AutismKB 2.0

Annotation Detail for RPS6KA3


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Basic Information Top
Gene Symbol:RPS6KA3 ( CLS,HU-3,ISPK-1,MAPKAPK1B,MRX19,RSK,RSK2,S6K-alpha3,p90-RSK2,pp90RSK2 )
Gene Full Name: ribosomal protein S6 kinase, 90kDa, polypeptide 3
Band: Xp22.12
Quick LinksEntrez ID:6197; OMIM: 300075; Uniprot ID:KS6A3_HUMAN; ENSEMBL ID: ENSG00000177189; HGNC ID: 10432
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04010MAPK signaling pathway
hsa04150mTOR signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04114Oocyte meiosis
Pathway IDPathway Name
Synaptic Transmission
Signalling by NGF
Axon guidance
Signaling in Immune system
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200113ErbB1 downstream signaling
Pathway IDPathway Name
P00047PDGF signaling pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P00036Interleukin signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
2001Mental retardation
2082Ataxia telangiectasia
Desease Name
DEVELOPMENTAL
Coffin-Lowry syndrome.
No data
Desease Name
Coffin-Lowry syndrome
Mental retardation, X-linked nonspecific, type 19
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of RPS6KA3 mRNAdecreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RPS6KA3 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen results in decreased expression of RPS6KA3 mRNAdecreases expression 11793227
D000082 Acetaminophen Acetaminophen affects the expression of RPS6KA3 mRNAaffects expression 17562736
D001104 Arbutin Arbutin results in increased expression of RPS6KA3 mRNAincreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RPS6KA3 mRNAdecreases expression 20106945
D002110 Caffeine Caffeine results in decreased expression of RPS6KA3 mRNAdecreases expression 11793227
D002211 Capsaicin Capsaicin results in increased expression of RPS6KA3 proteinincreases expression 18991268
D016572 Cyclosporine Cyclosporine results in decreased expression of RPS6KA3 mRNAdecreases expression 20106945
C004742 daidzein daidzein results in increased expression of RPS6KA3 mRNAincreases expression 15757668
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of RPS6KA3 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of RPS6KA3 mRNAincreases expression 15757668
19619570
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPS6KA3 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in increased expression of RPS6KA3 mRNAincreases expression 15757668
C086566 glycitein glycitein results in increased expression of RPS6KA3 mRNAincreases expression 15757668
C015329 lycopene lycopene results in decreased expression of RPS6KA3 proteindecreases expression 17337101
C093973 PD 98059 PD 98059 inhibits the reaction [CXCL2 protein results in increased phosphorylation of RPS6KA3 protein]decreases reaction|increases phosphorylation 15608143
D011374 Progesterone Progesterone results in increased phosphorylation of RPS6KA3 proteinincreases phosphorylation 17055699
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of RPS6KA3 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RPS6KA3 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RPS6KA3 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPS6KA3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RPS6KA3 mRNAdecreases expression 19933214
D013853 Thioacetamide Thioacetamide results in decreased expression of RPS6KA3 mRNAdecreases expression 11793227
D014212 Tretinoin RPS6KA3 protein promotes the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]increases phosphorylation|increases reaction 16280361
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 8.4918926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.4914514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D058186 Acute Kidney Injury Capsaicin 4.4818460982
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.3920464547 20127859
MESH:D000230 Adenocarcinoma daidzein 13.3911473722
MESH:D000230 Adenocarcinoma Estradiol 13.3911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.3914692618
MESH:D000230 Adenocarcinoma Genistein 13.3911473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.473712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.476695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3216835633
MESH:D000505 Alopecia Capsaicin 9.4017569567
MESH:D000505 Alopecia Tretinoin 9.4015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.0716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.961440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.0512125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 15.0519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.0516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001919 Bradycardia Capsaicin 4.9918207255
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2817868700
MESH:D001930 Brain Injuries Progesterone 4.1915845082 15665606 15380490
MESH:D002545 Brain Ischemia Capsaicin 4.9119211983
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9320146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.9317289903 16675129 12948864 17018787 18497071 14630087 17261762 19861407
MESH:D001943 Breast Neoplasms Genistein 2.9316873071 16541309 17200150
MESH:D001943 Breast Neoplasms Progesterone 2.9317614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9320435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1016168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.267296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.263084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.2616924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.2616924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 11.2617997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.261917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5020419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5016051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases daidzein 7.6416332659
MESH:D002318 Cardiovascular Diseases Genistein 7.6416332659
