AutismKB 2.0

Annotation Detail for RPS6KA1


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Basic Information Top
Gene Symbol:RPS6KA1 ( HU-1,MAPKAPK1A,RSK,RSK1 )
Gene Full Name: ribosomal protein S6 kinase, 90kDa, polypeptide 1
Band: 1p36.11
Quick LinksEntrez ID:6195; OMIM: 601684; Uniprot ID:KS6A1_HUMAN; ENSEMBL ID: ENSG00000117676; HGNC ID: 10430
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04010MAPK signaling pathway
hsa04150mTOR signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04114Oocyte meiosis
Pathway IDPathway Name
Synaptic Transmission
Signalling by NGF
Axon guidance
Signaling in Immune system
Pathway IDPathway Name
200182Trk receptor signaling mediated by the MAPK pathway
200189FGF signaling pathway
200188VEGFR3 signaling in lymphatic endothelium
200080mTOR signaling pathway
Pathway IDPathway Name
P00047PDGF signaling pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P00036Interleukin signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C097240 15-deoxy-delta(12,14)-prostaglandin J2 [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of RPS6KA1 proteinaffects cotreatment|decreases phosphorylation 16611854
C108123 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of RPS6KA1 protein]decreases reaction|increases phosphorylation 15772366
D000082 Acetaminophen Acetaminophen affects the expression of RPS6KA1 mRNAaffects expression 17562736
C103303 alitretinoin [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of RPS6KA1 proteinaffects cotreatment|decreases phosphorylation 16611854
C517975 AZD 6244 AZD 6244 results in decreased phosphorylation of RPS6KA1 proteindecreases phosphorylation 17876044
C517975 AZD 6244 Doxorubicin promotes the reaction [AZD 6244 results in decreased phosphorylation of RPS6KA1 protein]decreases phosphorylation|increases reaction 17876044
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased phosphorylation of RPS6KA1 proteinincreases phosphorylation 17003459
D020122 tert-Butylhydroperoxide U 0126 inhibits the reaction [tert-Butylhydroperoxide results in increased phosphorylation of RPS6KA1 protein]decreases reaction|increases phosphorylation 17003459
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of RPS6KA1 mRNAincreases expression 17032414
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of RPS6KA1 proteinincreases expression 17805973
C007262 deoxynivalenol 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of RPS6KA1 protein]decreases reaction|increases phosphorylation 15772366
C007262 deoxynivalenol deoxynivalenol results in increased phosphorylation of and results in increased activity of RPS6KA1 proteinincreases activity|increases phosphorylation 15976193
C007262 deoxynivalenol deoxynivalenol results in increased phosphorylation of RPS6KA1 proteinincreases phosphorylation 15772366
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of RPS6KA1 mRNAincreases expression 17032414
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of RPS6KA1 proteinincreases expression 17032414
D004317 Doxorubicin Doxorubicin promotes the reaction [AZD 6244 results in decreased phosphorylation of RPS6KA1 protein]decreases phosphorylation|increases reaction 17876044
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RPS6KA1 mRNAincreases expression 17942748
C067431 letrozole letrozole results in increased expression of and results in increased phosphorylation of RPS6KA1 proteinincreases expression|increases phosphorylation 15967659
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of RPS6KA1 mRNAdecreases expression 12057914
C015329 lycopene lycopene results in decreased expression of RPS6KA1 proteindecreases expression 17337101
C040015 myricetin myricetin inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KA1 protein]decreases reaction|increases phosphorylation 17693661
C040015 myricetin myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KA1 protein]decreases reaction|increases phosphorylation 17693661
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RPS6KA1 mRNAaffects binding|increases activity|increases expression 19710929
C059514 resveratrol resveratrol results in decreased phosphorylation of RPS6KA1 proteindecreases phosphorylation 16979140
D017975 Ruthenium Compounds Ruthenium Compounds results in decreased activity of RPS6KA1 proteindecreases activity 16858717
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of RPS6KA1 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of RPS6KA1 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of RPS6KA1 mRNAdecreases expression 12760830
C017947 sodium arsenite sodium arsenite results in decreased expression of RPS6KA1 proteindecreases expression 12760830
C016104 sodium bichromate sodium bichromate results in decreased expression of RPS6KA1 mRNAdecreases expression 12760830
D013755 Tetradecanoylphorbol Acetate myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KA1 protein]decreases reaction|increases phosphorylation 17693661
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KA1 proteinincreases phosphorylation 17693661
D014212 Tretinoin RPS6KA1 protein promotes the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]increases phosphorylation|increases reaction 16280361
C113580 U 0126 U 0126 inhibits the reaction [tert-Butylhydroperoxide results in increased phosphorylation of RPS6KA1 protein]decreases reaction|increases phosphorylation 17003459
