AutismKB 2.0

Annotation Detail for RPS6


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Basic Information Top
Gene Symbol:RPS6 ( - )
Gene Full Name: ribosomal protein S6
Band: 9p22.1
Quick LinksEntrez ID:6194; OMIM: 180460; Uniprot ID:RS6_HUMAN; ENSEMBL ID: ENSG00000137154; HGNC ID: 10429
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04150mTOR signaling pathway
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Signaling by Insulin receptor
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
Pathway IDPathway Name
200099IL2 signaling events mediated by PI3K
200113ErbB1 downstream signaling
No data
Pathway IDPathway Name
500993S6K1 signalling
501016Formation of a pool of free 40S subunits
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1894Abortion
2176Tuberous sclerosis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL8 protein results in increased phosphorylation of RPS6 protein]decreases reaction|increases phosphorylation 17606477
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RPS6 mRNAincreases expression 18648102
C041594 4-nonylphenol 4-nonylphenol affects the expression of RPS6 mRNAaffects expression 15792627
D000082 Acetaminophen Acetaminophen affects the expression of RPS6 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of RPS6 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPS6 mRNAaffects expression 16483693
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPS6 mRNAaffects cotreatment|increases expression 15654877
D001553 Benzbromarone Benzbromarone affects the expression of RPS6 mRNAaffects expression 19483382
D020001 1-Butanol 1-Butanol inhibits the reaction [Serotonin results in increased phosphorylation of and results in increased activity of RPS6 protein]decreases reaction|increases activity|increases phosphorylation 18621911
C059041 calyculin A calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of RPS6 protein]decreases phosphorylation|decreases reaction 18790744
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RPS6 mRNAaffects expression 15963342
D002994 Clofibrate Clofibrate affects the expression of RPS6 mRNAaffects expression 19483382
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPS6 mRNAaffects cotreatment|affects expression 17602206
D003474 Curcumin calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of RPS6 protein]decreases phosphorylation|decreases reaction 18790744
D003474 Curcumin Curcumin results in decreased phosphorylation of RPS6 proteindecreases phosphorylation 18790744
D016572 Cyclosporine Cyclosporine results in increased expression of RPS6 mRNAincreases expression 20106945
C107676 deguelin deguelin metabolite results in decreased expression of RPS6 proteindecreases expression 19139008
C107676 deguelin deguelin metabolite results in decreased expression of RPS6 protein modified formdecreases expression 19139008
C107676 deguelin deguelin results in decreased expression of RPS6 proteindecreases expression 19139008
C107676 deguelin deguelin results in decreased expression of RPS6 protein modified formdecreases expression 19139008
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPS6 mRNAaffects cotreatment|affects expression 17602206
C444299 diindolylmethane diindolylmethane promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]increases expression|increases reaction 11179685
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPS6 mRNAaffects cotreatment|increases expression 15654877
D004958 Estradiol diindolylmethane promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]increases expression|increases reaction 11179685
D004958 Estradiol Estradiol results in increased expression of RPS6 mRNAincreases expression 11179685
D004958 Estradiol Estradiol results in increased phosphorylation of RPS6 proteinincreases phosphorylation 16033851
D004958 Estradiol everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6 protein]decreases reaction|increases phosphorylation 16033851
D004958 Estradiol Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]increases expression|increases reaction 11179685
D005001 Ethionine Ethionine affects the expression of RPS6 mRNAaffects expression 19483382
C107135 everolimus everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6 protein]decreases reaction|increases phosphorylation 16033851
C107135 everolimus everolimus results in decreased phosphorylation of RPS6 proteindecreases phosphorylation 16033851
C107135 everolimus [letrozole co-treated with everolimus] results in decreased phosphorylation of RPS6 proteinaffects cotreatment|decreases phosphorylation 16033851
D005419 Flavonoids Flavonoids results in decreased expression of RPS6 mRNAdecreases expression 18035473
D005978 Glutathione Glutathione deficiency results in increased expression of RPS6 mRNAincreases expression 15345336
D018684 Glycine Agents Glycine Agents results in decreased expression of RPS6 mRNAdecreases expression 16532367
D012701 Serotonin 1-Butanol inhibits the reaction [Serotonin results in increased phosphorylation of and results in increased activity of RPS6 protein]decreases reaction|increases activity|increases phosphorylation 18621911
D012701 Serotonin Serotonin results in increased phosphorylation of and results in increased activity of RPS6 proteinincreases activity|increases phosphorylation 18621911
