AutismKB 2.0

Annotation Detail for RPL12


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Basic Information Top
Gene Symbol:RPL12 ( - )
Gene Full Name: ribosomal protein L12
Band: 9q33.3
Quick LinksEntrez ID:6136; OMIM: 180475; Uniprot ID:RL12_HUMAN; ENSEMBL ID: ENSG00000197958; HGNC ID: 10302
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RPL12 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RPL12 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPL12 mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of RPL12 mRNAaffects cotreatment|decreases expression 18636392
C019304 ciprofibrate ciprofibrate results in increased expression of RPL12 mRNAincreases expression 12771043
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RPL12 mRNAincreases expression 12771043
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RPL12 mRNAaffects expression 17555576
D018684 Glycine Agents Glycine Agents results in decreased expression of RPL12 mRNAdecreases expression 16532367
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of RPL12 mRNAaffects cotreatment|decreases expression 18636392
D018038 Sodium Selenite Sodium Selenite results in increased expression of RPL12 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of RPL12 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RPL12 mRNAincreases expression 15328365
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury Chlorine 4.4420601635
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.873712494
MESH:D000236 Adenoma Diethylnitrosamine 6.876695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.5817620307 16434500 19052882 17162532 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5816835633
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 2.6616373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8217474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.8218425577 19084267 19244106 19189210 19288272 18815881 19059307 15565566 20390343 15668708 17242785 18351453 18984771 19142967 20005174 16202921 18997820 18855134 19103187 17893378 20135344 20544844 11161223 17440819 16273361 19011961 19066611 16873071 18821012 20859285 19487384 19115204 21152245 19221464 17261762 19189212 19200415 19410462 20065188 19289846 17049068 18629630 16818667 21138602 19155303
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8220435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7618315731 14754758 15516495 17626835 16777450 19059883 18417511
MESH:D002100 Cachexia Ozone 4.8916183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.687296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.683084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6810737359 18506893 17055752 18788625 18978308 19701751 20214788 17761372 19383236 21159647 19335982 18393292 16807293 16878318 17162532 19822196 20512989 17978847 16935385 16502159 16698587 20727157 18691550 16328049 19107877 20084675 18971187 19539802 16540662 16288022 19418558 19519916 16681979 18210153 18494052 19052882 10672840 20524982 3581430 20007298 20432363 19171122 17428255 3084413 18665156 16779866 18785209 11831363 16569478 17138121 19394651 17173139 20935162 19208518 18056438 20514400 20101231 19919837 16830150
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6816924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.947505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.9417174075 21159647 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.6519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.6516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.139022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1316919318 11677210 16105132 17333356 17681005 15861022 17110522
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415668235 16354765 15340226 8697196 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.942524372 18759878 8970840 8156756 11298694 12868966 11906362 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.349022650 11289319 18692083 7440962 8291058 18648102 18289764 16192314 6482804 9653073 9328219 6679447 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3416393943 15968718 19420014 18071297 19164858 11287661 11739529 14725611 17562736 11461765 2444490 12153990 12392966 19739265 19923254 19416960 11529661 18713872 15619225 16109766 14550746 17906064 10663392 16177239 16081117 19085960 17522070 10915739 10774834 12705907 11834606 16781746 12540782 12594235 19370779 11743745 16227642 14986274 16485898 11421492 12958197
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.3419107877
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.3415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004417 Dyspnea Chlorine 4.8020016425
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1117893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.133581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Diethylnitrosamine 13.7521071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.7515345470
MESH:D005234 Fatty Liver Tamoxifen 13.7514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D005739 Gas Poisoning Chlorine 5.1820016425
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3810048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0312621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Diethylnitrosamine 8.5918785209
MESH:D007249 Inflammation Tamoxifen 8.5919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5912200463 12878042
MESH:D007333 Insulin Resistance Sodium Selenite 3.3414714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2612587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.696582329
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6918625569
MESH:D008064 Lipidoses Tamoxifen 3.2315342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8818665156 20032147 19638242 18522880 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008107 Liver Diseases Acetaminophen 3.9916610002 12969438 19784758 16611625 19014921 19460945 11587558 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms ciprofibrate 11.0812771043
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.0820492335 20118626 16942905 2862719 15175105 20434301 19073162 21071580 19499222 19551842 19426721 19256749 19812893 19255062 19427195 21047994 21278145 19833225 18648771 15885732 20137499 19996281 20405173 20583210 20101389 18978307 12771043 9163691 20452335 18977376 18754104 2422723 12112319 19090486 19690152 19642983 19638242 21167192 19294768 19850985 10737359 20501860 18644402 19254457
MESH:D008113 Liver Neoplasms Tamoxifen 11.0816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.176587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.1718775883 19519916 16267830 17174075 19539802 17854601 18544905 18282651 19126423 9362446 18079962 16842330 18164116 3124819 19009564 19004024 18253720 18308698 18093689 17942915 21159647 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1712151625
MESH:D008171 Lung Diseases Ozone 3.458266340 19066396
MESH:D055370 Lung Injury Ozone 3.9920417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9421163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Ozone 4.947614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 4.9418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9411884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6911731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008679 Metaplasia Ozone 5.2810496685
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.703581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.709029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.7019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.526482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010538 Peritonitis Ozone 4.2716369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D011014 Pneumonia Ozone 4.5518929643 18007984 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.652563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2618760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D012120 Respiration Disorders Chlorine 5.3918579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.401399818 6582329 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.407505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.168074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.168653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018