AutismKB 2.0

Annotation Detail for RPS15A


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Basic Information Top
Gene Symbol:RPS15A ( FLJ27457,MGC111208,S15a )
Gene Full Name: ribosomal protein S15a
Band: 16p12.3
Quick LinksEntrez ID:6210; OMIM: 603674; Uniprot ID:RS15A_HUMAN; ENSEMBL ID: ENSG00000134419; HGNC ID: 10389
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RPS15A mRNAaffects expression 21346803
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of RPS15A mRNAincreases expression 15890375
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RPS15A mRNAdecreases expression 18648102
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS15A mRNAincreases expression 15890375
C109238 acyline acyline results in increased expression of RPS15A mRNAincreases expression 17510436
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of RPS15A mRNAincreases expression 15890375
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPS15A mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of RPS15A mRNAincreases expression 14703492
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RPS15A mRNAaffects expression 15963342
16239168
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPS15A mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPS15A mRNAaffects cotreatment|affects expression 17602206
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RPS15A mRNAincreases expression 15890375
C444299 diindolylmethane diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPS15A mRNA]decreases expression|decreases reaction 11179685
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of RPS15A mRNAincreases expression 15890375
D004958 Estradiol diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPS15A mRNA]decreases expression|decreases reaction 11179685
D004958 Estradiol Estradiol results in decreased expression of RPS15A mRNAdecreases expression 11179685
D004958 Estradiol Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of RPS15A mRNA]decreases expression|increases reaction 11179685
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RPS15A mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in decreased expression of RPS15A mRNAdecreases expression 18035473
D008701 Methapyrilene Methapyrilene results in increased expression of RPS15A mRNAincreases expression 15890375
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of RPS15A mRNAincreases expression 15890375
C006253 pirinixic acid pirinixic acid results in increased expression of RPS15A mRNAincreases expression 15890375
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of RPS15A mRNA]decreases expression|increases reaction 11179685
D014303 Trinitrotoluene Trinitrotoluene affects the expression of RPS15A mRNAaffects expression 21346803
D014635 Valproic Acid Valproic Acid results in increased expression of RPS15A mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.4211752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 13.427525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.428875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7919490988
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.8819825857 11798837
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 9.8816033868
MESH:D000230 Adenocarcinoma Estradiol 9.8811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.8814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 15.343712494
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 15.3416176798
MESH:D000236 Adenoma Diethylnitrosamine 15.346695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 15.3419555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.3916434500 17620307 19052882 19061943 17162532 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.3916835633
MESH:D000550 Amblyopia Valproic Acid 5.0817688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3315469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.4517497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001321 Autistic Disorder Valproic Acid 2.0217507914 18775368 18940202 16609825 18177632 17157402 18558336 17688650 18985861 18316065 19460635 15238991 19232924 18396377 20603192
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8711289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.0020046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.4716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.4719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.708888407
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.3020146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3017474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3015324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 2.3017289903 12948864 17018787 16675129 17261762 18497071 19861407 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3020435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6316097048 15721981 16011737 16192424 16124888 15700767 3786805 16227642 18705752 16050911 10355542 15673190
MESH:D002277 Carcinoma Dimethylnitrosamine 7.9519555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9516835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.5116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.513581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.5112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.5114691202 11135700 15553829 15073043 16217749
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.5118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.5118056438 18506893 16698587 19171122 19107877 18393292 20084675 17978847 19394651 16935385 19335982 3084413 3581430 19701751 10672840 19539802 18978308 16502159 20512989 19519916 18785209 11831363 20432363 20214788 18494052 20524982 20007298 16288022 21159647 20935162 18665156 20727157 16807293 17173139 18971187 16328049 16878318 16569478 16540662 17138121 16681979 17761372 18788625 19052882 19822196 17428255 19208518 18210153 16830150 20101231 10737359 19919837 19383236 18691550 20514400 19418558 16779866 17162532 17055752
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.5116924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.5116924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7219014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.617296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9812490120
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 2.9116033868
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 18850075 16120746
MESH:D002386 Cataract Trinitrotoluene 3.7815817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.166135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.167505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.1621159647 17174075 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.1618566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6520734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.729022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.7217681005 17333356 16919318 11677210 16105132 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 12.7219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.048697196 15668235 16354765 12621046 15340226
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.8414669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.8415095906
