AutismKB 2.0

Annotation Detail for RPS6KB1


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Basic Information Top
Gene Symbol:RPS6KB1 ( PS6K,S6K,S6K1,STK14A,p70(S6K)-alpha,p70-S6K,p70-alpha )
Gene Full Name: ribosomal protein S6 kinase, 70kDa, polypeptide 1
Band: 17q23.1
Quick LinksEntrez ID:6198; OMIM: 608938; Uniprot ID:KS6B1_HUMAN; ENSEMBL ID: ENSG00000108443; HGNC ID: 10436
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04150mTOR signaling pathway
hsa04350TGF-beta signaling pathway
hsa05221Acute myeloid leukemia
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signaling by Insulin receptor
Pathway IDPathway Name
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200012Insulin Pathway
200080mTOR signaling pathway
200084IGF1 pathway
200066Angiopoietin receptor Tie2-mediated signaling
200099IL2 signaling events mediated by PI3K
200072Regulation of Telomerase
200018IL4-mediated signaling events
200162a6b1 and a6b4 Integrin signaling
200112RXR and RAR heterodimerization with other nuclear receptor
200109Integrins in angiogenesis
200195TGF-beta receptor signaling
200057CDC42 signaling events
Pathway IDPathway Name
P00048PI3 kinase pathway
P00047PDGF signaling pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P04397p53 pathway by glucose deprivation
Pathway IDPathway Name
500993S6K1 signalling
500921S6K1-mediated signalling
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1889Hyperinsulinism
1934Cancer
2176Tuberous sclerosis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C046782 14,15-epoxy-5,8,11-eicosatrienoic acid 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 16286479
C097240 15-deoxy-delta(12,14)-prostaglandin J2 [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of and results in decreased activity of RPS6KB1 proteinaffects cotreatment|decreases activity|decreases phosphorylation 16611854
C097240 15-deoxy-delta(12,14)-prostaglandin J2 RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased expression of TGFB1 mRNA]affects cotreatment|decreases expression|decreases reaction 16611854
C097240 15-deoxy-delta(12,14)-prostaglandin J2 RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein]affects cotreatment|decreases phosphorylation|decreases reaction 16611854
C120227 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C120227 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C120227 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C439584 2-(4-hydroxyphenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)-benzyl)-1H-indol-5-ol 2-(4-hydroxyphenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)-benzyl)-1H-indol-5-ol results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 16954435
C439584 2-(4-hydroxyphenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)-benzyl)-1H-indol-5-ol temsirolimus promotes the reaction [2-(4-hydroxyphenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)-benzyl)-1H-indol-5-ol results in decreased phosphorylation of RPS6KB1 protein]decreases phosphorylation|increases reaction 16954435
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 14640974
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 15919668
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of RPS6KB1 proteinaffects cotreatment|decreases phosphorylation 18622747
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one U 0126 promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]decreases reaction|increases activity|increases phosphorylation|increases reaction 15919668
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 16179367
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 14769825
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of RPS6KB1 proteindecreases activity|decreases phosphorylation 10993886
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RPS6KB1 mRNAdecreases expression 18648102
C103303 alitretinoin [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of and results in decreased activity of RPS6KB1 proteinaffects cotreatment|decreases activity|decreases phosphorylation 16611854
C103303 alitretinoin RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased expression of TGFB1 mRNA]affects cotreatment|decreases expression|decreases reaction 16611854
C103303 alitretinoin RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein]affects cotreatment|decreases phosphorylation|decreases reaction 16611854
D013196 Dihydrotestosterone Dihydrotestosterone inhibits the reaction [FSHB protein results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 17510244
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPS6KB1 mRNAaffects expression 16483693
D047310 Apigenin Apigenin results in decreased expression of RPS6KB1 proteindecreases expression 15947208
C006632 arsenic trioxide arsenic trioxide results in decreased activity of RPS6KB1 proteindecreases activity 14633726
C006632 arsenic trioxide arsenic trioxide results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 18048359
C015001 arsenite arsenite results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 17038550
D001241 Aspirin Aspirin results in decreased phosphorylation of and results in decreased activity of RPS6KB1 proteindecreases activity|decreases phosphorylation 10993886
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12720544
C032036 bromobenzene bromobenzene results in increased expression of RPS6KB1 mRNAincreases expression 15056800
D020001 1-Butanol 1-Butanol inhibits the reaction [Serotonin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 18621911
D020001 1-Butanol 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 15255942
D020001 1-Butanol 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 15919668
D020001 1-Butanol 1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 15705590
D020001 1-Butanol 1-Butanol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 14769825
D002118 Calcium Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]affects reaction|increases activity|increases phosphorylation 12935885
D002217 Carbachol 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 15255942
D002217 Carbachol Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 proteinincreases activity|increases phosphorylation 15255942
D003474 Curcumin Curcumin results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 18790744
D003609 Dactinomycin 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 14640974
D003609 Dactinomycin Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 proteinincreases activity|increases phosphorylation 14640974
D003609 Dactinomycin PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]increases activity|increases phosphorylation|increases reaction 14640974
D003609 Dactinomycin PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]increases activity|increases phosphorylation|increases reaction 14640974
C107676 deguelin deguelin metabolite results in decreased expression of RPS6KB1 proteindecreases expression 19139008
C107676 deguelin deguelin results in decreased expression of RPS6KB1 proteindecreases expression 19139008
C011612 diethyl sulfate diethyl sulfate inhibits the reaction [EGF protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12960407
C011612 diethyl sulfate diethyl sulfate inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 12960407
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased phosphorylation of and results in increased activity of RPS6KB1 proteinincreases activity|increases phosphorylation 12971962
D004317 Doxorubicin NRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of RPS6KB1 protein]affects phosphorylation|affects reaction 15833803