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of RPS6KA1 mRNAaffects cotreatment|increases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D000168 Acrocephalosyndactylia U 0126 5.2817694057
MESH:D058186 Acute Kidney Injury resveratrol 3.6816538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.4511850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.4518653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 6.9016033868
MESH:D000230 Adenocarcinoma Doxorubicin 6.9017418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9014692618
MESH:D000236 Adenoma Dimethylnitrosamine 6.7719555203
MESH:D000236 Adenoma resveratrol 6.7715688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.2916434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7116712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.3621441931
MESH:D000505 Alopecia Tretinoin 3.4615955085
MESH:D000544 Alzheimer Disease resveratrol 2.5316162502 16183991
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.6015885639
MESH:D001169 Arthritis, Experimental resveratrol 11.6017115116
MESH:D001169 Arthritis, Experimental Tretinoin 11.6016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2916456186
MESH:D050197 Atherosclerosis resveratrol 3.1617967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.2216935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4019483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.4016206674 16197459
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5114601052
MESH:D002545 Brain Ischemia resveratrol 4.0917600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.6417150277
MESH:D001943 Breast Neoplasms alitretinoin 2.3416344269
MESH:D001943 Breast Neoplasms Doxorubicin 2.3417369602 18695136 15668708 15567936 18628466 19526202 16595493 16826403 17426702 15994142 18234424 15692762 16935488 18382427 11325840 15993339 16322301 16096432 17983394 15136595 15634643 16264153 16115903 15939500
MESH:D001943 Breast Neoplasms letrozole 2.3416002280 17892469
MESH:D001943 Breast Neoplasms resveratrol 2.3416393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tretinoin 2.3416166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4016813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.3015673190 18705752 16192424 16124888 3786805 10355542 16227642 16011737 15721981 16097048 15700767 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.3016050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6216051944
MESH:D002277 Carcinoma Dimethylnitrosamine 3.8719555203
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.613084413
MESH:D006528 Carcinoma, Hepatocellular AZD 6244 13.6117876044
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.6118788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 13.6116023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.6119321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.6116507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.611917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4016675471
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.071485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 17.3616033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 17.366189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 17.3616227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 17.3618572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 17.3618922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 17.3616096774 16051514
MESH:D009202 Cardiomyopathies Doxorubicin 3.4116269455 16278810 17928571 15811867 15505089 16612575 16651473 15792986 16731534 17007740 18627295 17329180 15476868 16455267 17924179 17131338 16109756 16364871 17974986 17382496 17308081 16242529 17519947 16952015 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8817334414 16243910
MESH:D002318 Cardiovascular Diseases resveratrol 3.3415458977
MESH:D002386 Cataract Acetaminophen 6.8610977129
MESH:D002386 Cataract Tretinoin 6.8617460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.8619524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4016129372
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2817110522 17681005 17333356 16105132 11677210 16919318 15861022
MESH:D002779 Cholestasis pirinixic acid 7.2819176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9716461808
MESH:D002972 Cleft Palate Tretinoin 2.599407595
MESH:D003092 Colitis resveratrol 14.9516474422
MESH:D003092 Colitis Selenium 14.9517936198
MESH:D003092 Colitis Tretinoin 14.9517035595
MESH:D003110 Colonic Neoplasms resveratrol 2.4316338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6918802399 18259882
MESH:D015179 Colorectal Neoplasms resveratrol 2.6916550006
MESH:D003327 Coronary Disease resveratrol 3.6316507316
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.6316925845 17551590 9142499 10589399 8800419 9211117 9664655 14991402 9224671 9125849
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.6319769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6116873680
MESH:D003928 Diabetic Nephropathies resveratrol 3.8016286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.412444490 16081117 12594235 10663392 16485898 16781746 14986274 19085960 19164858 17906064 10774834 15968718 19420014 19416960 11529661 18713872 19923254 11461765 12958197 19739265 11743745 10915739 12540782 12705907 11739529 11287661 12392966 14725611 16393943 16109766 11421492 18071297 19370779 16177239 14550746 17522070 16227642 17562736 11834606 15619225 12153990
