AutismKB 2.0

Annotation Detail for RPL37A


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Basic Information Top
Gene Symbol:RPL37A ( MGC74786 )
Gene Full Name: ribosomal protein L37a
Band: 2q35
Quick LinksEntrez ID:6168; OMIM: 613314; Uniprot ID:RL37A_HUMAN; ENSEMBL ID: ENSG00000197756; HGNC ID: 10348
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RPL37A mRNAdecreases expression 18648102
C065250 4-hydroxy-equilenin 4-hydroxy-equilenin results in increased expression of RPL37A mRNAincreases expression 15135645
D000082 Acetaminophen Acetaminophen affects the expression of RPL37A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPL37A mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RPL37A mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RPL37A mRNAincreases expression 19150397
C020711 beryllium sulfate beryllium sulfate results in increased expression of RPL37A mRNAincreases expression 16314022
C009160 cyclonite cyclonite results in increased expression of RPL37A mRNAincreases expression 19417177
D018684 Glycine Agents Glycine Agents results in increased expression of RPL37A mRNAincreases expression 16532367
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RPL37A mRNAaffects cotreatment|increases expression 17183730
D012643 Selenium Selenium results in decreased expression of RPL37A mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of RPL37A mRNAincreases expression 18175754
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RPL37A mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.648875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6617497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518940202 20603192 19232924 15238991 17688650 18316065 19460635 17507914 17157402 18775368 18396377 18985861 18177632 18558336 16609825
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.191440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.1320046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.478888407
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.863581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.863084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.897505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8920889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2319486331 9022650
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9412868966 8970840 2524372 18759878 14531868 11298694 11906362 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.612952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.356679447 6482804 1440618 11289319 18648102 18289764 16192314 9022650 8291058 18692083 7440962 9653073 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3516485898 12153990 16227642 11529661 12392966 10915739 14986274 12705907 19923254 14550746 10774834 17906064 11834606 12958197 11743745 19739265 11739529 16781746 12594235 14725611 19164858 11287661 16109766 11421492 16081117 17522070 19370779 10663392 16393943 19416960 18713872 18071297 2444490 11461765 15619225 15968718 19085960 12540782 16177239 19420014 17562736
MESH:D056486 Drug-Induced Liver Injury Selenium 12.3515131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.3515131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.351733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2917275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.093922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.686426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.473581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4720426865
MESH:D005234 Fatty Liver Valproic Acid 3.4114986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2618558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7616612254
MESH:D007251 Influenza, Human Selenium 4.3716624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3414714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.199022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.2615629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.066582329
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 12969438 12587719 16610002 19784758 11587558 19014921 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.591399818 6587162 598648 3712494
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8315318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D008881 Migraine Disorders Valproic Acid 3.2718765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.496679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.4916359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.524026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9820603192
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3818760546
MESH:D019310 Pseudolymphoma Valproic Acid 4.7111422049 12752131
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures cyclonite 6.9219417177
MESH:D012640 Seizures Valproic Acid 6.923137016 16876388 1511512 14763951 17978042 11044598 15475178 11738929
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.976582329 7505956 3712494 6587162 1399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.318074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014581 Urticaria Acetaminophen 3.0910982225
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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