AutismKB 2.0

Annotation Detail for RPS12


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Basic Information Top
Gene Symbol:RPS12 ( - )
Gene Full Name: ribosomal protein S12
Band: 6q23.2
Quick LinksEntrez ID:6206; OMIM: 603660; Uniprot ID:RS12_HUMAN; ENSEMBL ID: ENSG00000112306; HGNC ID: 10385
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1779Cervical cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RPS12 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of RPS12 mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RPS12 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPS12 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RPS12 mRNAaffects expression 15963342
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of RPS12 mRNAaffects cotreatment|decreases expression 18636392
C056933 fumonisin B1 fumonisin B1 results in increased expression of RPS12 mRNAincreases expression 16221962
C424943 glutamyl-Se-methylselenocysteine glutamyl-Se-methylselenocysteine results in decreased expression of RPS12 mRNAdecreases expression 11306469
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RPS12 mRNAaffects cotreatment|increases expression 17183730
D009151 Mustard Gas Mustard Gas results in increased expression of RPS12 mRNAincreases expression 12884408
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of RPS12 mRNAaffects cotreatment|decreases expression 18636392
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPS12 mRNAaffects binding|increases expression 16214954
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RPS12 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7015322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.708875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury Chlorine 4.4120601635
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.803712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Mustard Gas 5.1610378619
MESH:D001249 Asthma Ozone 5.1617854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517688650 19460635 17507914 18558336 18316065 18396377 15238991 18940202 16609825 18985861 18775368 20603192 19232924 18177632 17157402
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.1120046352 17594078
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.198888407
MESH:D001943 Breast Neoplasms glutamyl-Se-methylselenocysteine 2.7111306469
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.7120435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7415516495 14754758 18417511 19059883 17626835 18315731 16777450
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D002100 Cachexia Ozone 4.8616183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8815721981 16011737 15700767 16192424 16124888 16097048 15673190 16050911 16227642 3786805 10355542 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.653581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.653084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6518788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.846135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.847505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.219022650 19486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 15340226 8697196 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5017688650 8888407 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9011298694 8156756 14531868 18759878 11906362 2524372 8970840 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 19.0721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 19.078291058 1440618 18648102 18289764 9653073 7440962 11289319 16192314 9022650 6679447 18692083 9328219 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 19.0719923254 11421492 11743745 19085960 11529661 16081117 14550746 17906064 12540782 15619225 18071297 12958197 19416960 16177239 12153990 19739265 16781746 17522070 12705907 12392966 11739529 15968718 18713872 19420014 11461765 11287661 16485898 11834606 19370779 14986274 17562736 16109766 10774834 16227642 16393943 10915739 19164858 10663392 14725611 2444490 12594235
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 19.0710915739 6884620 15027814 7179309 9327722 19085960 4309450 3786805 10092053 16177239 21278145 15998439 2869522 19336974 16227642 17522070 11566570 15968718 7120509 7440962 3732212 6623471
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 19.0716221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 19.0720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 19.071733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004417 Dyspnea Chlorine 4.7620016425
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:D004487 Edema Mustard Gas 7.119260866 11428647 11428631 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0516628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.666426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1415959796 61145 16045604 12795759 17595544 12631006 16239168 19224547
MESH:D005234 Fatty Liver Valproic Acid 8.1419224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005739 Gas Poisoning Chlorine 5.1420016425
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.546705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.5419110552 19900420
MESH:D006529 Hepatomegaly fumonisin B1 9.0816221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.0815340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 15340226 16959395 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7316612254
MESH:D007249 Inflammation Mustard Gas 5.1811428647 9357497 11428631 17524151 11428620 8975870 16001271 9260866 11402378
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1812200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2415629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.596582329
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1617596541 16294345
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8511408273 17334410 16943688 16239168 16221502 17174718 17157831 21278145 11903743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.249327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3115123356 17708605 15052691 12546737 12741479 16027843 18006644 15730626 17900296 12445418 16638106 18277467 15370692 16248980 15931870 18251166 16192424 18395914 15362042 18376398 17631135 18429990 14512876 15338365 12632512 17714472 15925388 17525996 17766677 15996030 14724832 15876570 15893842 12667390 12389079 18418968 17565644 12632514 17698563 12898905 11481614 17721639 16033810 18412020 18317297 15673190 12649538 17805973 18263696 18054572 16116963 18472332 18472094 13678700 18339082 12445421 12586293 14716496 18395095 15818738 17976157 17761835 14716833 18210741 18481824 12958196 17922224 14748882 18187930 12666154 18705752 18279442 18166357 17823541 16136751 16015684 14620537 18205269 18420326 10355542 16097048 18156304 15959796 17557913 17944888 17640975 16011737 12609069 17481882 20821823 15057751 15650968 17869086
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008107 Liver Diseases Acetaminophen 3.9619460945 12969438 19014921 19784758 16610002 12587719 16611625 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9616964402 15720792 15830285 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.6714706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.557678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.5519294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.516135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.511399818 6587162 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.5112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.5112151625
MESH:D008171 Lung Diseases Mustard Gas 7.8018161513 18702808
MESH:D008171 Lung Diseases Ozone 7.808266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D055370 Lung Injury Ozone 3.9520417186
MESH:D008175 Lung Neoplasms Mustard Gas 3.528781369 3148597
MESH:D008175 Lung Neoplasms Ozone 3.528597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5219555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008679 Metaplasia Ozone 5.2410496685
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.987678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.436679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.4316359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009503 Neutropenia Mustard Gas 4.0616761898 7688884
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.144026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010538 Peritonitis Ozone 4.2316369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D011014 Pneumonia Ozone 4.5118381685 18929643 18007984
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8611118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.8620603192
MESH:D011537 Pruritus Mustard Gas 4.2118058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.6711422049 12752131
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9517266442 17894541 17720292 17620002 10334151
MESH:D012120 Respiration Disorders Chlorine 5.3518579056
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1218551238
MESH:D012640 Seizures Valproic Acid 6.121511512 16876388 15475178 11738929 14763951 3137016 17978042 11044598
MESH:D012871 Skin Diseases Mustard Gas 2.7312880345 16961503 15451306
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.957505956 1399818 6587162 6582329 3712494
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.118074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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