AutismKB 2.0

Annotation Detail for BCR


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:BCR ( ALL,BCR1,CML,D22S11,D22S662,FLJ16453,PHL )
Gene Full Name: breakpoint cluster region
Band: 22q11.23
Quick LinksEntrez ID:613; OMIM: 151410; Uniprot ID:BCR_HUMAN; ENSEMBL ID: ENSG00000186716; HGNC ID: 1014
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by Rho GTPases
Pathway IDPathway Name
200165Regulation of RAC1 activity
200050Regulation of RhoA activity
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
H00004Chronic myeloid leukemia (CML)
H00001Acute lymphoblastic leukemia (ALL) (Precursor B lymphoblastic leukemia)
Desease IDDesease Name
1832Congenital abnormality
1914Cerebrovascular disorder
1934Cancer
2188Bone marrow disease
2201Myeloproliferative disease
Desease Name
bipolar disorder
colorectal cancer
height
melanoma
CANCER
PSYCH
depressive disorder, major
thyroid cancer
DEVELOPMENTAL
Desease Name
Height
Desease Name
Leukemia, chronic myeloid
Leukemia, acute lymphocytic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]affects binding|decreases reaction|increases chemical synthesis 16849647
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]affects binding|decreases reaction|increases expression 16849647
C498826 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]affects binding|decreases reaction|increases chemical synthesis 16849647
C498826 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]affects binding|decreases reaction|increases expression 16849647
C058317 arsenic disulfide arsenic disulfide results in decreased expression of and results in decreased activity of BCR protein mutant formdecreases activity|decreases expression 12421474
C006632 arsenic trioxide arsenic trioxide results in decreased expression of BCR mRNAdecreases expression 20458559
C006632 arsenic trioxide arsenic trioxide results in decreased expression of BCR protein mutant formdecreases expression 14633726
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of BCR proteinincreases expression 16790487
C052570 cyfluthrin cyfluthrin results in increased expression of BCR proteinincreases expression 16790487
D004052 Diethylnitrosamine [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of BCR mRNAaffects cotreatment|increases expression 18253720
D011345 Fenofibrate [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of BCR mRNAaffects cotreatment|increases expression 18253720
D005419 Flavonoids Flavonoids results in decreased expression of BCR mRNAdecreases expression 15465739
D006632 Histamine 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]affects binding|decreases reaction|increases chemical synthesis 16849647
D006632 Histamine 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]affects binding|decreases reaction|increases chemical synthesis 16849647
D006632 Histamine [BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamineaffects binding|increases chemical synthesis 16849647
D006632 Histamine imatinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]affects binding|decreases reaction|increases chemical synthesis 16849647
C097613 imatinib imatinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]affects binding|decreases reaction|increases chemical synthesis 16849647
C097613 imatinib imatinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]affects binding|decreases reaction|increases expression 16849647
C097613 imatinib imatinib results in decreased activity of BCR protein mutant formdecreases activity 15329907
C051890 irinotecan irinotecan analog results in decreased expression of BCR mRNAdecreases expression 18927307
D010936 Plant Extracts Plant Extracts results in decreased expression of BCR mRNAdecreases expression 15465739
C025299 polyphenols polyphenols results in decreased expression of BCR mRNAdecreases expression 15465739
D011794 Quercetin Quercetin results in decreased expression of BCR mRNAdecreases expression 14715546
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BCR mRNAincreases expression 11007951
C025643 vinclozolin vinclozolin affects the expression of BCR mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8411752688 14514962 15322242
MESH:D000015 Abnormalities, Multiple imatinib 5.2418322153
MESH:D000022 Abortion, Spontaneous imatinib 6.2118322153
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2819825857 11798837
MESH:D000236 Adenoma Diethylnitrosamine 2.846695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.0319061943 16434500 17620307 19052882 17162532 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0316835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.3317119214 16611668 11874814
MESH:D000544 Alzheimer Disease Plant Extracts 3.0116962711
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.2217084956
MESH:D001008 Anxiety Disorders vinclozolin 3.6219015723
MESH:D001169 Arthritis, Experimental Plant Extracts 3.9314686799
MESH:D001249 Asthma Histamine 3.8916387687
MESH:D001260 Ataxia Telangiectasia Quercetin 4.9715336622
MESH:D001327 Autoimmune Diseases Quercetin 4.3919761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.9016206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001859 Bone Neoplasms imatinib 5.3115867366
MESH:D002545 Brain Ischemia Plant Extracts 4.7216041641
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0217474063
MESH:D001943 Breast Neoplasms imatinib 2.0217614352
MESH:D001943 Breast Neoplasms Quercetin 2.0218628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D001986 Bronchial Spasm Histamine 5.8218298128
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3111589617
MESH:D002057 Burns, Chemical Plant Extracts 5.349625245
MESH:D002105 Cadmium Poisoning Quercetin 5.5516962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.6316217749 11135700 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6318210153 17978847 16328049 18785209 19052882 19335982 19539802 19822196 20727157 11831363 16569478 20524982 3084413 20007298 20214788 18506893 16935385 16807293 18393292 17761372 19208518 17138121 19701751 21159647 16502159 16288022 10737359 17173139 19919837 16779866 20101231 19171122 19519916 3581430 18978308 19394651 18494052 16681979 16878318 16698587 18971187 16830150 20432363 17055752 20935162 19418558 17428255 18691550 19107877 18056438 17162532 19383236 20084675 18665156 10672840 20512989 16540662 18788625 20514400