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6715322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.678888407 17688650 16575769
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4112952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.7218551238
MESH:D003490 Cyanosis Trinitrotoluene 10.7218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9515213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6611298694 14531868 12868966 11906362 18759878 8156756 8970840 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.352952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2819279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 21.4718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 21.479653073 11289319 8291058 6679447 18289764 7440962 18692083 1440618 9022650 6482804 9328219 16192314 18648102
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 21.473732212 19085960 15998439 7440962 6884620 10915739 3786805 16227642 7120509 2869522 10092053 19336974 15027814 16177239 7179309 11566570 6623471 4309450 21278145 15968718 9327722 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 21.4719107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 21.478172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.4720420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 21.4721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 21.471733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004421 Dystonia Valproic Acid 3.911851702
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0412538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.2216804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 7.2219148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.003659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.7716628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.467562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.157750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.913659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.103581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.1012903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.1017016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver arsenic trioxide 28.9115073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.9117595544 15959796 12795759 16239168 12631006 61145 16045604 19224547
MESH:D005234 Fatty Liver Diethylnitrosamine 28.9121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.9115345470
MESH:D005234 Fatty Liver pirinixic acid 28.9119236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 28.9114986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5616002989 15751030 16611131 16513791 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.988888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.876705139
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1116904648
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7916452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.897505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.736705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.7319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 13.6119176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.6115340226 12621046 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 13.6115817613
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006849 Hydrocephalus Valproic Acid 4.7117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8915340226 16959395 8697196 16354765 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.3315034207
MESH:D006965 Hyperplasia Diethylstilbestrol 10.3312960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.7416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.7416569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.2115036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5617937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.5612150543
MESH:D007249 Inflammation Diethylnitrosamine 7.8518785209
MESH:D007249 Inflammation Flavonoids 7.8517296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.8512200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.8716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.8716306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.878074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007674 Kidney Diseases Estradiol 2.5015618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.7516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.756582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.7516762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 16.7515610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9117184923
MESH:D007938 Leukemia arsenic trioxide 2.7615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6617077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8120471514 16467208 17050201 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8117596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1217649720 19225113 17869043 11161223 19075265 16330433 19035177 17107899 16891316 15336539 15213294 12018890 9834237 17217047 15622746 16331271 12712474 16966277 16112521 19642359 16823087 15748426 11468182 12679006 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2016882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3317157831 21278145 11903743 11408273 16221502 17334410 17174718 16943688 16239168
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3318665156 20032147 19638242 18522880 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5312445421 16136751 14716833 18006644 15123356 17698563 17631135 18472332 16192424 15925388 12632512 14716496 10355542 12389079 18420326 17481882 12546737 14512876 17565644 14748882 15730626 12666154 18395914 17714472 17721639 17976157 17525996 14620537 18481824 16638106 18279442 12649538 12667390 15893842 17805973 17823541 13678700 15959796 16027843 15650968 18429990 18472094 15673190 18317297 18339082 18277467 18210741 16011737 16097048 17869086 18187930 18376398 11481614 17922224 17900296 15818738 12609069 15370692 16248980 18054572 17557913 15931870 20821823 17761835 12586293 18251166 15362042 16015684 15338365 18263696 18418968 15052691 17766677 12445418 18205269 14724832 12898905 12741479 12958196 12632514 16033810 15996030 15876570 17640975 17944888 17708605 18395095 18156304 18412020 15057751 18705752 18166357 16116963
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.5315504291 16603200 16544323 18239293 15086199 15571005 17196135 17719030 14659978 14709902 15366600 15763062 15067225 14643895 17881167 15369754 12925901 17203207 15842777 15577212 15138612 17201889 15798949 18095165 15298665 17432682 17465448 18672772 16270385 17036385 17534399 17724770 18210741 16009107 12918455 15161499 18371158 14726149 18629640 15383259 15793283 16169303 15339415 17348192 18637143 15492853 17640959 15081153 18237412 15099470 15744066 14568256 15864749 15723089 15733078 17198567 15479170 17666798 15942678 16627068 18567088 15591649 16042886 16570917 18364076
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9415720792 16246199 17285989 15830285 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.3916899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.3917457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 51.397678174