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPS6 mRNAaffects cotreatment|increases expression 15654877
C067431 letrozole [letrozole co-treated with everolimus] results in decreased phosphorylation of RPS6 proteinaffects cotreatment|decreases phosphorylation 16033851
C067431 letrozole letrozole results in decreased phosphorylation of RPS6 proteindecreases phosphorylation 16033851
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to RPS6 protein]affects binding|increases reaction 17220478
D009853 Omeprazole Omeprazole affects the expression of RPS6 mRNAaffects expression 19483382
D010712 Phosphatidic Acids [Phosphatidic Acids results in increased phosphorylation of MTOR protein] which results in increased phosphorylation of RPS6 proteinincreases phosphorylation 18621911
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RPS6 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid affects the expression of RPS6 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of RPS6 mRNAaffects expression 19483382
C059514 resveratrol resveratrol results in decreased expression of and results in decreased phosphorylation of RPS6 proteindecreases expression|decreases phosphorylation 17554206
C059514 resveratrol resveratrol results in decreased expression of RPS6 proteindecreases expression 17534123
D020123 Sirolimus Sirolimus inhibits the reaction [IL8 protein results in increased phosphorylation of RPS6 protein]decreases reaction|increases phosphorylation 17606477
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]increases expression|increases reaction 11179685
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPS6 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RPS6 proteindecreases expression 16548065
D013853 Thioacetamide Thioacetamide affects the expression of RPS6 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4714514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D058186 Acute Kidney Injury resveratrol 3.5116538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma Estradiol 2.0011473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 9.913712494
MESH:D000236 Adenoma Diethylnitrosamine 9.916695378 10737359
MESH:D000236 Adenoma resveratrol 9.9115688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.0716434500 19052882 17620307 19061943 17162532 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.0716835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.8511874814
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6917887948
MESH:D000544 Alzheimer Disease Curcumin 4.1215590663
MESH:D000544 Alzheimer Disease resveratrol 4.1216183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D000799 Angioedema Acetaminophen 3.4610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4718057881 18218290 20041841
MESH:D001169 Arthritis, Experimental resveratrol 3.2617115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6416807698
MESH:D001259 Ataxia 1-Butanol 5.237820390
MESH:D050197 Atherosclerosis Curcumin 6.1518704882
MESH:D050197 Atherosclerosis resveratrol 6.1516873680 17967414
MESH:D001281 Atrial Fibrillation Amiodarone 3.6219698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 2.6918445737
MESH:D001321 Autistic Disorder Glutathione 2.6918929414 19267885 16917939 19056591
MESH:D001321 Autistic Disorder Serotonin 2.6918361446 8570775 19221690 17157402 18405062 18062943 15132762
MESH:D001321 Autistic Disorder Sirolimus 2.6921115397
MESH:D001327 Autoimmune Diseases Curcumin 4.1219761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.6311289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 51.5419483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 51.5419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 51.5419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 51.5419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 51.5419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 51.5419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 51.5419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 51.5412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 51.5419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D001919 Bradycardia Serotonin 5.098112388
MESH:D002545 Brain Ischemia Curcumin 9.0616770732
MESH:D002545 Brain Ischemia resveratrol 9.0617600658
MESH:D001932 Brain Neoplasms Curcumin 3.6117596214
MESH:D001943 Breast Neoplasms Curcumin 3.4916243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms deguelin 3.4918593368 17035597
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.4917474063
MESH:D001943 Breast Neoplasms Estradiol 3.4919861407 12948864 17289903 14630087 17261762 17018787 18497071 16675129
MESH:D001943 Breast Neoplasms letrozole 3.4916002280 17892469
MESH:D001943 Breast Neoplasms resveratrol 3.4916393696 17534123 17651959
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.4920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4115700767 15721981 16192424 16227642 10355542 18705752 3786805 15673190 16050911 16097048 16011737 16124888
MESH:D002277 Carcinoma Curcumin 7.2918593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.2916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 21.413581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 21.413084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 21.411701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 21.4118788625
