AutismKB 2.0

Annotation Detail for RPN2


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Basic Information Top
Gene Symbol:RPN2 ( RIBIIR,RPN-II,RPNII,SWP1 )
Gene Full Name: ribophorin II
Band: 20q11.23
Quick LinksEntrez ID:6185; OMIM: 180490; Uniprot ID:RPN2_HUMAN; ENSEMBL ID: ENSG00000118705; HGNC ID: 10382
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa00510N-Glycan biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
No data
No data
Pathway IDPathway Name
500128Insulin Synthesis and Processing
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
hippocampal atrophy
Desease Name
Hippocampal atrophy
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RPN2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RPN2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RPN2 mRNAdecreases expression 18648102
D000638 Amiodarone Amiodarone affects the expression of RPN2 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPN2 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of RPN2 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RPN2 mRNAincreases expression 20127859
C006780 bisphenol A bisphenol A results in increased expression of RPN2 mRNAincreases expression 17010207
D002994 Clofibrate Clofibrate affects the expression of RPN2 mRNAaffects expression 19483382
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPN2 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of RPN2 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPN2 mRNAaffects cotreatment|affects expression 17602206
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RPN2 mRNAincreases expression 17010207
D004958 Estradiol Estradiol results in increased expression of RPN2 mRNAincreases expression 17010207
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RPN2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPN2 mRNAaffects cotreatment|increases expression 17942748
D005001 Ethionine Ethionine affects the expression of RPN2 mRNAaffects expression 19483382
D019833 Genistein Genistein results in increased expression of RPN2 mRNAincreases expression 17010207
D007657 Ketone Bodies Ketone Bodies results in increased expression of RPN2 mRNAincreases expression 16807920
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPN2 protein]affects binding|increases reaction 17220478
C025256 nonylphenol nonylphenol results in increased expression of RPN2 mRNAincreases expression 17010207
C474055 octylphenol octylphenol results in increased expression of RPN2 mRNAincreases expression 17010207
D009853 Omeprazole Omeprazole affects the expression of RPN2 mRNAaffects expression 19483382
D010269 Paraquat Paraquat results in increased expression of RPN2 mRNAincreases expression 15458575
C006253 pirinixic acid pirinixic acid affects the expression of RPN2 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of RPN2 mRNAaffects expression 19483382
C009277 sodium arsenate sodium arsenate results in increased expression of RPN2 mRNAincreases expression 16882884
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPN2 mRNAaffects cotreatment|increases expression 17942748
D013853 Thioacetamide Thioacetamide affects the expression of RPN2 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.6220464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 9.6211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.6214692618
MESH:D000230 Adenocarcinoma Genistein 9.6211473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.313712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.316695378
MESH:D000236 Adenoma Diethylnitrosamine 10.316695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.8417162532 19052882 17620307 16434500 19061943 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.8416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.8416835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5211874814
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5920041841 18057881 18218290
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5115885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.7218651412 19698954
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.771440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 53.9819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 53.9819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 53.9819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 53.9819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 53.9819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 53.9819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 53.9819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 53.9812125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 53.9819483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001862 Bone Resorption bisphenol A 3.6411985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6020146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 3.6017123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6017474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.6017129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 3.6017289903 19861407 12948864 14630087 18497071 17018787 16675129 17261762
MESH:D001943 Breast Neoplasms Genistein 3.6016873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6020435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.0816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 19.0816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 19.083581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 19.081701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 19.0819418558 20007298 18978308 19701751 16830150 16328049 17428255 18210153 11831363 19539802 20514400 16288022 16698587 17978847 16878318 18393292 16540662 16569478 19107877 19822196 10737359 16502159 10672840 16779866 19919837 17173139 20935162 20214788 16807293 19335982 18056438 19208518 16935385 21159647 19519916 20727157 18691550 19171122 16681979 18506893 18665156 3581430 20101231 19052882 18788625 3084413 20524982 17138121 17162532 17761372 18785209 20512989 20084675 19394651 19383236 18494052 17055752 20432363 18971187
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 19.0816924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.0816924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 19.0816924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 19.0817997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.7417123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.567296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2318850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8119225199 15710769
MESH:D002318 Cardiovascular Diseases Genistein 3.1416332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8418974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 24.186135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 24.187505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 24.181399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 24.1812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 24.182727394 17174075 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 24.1818566989