D004958 Estradiol Estradiol results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 16033851
D004958 Estradiol everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 16033851
D000431 Ethanol Ethanol results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 18377926
D000431 Ethanol Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 12935885
C107135 everolimus everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 16033851
C063007 exoenzyme C3, Clostridium botulinum exoenzyme C3, Clostridium botulinum inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 14769825
D005419 Flavonoids Flavonoids results in increased expression of RPS6KB1 mRNAincreases expression 18035473
D005978 Glutathione Glutathione deficiency results in increased expression of RPS6KB1 mRNAincreases expression 15345336
D006632 Histamine 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
D006632 Histamine Histamine results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 11959800
D006632 Histamine PD 98059 inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
D006632 Histamine Pertussis Toxin inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
D006632 Histamine Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
D006632 Histamine Sirolimus inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
D006632 Histamine wortmannin inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 19451193
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of RPS6KB1 proteinincreases expression 18603805
D006861 Hydrogen Peroxide 1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 15705590
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of RPS6KB1 proteinincreases activity|increases phosphorylation 15705590
D012701 Serotonin 1-Butanol inhibits the reaction [Serotonin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 18621911
D012701 Serotonin PLD1 protein affects the reaction [Serotonin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]affects reaction|increases activity|increases phosphorylation 18621911
D012701 Serotonin Serotonin results in increased phosphorylation of and results in increased activity of RPS6KB1 proteinincreases activity|increases phosphorylation 18621911
C477872 IC 87114 IC 87114 results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 16179367
C097613 imatinib imatinib results in decreased expression of RPS6KB1 mRNAdecreases expression 19208803
C097613 imatinib imatinib results in decreased expression of RPS6KB1 proteindecreases expression 19208803
D007213 Indomethacin Indomethacin results in increased expression of RPS6KB1 mRNAincreases expression 18299717
C032881 lysophosphatidic acid lysophosphatidic acid results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 17919812
C032881 lysophosphatidic acid resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 17919812
C032881 lysophosphatidic acid 1-Butanol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 14769825
C032881 lysophosphatidic acid 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 14769825
C032881 lysophosphatidic acid exoenzyme C3, Clostridium botulinum inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 14769825
C032881 lysophosphatidic acid lysophosphatidic acid results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 14769825
D008727 Methotrexate Methotrexate results in increased expression of RPS6KB1 mRNAincreases expression 15120968
D009355 Neomycin Neomycin affects the phosphorylation of RPS6KB1 proteinaffects phosphorylation 16537399
C404397 NSC 680410 NSC 680410 results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 14647418
C115711 PD 173074 [PKI 166 co-treated with PD 173074] results in decreased activity of RPS6KB1 proteinaffects cotreatment|decreases activity 15377668
C093973 PD 98059 PD 98059 inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
C093973 PD 98059 PD 98059 inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
D037342 Pertussis Toxin Pertussis Toxin inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 17976640
D010656 Phenylephrine wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 17976640
D010656 Phenylephrine 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
D010656 Phenylephrine 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
D010656 Phenylephrine bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12720544
D010656 Phenylephrine Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]affects reaction|increases activity|increases phosphorylation 12935885
D010656 Phenylephrine DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 15757502
D010656 Phenylephrine Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 12935885
D010656 Phenylephrine [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 proteinincreases activity|increases phosphorylation 12935885
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 proteinincreases activity|increases phosphorylation 18562309
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 15795328
15757502
D010656 Phenylephrine Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12720544
D010656 Phenylephrine resveratrol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 18562309
D010656 Phenylephrine rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12720544
D010656 Phenylephrine SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]increases phosphorylation|increases reaction 15795328
D010656 Phenylephrine Sirolimus inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
D010656 Phenylephrine U 0126 inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
D010712 Phosphatidic Acids [Phosphatidic Acids results in increased phosphorylation of MTOR protein] which results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 18621911
D010712 Phosphatidic Acids Phosphatidic Acids results in increased phosphorylation of and results in increased activity of RPS6KB1 proteinincreases activity|increases phosphorylation 15255942
C410026 PKI 166 [PKI 166 co-treated with PD 173074] results in decreased activity of RPS6KB1 proteinaffects cotreatment|decreases activity 15377668
D011224 Prazosin Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12720544
D011433 Propranolol Propranolol results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 16537399
D011433 Propranolol Sirolimus inhibits the reaction [Propranolol results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 16537399
D011738 Pyrilamine Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
C059514 resveratrol resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 17919812
C059514 resveratrol resveratrol results in decreased expression of RPS6KB1 proteindecreases expression 17534123
C059514 resveratrol resveratrol results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 16979140
C059514 resveratrol resveratrol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 18562309
C059514 resveratrol resveratrol results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 18562309
C085746 rottlerin rottlerin affects the phosphorylation of RPS6KB1 proteinaffects phosphorylation 17976640
C085746 rottlerin rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 17976640
C085746 rottlerin rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12720544
C085746 rottlerin rottlerin results in decreased activity of RPS6KB1 proteindecreases activity 12720544
C093642 SB 203580 SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]increases activity|increases phosphorylation|increases reaction 10993886
C093642 SB 203580 Sodium Salicylate inhibits the reaction [SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]decreases reaction|increases activity|increases phosphorylation|increases reaction 10993886