MESH:D006528 Carcinoma, Hepatocellular deguelin 21.4118575727
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 21.4121159647 18971187 20935162 18506893 16540662 18393292 16779866 16288022 18785209 16502159 17428255 17055752 16830150 10672840 19335982 20101231 19822196 17173139 16698587 18056438 19539802 16328049 3581430 17761372 18978308 18665156 19701751 17978847 20524982 19418558 18210153 16681979 19394651 19208518 19519916 17162532 20084675 16878318 3084413 10737359 19052882 20214788 16807293 16935385 20007298 19383236 11831363 20432363 17138121 18788625 20512989 20514400 20727157 18691550 18494052 16569478 19107877 19171122 19919837
MESH:D006528 Carcinoma, Hepatocellular Estradiol 21.4116924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 21.4119321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 21.4119335982
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 21.4117997003
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2116675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8418414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.497296757
MESH:D002294 Carcinoma, Squamous Cell Curcumin 9.9318462866
MESH:D002294 Carcinoma, Squamous Cell Glutathione 9.9317015178
MESH:D002294 Carcinoma, Squamous Cell resveratrol 9.9316227395
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 9.9319435901
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1516120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7615710769 19225199
MESH:D002318 Cardiovascular Diseases resveratrol 3.2115458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7018974383
MESH:D002386 Cataract Acetaminophen 2.3610977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 18.307505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 18.301399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.3012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.3017174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.3018566989
MESH:D002637 Chest Pain Omeprazole 4.7215447763
MESH:D002659 Child Development Disorders, Pervasive Serotonin 4.0221254450
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.2719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.2716835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.2718291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 11.7519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 11.7519486331
MESH:D002779 Cholestasis pirinixic acid 11.7519176532
MESH:D021081 Chronobiology Disorders Serotonin 6.3017157402
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9415340226 15668235 8697196 16354765 12621046
MESH:D003092 Colitis Curcumin 8.5616782535 18200517 16804969
MESH:D003092 Colitis resveratrol 8.5616474422
MESH:D003103 Coloboma Curcumin 4.2118809619
MESH:D003110 Colonic Neoplasms Curcumin 3.7416340194 19359593
MESH:D003110 Colonic Neoplasms resveratrol 3.7416338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7417141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.5218497527
MESH:D003327 Coronary Disease resveratrol 3.5116507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 20055451 10048152
MESH:D003550 Cystic Fibrosis Glutathione 4.1619747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.452524372 14531868 8970840 8156756 11906362 18759878 11298694 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.143621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.4616873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.5118403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5117107852
MESH:D003928 Diabetic Nephropathies Curcumin 13.2518204486
MESH:D003928 Diabetic Nephropathies Estradiol 13.2519279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.2516286809
MESH:D003967 Diarrhea Serotonin 4.4111488427 10446763 8112388
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 16.746679447 18692083 8291058 7440962 9022650 9328219 18648102 1440618 11289319 16192314 18289764 9653073 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.7412705907 11834606 19420014 17522070 10663392 19923254 16485898 19085960 11529661 2444490 16781746 17906064 11461765 12958197 11743745 10915739 16393943 12594235 18713872 11421492 11739529 11287661 18071297 16081117 12153990 14986274 12392966 19739265 12540782 16177239 10774834 16109766 14725611 19164858 14550746 16227642 19370779 15968718 19416960 17562736 15619225
MESH:D056486 Drug-Induced Liver Injury Amiodarone 16.7418218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 16.746884620 15027814 21278145 6623471 7179309 9327722 16227642 15968718 17522070 7440962 10915739 16177239 4309450 3732212 2869522 10092053 11566570 19085960 3786805 15998439 7120509 19336974
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.7419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.7420420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 16.7412963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D004381 Duodenal Ulcer Curcumin 8.2917351913
MESH:D004381 Duodenal Ulcer Omeprazole 8.2921218061 17151854 16613094 15991576
MESH:D050171 Dyslipidemias Clofibrate 3.7916707586
MESH:D004487 Edema pirinixic acid 13.7412083418
MESH:D004487 Edema resveratrol 13.748985016
MESH:D004487 Edema Serotonin 13.7418841975
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5118230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.6717872969