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 6.6318834353
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.6319519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.9417234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1012490120
MESH:D006332 Cardiomegaly Plant Extracts 11.4417645561
MESH:D006332 Cardiomegaly Quercetin 11.4419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.4418670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.8421159647 17174075 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0912621046 8697196 15668235 16354765 15340226
MESH:D003110 Colonic Neoplasms irinotecan 5.9817287894 17725105
MESH:D003110 Colonic Neoplasms polyphenols 5.9816293270
MESH:D003110 Colonic Neoplasms Quercetin 5.9817148506 11134977 19440933 16640504 17191121 19056647 15741050
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.5220501625
MESH:D015179 Colorectal Neoplasms irinotecan 3.5218259882 16391804 17159606 16303861 17454858 15273666 18509181
MESH:D015179 Colorectal Neoplasms Quercetin 3.5218095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9410525206
MESH:D019465 Craniofacial Abnormalities imatinib 3.9418322153
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9415322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.3214966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0815213294
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.7119496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.3919706694
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2519107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.2519370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D050171 Dyslipidemias Fenofibrate 4.4116707586
MESH:D004487 Edema imatinib 11.6419703484
MESH:D004487 Edema Plant Extracts 11.6412787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.6411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 16714409 15322242
MESH:D016889 Endometrial Neoplasms Fenofibrate 4.0816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.6815268973
MESH:D004802 Eosinophilia Histamine 5.0312689652
MESH:D004827 Epilepsy Plant Extracts 3.7219439326 19700373
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3012903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver arsenic trioxide 13.1815073043
MESH:D005234 Fatty Liver Diethylnitrosamine 13.1821071580 20387270
MESH:D005234 Fatty Liver Plant Extracts 13.1815975614
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D018222 Fibromatosis, Aggressive imatinib 5.6417453242
MESH:D005355 Fibrosis Quercetin 8.7219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2416904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3016417039
MESH:D005909 Glioblastoma Quercetin 3.3819804834
MESH:D005910 Glioma Quercetin 3.0417643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3211294989 10048152
MESH:D006333 Heart Failure Plant Extracts 3.8518097624
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8815340226 12621046 16120746
MESH:D006561 Herpes Simplex Plant Extracts 4.6210715843
MESH:D015658 HIV Infections Plant Extracts 3.6712878215
MESH:D019584 Hot Flashes Plant Extracts 4.7516566672 17454163 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516959395 8697196 16354765 15340226 18606429
MESH:D006943 Hyperglycemia Quercetin 4.0118262572 11834736
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.4416484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.4515975614 15268973
MESH:D006973 Hypertension Quercetin 5.2018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2018670907 18850075
MESH:D007248 Infertility, Male vinclozolin 3.0316467254
MESH:D007249 Inflammation Diethylnitrosamine 15.7818785209
MESH:D007249 Inflammation Flavonoids 15.7817296493
MESH:D007249 Inflammation Plant Extracts 15.7816366677 12787963 15997105 19332304
MESH:D007249 Inflammation polyphenols 15.7816366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.7812878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.5116624496
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.6012628509 12584176 12351151
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007627 Keloid Quercetin 4.9417086741
MESH:D007674 Kidney Diseases Quercetin 3.0816962696
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10.6012970779
MESH:D007938 Leukemia arsenic trioxide 10.6015070760
MESH:D007938 Leukemia Quercetin 10.6017468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive marker/mechanism
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 14.2912421474
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 14.2914633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 14.2915107311 17301526 19208803 15748426
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.9319077051
MESH:D007951 Leukemia, Myeloid imatinib 9.9317236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1320471514 16968895 19850784 16467208 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2019642359 15622746 19035177 17869043 12712474 15213294 16330433 17712046 17107899 19075265 11468182 17649720 9834237 12679006 16112521 16823087 15748426 16891316 16331271 16966277 17217047 19225113 15336539 12018890 11161223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3416882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7216417039
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9119638242 20032147 18665156 18522880 18407596
MESH:D008103 Liver Cirrhosis Plant Extracts 6.9117157831
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 6.7715474484
MESH:D008106 Liver Cirrhosis, Experimental imatinib 6.7716596278
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 6.7715479170
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.7712741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7712878042
MESH:D008107 Liver Diseases Chlorpyrifos 9.4815991261