D020123 Sirolimus Sirolimus inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
D020123 Sirolimus Sirolimus inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
D020123 Sirolimus Sirolimus inhibits the reaction [EGF protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12960407
D020123 Sirolimus Sirolimus inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 12960407
D020123 Sirolimus [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of RPS6KB1 proteinaffects cotreatment|decreases phosphorylation 18622747
D020123 Sirolimus Sirolimus inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 15919668
D020123 Sirolimus [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases activity|decreases reaction|increases activity|increases phosphorylation 15919668
D020123 Sirolimus Sirolimus results in decreased phosphorylation of and results in decreased activity of RPS6KB1 proteindecreases activity|decreases phosphorylation 17616671
15914125
D020123 Sirolimus Sirolimus results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 15782132
D020123 Sirolimus Sirolimus inhibits the reaction [Propranolol results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 16537399
D020123 Sirolimus Sirolimus inhibits the reaction [TSC1 gene mutant form results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 18495876
D020123 Sirolimus Sirolimus results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 16537399
D020123 Sirolimus Sirolimus inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
D020123 Sirolimus Sirolimus inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
D020123 Sirolimus Sirolimus inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
D020123 Sirolimus Sirolimus results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 16391472
D020123 Sirolimus Sirolimus results in decreased activity of RPS6KB1 proteindecreases activity 9836529
D020123 Sirolimus Sirolimus results in decreased phosphorylation of and results in decreased activity of RPS6KB1 proteindecreases activity|decreases phosphorylation 10993886
D012980 Sodium Salicylate Sodium Salicylate inhibits the reaction [SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]decreases reaction|increases activity|increases phosphorylation|increases reaction 10993886
D012980 Sodium Salicylate Sodium Salicylate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 10993886
D012980 Sodium Salicylate Sodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]affects cotreatment|increases activity|increases phosphorylation|increases reaction 10993886
D012980 Sodium Salicylate Sodium Salicylate results in decreased phosphorylation of and results in decreased activity of RPS6KB1 proteindecreases activity|decreases phosphorylation 10993886
C116890 SU 5416 SU 5416 results in decreased activity of RPS6KB1 proteindecreases activity 15474452
D013629 Tamoxifen [Tamoxifen results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 proteindecreases activity|decreases phosphorylation 19931998
D013629 Tamoxifen Tamoxifen results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 19931998
D013629 Tamoxifen [Tamoxifen results in increased activity of AKT1 protein] which results in increased activity of RPS6KB1 proteinincreases activity 20372086
C401859 temsirolimus temsirolimus promotes the reaction [2-(4-hydroxyphenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)-benzyl)-1H-indol-5-ol results in decreased phosphorylation of RPS6KB1 protein]decreases phosphorylation|increases reaction 16954435
C401859 temsirolimus temsirolimus results in decreased phosphorylation of RPS6KB1 proteindecreases phosphorylation 16033649
16954435
D013739 Testosterone [Testosterone results in increased activity of RAF1 protein] which results in increased activity of RPS6KB1 proteinincreases activity 20372086
D013755 Tetradecanoylphorbol Acetate RAF1 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KB1 protein]affects reaction|increases phosphorylation 17976640
D013755 Tetradecanoylphorbol Acetate rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 17976640
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KB1 proteinincreases phosphorylation 17976640
D013755 Tetradecanoylphorbol Acetate SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]increases activity|increases phosphorylation|increases reaction 10993886
D013755 Tetradecanoylphorbol Acetate Sodium Salicylate inhibits the reaction [SB 203580 promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]decreases reaction|increases activity|increases phosphorylation|increases reaction 10993886
D013755 Tetradecanoylphorbol Acetate Sodium Salicylate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 10993886
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of RPS6KB1 proteinincreases activity|increases phosphorylation 10993886
D014415 Tunicamycin Tunicamycin results in increased expression of RPS6KB1 mRNAincreases expression 17127020
C113580 U 0126 U 0126 inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 15919668
C113580 U 0126 U 0126 promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]decreases reaction|increases activity|increases phosphorylation|increases reaction 15919668
C113580 U 0126 U 0126 inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C113580 U 0126 U 0126 inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
C113580 U 0126 U 0126 inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]decreases reaction|increases activity 12411397
D014639 Vanadium PRKCA protein affects the reaction [Vanadium results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]affects reaction|increases activity|increases phosphorylation 14971662
D014639 Vanadium Vanadium results in increased phosphorylation of and results in increased activity of RPS6KB1 proteinincreases activity|increases phosphorylation 14971662
C009687 wortmannin wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
C009687 wortmannin wortmannin inhibits the reaction [Histamine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 11959800
C009687 wortmannin wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 12960407
C009687 wortmannin wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 17976640
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.8914745880
MESH:D015746 Abdominal Pain SU 5416 6.5512673719
MESH:D000014 Abnormalities, Drug-Induced Ethanol 6.8817676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 6.8812039119
MESH:D000015 Abnormalities, Multiple imatinib 4.6818322153
MESH:D000022 Abortion, Spontaneous imatinib 5.5618322153
MESH:D000138 Acidosis Ammonium Chloride 8.3518287403
MESH:D000138 Acidosis Ethanol 8.3511192467
MESH:D000168 Acrocephalosyndactylia U 0126 4.8517694057
MESH:D058186 Acute Kidney Injury resveratrol 3.2816538975
MESH:D000230 Adenocarcinoma arsenic trioxide 11.2711798837 19825857
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 11.2716033868
MESH:D000230 Adenocarcinoma Doxorubicin 11.2717418594
MESH:D000230 Adenocarcinoma Estradiol 11.2711473722
MESH:D000230 Adenocarcinoma Indomethacin 11.2716537180
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 12.703712494
MESH:D000236 Adenoma Dimethylnitrosamine 12.7019555203
MESH:D000236 Adenoma Indomethacin 12.7011497255
MESH:D000236 Adenoma resveratrol 12.7015688382
MESH:D000419 Albuminuria Doxorubicin 3.9321441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.6615451040 15451039
MESH:D019973 Alcohol-Related Disorders Curcumin 4.4317887948
MESH:D016301 Alveolar Bone Loss Indomethacin 4.7217225004
