AutismKB 2.0

Annotation Detail for RPS6KB2


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Basic Information Top
Gene Symbol:RPS6KB2 ( KLS,P70-beta,P70-beta-1,P70-beta-2,S6K-beta2,S6K2,SRK,STK14B,p70(S6K)-beta,p70S6Kb )
Gene Full Name: ribosomal protein S6 kinase, 70kDa, polypeptide 2
Band: 11q13.2
Quick LinksEntrez ID:6199; OMIM: 608939; Uniprot ID:KS6B2_HUMAN; ENSEMBL ID: ENSG00000175634; HGNC ID: 10437
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04150mTOR signaling pathway
hsa04350TGF-beta signaling pathway
hsa05221Acute myeloid leukemia
hsa04666Fc gamma R-mediated phagocytosis
Pathway IDPathway Name
Signalling by NGF
No data
Pathway IDPathway Name
P00048PI3 kinase pathway
P00047PDGF signaling pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P04397p53 pathway by glucose deprivation
Pathway IDPathway Name
500641AKT phosphorylates targets in the nucleus
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]decreases reaction|increases activity 12720544
C006780 bisphenol A bisphenol A results in increased expression of RPS6KB2 mRNAincreases expression 18180321
D020001 1-Butanol 1-Butanol results in decreased activity of RPS6KB2 proteindecreases activity 12087098
C038753 leptomycin B leptomycin B results in decreased activity of RPS6KB2 proteindecreases activity 12087098
D010656 Phenylephrine bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]decreases reaction|increases activity 12720544
D010656 Phenylephrine Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]decreases reaction|increases activity 12720544
D010656 Phenylephrine rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]decreases reaction|increases activity 12720544
D010712 Phosphatidic Acids MTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]affects reaction|increases activity 12087098
D010712 Phosphatidic Acids Phosphatidic Acids results in increased activity of RPS6KB2 proteinincreases activity 12087098
D010712 Phosphatidic Acids Sirolimus inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]decreases reaction|increases activity 12087098
D010712 Phosphatidic Acids wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]decreases reaction|increases activity 12087098
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RPS6KB2 mRNAaffects binding|decreases expression|increases activity 19710929
D011224 Prazosin Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]decreases reaction|increases activity 12720544
C085746 rottlerin rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]decreases reaction|increases activity 12720544
C085746 rottlerin rottlerin results in decreased activity of RPS6KB2 proteindecreases activity 12720544
D020123 Sirolimus MTOR protein inhibits the reaction [Sirolimus results in decreased activity of RPS6KB2 protein]decreases activity|decreases reaction 12087098
D020123 Sirolimus Sirolimus inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]decreases reaction|increases activity 12087098
D020123 Sirolimus Sirolimus results in decreased activity of RPS6KB2 proteindecreases activity 12087098
D018038 Sodium Selenite Sodium Selenite results in increased expression of RPS6KB2 mRNAincreases expression 18175754
C009687 wortmannin wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]decreases reaction|increases activity 12087098
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2117460149
MESH:D001259 Ataxia 1-Butanol 5.707820390
MESH:D001321 Autistic Disorder Sirolimus 3.2021115397
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001862 Bone Resorption bisphenol A 3.9711985600
MESH:D001919 Bradycardia Phenylephrine 4.7015306635
MESH:D001943 Breast Neoplasms marker/mechanism 20953835
MESH:D001943 Breast Neoplasms bisphenol A 2.4617123778
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 3.1719335982
MESH:D002278 Carcinoma in Situ bisphenol A 5.1417123778
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 3.5919435901
MESH:D006332 Cardiomegaly Phenylephrine 3.5915728586 11754973 16170337 11179087 17287366 17124262
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D056486 Drug-Induced Liver Injury Prazosin 4.7218071297
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.7215131321
MESH:D004487 Edema bisindolylmaleimide I 7.658273558
MESH:D004487 Edema pirinixic acid 7.6512083418
MESH:D005234 Fatty Liver pirinixic acid 2.8720131406 19236843
MESH:D006258 Head and Neck Neoplasms Sirolimus 4.5319435901
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1319772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Prazosin 4.9512727271
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Phenylephrine 3.118949925 12717712
MESH:D006984 Hypertrophy Phenylephrine 11.3812791704 18502941
MESH:D006984 Hypertrophy Sirolimus 11.3819211884
MESH:D007249 Inflammation bisindolylmaleimide I 3.948273558
MESH:D007333 Insulin Resistance bisphenol A 12.7716393666
MESH:D007333 Insulin Resistance pirinixic acid 12.7716306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.7714714311
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.8415474484
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 2.8417050028
MESH:D008113 Liver Neoplasms pirinixic acid 1.8520007298 16377806 15890375
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008545 Melanoma Sirolimus 3.2319282848
MESH:D009062 Mouth Neoplasms Sirolimus 4.7919435901
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009421 Nervous System Malformations bisphenol A 4.1016427766 11399458
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010049 Ovarian Diseases bisphenol A 5.1411985600
MESH:D010300 Parkinson Disease Sirolimus 3.7719682553
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1010548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3616740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3618760546
MESH:D011629 Puberty, Precocious bisphenol A 4.9410548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012852 Sinusitis Phenylephrine 4.867327846
MESH:D019966 Substance-Related Disorders bisphenol A 4.1416045194 16684133
MESH:D014402 Tuberous Sclerosis Sirolimus 5.6921115397 18495876
MESH:D014591 Uterine Diseases bisphenol A 5.1814652134
MESH:D014605 Uveitis Sirolimus 5.811336536
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04012 ErbB signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04910 Insulin signaling pathway
KEGG:04150 mTOR signaling pathway
REACT:11061 Signalling by NGF
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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