.5419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.5416919318 17333356 11677210 15861022 16105132 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 18.5419176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6415894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.068697196 12621046 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms decitabine 3.9317616700
MESH:D003110 Colonic Neoplasms irinotecan 3.9317287894 17725105
MESH:D015179 Colorectal Neoplasms decitabine 2.7418981723
MESH:D015179 Colorectal Neoplasms irinotecan 2.7418509181 16303861 17454858 18259882 16391804 17159606 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.8812868966 18759878 8156756 8970840 11298694 2524372 11906362 14531868
MESH:D017449 Dermatitis, Allergic Contact Nickel 6.8817244072 17100760 19470301
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 9.192952479 3621924
MESH:D003877 Dermatitis, Contact Nickel 9.192952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6816285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.856482804 9022650 18289764 9328219 18648102 16192314 18692083 7440962 11289319 1440618 9653073 6679447 8291058
MESH:D056486 Drug-Induced Liver Injury Amiodarone 14.8515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.8510092053 4309450 15998439 16177239 2869522 10915739 6884620 17522070 6623471 19336974 15027814 15968718 7179309 16227642 11566570 7440962 7120509 9327722 3786805 3732212 19085960 21278145
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 14.8515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.8520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 14.8512963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.2216613094 21218061 15991576 17151854
MESH:D050171 Dyslipidemias Clofibrate 3.9916707586
MESH:D004487 Edema pirinixic acid 6.2012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0812538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0119294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.083581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005218 Fat Necrosis Thioacetamide 5.6116456712
MESH:D005234 Fatty Liver Amiodarone 29.4114986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.4116045604 12795759 19224547 15959796 61145 17595544 12631006 16239168
MESH:D005234 Fatty Liver Clofibrate 29.4119224547
MESH:D005234 Fatty Liver Cyclosporine 29.4119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.4115345470
MESH:D005234 Fatty Liver pirinixic acid 29.4120131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Carbon Tetrachloride 14.0818705752
MESH:D005355 Fibrosis Cyclosporine 14.0812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.0820067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.4119215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4715929193 17276928 18665440
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 15.106705139
MESH:D006505 Hepatitis Carbon Tetrachloride 15.1019900420 19110552
MESH:D006505 Hepatitis Thioacetamide 15.1016456712
MESH:D006529 Hepatomegaly Amiodarone 13.7915265979
MESH:D006529 Hepatomegaly pirinixic acid 13.7919176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.7912621046 16120746 15340226
MESH:D015658 HIV Infections Nickel 3.7617263646
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9418606429 16959395 15340226 16354765 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4216899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.779751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8315034207
MESH:D006973 Hypertension Cyclosporine 4.8110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9815338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 11.2517991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.2518031379 8137927
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male decitabine 6.4817581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4817937319
MESH:D007249 Inflammation Flavonoids 8.1217296493
MESH:D007249 Inflammation Nickel 8.1216166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 7.0716306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.0714714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.918074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Cyclosporine 2.288314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.976582329
MESH:D007680 Kidney Neoplasms Cyclosporine 6.9712371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.0019248655
MESH:D007938 Leukemia decitabine 3.0218980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 3.9017236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3617679729 18206229 19010910 18460780 18704418 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3618055864
MESH:D008064 Lipidoses Amiodarone 3.4315342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7516221502 17157831 11408273 16943688 17334410 17174718 16239168 21278145 11903743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8414716833 16136751 17640975 17805973 17976157 16015684 12546737 15650968 18395095 17944888 16027843 14748882 18156304 15057751 17721639 17761835 18251166 17698563 18205269 16638106 18420326 17922224 17631135 12666154 12958196 20821823 16192424 17565644 18187930 14512876 12667390 18210741 12741479 18166357 15362042 15893842 16033810 16248980 18418968 18395914 12586293 11481614 12445421 16097048 15996030 15673190 15876570 16116963 12609069 18006644 17714472 18705752 18339082 18472094 17525996 14620537 15959796 14724832 17557913 18277467 13678700 12445418 10355542 15931870 16011737 17823541 12632512 12632514 17766677 12649538 18279442 17900296 18263696 18054572 15052691 15925388 15818738 17708605 18376398 15370692 12898905 14716496 18429990 17481882 15123356 18481824 12389079 18317297 17869086 15338365 18472332 18412020 15730626
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8412878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.8418615449 11172339 18606216 11682029 18263696 15474484 15158331 15288473 15362042 18032466 12175628 18458672 12557150 15316131 15465738 18295389 16511523 12531686 17127702 16098781 12085344 18380797 10677585 18416461 12891558 15334695 17355460 17050028 16097051 16248980 16489207 15716488 18395095 11481614 15288472 15078482 16343077 18031379 16126171 17292413 15095483 15075984 17629604 14739098 12679928
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2016246199 15830285 16964402 15720792 17285989
MESH:D008107 Liver Diseases Thioacetamide 4.2018374380 15158337 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.4814706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 9.4815633222 12479984 17276928 15313186
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.0919294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.0916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.0916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.38598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.3812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3812151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4917391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.3012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3718516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2319555203 11884234
MESH:D008223 Lymphoma decitabine 3.3419470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9514737004
MESH:D008545 Melanoma decitabine 2.2317785578 16505122
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D052016 Mucositis irinotecan 4.9017159606
MESH:D009101 Multiple Myeloma decitabine 3.2718172295
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009181 Mycoses Amiodarone 4.8012754197 17974566
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3216882708 19010910 19157545 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8616411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.783581430
MESH:D009362 Neoplasm Metastasis irinotecan 5.7818259882
MESH:D009369 Neoplasms decitabine 4.8417925555 19470736 19116145
MESH:D009369 Neoplasms pirinixic acid 4.8417405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1918481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.846679447
MESH:D009447 Neuroblastoma irinotecan 3.428761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.628761367
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.839802331
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.326482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010051 Ovarian Neoplasms decitabine 2.6219331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.7319294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1312371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.6217616702
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.4318760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.2015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8112490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.3019155313
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9818724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8416709447
MESH:D013272 Stomach Diseases Omeprazole 4.5018545984
MESH:D013274 Stomach Neoplasms decitabine 2.7319037991
MESH:D013274 Stomach Neoplasms irinotecan 2.7315723263
MESH:D013276 Stomach Ulcer Amiodarone 7.2418087811
MESH:D013276 Stomach Ulcer Omeprazole 7.2415991576 16755016 17977527 10750652 11906479 18237397
MESH:D013610 Tachycardia Amiodarone 4.1811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0819225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0615669648
MESH:D013959 Thyroid Diseases Amiodarone 11.7019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.7012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.597505956 3712494 1399818 6582329 6587162
MESH:D013964 Thyroid Neoplasms decitabine 11.5917967635
MESH:D013964 Thyroid Neoplasms Propylthiouracil 11.5915710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.7518020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.0811989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.028074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.0219087683 17616700
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1914692618
MESH:D014604 Uveal Neoplasms decitabine 4.8117785578
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4415869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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