MESH:D000544 Alzheimer Disease Curcumin 5.6115590663
MESH:D000544 Alzheimer Disease Indomethacin 5.6117627676 15579461
MESH:D000544 Alzheimer Disease resveratrol 5.6116162502 16183991
MESH:D000853 Anophthalmos Ethanol 4.1915513904
MESH:D000987 Antisocial Personality Disorder Testosterone 5.207506515
MESH:D001008 Anxiety Disorders Ethanol 3.4911141031
MESH:D001014 Aortic Aneurysm Indomethacin 4.2410231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.2510388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.5617460149
MESH:D018771 Arthralgia Indomethacin 4.512160914
MESH:D001169 Arthritis, Experimental resveratrol 3.0817115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 6.4216807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 6.4211248219
MESH:D001172 Arthritis, Rheumatoid Methotrexate 6.4217286800
MESH:D001249 Asthma Histamine 3.6716387687
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.1620485159 12372130
MESH:D001259 Ataxia 1-Butanol 4.997820390
MESH:D050197 Atherosclerosis Curcumin 5.5418704882
MESH:D050197 Atherosclerosis resveratrol 5.5416873680 17967414
MESH:D001284 Atrophy marker/mechanism 16391472
MESH:D001321 Autistic Disorder Glutathione 2.6319056591 19267885 18929414 16917939
MESH:D001321 Autistic Disorder Propranolol 2.6318766980
MESH:D001321 Autistic Disorder Serotonin 2.6318405062 18361446 8570775 19221690 18062943 15132762 17157402
MESH:D001321 Autistic Disorder Sirolimus 2.6321115397
MESH:D001327 Autoimmune Diseases Curcumin 3.8719761891
MESH:D001477 Bartter Syndrome Indomethacin 4.3610684365
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.3611289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.1016206674
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 10.1314601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 10.1314601052
MESH:D001859 Bone Neoplasms imatinib 4.7315867366
MESH:D001919 Bradycardia Carbachol 19.9612411408
MESH:D001919 Bradycardia Phenylephrine 19.9615306635
MESH:D001919 Bradycardia Propranolol 19.966740701
MESH:D001919 Bradycardia Serotonin 19.968112388
MESH:D001929 Brain Edema Indomethacin 4.3711481608
MESH:D002545 Brain Ischemia Curcumin 13.4116770732
MESH:D002545 Brain Ischemia Indomethacin 13.4112524144
MESH:D002545 Brain Ischemia resveratrol 13.4117600658
MESH:D001932 Brain Neoplasms Aspirin 11.5615481559
MESH:D001932 Brain Neoplasms Curcumin 11.5617596214
MESH:D001932 Brain Neoplasms Doxorubicin 11.5617150277
MESH:D001943 Breast Neoplasms 2-(4-hydroxyphenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)-benzyl)-1H-indol-5-ol 14.1116954435
MESH:D001943 Breast Neoplasms alitretinoin 14.1116344269
MESH:D001943 Breast Neoplasms Apigenin 14.1117132221 16541309
MESH:D001943 Breast Neoplasms Aspirin 14.1115161893
MESH:D001943 Breast Neoplasms Curcumin 14.1119250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms deguelin 14.1118593368 17035597
MESH:D001943 Breast Neoplasms Doxorubicin 14.1115692762 15668708 15634643 19526202 16595493 17983394 15993339 17369602 15567936 16096432 16935488 15939500 17426702 11325840 16826403 18628466 16264153 16115903 18695136 15136595 15994142 18234424 18382427 16322301
MESH:D001943 Breast Neoplasms Estradiol 14.1112948864 19861407 17289903 17261762 18497071 16675129 17018787 14630087
MESH:D001943 Breast Neoplasms imatinib 14.1117614352
MESH:D001943 Breast Neoplasms Indomethacin 14.1117401462
MESH:D001943 Breast Neoplasms Methotrexate 14.1116978400
MESH:D001943 Breast Neoplasms resveratrol 14.1117651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 14.1119011961 19103187 19487384 11161223 19289846 19115204 16818667 19059307 20390343 19155303 18997820 20544844 15565566 18351453 18821012 19142967 21152245 16202921 17893378 20135344 17440819 18855134 18815881 16273361 19244106 18629630 15668708 19066611 19200415 18425577 19084267 17242785 19221464 18984771 17049068 16873071 20005174 19288272 19189212 20859285 21138602 17261762 19189210 19410462 20065188
MESH:D001943 Breast Neoplasms temsirolimus 14.1116954435
MESH:D001943 Breast Neoplasms Testosterone 14.1117261762
MESH:D001943 Breast Neoplasms Vanadium 14.1115565634
MESH:D001986 Bronchial Spasm Histamine 5.1718298128
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.7311589617
MESH:D002056 Burns Ethanol 9.3016374292
MESH:D002056 Burns Indomethacin 9.3010459503
MESH:D002100 Cachexia Indomethacin 4.3611239499 15141370 15625704 16537180
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8216111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.1616051944
MESH:D002277 Carcinoma Curcumin 7.0218593918
MESH:D002277 Carcinoma Dimethylnitrosamine 7.0219555203
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8819066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 22.533581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 22.5311135700 14691202 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular deguelin 22.5318575727
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 22.5316023760 18059187 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Estradiol 22.5316924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 22.5315289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 22.5316391822
MESH:D006528 Carcinoma, Hepatocellular resveratrol 22.5319321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 22.5319335982
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 22.5316924424
MESH:D006528 Carcinoma, Hepatocellular Vanadium 22.5316830150 16878318
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 9.3011053908
MESH:D018827 Carcinoma, Lewis Lung resveratrol 9.3016675471
MESH:D018276 Carcinoma, Medullary Indomethacin 4.7114736730 18791128 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7218414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.2219014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 8.827296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 8.8216201981 1485588
MESH:D002292 Carcinoma, Renal Cell Indomethacin 8.8217341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.5512490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 21.8218462866
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 21.8216033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 21.826189445
MESH:D002294 Carcinoma, Squamous Cell Glutathione 21.8217015178
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 21.8212636206 15482327
MESH:D002294 Carcinoma, Squamous Cell resveratrol 21.8216227395
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 21.8219435901
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 21.8218922899
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.0517572228
MESH:D006332 Cardiomegaly Ethanol 5.9719332462
MESH:D006332 Cardiomegaly Phenylephrine 5.9715728586 11179087 11754973 17287366 17124262 16170337
MESH:D009202 Cardiomyopathies Doxorubicin 3.0917308081 17974986 15476868 17924179 17131338 16952015 17329180 16242529 17351982 15811867 16269455 15792986 18627295 16109756 17519947 17382496 16364871 17928571 17007740 15505089 16612575 16731534 16455267 16651473 16278810
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.6916243910 17334414
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.0416936243
MESH:D002318 Cardiovascular Diseases resveratrol 6.0415458977
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 8.737505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 8.7318566989
MESH:D002471 Cell Transformation, Neoplastic Vanadium 8.7317174075
MESH:D002659 Child Development Disorders, Pervasive Serotonin 5.8621254450
MESH:D002659 Child Development Disorders, Pervasive Testosterone 5.8620678186