MESH:D016889 Endometrial Neoplasms Estradiol 2.7318566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.6910568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4817923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7316302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.013581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7311564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3316456712
MESH:D005234 Fatty Liver Amiodarone 31.7514986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 31.7517595544 12631006 19224547 12795759 16239168 16045604 61145 15959796
MESH:D005234 Fatty Liver Clofibrate 31.7519224547
MESH:D005234 Fatty Liver Curcumin 31.7519297423
MESH:D005234 Fatty Liver Cyclosporine 31.7519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 31.7521071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 31.7519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.636705139
MESH:D005355 Fibrosis Carbon Tetrachloride 18.1018705752
MESH:D005355 Fibrosis Curcumin 18.1018705752
MESH:D005355 Fibrosis Cyclosporine 18.1012168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.1020067830
MESH:D005756 Gastritis Acetaminophen 3.2916983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3218462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.848708960
MESH:D005909 Glioblastoma Curcumin 3.2317596214
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.697505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.5018462866 18829502
MESH:D006258 Head and Neck Neoplasms Sirolimus 7.5019435901
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2318665440 17276928 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 13.636705139
MESH:D006505 Hepatitis Carbon Tetrachloride 13.6319110552 19900420
MESH:D006505 Hepatitis Thioacetamide 13.6316456712
MESH:D006529 Hepatomegaly Amiodarone 12.2715265979
MESH:D006529 Hepatomegaly pirinixic acid 12.2719772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.2715340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6717701891
MESH:D006558 Herpes Genitalis Estradiol 4.6415709030
MESH:D006561 Herpes Simplex resveratrol 3.8016876885
MESH:D019584 Hot Flashes Estradiol 3.3717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6615340226 18606429 16959395 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.4116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1516899240
MESH:D006937 Hypercholesterolemia Amiodarone 13.448137927 9751232
MESH:D006937 Hypercholesterolemia Curcumin 13.4418704882
MESH:D006937 Hypercholesterolemia resveratrol 13.4417188708
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006949 Hyperlipidemias resveratrol 3.6816873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5715034207
MESH:D006973 Hypertension Cyclosporine 4.4310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7215338365
MESH:D006984 Hypertrophy Sirolimus 4.8919211884
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9717488730
MESH:D007037 Hypothyroidism Amiodarone 10.3717991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.378137927 18031379
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.2717600658
MESH:D007248 Infertility, Male Atrazine 3.4612948887
MESH:D007249 Inflammation Curcumin 13.6917151092 18403477 16956363
MESH:D007249 Inflammation Diethylnitrosamine 13.6918785209
MESH:D007249 Inflammation Flavonoids 13.6917296493
MESH:D007249 Inflammation resveratrol 13.6916366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.6912878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0518200517 18596194
MESH:D007251 Influenza, Human resveratrol 4.1616624496
MESH:D007333 Insulin Resistance Estradiol 6.3616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.3616306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.8910783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.638074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 8.6712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 8.678314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 8.6715618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 10.596582329
MESH:D007680 Kidney Neoplasms Cyclosporine 10.5912371664
MESH:D007680 Kidney Neoplasms Estradiol 10.5915610895
MESH:D007889 Leiomyoma Curcumin 4.2218555241
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.7919248655
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6.2212970779
MESH:D007938 Leukemia Curcumin 6.2218462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8716106398
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.3316087638
MESH:D015458 Leukemia, T-Cell Curcumin 4.4016106398
MESH:D008064 Lipidoses Amiodarone 3.2415342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.8916943688 21278145 11903743 16239168 11408273 17334410 17174718 16221502 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.8920032147 19638242 18522880 18407596 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.0615123356 18166357 18006644 17976157 14620537 20821823 12898905 15052691 17557913 18472332 13678700 12958196 18210741 16097048 17922224 12632512 18279442 18705752 12389079 18481824 15876570 14716833 18395914 18317297 14512876 16033810 17805973 16116963 18472094 15057751 18412020 16015684 17766677 16011737 17698563 18277467 17761835 14748882 17721639 12609069 12666154 14724832 15818738 15650968 18187930 15893842 15931870 17944888 15370692 17565644 17869086 11481614 14716496 15996030 17525996 17900296 12632514 18395095 15673190 18263696 18205269 15959796 12445418 12741479 18429990 17631135 16027843 12586293 17714472 18420326 18418968 16192424 15730626 18054572 17640975 12546737 12667390 18376398 18156304 17823541 15338365 18251166 16136751 10355542 15925388 15362042 12445421 17708605 16638106 12649538 18339082 16248980 17481882