MESH:D008107 Liver Diseases Diethylnitrosamine 9.4817034775
MESH:D008107 Liver Diseases Plant Extracts 9.4817034775
MESH:D008107 Liver Diseases polyphenols 9.4816698588
MESH:D008113 Liver Neoplasms arsenic trioxide 17.9114682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.9120101389 9163691 18754104 20492335 18977376 19551842 19294768 19256749 18644402 2422723 19254457 19850985 19426721 19833225 15175105 19642983 18648771 21071580 19690152 10737359 21278145 20434301 19073162 19255062 21047994 21167192 19812893 20118626 19427195 19996281 16942905 2862719 20452335 19090486 20137499 20501860 19499222 20583210 12771043 15885732 12112319 18978307 19638242 20405173
MESH:D008113 Liver Neoplasms Fenofibrate 17.9118978307
MESH:D008113 Liver Neoplasms Plant Extracts 17.9119168119
MESH:D008113 Liver Neoplasms Quercetin 17.9118980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.9116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 18.5420377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.5418775883 9362446 18253720 19519916 3124819 19004024 19126423 17174075 17942915 2563599 18544905 18282651 18079962 19539802 18164116 16267830 21159647 17854601 19009564 16842330 18308698 18093689
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 18.5418253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Quercetin 18.5419519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.5412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 6.5811798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.5821163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Plant Extracts 6.5820869020
MESH:D008175 Lung Neoplasms Quercetin 6.5816280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5819555203 11884234
MESH:D008545 Melanoma Histamine 3.4917709802
MESH:D052016 Mucositis irinotecan 5.0017159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0915949261 14977855 19417148 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1316105982 16882451
MESH:D009203 Myocardial Infarction Quercetin 2.9819595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.7819207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9416624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.713581430 9029167
MESH:D009362 Neoplasm Metastasis imatinib 9.7115867366
MESH:D009362 Neoplasm Metastasis irinotecan 9.7118259882
MESH:D009369 Neoplasms Quercetin 2.7815185748
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 5.4617614352
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2014600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1010525206
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 5.1717168769
MESH:D009447 Neuroblastoma irinotecan 3.478761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3220387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.728761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.3417929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.1515081274
MESH:D009765 Obesity Plant Extracts 3.1420132043 19056576
MESH:D010014 Osteolysis imatinib 5.7315867366
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.2019495926
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 8.0416211241
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.0416624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Quercetin 8.0419005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.6215580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.6216540662
MESH:D010190 Pancreatic Neoplasms Quercetin 8.6216965848
MESH:D010212 Papilloma Plant Extracts 4.4816517061 15173996
MESH:D010235 Paraganglioma arsenic trioxide 4.1419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.162563599
MESH:D011230 Precancerous Conditions Quercetin 9.1619056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma marker/mechanism
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.4712476293
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4611896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.4618042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.9318220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7519131511
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.7517804756 14666653
MESH:D011471 Prostatic Neoplasms Quercetin 2.7517292933 14715546
MESH:D011472 Prostatitis vinclozolin 4.9318629315
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.6216611668 11874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.8917119214 16611668
MESH:D012220 Rhinitis Histamine 4.9612689652
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9416646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.5516862918
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.096418539
MESH:D012878 Skin Neoplasms Plant Extracts 5.8515173996 16517061
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.8017007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.8018456281
MESH:D013274 Stomach Neoplasms imatinib 4.8015786421
MESH:D013274 Stomach Neoplasms irinotecan 4.8015723263
MESH:D013276 Stomach Ulcer Plant Extracts 3.8818237397 18193104 15255614 17135157 12787963
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 13.2717997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 13.2717997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.0719014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.077505956
MESH:D013964 Thyroid Neoplasms imatinib 12.0716940797
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2412973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.2416720314
MESH:D014581 Urticaria Histamine 5.0218298128
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.7318097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.3118097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014947 Wounds and Injuries Plant Extracts 4.2319894650 20213670
Pathway ID Pathway Name
KEGG:05220 Chronic myeloid leukemia
KEGG:05200 Pathways in cancer
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25321
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA10804imatinib
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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