MESH:D002764 Cholecystitis Indomethacin 4.5111181007
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.669022650 19486331
MESH:D021081 Chronobiology Disorders Serotonin 6.0417157402
MESH:D002971 Cleft Lip Ethanol 3.2115513904
MESH:D002972 Cleft Palate Ethanol 2.8715513904
MESH:D003092 Colitis Curcumin 7.7318200517 16782535 16804969
MESH:D003092 Colitis resveratrol 7.7316474422
MESH:D003103 Coloboma Curcumin 3.9718809619
MESH:D003110 Colonic Neoplasms arsenite 11.8915037631
MESH:D003110 Colonic Neoplasms Aspirin 11.8912411196
MESH:D003110 Colonic Neoplasms Curcumin 11.8919359593 16340194
MESH:D003110 Colonic Neoplasms Indomethacin 11.8915637740 15786552 15625704 15936596 11260862 15963497
MESH:D003110 Colonic Neoplasms resveratrol 11.8916338953
MESH:D003110 Colonic Neoplasms Vanadium 11.8918155637
MESH:D015179 Colorectal Neoplasms arsenic trioxide 5.5320501625
MESH:D015179 Colorectal Neoplasms Aspirin 5.5317047198
MESH:D015179 Colorectal Neoplasms Doxorubicin 5.5318802399 18259882
MESH:D015179 Colorectal Neoplasms Indomethacin 5.5312606626 11197048 18059344 17054584
MESH:D015179 Colorectal Neoplasms resveratrol 5.5316550006
MESH:D016510 Corneal Neovascularization Curcumin 4.2718497527
MESH:D003327 Coronary Disease resveratrol 3.3116507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.5712609071
MESH:D018352 Coronavirus Infections Indomethacin 5.0617302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.7210525206
MESH:D019465 Craniofacial Abnormalities Ethanol 4.7215451039 15451040 11198716 19302082 10194807 15513904 11873399
MESH:D019465 Craniofacial Abnormalities imatinib 4.7218322153
MESH:D019465 Craniofacial Abnormalities Methotrexate 4.7212039119 9562676
MESH:D003550 Cystic Fibrosis Glutathione 7.3119747007
MESH:D003550 Cystic Fibrosis Methotrexate 7.3119747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5015213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.7419031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.2212868966 14531868 11906362 2524372 8156756 11298694 8970840 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.903621924 2952479
MESH:D003882 Dermatomyositis Methotrexate 4.5120191521
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.2416873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.5218403477
MESH:D003928 Diabetic Nephropathies Curcumin 16.9718204486
MESH:D003928 Diabetic Nephropathies Estradiol 16.9719279558
MESH:D003928 Diabetic Nephropathies resveratrol 16.9716286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.9719279558
MESH:D003967 Diarrhea Indomethacin 10.297237001 7907874
MESH:D003967 Diarrhea Serotonin 10.298112388 10446763 11488427
MESH:D003967 Diarrhea SU 5416 10.2912673719
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.119022650 6679447 16192314 18692083 8291058 9328219 18648102 7440962 9653073 18289764 6482804 11289319 1440618
MESH:D056486 Drug-Induced Liver Injury bromobenzene 12.1110092053 12628495
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 12.118172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.1117416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 12.1111566570
MESH:D056486 Drug-Induced Liver Injury Prazosin 12.1118071297
MESH:D004362 Drug Toxicity Doxorubicin 3.1818602426
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.5118446180 16133044 18043480 16326151 17190690 12774134
MESH:D004381 Duodenal Ulcer Curcumin 7.4017351913
MESH:D004381 Duodenal Ulcer Indomethacin 7.4011535926 17351913 17151854 10671773 16699067 11595431 17329845 17202747 11595415 11991626 17045617
MESH:D004417 Dyspnea SU 5416 5.2812649163 12673719
MESH:D004487 Edema Aspirin 28.2917259670
MESH:D004487 Edema bisindolylmaleimide I 28.298273558
MESH:D004487 Edema imatinib 28.2919703484
MESH:D004487 Edema Indomethacin 28.297907874 10653021 16100529 7990266 19703484 8273558 8985016
MESH:D004487 Edema resveratrol 28.298985016
MESH:D004487 Edema Serotonin 28.2918841975
MESH:D004487 Edema Sodium Salicylate 28.2910653021
MESH:D004487 Edema Tetradecanoylphorbol Acetate 28.297812673 15177302 16716910 8273558 11698051 8113982 9599246
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 15-deoxy-delta(12,14)-prostaglandin J2 12.0916844232
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 12.0917872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 12.0919031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 9.8817359293
MESH:D016889 Endometrial Neoplasms Estradiol 9.8818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 9.8816202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Indomethacin 3.5915652904
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.5018037988
MESH:D019446 Endotoxemia Indomethacin 3.8618509659
MESH:D004751 Enteritis Indomethacin 4.0910567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 10.2917980183
MESH:D020345 Enterocolitis, Necrotizing resveratrol 10.2917923197
MESH:D004802 Eosinophilia Histamine 11.7512689652
MESH:D004802 Eosinophilia Indomethacin 11.7511298111
MESH:D004802 Eosinophilia Pyrilamine 11.751355641
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 11.523581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 11.5212903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 11.5217016578
MESH:D004938 Esophageal Neoplasms Ethanol 11.5216704527
MESH:D004938 Esophageal Neoplasms Indomethacin 11.5211005569
MESH:D005221 Fatigue SU 5416 5.7412649163 12673719
MESH:D005234 Fatty Liver arsenic trioxide 18.6215073043
MESH:D005234 Fatty Liver arsenite 18.6218296743
MESH:D005234 Fatty Liver Curcumin 18.6219297423
MESH:D005234 Fatty Liver Ethanol 18.6219236843 18620774 16409862
MESH:D005234 Fatty Liver Tamoxifen 18.6219224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.0117920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8116709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.6610194807 16946407 15513904 15451040
MESH:D005334 Fever Indomethacin 3.5611852909 10431976 17627676
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.366705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.8914745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 15.9119069698
MESH:D018222 Fibromatosis, Aggressive imatinib 15.9117453242
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 15.9119069698
MESH:D005354 Fibrosarcoma Indomethacin 4.2510962813
MESH:D005355 Fibrosis arsenite 11.4618296743
MESH:D005355 Fibrosis Curcumin 11.4618705752
MESH:D005355 Fibrosis Indomethacin 11.4617994277
MESH:D005391 Firesetting Behavior Testosterone 5.207506515
MESH:D005499 Folliculitis Indomethacin 4.5111298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.6516904648
MESH:D005756 Gastritis Ethanol 9.3515046732
MESH:D005756 Gastritis Indomethacin 9.3515046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.0718462866
MESH:D005909 Glioblastoma Aspirin 17.5912870263
MESH:D005909 Glioblastoma Curcumin 17.5917596214
MESH:D005909 Glioblastoma Doxorubicin 17.5917150277
MESH:D005909 Glioblastoma Indomethacin 17.5912870263
MESH:D005909 Glioblastoma Testosterone 17.5917162496
MESH:D005910 Glioma Indomethacin 2.9316487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.7611849393
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.447505956
MESH:D006073 Gout Indomethacin 4.7111248219
MESH:D006086 Graft vs Host Disease Methotrexate 4.5216518429
MESH:D006261 Headache Aspirin 9.4515240983
MESH:D006261 Headache SU 5416 9.4512649163 12673719
MESH:D006258 Head and Neck Neoplasms Curcumin 14.8018462866 18829502
MESH:D006258 Head and Neck Neoplasms Doxorubicin 14.8015692506
MESH:D006258 Head and Neck Neoplasms Indomethacin 14.8015482327
MESH:D006258 Head and Neck Neoplasms Sirolimus 14.8019435901