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.4111566570 10092053 16177239 6884620 7440962 6623471 17522070 15027814 15968718 7179309 2869522 3786805 4309450 15998439 16227642 10915739 9327722 3732212 19085960 7120509 19336974 21278145
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 11.418172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.4117416283
MESH:D056486 Drug-Induced Liver Injury Selenium 11.4115131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Doxorubicin 3.5318602426
MESH:C538011 Eales disease Vitamin E 4.519068938
MESH:D004487 Edema pirinixic acid 10.6012083418
MESH:D004487 Edema resveratrol 10.608985016
MESH:D004487 Edema Tetradecanoylphorbol Acetate 10.6015177302 7812673 16716910 9599246 11698051 8273558 8113982
MESH:D004489 Edema, Cardiac Tretinoin 4.2718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 15-deoxy-delta(12,14)-prostaglandin J2 14.4916844232
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.4912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.4917872969
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.1817359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.1816569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9618037988
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2015821434 17637181 15328337
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6617923197
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 2.8617016578
MESH:D005124 Eye Abnormalities Tretinoin 3.449664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.0461145 15959796 19224547 17595544 12795759 12631006 16045604 16239168
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.0415345470
MESH:D005234 Fatty Liver pirinixic acid 12.0419236843 20131406
MESH:D005334 Fever Lipopolysaccharides 3.8511852909 9205823
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1818705752
MESH:D005355 Fibrosis Tretinoin 8.1817994277
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4916452187
MESH:D005909 Glioblastoma Doxorubicin 11.4117150277
MESH:D005909 Glioblastoma myricetin 11.4119804834
MESH:D005909 Glioblastoma Tretinoin 11.4117312396
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.8616524712 15173396
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.4215692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.4216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 6.459664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 6.4516080930
MESH:D006331 Heart Diseases Doxorubicin 3.3517875725 17888722 18006777 16144979 16495754 12587719 16244372 16879835 16707910 16330681 18674790 16244371 14766674
MESH:D006333 Heart Failure Doxorubicin 11.1317481944
MESH:D006333 Heart Failure pirinixic acid 11.1320558911
MESH:D006333 Heart Failure Selenium 11.1317162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7315692506
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2216366002
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4119900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 2.8119772884 16221962 19176532 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6416490937 16863852
MESH:D006561 Herpes Simplex resveratrol 3.9916876885
MESH:D006689 Hodgkin Disease Doxorubicin 6.9517606976 18501091 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 6.9512676792
MESH:D019584 Hot Flashes Vitamin E 3.7814716179
MESH:D006930 Hyperalgesia Acetaminophen 7.1316870215
MESH:D006930 Hyperalgesia Tretinoin 7.1316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006937 Hypercholesterolemia resveratrol 3.8317188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006949 Hyperlipidemias resveratrol 3.8516873680
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1317488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4617600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2217937319
MESH:D007248 Infertility, Male sodium arsenite 6.2212646999 15346721
MESH:D007249 Inflammation Lipopolysaccharides 7.999205823 17255318 12878042 17237260 17963957
MESH:D007249 Inflammation resveratrol 7.9916366677
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 7.997812673 8273558 7562506 11698051 15177302
MESH:D007251 Influenza, Human resveratrol 17.5116624496
MESH:D007251 Influenza, Human Selenium 17.5116624496
MESH:D007251 Influenza, Human Vitamin E 17.5116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5817994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4517255318
MESH:D007569 Jaw Abnormalities Tretinoin 3.7315992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.4516144296
MESH:D007674 Kidney Diseases Acetaminophen 13.5615629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 13.5616775033 15369732 15699352
MESH:D007674 Kidney Diseases sodium arsenite 13.5620008137
MESH:D007674 Kidney Diseases Vitamin E 13.5612488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.4116707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.4116518626
MESH:D007938 Leukemia Tretinoin 2.6817143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9616085563
MESH:D007948 Leukemia, Monocytic, Acute U 0126 5.1116972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5319285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0519850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.3616087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.3616788101 15748426 17107899 17217047 17301526 19225113 16823087 16140955 19642359 16766008 17294898 16331271 16935935 19029980 17649720 17506722 16891316 12679006 19035177 17368321 17339181 17712046 17361223 9834237 19075265