MESH:D008113 Liver Neoplasms 2-nitrofluorene 51.3915890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 51.3915890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 51.3915890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 51.3914682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 51.3919294768
MESH:D008113 Liver Neoplasms Clofibric Acid 51.3917602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 51.3912112319 20492335 12771043 2422723 20101389 15885732 18754104 19850985 9163691 2862719 18644402 18978307 21278145 21047994 19499222 19642983 19812893 15175105 18977376 19833225 19256749 16942905 20452335 20434301 19426721 20118626 20137499 19090486 19638242 21167192 19690152 19551842 18648771 19996281 19294768 19255062 21071580 19254457 20583210 20501860 20405173 19073162 19427195 10737359
MESH:D008113 Liver Neoplasms Diethylstilbestrol 51.3916712894 15890375
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 51.3915890375 3113478
MESH:D008113 Liver Neoplasms Methapyrilene 51.3915890375
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 51.3918648771 19690152 15890375 20101389
MESH:D008113 Liver Neoplasms pirinixic acid 51.3916377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 51.3916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 31.706135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 31.70598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 31.708603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 31.7020377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 31.7015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 31.7018079962 16267830 18544905 17174075 18775883 19004024 18164116 16842330 18253720 9362446 17942915 17854601 2563599 19009564 18308698 19539802 19519916 19126423 18093689 18282651 21159647 3124819
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 31.7015603536 1848544 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 31.7012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2315213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1117228818
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 8.3212438228 18813816 15893417 16061637 19931552 9255578 17139156 15172992 18508827 14755239 16401635
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.3214755239
MESH:D008175 Lung Neoplasms arsenic trioxide 8.3211798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.3221163286 6695378 20970405 20512841
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 8.3211884234 16061637 19555203
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3211884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3715700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3616002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4717203775 16891317 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008881 Migraine Disorders Valproic Acid 3.0818803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0019549372 19417148 11468182 15949261 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.898888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.1316105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.1317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8616411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.1718551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 10.1718551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8116624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.503581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.503581430 9029167
MESH:D009369 Neoplasms Diethylstilbestrol 4.7915313581
MESH:D009369 Neoplasms pirinixic acid 4.7917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.5211399458
MESH:D009421 Nervous System Malformations Estradiol 15.5216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.576679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.5710525206
MESH:D009436 Neural Tube Defects Valproic Acid 11.578888407 16359493
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.4116049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.414026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 14.4117852074 14694615 12819281
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.873988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.6716624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 4.6719401270
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 8.4312384795
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.4315580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.4316540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.337296757
MESH:D010235 Paraganglioma arsenic trioxide 4.0219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.326228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5216977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.422563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.3817184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.3811118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.3820603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6419131511
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.6415846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.6416740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.1615861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.3912752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.263692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0319155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8116646077
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 9.3418551238
MESH:D012640 Seizures Trinitrotoluene 9.3418551238
MESH:D012640 Seizures Valproic Acid 9.3414763951 11738929 1511512 15475178 3137016 11044598 16876388 17978042
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9716192470
MESH:D013088 Spermatocele Diethylstilbestrol 11.2116002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 11.2116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6619490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.1212587719
MESH:D013163 Splenomegaly Trinitrotoluene 5.0515817613
MESH:D013226 Status Epilepticus Valproic Acid 4.3912833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3717007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3718456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.3716033868
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.293712494 6582329 7505956 6587162 1399818
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.2919014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.297505956
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8115213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.0817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.373119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.4516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.458074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.4512973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.4516712894 16452187 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.498888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1710091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.9016175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.9816690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9814692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2916513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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