MESH:D006331 Heart Diseases Doxorubicin 3.0217875725 18006777 16144979 16879835 16330681 17888722 18674790 16707910 16244371 12587719 16244372 16495754 14766674
MESH:D006333 Heart Failure Doxorubicin 6.4017481944
MESH:D006333 Heart Failure Propranolol 6.4020082655
MESH:D006394 Hemangiosarcoma Doxorubicin 3.3315692506
MESH:D006501 Hepatic Encephalopathy Indomethacin 3.9915633222
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 2.916705139
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.0715135802
MESH:D006529 Hepatomegaly Propranolol 4.4716371745
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.4117701891
MESH:D006558 Herpes Genitalis Estradiol 4.3815709030
MESH:D006561 Herpes Simplex resveratrol 3.5516876885
MESH:D006628 Hirsutism Testosterone 5.0017019078
MESH:D006689 Hodgkin Disease Doxorubicin 2.8815147373 18501091 17606976
MESH:D019584 Hot Flashes Estradiol 3.1017088409
MESH:D012001 Hyperacusis Aspirin 5.1115240983
MESH:D006930 Hyperalgesia Ethanol 10.4518783367
MESH:D006930 Hyperalgesia Indomethacin 10.4512727271
MESH:D006930 Hyperalgesia Prazosin 10.4512727271
MESH:D034321 Hyperamylasemia Indomethacin 5.0617883296
MESH:D017588 Hyperandrogenism Testosterone 4.6517019078
MESH:D006937 Hypercholesterolemia Curcumin 7.4718704882
MESH:D006937 Hypercholesterolemia resveratrol 7.4717188708
MESH:D006940 Hyperemia Indomethacin 4.3612524144
MESH:D006949 Hyperlipidemias Indomethacin 7.5317546600
MESH:D006949 Hyperlipidemias resveratrol 7.5316873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.3115034207
MESH:D006973 Hypertension Phenylephrine 2.8012717712 8949925
MESH:D006984 Hypertrophy Phenylephrine 9.0918502941 12791704
MESH:D006984 Hypertrophy Sirolimus 9.0919211884
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.7417488730
MESH:D007006 Hypogonadism Testosterone 4.1112002444
MESH:D007018 Hypopituitarism Testosterone 5.5517426086
MESH:D007022 Hypotension Propranolol 4.596740701
MESH:D007077 Ileal Diseases Indomethacin 4.3718306037 10574470
MESH:D007079 Ileitis Indomethacin 4.7110651667 10647630 16133968
MESH:D007174 Impulse Control Disorders Testosterone 5.207506515
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.7216133044
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.0217600658
MESH:D007249 Inflammation bisindolylmaleimide I 18.518273558
MESH:D007249 Inflammation Curcumin 18.5116956363 17151092 18403477
MESH:D007249 Inflammation Flavonoids 18.5117296493
MESH:D007249 Inflammation Indomethacin 18.517812673 3291741 12568917
MESH:D007249 Inflammation resveratrol 18.5116366677
MESH:D007249 Inflammation Tamoxifen 18.5119457130
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 18.518273558 7562506 7812673 11698051 15177302
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9118596194 18200517
MESH:D007251 Influenza, Human resveratrol 3.8916624496
MESH:D007333 Insulin Resistance Estradiol 2.5316627594 16393666
MESH:D007410 Intestinal Diseases Indomethacin 3.7015610444 15831440 11855677 11713966 10210152 11686837 17994277 17329856 18236018
MESH:D007414 Intestinal Neoplasms Curcumin 3.6610783313
MESH:D019586 Intracranial Hypertension Indomethacin 4.7215241188
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.369022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 3.8315513904
MESH:D007579 Jejunal Diseases Indomethacin 4.3716133968 18306037 10574470
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.0016144296
MESH:D007674 Kidney Diseases Doxorubicin 7.8716775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 7.8715618244
MESH:D007674 Kidney Diseases Indomethacin 7.8717190690
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.2116707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.2116518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 9.356582329
MESH:D007680 Kidney Neoplasms Estradiol 9.3515610895
MESH:D007680 Kidney Neoplasms Tamoxifen 9.3518625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.3916316344
MESH:D007805 Language Development Disorders Methotrexate 4.519562676
MESH:D007859 Learning Disorders Ethanol 3.5915451040
MESH:D007889 Leiomyoma Curcumin 3.9818555241
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.3811703811 12228301 10320625
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 8.5612970779
MESH:D007938 Leukemia arsenic trioxide 8.5615070760
MESH:D007938 Leukemia Curcumin 8.5618462866
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.5016085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 7.8517077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 7.8516106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 15.9716972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 15.9716972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 15.9716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 11.4014633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 11.4019208803 17301526 15107311 15748426
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 11.4016572323 15631656 10785260
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.0719077051
MESH:D007951 Leukemia, Myeloid imatinib 8.0717236224
MESH:D015470 Leukemia, Myeloid, Acute 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 7.5917077328 16467208
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 7.5916467208 17050201 19850784 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 7.5918360721
MESH:D015470 Leukemia, Myeloid, Acute SU 5416 7.5912649163
MESH:D015473 Leukemia, Promyelocytic, Acute 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 10.4717077328
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 10.4711161223 16331271 12679006 16112521 16823087 15748426 16966277 17712046 17649720 12018890 17217047 15336539 17869043 12712474 15622746 19642359 19225113 17107899 16330433 9834237 15213294 19035177 16891316 19075265 11468182
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 10.4716087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 9.6816882451
MESH:D015458 Leukemia, T-Cell Curcumin 9.6816106398
MESH:D007964 Leukocytosis Indomethacin 4.7216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.0617980183
MESH:D017880 Limb Deformities, Congenital Ethanol 3.3417676605
MESH:D008064 Lipidoses Tamoxifen 2.6815342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.0611479899
MESH:D008103 Liver Cirrhosis arsenite 9.0118296743
MESH:D008103 Liver Cirrhosis Ethanol 9.0115289165
MESH:D008103 Liver Cirrhosis Methotrexate 9.0114986274
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.4518295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.779327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 13.3417355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 13.3418637143 17666798 16603200 16009107 15793283 17036385 18239293 15067225 14659978 15081153 15504291 15366600 16627068 17640959 17203207 17724770 18629640 17201889 15744066 18237412 15138612 15479170 17534399 15339415 15577212 16042886 17881167 17432682 18567088 15763062 15591649 15383259 15723089 16270385 18210741 18364076 15161499 15864749 15798949 14643895 16169303 14709902 16570917 14726149 17348192 15942678 17198567 15571005 17465448 17196135 14568256 18672772 18371158 15298665 15369754 17719030 18095165 15733078 12918455 12925901 16544323 15842777 15099470 15086199 15492853
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 13.3416595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 13.3414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 13.3418166357
MESH:D008106 Liver Cirrhosis, Experimental imatinib 13.3416596278
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 13.3418194892
