AutismKB 2.0

Annotation Detail for RPL34


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Basic Information Top
Gene Symbol:RPL34 ( MGC111005 )
Gene Full Name: ribosomal protein L34
Band: 4q25
Quick LinksEntrez ID:6164; OMIM: NA; Uniprot ID:RL34_HUMAN; ENSEMBL ID: ENSG00000109475; HGNC ID: 10340
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RPL34 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPL34 mRNAaffects expression 16483693
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPL34 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPL34 mRNAaffects cotreatment|affects expression 17602206
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RPL34 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RPL34 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000236 Adenoma Diethylnitrosamine 3.0110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3616434500 17620307 19061943 17162532 18056438 19052882
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8616609825 19460635 18775368 18396377 17157402 15238991 18177632 19232924 17688650 20603192 17507914 18985861 18940202 18558336 18316065
MESH:D001714 Bipolar Disorder Valproic Acid 3.2120046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9716502159 20935162 19208518 19107877 20214788 16830150 17978847 16540662 16935385 18665156 3581430 20727157 19052882 18788625 16328049 18971187 18210153 17428255 19701751 20514400 19822196 20512989 19539802 19418558 17138121 18691550 3084413 16878318 17761372 20432363 16288022 16681979 19335982 16698587 21159647 17162532 17173139 18056438 16779866 11831363 20007298 10672840 19171122 19919837 18506893 19519916 18393292 17055752 19383236 18978308 20524982 16807293 16569478 18785209 20084675 18494052 19394651 10737359 20101231
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.067505956 17174075 21159647 2727394
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6617522070 12540782 16781746 16109766 17906064 16485898 11739529 11834606 18071297 12392966 14725611 10663392 16177239 12153990 15968718 16393943 18713872 14986274 19416960 12594235 11421492 19923254 10915739 2444490 12705907 12958197 14550746 15619225 19085960 10774834 11461765 16081117 11287661 19420014 19739265 17562736 11743745 11529661 19164858 19370779 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6619107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.6619641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.4416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0718234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.9820387270 21071580
MESH:D005234 Fatty Liver Valproic Acid 8.9814986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.0416612254
MESH:D007249 Inflammation Diethylnitrosamine 2.5218785209
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9818522880 18407596 20032147 19638242 18665156
MESH:D008107 Liver Diseases Acetaminophen 4.1216611625 19784758 12969438 11587558 19014921 16610002 19460945 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1217034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Clofibric Acid 5.0917602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.0921047994 21167192 20101389 19642983 20137499 19090486 16942905 20118626 18644402 19255062 20452335 19833225 18648771 19996281 19254457 20501860 19294768 19551842 19690152 9163691 21278145 18978307 19073162 2422723 12771043 15885732 19499222 20583210 19426721 18977376 12112319 10737359 19427195 20492335 15175105 20434301 19638242 20405173 19812893 19850985 18754104 2862719 19256749 21071580
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.8119126423 18308698 18544905 17942915 3124819 19009564 18079962 19519916 18775883 18164116 19004024 17174075 2563599 18282651 9362446 21159647 19539802 16842330 18253720 17854601 18093689 16267830
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 6695378 20512841 20970405
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008881 Migraine Disorders Valproic Acid 3.4118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.679029167 3581430
MESH:D009436 Neural Tube Defects Valproic Acid 3.328888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.0918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 9.0920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.0612752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.943137016 15475178 14763951 16876388 11044598 11738929 17978042 1511512
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.227505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D014581 Urticaria Acetaminophen 3.3310982225
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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