MESH:D002637 Chest Pain Omeprazole 4.8615447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.9319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.9316835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.9318291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.7419486331 9022650
MESH:D002779 Cholestasis Cyclosporine 17.7419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.7416919318 15861022 17681005 17110522 16105132 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 17.7419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0012621046 16354765 15668235 15340226 8697196
MESH:D003110 Colonic Neoplasms Genistein 2.2517182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D019465 Craniofacial Abnormalities sodium arsenate 2.7010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7010048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3216002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.0918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.0918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5711906362 8156756 14531868 18759878 12868966 11298694 2524372 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.263621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7320387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2119279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 20.9221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 20.9218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 20.929022650 6679447 6482804 9653073 18289764 8291058 18692083 18648102 11289319 1440618 7440962 16192314 9328219
MESH:D056486 Drug-Induced Liver Injury Amiodarone 20.9218218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 20.9219107877
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 20.9218186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 20.9220420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 20.9212963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.1017151854 21218061 15991576 16613094
MESH:D050171 Dyslipidemias Clofibrate 3.8916707586
MESH:D004487 Edema pirinixic acid 5.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9512538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.0716402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.0716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.6016804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 11.6019148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 11.6011473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.819294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8716302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.143581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005218 Fat Necrosis Thioacetamide 5.4716456712
MESH:D005234 Fatty Liver Amiodarone 27.8514986274
MESH:D005234 Fatty Liver Clofibrate 27.8519224547
MESH:D005234 Fatty Liver Cyclosporine 27.8519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 27.8521071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.8515345470
MESH:D005234 Fatty Liver pirinixic acid 27.8519236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5116513791 16534752 16611131 16002989 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.776705139
MESH:D005355 Fibrosis Cyclosporine 7.6812168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.6820067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Genistein 3.1016598420
MESH:D005911 Gliosis Paraquat 4.9111124998
MESH:D018149 Glucose Intolerance sodium arsenate 4.8519446573
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.817505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3517276928 15929193 18665440
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.676705139
MESH:D006505 Hepatitis Thioacetamide 8.6716456712
MESH:D006529 Hepatomegaly Amiodarone 13.0215265979
MESH:D006529 Hepatomegaly pirinixic acid 13.0219772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0216120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.808697196 18606429 15340226 16354765 16959395
MESH:D006937 Hypercholesterolemia Amiodarone 3.658137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.0315034207
MESH:D006965 Hyperplasia Diethylstilbestrol 10.0314722030 12960047
MESH:D006973 Hypertension Cyclosporine 4.6310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6318670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 10.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.4416569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.8117991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.8118031379 8137927
MESH:D007246 Infertility Diethylstilbestrol 4.1215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2017937319
MESH:D007248 Infertility, Male Paraquat 6.204850670
MESH:D007249 Inflammation Diethylnitrosamine 4.4818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.4812878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 11.4016393666
MESH:D007333 Insulin Resistance Estradiol 11.4016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.4016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.778074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases Cyclosporine 5.4718776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 5.4715618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 26.5216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 26.5216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 26.526582329
MESH:D007680 Kidney Neoplasms Cyclosporine 26.5212371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 26.5215003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 26.5215610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8217184923
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9019248655
MESH:D007938 Leukemia Genistein 2.9017468513 18980019
MESH:D008064 Lipidoses Amiodarone 3.3415342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.6918407596 18522880 19638242 18665156 20032147
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.049327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.3917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3912878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.3918263696 15288472 12891558 11172339 12531686 17355460 16511523 15474484 15075984 15095483 18615449 17629604 12557150 18032466 16489207 11682029 16248980 17292413 14739098 17050028 17127702 18395095 15288473 16126171 18458672 18380797 15465738 15078482 15716488 15316131 18031379 18295389 10677585 16343077 15158331 15334695 18416461 12679928 11481614 16098781 15362042 12085344 16097051 12175628 18606216
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D008107 Liver Diseases Thioacetamide 4.0818374380 16337175 15158337
MESH:D017114 Liver Failure, Acute Thioacetamide 4.1015313186 15633222 17276928 12479984
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.457678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.4521137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 20.4517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.4512771043 2862719 20101389 15885732 18644402 20583210 19812893 9163691 19638242 19850985 20452335 19833225 19499222 2422723 12112319 18978307 19427195 19255062 20137499 20434301 21047994 19256749 19690152 19642983 18754104 19090486 21278145 20405173 19426721 21071580 19254457 21167192 18648771 10737359 18977376 20492335 19294768 19996281 16942905 20118626 15175105 19551842 19073162 20501860