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 13.3417050028
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 13.3418564211
MESH:D008107 Liver Diseases Curcumin 2.4416956363
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.0317347304 17207112
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 3.8517457977
MESH:D008113 Liver Neoplasms arsenic trioxide 8.3614682389
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 8.363113478 15890375
MESH:D008113 Liver Neoplasms resveratrol 8.3620405173 19812893 19321006 19073162
MESH:D008113 Liver Neoplasms Tamoxifen 8.3616684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.151399818 598648 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.1520377131
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 14.1515603536 6150874 1848544
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.1517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Vanadium 14.1517174075
MESH:D008133 Long QT Syndrome arsenic trioxide 2.8515213294
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.3718516814
MESH:D008175 Lung Neoplasms alitretinoin 15.3316413115
MESH:D008175 Lung Neoplasms arsenic trioxide 15.3311798837 19825857
MESH:D008175 Lung Neoplasms arsenite 15.3316809336
MESH:D008175 Lung Neoplasms Curcumin 15.3318462866 19359593 16243823
MESH:D008175 Lung Neoplasms deguelin 15.3319336726 16288123
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 15.3319555203 16061637 11884234
MESH:D008175 Lung Neoplasms Doxorubicin 15.336189445 17418594
MESH:D008175 Lung Neoplasms Indomethacin 15.3316537180 11497255 11053908
MESH:D008175 Lung Neoplasms Tamoxifen 15.3318625569
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 15.3311807781
MESH:D008223 Lymphoma Curcumin 9.9618462866
MESH:D008223 Lymphoma Doxorubicin 9.9616098063
MESH:D008223 Lymphoma Methotrexate 9.9617352296
MESH:D016393 Lymphoma, B-Cell resveratrol 3.7117088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.1117654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.1114749477
MESH:D016399 Lymphoma, T-Cell Curcumin 9.4816173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 9.4815621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 7.8815688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 7.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 14.1915458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 14.1911807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 14.1911606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 14.1916827153 19196723 11731420 19196722 14580682
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 14.198985016
MESH:D020149 Manganese Poisoning Estradiol 10.4819453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.4819453300
MESH:D008545 Melanoma Curcumin 12.9318462866 17885582
MESH:D008545 Melanoma Doxorubicin 12.9316827129
MESH:D008545 Melanoma Histamine 12.9317709802
MESH:D008545 Melanoma resveratrol 12.9317992120
MESH:D008545 Melanoma Sirolimus 12.9319282848
MESH:D008545 Melanoma Tamoxifen 12.9312393984 19393235
MESH:D008545 Melanoma temsirolimus 12.9317508024
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.5415990972
MESH:D008569 Memory Disorders Curcumin 7.7317263510
MESH:D008569 Memory Disorders Ethanol 7.7318411066 15451040
MESH:D008654 Mesothelioma Doxorubicin 2.7617638057
MESH:D008659 Metabolic Diseases resveratrol 3.8017112576
MESH:D008881 Migraine Disorders Aspirin 6.4615240983
MESH:D008881 Migraine Disorders Indomethacin 6.4611903285
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.9215792986
MESH:D009062 Mouth Neoplasms Indomethacin 7.5412636206
MESH:D009062 Mouth Neoplasms Sirolimus 7.5419435901
MESH:D052016 Mucositis Doxorubicin 10.3917415656
MESH:D052016 Mucositis Methotrexate 10.3917488658
MESH:D009101 Multiple Myeloma arsenic trioxide 9.4415949261 11468182 19417148 14977855 19549372
MESH:D009101 Multiple Myeloma Curcumin 9.4419372569
MESH:D009101 Multiple Myeloma resveratrol 9.4416490592 17049120 17935668 14749477 17164350 16267019
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.2817962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.2817962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.8016105982 16882451
MESH:D009190 Myelodysplastic Syndromes SU 5416 6.8012649163
MESH:D009203 Myocardial Infarction Aspirin 7.8612692751
MESH:D009203 Myocardial Infarction Doxorubicin 7.8619429709 15857846
MESH:D009203 Myocardial Infarction resveratrol 7.8616317513 16456233 17015251 17125593 17188708 16525036
MESH:D017202 Myocardial Ischemia resveratrol 3.4917125593 17015251
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.7816810080
MESH:D009205 Myocarditis resveratrol 4.1217322642
MESH:D009325 Nausea Aspirin 4.5615240983
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.3016624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.3018495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 14.713581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 14.7118259882
MESH:D009362 Neoplasm Metastasis imatinib 14.7115867366
MESH:D009362 Neoplasm Metastasis Indomethacin 14.7111239499 11053908 16537180
MESH:D009362 Neoplasm Metastasis Tamoxifen 14.7119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2719410462
MESH:D009369 Neoplasms alitretinoin 6.8216946489
MESH:D009369 Neoplasms deguelin 6.8217764071
MESH:D009369 Neoplasms SU 5416 6.8217264769
MESH:D009374 Neoplasms, Experimental Indomethacin 7.3415625704 10663608
MESH:D009374 Neoplasms, Experimental resveratrol 7.348985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 14.6412497104
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 14.6417614352
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 14.6419200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic arsenite 8.0315738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.0317289903
MESH:D009401 Nephrosis Doxorubicin 4.1416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.4516889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 3.0516427766 11399458
MESH:D009423 Nervous System Neoplasms Curcumin 4.9818462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 5.776679447
MESH:D009436 Neural Tube Defects arsenic trioxide 5.7710525206
MESH:D009447 Neuroblastoma Doxorubicin 2.9015555623
MESH:D019636 Neurodegenerative Diseases Indomethacin 6.9812349958
MESH:D019636 Neurodegenerative Diseases resveratrol 6.9817652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.8117929310
MESH:D009765 Obesity Curcumin 2.5619297423
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.516374098
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.866482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.363988306
MESH:D010003 Osteoarthritis Aspirin 6.627009135
MESH:D010003 Osteoarthritis Indomethacin 6.627009135
MESH:D010014 Osteolysis imatinib 5.1015867366
MESH:D010024 Osteoporosis Calcium 6.1417882678
MESH:D010024 Osteoporosis Curcumin 6.1418719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.6617513867
MESH:D012516 Osteosarcoma Doxorubicin 3.5915930896
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 12.3016211241
MESH:D010051 Ovarian Neoplasms arsenic trioxide 12.3019769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 12.3019020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 12.3019401270
MESH:D010051 Ovarian Neoplasms U 0126 12.3016211241
MESH:D010146 Pain Aspirin 5.616995502 6363464
MESH:D010146 Pain Indomethacin 5.613291741 17440234 13679232 17627676
MESH:D010149 Pain, Postoperative Indomethacin 4.0318702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 10.0815580305
