AutismKB 2.0

Annotation Detail for RPL39


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Basic Information Top
Gene Symbol:RPL39 ( - )
Gene Full Name: ribosomal protein L39
Band: Xq24
Quick LinksEntrez ID:6170; OMIM: 601904; Uniprot ID:RL39_HUMAN; ENSEMBL ID: ENSG00000198918; HGNC ID: 10350
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of RPL39 mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen affects the expression of RPL39 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPL39 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RPL39 mRNAaffects expression 15963342
C099555 CD 437 CD 437 results in decreased expression of RPL39 mRNAdecreases expression 12958071
C017180 decamethrin RPL39 protein results in decreased susceptibility to decamethrindecreases response to substance 17092499
D005419 Flavonoids Flavonoids results in decreased expression of RPL39 mRNAdecreases expression 18035473
D019833 Genistein Genistein results in increased expression of RPL39 mRNAincreases expression 17341692
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RPL39 mRNAaffects cotreatment|increases expression 17183730
D015735 Mifepristone Mifepristone results in increased expression of RPL39 mRNAincreases expression 17584828
D012643 Selenium Selenium results in decreased expression of RPL39 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RPL39 mRNAdecreases expression 15716485
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RPL39 mRNAdecreases expression 11752688
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RPL39 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7015322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.708875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Genistein 2.5011473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518985861 18177632 17688650 16609825 18316065 18940202 18558336 19232924 20603192 19460635 17157402 18775368 17507914 15238991 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1120046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.198888407
MESH:D001943 Breast Neoplasms Genistein 2.0716873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8815721981 16124888 3786805 16097048 16227642 18705752 15700767 16011737 16192424 10355542 16050911 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.643084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6418788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.6416924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Genistein 3.3616332659
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 12621046 8697196 15340226 15668235
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities decamethrin 3.9819861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9816575769 8888407 17688650
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2616393943 11739529 19085960 12540782 14725611 19923254 17522070 19739265 16081117 11461765 11421492 19164858 16781746 19416960 16485898 11529661 19370779 18713872 17562736 11743745 12958197 2444490 15968718 12594235 17906064 14550746 12705907 19420014 10774834 12153990 10915739 10663392 15619225 16177239 14986274 18071297 16109766 11287661 11834606 12392966 16227642
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.264309450 16177239 3732212 16227642 7179309 2869522 9327722 7440962 15027814 21278145 17522070 19085960 6623471 15968718 15998439 10915739 6884620 10092053 3786805 19336974 7120509 11566570
MESH:D056486 Drug-Induced Liver Injury Selenium 12.2615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.261733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 18230668 15322242
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4111473722
MESH:D004715 Endometriosis Mifepristone 9.4116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.419294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.053922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.666426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1416045604 17595544 15959796 16239168 12631006 19224547 12795759 61145
MESH:D005234 Fatty Liver Valproic Acid 8.1414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0012621046 16120746 15340226
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1818606429 16959395 16354765 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7316612254
MESH:D007249 Inflammation Flavonoids 5.1317296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1312878042 12200463
MESH:D007251 Influenza, Human Selenium 4.3316624496
MESH:D007299 Insect Bites and Stings decamethrin 5.9315189238
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2415629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007938 Leukemia Genistein 3.0618980019 17468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8516221502 16943688 16239168 11408273 11903743 17157831 17334410 17174718 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5317698563 16248980 17976157 17869086 13678700 15730626 18006644 17481882 12741479 12445421 15650968 18251166 16033810 17714472 18205269 18412020 17922224 12958196 17900296 17525996 14620537 15818738 18481824 12632512 15925388 17761835 15996030 12632514 16097048 12546737 16015684 18472332 15123356 14748882 17823541 15876570 10355542 15338365 12666154 12667390 18279442 12649538 15057751 17631135 14724832 17557913 15370692 18418968 15052691 17766677 14512876 15673190 12586293 16192424 14716496 18187930 16027843 18277467 18054572 17640975 17944888 15931870 18317297 17708605 20821823 17805973 12445418 18472094 15959796 16136751 14716833 18156304 18263696 18210741 16116963 18395914 12389079 18376398 11481614 12898905 17565644 16638106 12609069 18395095 15893842 15362042 18166357 17721639 18420326 16011737 18705752 18339082 18429990
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5317823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008107 Liver Diseases Acetaminophen 3.9619784758 16610002 19460945 12587719 12969438 19014921 11587558 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9616964402 16246199 15830285 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.6716899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.4919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9212151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.3312929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3315318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D008881 Migraine Disorders Valproic Acid 3.2518803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2017596541
MESH:D009203 Myocardial Infarction Genistein 2.8917141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7217141266
MESH:D009421 Nervous System Malformations Genistein 9.9216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.9214600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.1816359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010051 Ovarian Neoplasms CD 437 8.2917474084
MESH:D010051 Ovarian Neoplasms Genistein 8.2919005980
MESH:D010051 Ovarian Neoplasms Mifepristone 8.2916525653
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8611118676 11399792 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.8620603192
MESH:D011471 Prostatic Neoplasms Genistein 3.4516925846 15378649 15256057
MESH:D019310 Pseudolymphoma Valproic Acid 4.6711422049 12752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.793137016 16876388 1511512 17978042 15475178 14763951 11738929 11044598
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms CD 437 3.4116720286
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34743
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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