MESH:D002386 Cataract Acetaminophen 7.1010977129
MESH:D002386 Cataract Tretinoin 7.1017460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.877505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.8712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.8718566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.3516835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.3518291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.1019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.1019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.1017110522 17681005 17333356 16105132 11677210 16919318 15861022
MESH:D002822 Choriocarcinoma Tretinoin 5.1016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6715668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.679407595
MESH:D038921 Coffin-Lowry Syndrome marker/mechanism
MESH:D003092 Colitis Tretinoin 3.6417035595
MESH:D003110 Colonic Neoplasms Genistein 2.2817182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D003371 Cough Capsaicin 5.1210350223
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.439664655 16925845 9125849 9211117 14991402 9224671 8800419 9142499 17551590 10589399
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.742524372 18759878 8970840 11298694 8156756 12868966 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.432952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 7.1816647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.1816647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.1817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4317187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.819328219 18692083 1440618 18648102 8291058 6482804 7440962 18289764 6679447 9653073 16192314 11289319 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.8116109766 18071297 19420014 19416960 17562736 16781746 16177239 16227642 16081117 19739265 19370779 11287661 15968718 18713872 19923254 14986274 2444490 12705907 12540782 17522070 15619225 10915739 12958197 11421492 10774834 14725611 11739529 17906064 19164858 11461765 16393943 11834606 11743745 12153990 12594235 10663392 12392966 11529661 14550746 16485898 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8120420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.8112963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004381 Duodenal Ulcer Capsaicin 4.6310671773 11535926
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.7618230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.7618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.8217692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.5316402032
MESH:D016889 Endometrial Neoplasms daidzein 17.4811473722
MESH:D016889 Endometrial Neoplasms Estradiol 17.4819148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 17.4811473722
MESH:D016889 Endometrial Neoplasms Tretinoin 17.4816569247
MESH:D004715 Endometriosis Progesterone 8.7316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.739294722 10568697
MESH:D007172 Erectile Dysfunction daidzein 4.9514972507
MESH:D004935 Esophageal Diseases Capsaicin 5.6419566590
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.303581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.6716938888 9664655
MESH:D005218 Fat Necrosis Thioacetamide 5.6616456712
MESH:D005234 Fatty Liver Cyclosporine 7.3719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.3715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D005355 Fibrosis Cyclosporine 14.3512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.3520067830
MESH:D005355 Fibrosis Tretinoin 14.3517994277
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005909 Glioblastoma Capsaicin 11.7818405923
MESH:D005909 Glioblastoma Genistein 11.7816598420
MESH:D005909 Glioblastoma Tretinoin 11.7817312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1016084493
MESH:D006356 Heartburn Capsaicin 5.6419566590
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.8920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8911294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.8914991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.5117276928 15929193 18665440
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 15.546705139
MESH:D006505 Hepatitis Caffeine 15.5411394713
MESH:D006505 Hepatitis Thioacetamide 15.5416456712
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8315340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 12.8416870215
MESH:D006930 Hyperalgesia Capsaicin 12.8417043245 17434803
MESH:D006930 Hyperalgesia Tretinoin 12.8416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5016778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006973 Hypertension Cyclosporine 8.5410903974
MESH:D006973 Hypertension daidzein 8.5417169123
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5418670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4417937319
MESH:D007249 Inflammation Capsaicin 8.2616956363
MESH:D007249 Inflammation Progesterone 8.2615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2612878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.9216627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.7017994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.968074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.7317551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Acetaminophen 9.7512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.7518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.7515618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.046582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.0412371664
MESH:D007680 Kidney Neoplasms Estradiol 12.0415610895
MESH:D007938 Leukemia Genistein 6.3017468513 18980019
MESH:D007938 Leukemia Tretinoin 6.3017143497
