AutismKB 2.0

Annotation Detail for RPL37


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Basic Information Top
Gene Symbol:RPL37 ( DKFZp686G1699,MGC99572 )
Gene Full Name: ribosomal protein L37
Band: 5p13.1
Quick LinksEntrez ID:6167; OMIM: 604181; Uniprot ID:RL37_HUMAN; ENSEMBL ID: ENSG00000145592; HGNC ID: 10347
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of RPL37 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPL37 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of RPL37 mRNAincreases expression 20458559
D001554 Benzene Benzene results in decreased expression of RPL37 mRNAdecreases expression 15878777
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RPL37 mRNAincreases expression 19150397
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPL37 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPL37 mRNAaffects cotreatment|affects expression 17602206
D005472 Fluorouracil Fluorouracil results in decreased expression of RPL37 mRNAdecreases expression 16557594
C056507 gemcitabine gemcitabine results in increased expression of RPL37 mRNAincreases expression 17039268
C006253 pirinixic acid pirinixic acid results in decreased expression of RPL37 mRNAdecreases expression 16940010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPL37 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RPL37 mRNAdecreases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RPL37 mRNAincreases expression 15328365
18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.147525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6211798837 19825857
MESH:D000230 Adenocarcinoma Fluorouracil 4.6217638652
MESH:D000236 Adenoma Diethylnitrosamine 2.9310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 18.4619052882 19061943 18056438 16434500 17620307 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.4616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.4616835633
MESH:D000740 Anemia Fluorouracil 9.1215504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.1211748828
MESH:D000741 Anemia, Aplastic Benzene 4.4811369114 17661222 14761424
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.1216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.1219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001855 Bone Marrow Diseases Benzene 5.4516183116
MESH:D001943 Breast Neoplasms Benzene 2.4011921183 17162533
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.4017474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.4016110121 15136595 16557594 19217205 18357371 16595493 18608205
MESH:D001943 Breast Neoplasms gemcitabine 2.4018382427 17039268
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4020435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 8.5617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5616835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7514691202 15073043 11135700 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7518978308 10672840 18056438 17761372 16830150 20084675 18788625 18393292 16540662 18506893 16681979 20935162 18691550 16807293 17162532 19394651 19919837 11831363 16698587 16288022 18494052 17138121 20432363 18210153 16935385 19701751 20727157 19539802 16878318 19052882 16328049 17055752 20007298 17978847 19822196 17428255 19418558 20514400 20214788 19519916 20512989 18785209 19383236 3084413 16502159 17173139 16779866 19171122 18665156 19208518 16569478 10737359 20524982 20101231 19107877 21159647 18971187 3581430 19335982
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7517971768 18930000 16799960 17045692 17088986 16332177
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0718695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5217066447 16757204 16280240 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 16120746 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7114694615
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9920889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.997505956 2727394 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 15340226 8697196 15668235 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517287894 16510598 17725105 15001691 17018589 18772588 17169374 16340194 17172411 17016597
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5720501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5716282729 18288408 18802399 18509181 17094418 17016601 16391804 17401013 17695437 16331619 20501625 16303861 18448328 17255274 14970324 18949393 15289873 15148649 16524972 17594712 17454858 18383874
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.6115095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.6114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9210525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.9215643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9210048152 20055451 15322242
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003872 Dermatitis Benzene 4.9415902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.4921346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4620426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.4612903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.4616785472 16337965 16481741 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver arsenic trioxide 13.9415073043
MESH:D005234 Fatty Liver Diethylnitrosamine 13.9420387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 13.9419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4818337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006402 Hematologic Diseases Benzene 4.8016183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8519176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 8697196 16959395 18606429 15340226
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Benzene 5.4717940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4718670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 5.1218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4216985049
MESH:D007938 Leukemia arsenic trioxide 6.7815070760
MESH:D007938 Leukemia Benzene 6.7818335105 14694614 15935818 17119257
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.1719077051
MESH:D007951 Leukemia, Myeloid Benzene 10.1717506065
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.1817050201 16467208 16968895 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.1819478238
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.309834237 12679006 11468182 19642359 17107899 17217047 19035177 15748426 19225113 12712474 16966277 17712046 17869043 16331271 19075265 12018890 16112521 15336539 15622746 16330433 17649720 16891316 11161223 16823087 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8919638242 18665156 18407596 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1712878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms arsenic trioxide 18.6314682389
MESH:D008113 Liver Neoplasms Clofibric Acid 18.6317602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.6320137499 2422723 21278145 15885732 19256749 19996281 19812893 19833225 9163691 19427195 19426721 18977376 18754104 19254457 12771043 20118626 20405173 18978307 12112319 19642983 19690152 2862719 19499222 20501860 18644402 15175105 19638242 21167192 10737359 16942905 20492335 18648771 20452335 20583210 21071580 19255062 19551842 19073162 20434301 20101389 19294768 19850985 21047994 19090486
MESH:D008113 Liver Neoplasms Fluorouracil 18.6318383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 18.6320007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.6316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.8520377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.8512562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.8518544905 19519916 17942915 19004024 19009564 18164116 18079962 18253720 18775883 16267830 21159647 18282651 16842330 18093689 19539802 2563599 17174075 18308698 17854601 3124819 19126423 9362446
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D017563 Lung Diseases, Interstitial Benzene 5.0214698565
MESH:D008175 Lung Neoplasms arsenic trioxide 6.7619825857 11798837
MESH:D008175 Lung Neoplasms Benzene 6.7612562636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.7620970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 6.7615246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D008223 Lymphoma Benzene 3.8317584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.6412562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.3911921183
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7416757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 7.8214977855 15949261 19417148 11468182 19549372
MESH:D009101 Multiple Myeloma Benzene 7.8217119195
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2216105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms Fluorouracil 5.1916928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 5.1917405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.8210525206
MESH:D009436 Neural Tube Defects Benzene 7.8215643154
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.8514694615
MESH:D009784 Occupational Diseases Benzene 9.8517479406 15576619 15727169 15935809 17119257 15913788 17178637 15612468 16737584
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2319769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Benzene 5.2312562636
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.7715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.7716540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 12.7716500647 19003803 15113037 16929163
MESH:D010190 Pancreatic Neoplasms gemcitabine 12.7717440100 16929163 11504793 18992248 18383843
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11896295 11118676 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3119131511
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3119082440 18626508
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1418286688 18722050 16160472 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.8617007042
MESH:D013274 Stomach Neoplasms Benzene 4.8612562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.8618456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.8618567086 16424979 16951190 19084572 18396642 17522103 17498489 15786421 19015929 17172411
MESH:D013953 Thymus Neoplasms Benzene 5.1510850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5519014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.557505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5320435036 12973940 12845720 11780464
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D014594 Uterine Neoplasms Benzene 4.4912562636
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02494 - Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB04602 - PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE
DB04805 - Virginiamycin factor S1 Antibacterial Agents
DB07374 - ANISOMYCIN
DB08437 - PUROMYCIN
DB08769 - N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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