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 10.0618705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.0614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.0615474484
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 10.0617050028
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.0612878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 10.0612531686 18606216 18263696 18380797 17629604 15288472 15075984 18031379 12679928 15158331 15316131 12085344 12175628 16489207 15095483 16248980 14739098 16343077 17127702 17292413 15465738 15362042 18416461 12557150 17050028 16097051 18032466 10677585 15288473 15078482 18295389 11682029 18395095 18458672 16098781 11172339 15334695 16126171 11481614 12891558 15474484 17355460 15716488 16511523 18615449
MESH:D008107 Liver Diseases Acetaminophen 11.3416611625 19460945 19784758 12587719 12969438 11587558 16610002 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.3417285989 15830285 15720792 16964402 16246199
MESH:D008107 Liver Diseases Curcumin 11.3416956363
MESH:D008107 Liver Diseases Diethylnitrosamine 11.3417034775
MESH:D008107 Liver Diseases Thioacetamide 11.3415158337 18374380 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.3516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.3514706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 14.3515313186 17276928 15633222 12479984
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.9619294768
MESH:D008113 Liver Neoplasms Clofibric Acid 15.9617602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.9621278145 19690152 12771043 10737359 18977376 21071580 19812893 19427195 19642983 9163691 18978307 20405173 19850985 2862719 20101389 19996281 18648771 20583210 20452335 19256749 15885732 19255062 20137499 19426721 19551842 20492335 20118626 16942905 19638242 19833225 19294768 21047994 12112319 18644402 20434301 19073162 15175105 18754104 19254457 19499222 20501860 19090486 2422723 21167192
MESH:D008113 Liver Neoplasms pirinixic acid 15.9615890375 20007298 16377806
MESH:D008113 Liver Neoplasms resveratrol 15.9619321006 19073162 19812893 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.9616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.123712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.1212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.1218164116 21159647 16842330 18079962 9362446 16267830 18093689 19539802 18253720 18775883 19126423 18308698 18282651 17174075 3124819 17854601 19519916 19004024 17942915 2563599 19009564 18544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.1212151625
MESH:D008133 Long QT Syndrome Amiodarone 3.2915350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.1212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.0918516814
MESH:D008175 Lung Neoplasms Curcumin 4.5118462866 16243823 19359593
MESH:D008175 Lung Neoplasms deguelin 4.5119336726 16288123
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.516695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5119555203 11884234
MESH:D008223 Lymphoma Curcumin 3.3218462866
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9517088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.5614749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3216173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.8715688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.3316891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.3311606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.0919453300
MESH:D008545 Melanoma Curcumin 4.9318462866 17885582
MESH:D008545 Melanoma resveratrol 4.9317992120
MESH:D008545 Melanoma Sirolimus 4.9319282848
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2019513568
MESH:D008569 Memory Disorders Curcumin 3.7917263510
MESH:D008654 Mesothelioma Atrazine 3.371916698
MESH:D008659 Metabolic Diseases resveratrol 4.0417112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4016801185
MESH:D009062 Mouth Neoplasms Sirolimus 4.4219435901
MESH:D009101 Multiple Myeloma Curcumin 6.6719372569
MESH:D009101 Multiple Myeloma resveratrol 6.6717164350 16490592 17049120 16267019 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal Curcumin 11.1417962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 11.1417962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009181 Mycoses Amiodarone 4.5117974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 5.1819151258
MESH:D009203 Myocardial Infarction resveratrol 5.1816525036 17125593 17188708 16317513 17015251 16456233
MESH:D017202 Myocardial Ischemia resveratrol 8.0117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.0112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2816411023
MESH:D009205 Myocarditis resveratrol 4.3817322642
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0118495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.163581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.169029167 3581430
MESH:D009369 Neoplasms deguelin 4.8517764071