MESH:D010190 Pancreatic Neoplasms Curcumin 10.0819196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Ethanol 10.0812384795
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 10.0815976015
MESH:D010195 Pancreatitis Indomethacin 3.3415028970 17883296
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 12.037296757
MESH:D010212 Papilloma Hydrogen Peroxide 12.0312065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 12.0318404319 12065085 18922899 8330346
MESH:D010235 Paraganglioma arsenic trioxide 3.5719927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.0616537180
MESH:D010300 Parkinson Disease Sirolimus 3.4719682553
MESH:D020734 Parkinsonian Disorders Indomethacin 3.5612349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.0611903285
MESH:D010437 Peptic Ulcer Indomethacin 4.5111148446
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 4.9011156591
MESH:D010518 Periodontitis Indomethacin 4.2617225004
MESH:D020795 Photophobia Aspirin 5.1115240983
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.826228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.5017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.5017638057
MESH:D017499 Porokeratosis alitretinoin 5.3516144296
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.0912476293
MESH:D047928 Premature Birth Indomethacin 4.5017000239
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.5516679765
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.9420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 8.9420887781
MESH:D011471 Prostatic Neoplasms Apigenin 1.9817132221
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9819131511
MESH:D011471 Prostatic Neoplasms Curcumin 1.9818769126 11398177 12497104 18226269 18156803 10851300 15129424
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9815749863 15897917 16868541 18437689 16888761 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 1.9816740699
MESH:D011471 Prostatic Neoplasms resveratrol 1.9817636462 17718901 17675339 15767336 16731767 17804756
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9815067354
MESH:D011507 Proteinuria Indomethacin 3.5711849393
MESH:D011565 Psoriasis Methotrexate 3.1717410198
MESH:D011656 Pulmonary Emphysema Curcumin 3.9619168576
MESH:D051437 Renal Insufficiency Doxorubicin 8.4217922066
MESH:D051437 Renal Insufficiency Methotrexate 8.4217352296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.9316325855
MESH:D015427 Reperfusion Injury resveratrol 2.9217520802 16317513 16314181 17058453 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.4410666014 18379247
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.883692021
MESH:D012220 Rhinitis Aspirin 7.5912372130
MESH:D012220 Rhinitis Histamine 7.5912689652
MESH:D012509 Sarcoma Curcumin 7.7018462866
MESH:D012509 Sarcoma Doxorubicin 7.7018313854 17710206 16767912 17203757 15675481 15625365
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 13.8516646077
MESH:D012512 Sarcoma, Ewing's Dactinomycin 13.8514601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 13.8516326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.1517846226
MESH:D012640 Seizures Ethanol 2.749754883
MESH:D018805 Sepsis Curcumin 3.5418389075
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.5516631401
MESH:D012852 Sinusitis Phenylephrine 4.067327846
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.6412269725
MESH:D012878 Skin Neoplasms deguelin 14.3016041863
MESH:D012878 Skin Neoplasms Doxorubicin 14.3015692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 14.3012065085
MESH:D012878 Skin Neoplasms resveratrol 14.308985016 15837718
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 14.308985016 11807781 18404319 8330346 12065085
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.9417203757 15625365 16767912
MESH:D013088 Spermatocele Tamoxifen 3.6416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.4019457130
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.6212587719
MESH:D013272 Stomach Diseases Indomethacin 3.7818209964 17160473 10192188 17207306 16113693 16184426 17638125 10486359 18545984 10215738 15038085 16280098 15472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.4417007042
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 5.4416033868
MESH:D013274 Stomach Neoplasms Ethanol 5.4418456281
MESH:D013274 Stomach Neoplasms imatinib 5.4415786421
MESH:D013274 Stomach Neoplasms Indomethacin 5.4415609394
MESH:D013276 Stomach Ulcer Curcumin 8.9119188055 16631530
MESH:D013276 Stomach Ulcer Ethanol 8.919211565 9562338 16755016 11906479 17189318 17918041
MESH:D013276 Stomach Ulcer Indomethacin 8.9111595415 10878458 11145282 10750652 18181030 16169175 14567935 16150113 18209962 17918041 12467913 17977527 11595431 16631530 16934674 17895592 11729361 10423059 12498302 17135157 12500499 18543354 16252198 17657623 16397915 17627676 15104355 11906479 18299717 18193104 12077510 12787963 18237397 18431645 18087811 1323529 15138204 17654042 11523592 16755016 15255614 18726076
MESH:D020521 Stroke Aspirin 3.8616403987
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.9116321402
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.699754883
MESH:D013576 Syndactyly Methotrexate 4.429562676
MESH:D013927 Thrombosis Aspirin 8.2917672075
MESH:D013927 Thrombosis SU 5416 8.2912649163
MESH:D013964 Thyroid Neoplasms 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 21.5916940797
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 21.593712494 6582329 6587162 1399818 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 21.5919014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 21.5917909728 16010429
MESH:D013964 Thyroid Neoplasms imatinib 21.5916940797
MESH:D013964 Thyroid Neoplasms Indomethacin 21.5914736730 18791128 11352223
MESH:D013978 Tibial Fractures Estradiol 4.0319048282
MESH:D014062 Tongue Neoplasms resveratrol 3.6516227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.3215213294
MESH:D014402 Tuberous Sclerosis everolimus 10.7818495876
MESH:D014402 Tuberous Sclerosis Sirolimus 10.7818495876 21115397
MESH:D014456 Ulcer Indomethacin 4.2517380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.608074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.6011780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Curcumin 12.6018593936
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 12.6017653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.6016712894 17572228 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 4.6218462866
MESH:D014581 Urticaria Aspirin 7.7020485159 10982225
MESH:D014581 Urticaria Histamine 7.7018298128
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.5417473185
MESH:D014594 Uterine Neoplasms resveratrol 3.5317044934
MESH:D014605 Uveitis Sirolimus 4.981336536
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.2717638931 17678736 16364871 17334414
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.2717488730
MESH:D014839 Vomiting Indomethacin 4.0911897121
MESH:D014947 Wounds and Injuries lysophosphatidic acid 4.7815541073
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04012 ErbB signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04910 Insulin signaling pathway
KEGG:04150 mTOR signaling pathway
REACT:498 Signaling by Insulin receptor
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34851
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA10804imatinib
    PA451746tretinoin
    PA451365sirolimus
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    PA451283rosiglitazone
    PA450395metformin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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