AutismKB 2.0

Annotation Detail for RPN1


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Basic Information Top
Gene Symbol:RPN1 ( DKFZp686B16177,OST1,RBPH1 )
Gene Full Name: ribophorin I
Band: 3q21.3
Quick LinksEntrez ID:6184; OMIM: 180470; Uniprot ID:RPN1_HUMAN; ENSEMBL ID: ENSG00000163902; HGNC ID: 10381
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa00510N-Glycan biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
No data
No data
Pathway IDPathway Name
500128Insulin Synthesis and Processing
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RPN1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of RPN1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPN1 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in increased expression of RPN1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RPN1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPN1 mRNAaffects cotreatment|increases expression 17942748
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of RPN1 mRNAincreases expression 16966085
D010269 Paraquat Paraquat results in increased expression of RPN1 mRNAincreases expression 15458575
C009277 sodium arsenate sodium arsenate results in increased expression of RPN1 mRNAincreases expression 16882884
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPN1 mRNAaffects cotreatment|increases expression 17942748
D014303 Trinitrotoluene Trinitrotoluene affects the expression of RPN1 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.3714514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.377525203
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.0011874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.893084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.8210977129
MESH:D002386 Cataract Trinitrotoluene 7.8215817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.2019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2016919318 17110522 15861022 17681005 16105132 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 16354765 8697196 12621046 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.7917141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.7915095906
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.8210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8210048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9618551238
MESH:D003490 Cyanosis Trinitrotoluene 11.9618551238
MESH:D003704 Dementia Methylmercury Compounds 5.1716140633
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5315968718 14725611 17906064 11529661 16109766 11743745 17522070 12540782 11834606 14550746 12392966 2444490 19739265 12153990 16227642 11461765 15619225 11739529 14986274 12705907 11421492 12594235 16081117 19370779 16177239 19923254 11287661 17562736 10915739 18071297 19420014 16393943 12958197 10774834 19085960 18713872 19164858 10663392 16781746 19416960 16485898
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 12.5318186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5320420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 12.5318551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 8.1519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 9.2112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005911 Gliosis Paraquat 5.4311124998
MESH:D018149 Glucose Intolerance sodium arsenate 5.2619446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4412621046 15340226 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 9.4415817613
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.9817937319
MESH:D007248 Infertility, Male Paraquat 11.984850670
MESH:D007248 Infertility, Male Trinitrotoluene 11.9812150543
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.108314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7612371664
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6611587558 19784758 16610002 12969438 19014921 19460945 16611625 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.567678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.076135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0712151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008569 Memory Disorders Methylmercury Compounds 5.1018436314
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009069 Movement Disorders Methylmercury Compounds 5.5118436314
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 5.0318186108
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.497678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 11.4918551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.8516893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects sodium arsenate 4.0619446573 18186108 10525206 11749123
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7616049721
MESH:D009784 Occupational Diseases Trinitrotoluene 9.7612819281 17852074 14694615
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010300 Parkinson Disease Paraquat 2.8716140633 11445065 16510128 11124998 12911755 11181820 15451049 15824117
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.6516190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D011014 Pneumonia Paraquat 4.6912504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 10.6918436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6911118676 11896295 11399792 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9717997886 16324872
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.0911700416
MESH:D012135 Respiratory Sounds Paraquat 4.2711874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration Paraquat 3.9916458197
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5818551238
MESH:D012640 Seizures Trinitrotoluene 6.5818551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013163 Splenomegaly Trinitrotoluene 5.4215817613
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3416049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
KEGG:00510 N-Glycan biosynthesis
KEGG:03050 Proteasome
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34777
    • No data
    No data
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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