AutismKB 2.0

Annotation Detail for RPL9


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Basic Information Top
Gene Symbol:RPL9 ( DKFZp313J1510,FLJ27456,MGC15545,NPC-A-16,RPL9P7,RPL9P8,RPL9P9 )
Gene Full Name: ribosomal protein L9
Band: 4p14
Quick LinksEntrez ID:6133; OMIM: 603686; Uniprot ID:RL9_HUMAN; ENSEMBL ID: ENSG00000163682; HGNC ID: 10369
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RPL9 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RPL9 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RPL9 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPL9 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of RPL9 mRNAdecreases expression 20458559
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPL9 mRNAaffects cotreatment|increases expression 16532367
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RPL9 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPL9 mRNA]decreases reaction|increases expression 17942915
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RPL9 mRNAincreases expression 20360939
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPL9 mRNAaffects cotreatment|increases expression 16532367
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RPL9 mRNAdecreases expression 17557909
D018684 Glycine Agents Glycine Agents results in increased expression of RPL9 mRNAincreases expression 16532367
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPL9 mRNAaffects cotreatment|increases expression 16532367
C017947 sodium arsenite sodium arsenite results in increased expression of RPL9 mRNAincreases expression 20308225
D018038 Sodium Selenite Sodium Selenite results in increased expression of RPL9 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3519825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.823712494
MESH:D000236 Adenoma Diethylnitrosamine 6.8210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0218056438 19052882 16434500 19061943 17162532 17620307
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0417306315 16712894
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.3411874814
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7516206674
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.5616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.567296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.563084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.5614691202 16217749 15073043 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.5617055752 17162532 16502159 20007298 18506893 16540662 20214788 19107877 20727157 19383236 18971187 17761372 16288022 19394651 19701751 18785209 19418558 20524982 16328049 19335982 16878318 16698587 18665156 20432363 16569478 19519916 17978847 3084413 18788625 19052882 16935385 18691550 19919837 16681979 19539802 17428255 10737359 16807293 10672840 18056438 19208518 18210153 17138121 18393292 17173139 20935162 20514400 21159647 19171122 20084675 16779866 11831363 18978308 20512989 19822196 18494052 16830150 20101231 3581430
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.5617306315 16507464 15276417
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4018572023
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.506135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.507505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.507505956 2727394 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.5020056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.0619486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0616105132 15861022 17681005 17333356 11677210 17110522 16919318
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9011298694 12868966 8970840 11906362 14531868 18759878 2524372 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.2618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.2618692083 9022650 7440962 16192314 6679447 11289319 9328219 6482804 1440618 18289764 18648102 8291058 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2619739265 14725611 19416960 16227642 10663392 11834606 11461765 16393943 11743745 12392966 19164858 11421492 11529661 17522070 18713872 15968718 12153990 16177239 14550746 16081117 19420014 11287661 11739529 19370779 19923254 10774834 12594235 16485898 2444490 12705907 12540782 17562736 10915739 14986274 19085960 18071297 17906064 16109766 15619225 12958197 16781746
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.2619107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.2615131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.543581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D005234 Fatty Liver arsenic trioxide 13.6015073043
MESH:D005234 Fatty Liver Diethylnitrosamine 13.6021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.6015345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006689 Hodgkin Disease sodium arsenite 3.2212676792
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Atrazine 11.6112948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.6117937319
MESH:D007248 Infertility, Male sodium arsenite 11.6112646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 2.4118785209
MESH:D007333 Insulin Resistance Sodium Selenite 3.3314714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 6.1115629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.1120008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.596582329
MESH:D007938 Leukemia arsenic trioxide 2.8715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1516968895 16467208 20471514 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2619642359 15622746 19035177 12018890 16823087 15213294 9834237 19225113 16112521 17869043 11468182 17217047 17107899 12679006 15336539 11161223 17712046 16891316 17649720 16966277 16330433 12712474 15748426 16331271 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718407596 19638242 18665156 20032147 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 3.9712587719 16611625 19014921 19460945 11587558 12969438 16610002 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.977678174
MESH:D008113 Liver Neoplasms arsenic trioxide 10.9714682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.9720137499 20501860 18648771 9163691 12112319 21167192 19254457 16942905 15175105 18978307 21071580 20118626 2422723 18644402 19499222 19427195 19551842 19833225 18977376 10737359 19690152 19812893 19090486 15885732 2862719 20583210 20101389 20492335 19638242 19850985 19642983 20405173 12771043 20434301 19294768 19073162 20452335 21278145 19996281 18754104 19255062 19256749 19426721 21047994
MESH:D008113 Liver Neoplasms sodium arsenite 10.9716712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.552876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.55598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.5520377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5518093689 19539802 18775883 19009564 21159647 2563599 17174075 9362446 19126423 16267830 18544905 19519916 18253720 17942915 19004024 3124819 17854601 16842330 18164116 18079962 18282651 18308698
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008171 Lung Diseases sodium arsenite 3.2219095001
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5211798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.526695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 3.5217306315 17077188 16712894 15276417 19931552
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D008545 Melanoma sodium arsenite 2.0419082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Atrazine 3.561916698
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1611468182 19417148 19549372 14977855 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1816882451 16105982
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9818551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.803581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.803581430 9029167
MESH:D009369 Neoplasms sodium arsenite 2.5311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.446679447
MESH:D009436 Neural Tube Defects arsenic trioxide 12.4410525206
MESH:D009436 Neural Tube Defects sodium arsenite 12.4412854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.146482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9812452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9815276417 17306315
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3615580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3616540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010300 Parkinson Disease Atrazine 3.3017218051
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5919131511
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5916039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5918760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D012135 Respiratory Sounds Atrazine 4.6211874814
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5918551238
MESH:D012878 Skin Neoplasms sodium arsenite 2.7319524636 18572023
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4617007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.336582329 3712494 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.3319014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.337505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.1816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.188074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.1811780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.1816712894 11723127 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8411813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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