MESH:D007970 Leukopenia Lipopolysaccharides 4.5115821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.179224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7011408273 11903743 17334410 17157831 21278145 17174718 16239168 16943688 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.5515893842 17698563 18481824 20821823 18205269 17481882 18166357 18054572 15730626 16638106 16116963 18420326 18279442 15931870 18317297 18277467 12632512 15959796 12632514 17557913 17708605 18472094 17525996 16033810 16248980 16015684 15338365 16136751 16027843 12445418 18210741 12649538 17944888 18376398 18418968 17869086 12586293 18251166 12667390 16097048 15057751 17714472 18705752 18395914 17721639 14748882 17631135 18472332 17565644 15052691 17640975 17823541 14724832 12666154 15996030 15370692 12741479 14512876 12958196 12546737 18429990 11481614 18156304 17900296 12445421 14716496 17805973 16011737 15362042 18412020 17766677 18395095 10355542 15925388 18339082 15818738 15673190 17922224 13678700 18006644 15123356 14620537 16192424 14716833 15876570 18263696 15650968 12609069 17761835 17976157 18187930 12389079 12898905
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 10.5517201889 16570917 18672772 18567088 15763062 16042886 16169303 15138612 14726149 17640959 18629640 15942678 14709902 12918455 15369754 17719030 18095165 17196135 14643895 15339415 15492853 15733078 14568256 18637143 17432682 15842777 17724770 17465448 16009107 15479170 15571005 18237412 15744066 15099470 17666798 16544323 15864749 18371158 15081153 15086199 17036385 14659978 17203207 16270385 15577212 15798949 15504291 15298665 17198567 15161499 18364076 18210741 17348192 15366600 15723089 17881167 16627068 17534399 16603200 15067225 15793283 12925901 15383259 15591649 18239293
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 10.5516439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.5512878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.5515474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.5516248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.5516169303
MESH:D008107 Liver Diseases Acetaminophen 3.7319784758 12969438 12587719 16611625 19460945 11587558 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.7315720792 17285989 16246199 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.3017185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.3016899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 15.3017457977
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.4819294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 13.4815890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 13.4816377806 15890375 20007298
MESH:D008113 Liver Neoplasms resveratrol 13.4820405173 19812893 19073162 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 13.4816712894 15276417
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.3315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 9.336150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.3316842330 17085340
MESH:D008171 Lung Diseases sodium arsenite 7.0219095001
MESH:D008171 Lung Diseases Vitamin E 7.0216863852
MESH:D055370 Lung Injury Lipopolysaccharides 3.8221114838
MESH:D008175 Lung Neoplasms alitretinoin 8.2616413115
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 8.2611884234 16061637 19555203
MESH:D008175 Lung Neoplasms Doxorubicin 8.2617418594 6189445
MESH:D008175 Lung Neoplasms sodium arsenite 8.2615276417 16712894 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 8.2611807781
MESH:D008175 Lung Neoplasms Vitamin E 8.2611062179
MESH:D008223 Lymphoma Doxorubicin 3.3316098063
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1217088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.3617654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 8.3614749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3815621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0615688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 13.3415458769
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 13.3411606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Selenium 13.3415318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 13.348985016
MESH:D008527 Medulloblastoma Tretinoin 2.7117453147
MESH:D008545 Melanoma Doxorubicin 9.4716827129
MESH:D008545 Melanoma resveratrol 9.4717992120
MESH:D008545 Melanoma Ruthenium Compounds 9.4717210701
MESH:D008545 Melanoma sodium arsenite 9.4719082730 16487513
MESH:D008545 Melanoma Tretinoin 9.4716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008591 Meningomyelocele Tretinoin 4.2416940565
MESH:D008654 Mesothelioma Doxorubicin 6.0417638057
MESH:D008654 Mesothelioma Selenium 6.0415107826
MESH:D008659 Metabolic Diseases resveratrol 4.2017112576
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3215792986
MESH:D052016 Mucositis Doxorubicin 4.6017415656
MESH:D009101 Multiple Myeloma resveratrol 3.3316267019 17049120 17164350 16490592 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9717596541
MESH:D009203 Myocardial Infarction Doxorubicin 9.0519429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 9.0519151258
MESH:D009203 Myocardial Infarction resveratrol 9.0517015251 16317513 17188708 17125593 16525036 16456233
MESH:D017202 Myocardial Ischemia resveratrol 3.8617125593 17015251
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8016411023
MESH:D009205 Myocarditis resveratrol 4.5717322642
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8818259882
MESH:D009369 Neoplasms alitretinoin 14.7616946489