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 5.1716972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6419285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0717596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1119075265 16331271 17301526 17339181 17649720 17506722 17294898 17368321 17712046 19642359 16823087 16140955 16935935 19225113 16891316 17107899 9834237 19035177 16788101 19029980 17361223 12679006 17217047 16766008 15748426
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.269224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.6617823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6612878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.6618395095 12679928 18606216 15078482 12891558 15075984 16489207 17629604 18380797 12531686 15465738 18458672 17050028 15334695 18615449 16126171 10677585 11481614 15716488 15316131 18031379 14739098 16248980 11682029 12085344 15474484 12175628 16098781 16097051 15288472 18263696 16343077 17127702 18295389 12557150 15158331 17292413 15095483 16511523 17355460 15362042 11172339 18032466 15288473 18416461
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6616248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.6119460945 16611625 19014921 11587558 19784758 12587719 12969438 16610002
MESH:D008107 Liver Diseases Capsaicin 6.6116956363
MESH:D008107 Liver Diseases Thioacetamide 6.6115158337 16337175 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 9.4416871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 9.4417276928 15313186 12479984 15633222
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.2520195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.2516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.593712494 1399818 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.5912151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.1617053015 6695378 18520028 18569708 20464547 18816296 20869020 20064080 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.1619555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.7611807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.7614578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.7611408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008527 Medulloblastoma Tretinoin 2.7617453147
MESH:D008545 Melanoma Tretinoin 1.9316752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008591 Meningomyelocele Tretinoin 4.3616940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D009101 Multiple Myeloma Capsaicin 4.1117505005
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0417596541
MESH:D009203 Myocardial Infarction Genistein 2.8317141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.3417141266
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.443581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.2411141357
MESH:D009369 Neoplasms lycopene 8.2417051425
MESH:D009369 Neoplasms Tretinoin 8.2416946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2318481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 22.9216427766 11399458
MESH:D009421 Nervous System Malformations Genistein 22.9216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.9214600291
MESH:D009421 Nervous System Malformations Tretinoin 22.929125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.086679447
MESH:D009436 Neural Tube Defects Tretinoin 7.089142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D020078 Neurogenic Inflammation Capsaicin 5.0317961222
MESH:D009765 Obesity Capsaicin 3.3719056576
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.364026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D010024 Osteoporosis Genistein 3.2119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0216169203
MESH:D010051 Ovarian Neoplasms Estradiol 11.1419401270
MESH:D010051 Ovarian Neoplasms Genistein 11.1419005980
MESH:D010051 Ovarian Neoplasms Progesterone 11.1416525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 11.1416936753
MESH:D010146 Pain Acetaminophen 11.0216870215
MESH:D010146 Pain Capsaicin 11.0217043245 17084039 16996476 18987195 19081190 17434803
MESH:D010146 Pain Tretinoin 11.0216870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1417292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1416740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1415378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms lycopene 2.1415084515 17337101
MESH:D011507 Proteinuria Tretinoin 3.5416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7316723453
MESH:D015427 Reperfusion Injury Capsaicin 3.9319211983 18460982
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0416116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2119755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2116192470
MESH:D012878 Skin Neoplasms Tretinoin 9.2116467112
MESH:D012893 Sleep Disorders Caffeine 5.2519395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 5.0517225163
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.2215862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3320155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3317261132
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.6717997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.961399818 6587162 7505956 6582329 3712494
MESH:D013964 Thyroid Neoplasms Tretinoin 6.9616026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7316051514
MESH:D014376 Tuberculosis Tretinoin 3.1916040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.888074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.8817053015
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5516752155
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4815869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.9916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D009396 Wilms Tumor Tretinoin 3.9116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04150 mTOR signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:04114 Oocyte meiosis
KEGG:04914 Progesterone-mediated oocyte maturation
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34847
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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