MESH:D009369 Neoplasms pirinixic acid 4.8517405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.638985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.1512497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.2611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2614600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.2418462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.676679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.2718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 12.2720387270
MESH:D019636 Neurodegenerative Diseases resveratrol 12.2717652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.0517929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7320387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.579802331
MESH:D009765 Obesity Curcumin 4.2519297423
MESH:D009765 Obesity pirinixic acid 4.2520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.096482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.633988306
MESH:D010024 Osteoporosis Curcumin 3.2318719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.9117513867
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 7.3016211241
MESH:D010051 Ovarian Neoplasms Curcumin 7.3019020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 7.3019401270
MESH:D010146 Pain Acetaminophen 2.1016870215
MESH:D010190 Pancreatic Neoplasms Curcumin 4.9319401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 4.9316540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.117296757
MESH:D010300 Parkinson Disease Atrazine 5.5217218051
MESH:D010300 Parkinson Disease Sirolimus 5.5219682553
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.086228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.8812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.882563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.3316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3311222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5420887781
MESH:D011471 Prostatic Neoplasms Curcumin 2.7915129424 18156803 10851300 18769126 12497104 11398177 18226269
MESH:D011471 Prostatic Neoplasms Estradiol 2.7916740699
MESH:D011471 Prostatic Neoplasms resveratrol 2.7917804756 15767336 17636462 17718901 17675339 16731767
MESH:D011565 Psoriasis Cyclosporine 2.0916882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.2019168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7012832656 12490602 11597910
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1916325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.9319058328
MESH:D015427 Reperfusion Injury resveratrol 5.9317520802 16314181 17058453 15827377 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.6818379247 10666014
MESH:D012135 Respiratory Sounds Atrazine 4.1511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.093692021
MESH:D012509 Sarcoma Curcumin 3.7918462866
MESH:D018805 Sepsis Curcumin 3.7718389075
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7018724381
MESH:D012878 Skin Neoplasms deguelin 8.6016041863
MESH:D012878 Skin Neoplasms resveratrol 8.6015837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.6016192470
MESH:D013272 Stomach Diseases Omeprazole 4.2318545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Amiodarone 10.2518087811
MESH:D013276 Stomach Ulcer Curcumin 10.2519188055 16631530
MESH:D013276 Stomach Ulcer Omeprazole 10.2510750652 11906479 16755016 18237397 15991576 17977527
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1516321402
MESH:D013610 Tachycardia Amiodarone 3.9311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8319225199
MESH:D013959 Thyroid Diseases Amiodarone 10.7619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.7612697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.376582329 3712494 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.377505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 10.3715710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.4919584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.3019048282
MESH:D014062 Tongue Neoplasms resveratrol 3.8816227395
MESH:D016171 Torsades de Pointes Amiodarone 3.8117467628 11989578
MESH:D014402 Tuberous Sclerosis everolimus 11.6018495876
MESH:D014402 Tuberous Sclerosis Sirolimus 11.6018495876 21115397
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.708074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 4.7018593936
MESH:D014565 Urogenital Neoplasms Curcumin 4.8818462866
MESH:D014581 Urticaria Acetaminophen 2.6310982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.7717473185
MESH:D014594 Uterine Neoplasms resveratrol 3.7817044934
MESH:D014605 Uveitis Cyclosporine 10.771336536
MESH:D014605 Uveitis Sirolimus 10.771336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.9317488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0517120751
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
KEGG:04910 Insulin signaling pathway
REACT:17015 Metabolism of proteins
KEGG:04150 mTOR signaling pathway
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
REACT:498 Signaling by Insulin receptor
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34844
    • No data
    Releated disease ID Related disease Name
    PA445537Retinitis Pigmentosa
    Releated drug ID Related drug Name
    PA451365sirolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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