AutismKB 2.0

Annotation Detail for RPLP1


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Basic Information Top
Gene Symbol:RPLP1 ( FLJ27448,MGC5215,P1,RPP1 )
Gene Full Name: ribosomal protein, large, P1
Band: 15q23
Quick LinksEntrez ID:6176; OMIM: 180520; Uniprot ID:RLA1_HUMAN; ENSEMBL ID: ENSG00000137818; HGNC ID: 10372
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
Pathway IDPathway Name
500526L13a-mediated translational silencing of Ceruloplasmin expression
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of RPLP1 mRNAdecreases expression 12958071
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RPLP1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RPLP1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPLP1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RPLP1 mRNAdecreases expression 20504355
C099555 CD 437 CD 437 results in decreased expression of RPLP1 mRNAdecreases expression 12958071
D004391 Dust Dust results in decreased expression of RPLP1 mRNAdecreases expression 17805423
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RPLP1 mRNAaffects cotreatment|increases expression 17183730
D017239 Paclitaxel RPLP1 mRNA results in decreased susceptibility to Paclitaxeldecreases response to substance 16322897
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RPLP1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.913712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.916695378
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618558336 16609825 17507914 20603192 15238991 18396377 17688650 18775368 18316065 18177632 17157402 19460635 18985861 18940202 19232924
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001859 Bone Neoplasms Paclitaxel 4.7515867366
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3220146248 17474063
MESH:D001943 Breast Neoplasms Paclitaxel 2.3218223236 16273361 18234424 16244791 16115903 15136595 18323546 11325840
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.743581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 4.7416313753
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.877505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.279022650 19486331
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 16575769 17688650
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0111298694 2524372 18759878 12868966 8970840 8156756 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.461440618 6679447 9328219 8291058 7440962 16192314 18648102 11289319 18289764 9653073 18692083 6482804 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.462444490 19420014 11287661 14986274 10663392 16485898 19164858 19370779 10915739 18071297 19923254 11461765 12153990 16227642 17906064 15968718 15619225 11834606 12594235 16781746 11739529 11421492 14550746 17562736 11529661 14725611 12705907 17522070 12540782 19085960 18713872 19416960 11743745 12392966 12958197 16393943 16109766 10774834 19739265 16177239 16081117
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.4619641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.523581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5216530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.5216481741
MESH:D005234 Fatty Liver Valproic Acid 3.4714986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3318558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.116582329
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008080 Liposarcoma Paclitaxel 5.0117353645
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 12587719 12969438 19784758 19460945 11587558 16611625 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0920195826 21137059
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.633712494 6587162 1399818 598648
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618569708 20869020 20464547 6695378 18816296 20135361 20064080 18520028 17053015
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2314749477
MESH:D008545 Melanoma Paclitaxel 2.6112025231 16342250 12040289
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma Paclitaxel 3.8114749477
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.163581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.1615867366
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.616679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.6116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010014 Osteolysis Paclitaxel 5.2215867366
MESH:D010051 Ovarian Neoplasms CD 437 5.6017474084
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.6011161223
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3517292933
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.3517136230 16356831 16729912 17172428
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.853137016 15475178 1511512 17978042 11044598 11738929 14763951 16876388
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4419755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6220155912 2093021
MESH:D013274 Stomach Neoplasms Paclitaxel 2.6218506536 18396642
MESH:D024801 Tauopathies Paclitaxel 5.0516930453
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.013712494 6582329 6587162 7505956 1399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.768074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7617053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 8.7616720286
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014581 Urticaria Acetaminophen 3.1610982225
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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