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.4515890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 20.4515890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.4516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.846135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.846587162 598648 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.8419126423 2563599 18544905 9362446 3124819 18282651 18079962 18093689 18775883 17854601 19004024 19539802 19009564 18308698 21159647 16267830 18164116 17942915 18253720 17174075 16842330 19519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.8412151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3917391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.2112587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2318516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.1817053015 20135361 18520028 6695378 20064080 18816296 20869020 18569708 20464547
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.1820512841 21163286 6695378 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.1819555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3015700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2716002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.5716891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.5714578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.2319453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.6318186108
MESH:D009181 Mycoses Amiodarone 4.6512754197 17974566
MESH:D009203 Myocardial Infarction Genistein 5.3317141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.3319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.0916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.0917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.0916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.5218551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.373581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.379029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 7.5311141357
MESH:D009369 Neoplasms Diethylstilbestrol 7.5315313581
MESH:D009369 Neoplasms pirinixic acid 7.5317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.5316893418
MESH:D009421 Nervous System Malformations bisphenol A 28.2411399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 28.2411399458
MESH:D009421 Nervous System Malformations Estradiol 28.2416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 28.2416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.2414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.036679447
MESH:D009436 Neural Tube Defects sodium arsenate 7.0310525206 11749123 18186108 19446573
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1420387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8720387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.709802331
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.8316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 13.8316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 13.834026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.773988306
MESH:D010024 Osteoporosis Genistein 3.1019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8616169203
MESH:D010049 Ovarian Diseases bisphenol A 4.7411985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.6419401270
MESH:D010051 Ovarian Neoplasms Genistein 4.6419005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.247296757
MESH:D010300 Parkinson Disease Paraquat 2.7215451049 16140633 12911755 16510128 11445065 11181820 11124998 15824117
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1916190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.226228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4315687265 16977796
MESH:D011014 Pneumonia Paraquat 4.2112504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.2612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.262563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.8510548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.8517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.8511896295 11118676 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8220887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8817136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8815256057 15378649 16925846
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5410548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.5212832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Paraquat 5.5216324872 17997886
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6811700416
MESH:D012135 Respiratory Sounds Paraquat 3.8211874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.313692021
MESH:D012162 Retinal Degeneration Paraquat 8.3116458197
MESH:D012640 Seizures 2,4-dinitrotoluene 5.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.3218551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8418724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.0910029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.0916192470
MESH:D013088 Spermatocele Diethylstilbestrol 10.8816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8816709447
MESH:D013272 Stomach Diseases Omeprazole 4.3718545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.2720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.2718456281
MESH:D013276 Stomach Ulcer Amiodarone 6.8518087811
MESH:D013276 Stomach Ulcer Omeprazole 6.8510750652 17977527 18237397 11906479 16755016 15991576
MESH:D019966 Substance-Related Disorders bisphenol A 3.7416684133 16045194
MESH:D013610 Tachycardia Amiodarone 4.0511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9519225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Amiodarone 11.2219731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.971399818 7505956 6587162 6582329 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.977505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 10.9715710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.6219584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D016171 Torsades de Pointes Amiodarone 3.9417467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.7616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.7616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.768074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.7617053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 14.7616712894 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.1710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.1710091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8216175088
MESH:D014591 Uterine Diseases bisphenol A 12.9814652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.9814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.6916690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6914692618
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
KEGG:00510 N-Glycan biosynthesis
KEGG:03050 Proteasome
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34778
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA449383docetaxel
    PA164743471adenosine triphosphate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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