MESH:D009369 Neoplasms lycopene 14.7617051425
MESH:D009369 Neoplasms pirinixic acid 14.7617405874
MESH:D009369 Neoplasms sodium arsenite 14.7611559025
MESH:D009369 Neoplasms Tretinoin 14.7616946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 8.608985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.6020056578
MESH:D009401 Nephrosis Doxorubicin 4.5816899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8415640375 16889571
MESH:D009421 Nervous System Malformations Tretinoin 3.599125849
MESH:D009436 Neural Tube Defects sodium arsenite 6.9012854658
MESH:D009436 Neural Tube Defects Tretinoin 6.909142499
MESH:D009447 Neuroblastoma Doxorubicin 3.1715555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.8417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2217929310
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0817513867
MESH:D012516 Osteosarcoma Doxorubicin 3.9615930896
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.6817306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 7.6816936753
MESH:D010051 Ovarian Neoplasms U 0126 7.6816211241
MESH:D010146 Pain Acetaminophen 6.0816870215
MESH:D010146 Pain Tretinoin 6.0816870215
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.2815976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.1112065085 18404319 18922899 8330346
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9617983394
MESH:D010954 Plasmacytoma Selenium 4.7015087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9617638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.3612224865 11605937
MESH:D017499 Porokeratosis alitretinoin 5.8116144296
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.9916679765
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9118437689 15749863 15897917 16888761 16868541 16729912
MESH:D011471 Prostatic Neoplasms lycopene 1.9117337101 15084515
MESH:D011471 Prostatic Neoplasms resveratrol 1.9117636462 16731767 17804756 15767336 17675339 17718901
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9116039940
MESH:D011471 Prostatic Neoplasms Vitamin E 1.9115084515
MESH:D011507 Proteinuria Tretinoin 3.4316636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1215861022 16919318
MESH:D011625 Pterygium Tretinoin 4.6016723453
MESH:D051437 Renal Insufficiency Doxorubicin 4.0317922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3916325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.2619058328
MESH:D015427 Reperfusion Injury resveratrol 6.2617520802 17058453 16317513 16314181 15827377
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6110835634
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9216116481 16283617
MESH:D012509 Sarcoma Doxorubicin 3.8215625365 17203757 16767912 18313854 15675481 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6017846226
MESH:D012871 Skin Diseases Vitamin E 2.3918709164
MESH:D012878 Skin Neoplasms Doxorubicin 21.3315692506
MESH:D012878 Skin Neoplasms resveratrol 21.3315837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 21.3318572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 21.338532709
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 21.338330346 12065085 18404319 11807781 8985016
MESH:D012878 Skin Neoplasms Tretinoin 21.3316467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3815625365 16767912 17203757
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7516709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6512854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.0812587719
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.6316033868
MESH:D013274 Stomach Neoplasms Tretinoin 2.6317261132
MESH:D020521 Stroke Vitamin E 3.3716517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3116321402
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013964 Thyroid Neoplasms 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 11.4316940797
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.4317909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 11.4316026305 17045167
MESH:D014062 Tongue Neoplasms resveratrol 9.3516227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.3516051514
MESH:D014376 Tuberculosis Tretinoin 3.1116040207
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.0217653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.0216452187 11723127 17306315 16712894
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 14.9217473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.9211813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.9216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8914692618
MESH:D014594 Uterine Neoplasms resveratrol 8.8917044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.4216752155
MESH:D014652 Vascular Diseases sodium arsenite 4.2317056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3715869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.7117678736 17334414 17638931 16364871
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.7117488730
MESH:D014820 Vitiligo Tretinoin 3.8716761959
MESH:D009396 Wilms Tumor Tretinoin 3.8116287080
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04150 mTOR signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:04114 Oocyte meiosis
KEGG:04914 Progesterone-mediated oocyte maturation
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34845
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04751 - Purvalanol A
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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