AutismKB 2.0

Annotation Detail for RPL23A


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Basic Information Top
Gene Symbol:RPL23A ( FLJ27455,MDA20 )
Gene Full Name: ribosomal protein L23a
Band: 17q11.2
Quick LinksEntrez ID:6147; OMIM: 602326; Uniprot ID:RL23A_HUMAN; ENSEMBL ID: ENSG00000198242; HGNC ID: 10317
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in increased expression of RPL23A mRNAincreases expression 15135645
D000082 Acetaminophen Acetaminophen affects the expression of RPL23A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPL23A mRNAaffects expression 16483693
D002995 Clofibric Acid Clofibric Acid affects the expression of RPL23A mRNAaffects expression 17602206
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RPL23A mRNAaffects cotreatment|increases expression 17183730
D008727 Methotrexate RPL23A protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D017239 Paclitaxel RPL23A mRNA results in decreased susceptibility to Paclitaxeldecreases response to substance 16322897
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPL23A mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RPL23A mRNAdecreases expression 19465110
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RPL23A mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 16.0512039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.0514514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 16.058875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1417286800
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8615238991 18940202 16609825 17688650 17507914 17157402 18775368 18396377 19460635 18316065 20603192 19232924 18558336 18177632 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.438888407
MESH:D001859 Bone Neoplasms Paclitaxel 4.7915867366
MESH:D001943 Breast Neoplasms Methotrexate 2.0416978400
MESH:D001943 Breast Neoplasms Paclitaxel 2.0416244791 15136595 16273361 16115903 18223236 11325840 18234424 18323546
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.183084413
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 3.1816313753
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 12621046 15340226 15668235 16354765
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.989562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9820055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9817688650 8888407 16575769
MESH:D003550 Cystic Fibrosis Methotrexate 4.4319747007
MESH:D003882 Dermatomyositis Methotrexate 5.3620191521
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4516393943 14550746 16081117 11834606 2444490 19739265 16485898 11461765 12958197 18071297 17562736 10663392 19923254 11287661 15619225 19416960 19164858 16227642 11739529 12153990 11743745 14986274 16109766 12540782 12594235 11529661 19370779 12705907 10774834 10915739 19085960 17522070 18713872 11421492 16177239 15968718 19420014 14725611 12392966 17906064 16781746
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.4519641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.413659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.777562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.9316481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Valproic Acid 3.5019224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.378888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006086 Graft vs Host Disease Methotrexate 5.4116518429
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3618606429 16354765 15340226 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8816612254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D007805 Language Development Disorders Methotrexate 5.329562676
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008080 Liposarcoma Paclitaxel 5.0417353645
MESH:D008103 Liver Cirrhosis Methotrexate 3.8014986274
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6719784758 12587719 19014921 16610002 19460945 11587558 12969438 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms Clofibric Acid 4.7917602206
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D017563 Lung Diseases, Interstitial Methotrexate 12.5518516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 12.5517228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008223 Lymphoma Methotrexate 4.0917352296
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2614749477
MESH:D008545 Melanoma Paclitaxel 2.6116342250 12025231 12040289
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D052016 Mucositis Methotrexate 5.5717488658
MESH:D009101 Multiple Myeloma Paclitaxel 3.8314749477
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.3215867366
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2516359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D010014 Osteolysis Paclitaxel 5.2615867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0411161223
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4311118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.4320603192
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.8217136230 17172428 16729912 16356831
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D011565 Psoriasis Methotrexate 3.4917410198
MESH:D051437 Renal Insufficiency Methotrexate 4.9717352296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8714763951 15475178 16876388 11044598 1511512 3137016 11738929 17978042
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4418506536 18396642
MESH:D013576 Syndactyly Methotrexate 5.279562676
MESH:D024801 Tauopathies Paclitaxel 5.1016930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02494 - Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 - ANISOMYCIN
DB08437 - PUROMYCIN
DB08769 - N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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