AutismKB 2.0

Annotation Detail for RPS17


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Basic Information Top
Gene Symbol:RPS17 ( DBA4,MGC72007,RPS17L1,RPS17L2 )
Gene Full Name: ribosomal protein S17
Band: 15q25.2
Quick LinksEntrez ID:6218; OMIM: 180472; Uniprot ID:RS17_HUMAN; ENSEMBL ID: ENSG00000184779; HGNC ID: 10397
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00237Diamond-Blackfan anemia
Desease IDDesease Name
1863Aplastic anemia
No data
No data
Desease Name
Diamond-Blackfan anemia 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RPS17 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of RPS17 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of RPS17 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPS17 mRNAaffects expression 16483693
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPS17 mRNAaffects cotreatment|increases expression 15654877
C099555 CD 437 CD 437 results in decreased expression of RPS17 mRNAdecreases expression 12958071
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of RPS17 mRNAaffects cotreatment|decreases expression 18636392
D003976 Diazinon Diazinon affects the expression of RPS17 mRNAaffects expression 17474016
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RPS17 mRNAincreases expression 20360939
C444299 diindolylmethane diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPS17 mRNA]decreases expression|decreases reaction 11179685
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPS17 mRNAaffects cotreatment|increases expression 15654877
D004958 Estradiol diindolylmethane inhibits the reaction [Estradiol results in decreased expression of RPS17 mRNA]decreases expression|decreases reaction 11179685
D004958 Estradiol Estradiol results in decreased expression of RPS17 mRNAdecreases expression 11179685
D004958 Estradiol Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of RPS17 mRNA]decreases expression|increases reaction 11179685
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RPS17 mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in decreased expression of RPS17 mRNAdecreases expression 18035473
C424943 glutamyl-Se-methylselenocysteine glutamyl-Se-methylselenocysteine results in decreased expression of RPS17 mRNAdecreases expression 11306469
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPS17 mRNAaffects cotreatment|increases expression 15654877
D008701 Methapyrilene Methapyrilene results in increased expression of RPS17 mRNAincreases expression 15120968
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of RPS17 mRNAaffects cotreatment|decreases expression 18636392
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of RPS17 mRNA]decreases expression|increases reaction 11179685
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7914514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D055371 Acute Lung Injury Chlorine 4.2620601635
MESH:D000230 Adenocarcinoma Estradiol 4.1611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.543712494
MESH:D000236 Adenoma Diethylnitrosamine 6.546695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.8516434500 17620307 18056438 19052882 19061943 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8516835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 8.9311874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.9316487989
MESH:D000544 Alzheimer Disease Ozone 2.4215513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D029503 Anemia, Diamond-Blackfan marker/mechanism 17647292
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6215885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5415570426
MESH:D001249 Asthma Ozone 2.6216373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9611289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0217474063
MESH:D001943 Breast Neoplasms Estradiol 2.0217289903 12948864 18497071 16675129 17261762 17018787 19861407 14630087
MESH:D001943 Breast Neoplasms glutamyl-Se-methylselenocysteine 2.0211306469
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6218417511 17626835 15516495 19059883 18315731 14754758 16777450
MESH:D002100 Cachexia Ozone 4.6816183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.7516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.753581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.753084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.7516569478 16502159 20084675 20524982 10672840 18691550 20935162 20512989 16779866 20007298 17138121 20432363 16288022 18788625 17173139 18056438 19539802 16698587 19208518 16328049 21159647 18665156 16807293 18494052 19052882 16681979 19171122 20727157 19335982 18978308 17055752 19822196 19394651 19418558 18210153 16830150 3084413 16878318 3581430 19383236 17428255 17162532 18506893 18971187 18785209 19107877 11831363 16540662 17978847 10737359 17761372 20101231 19919837 16935385 19519916 18393292 20514400 19701751 20214788
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7516924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.646135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.647505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.6421159647 17174075 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.6418566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.1319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.6919486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6917333356 11677210 17110522 16919318 15861022 16105132 17681005
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815340226 8697196 15668235 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9518551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7411298694 12868966 8970840 8156756 18759878 11906362 2524372 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.433621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3519279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.7918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.7918648102 6679447 18289764 9328219 9653073 7440962 6482804 9022650 18692083 1440618 8291058 16192314 11289319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.7911421492 12153990 17522070 11743745 19739265 19923254 11461765 2444490 11287661 19085960 11529661 12594235 19416960 18713872 12958197 14986274 18071297 10774834 12705907 19420014 12540782 19370779 16781746 17562736 10915739 16081117 14725611 16485898 11834606 19164858 16227642 12392966 14550746 15619225 17906064 10663392 11739529 16393943 15968718 16109766 16177239
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.7919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.7920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004417 Dyspnea Chlorine 10.4920016425
MESH:D004417 Dyspnea Diazinon 10.4916487989
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1212538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.9419148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0616302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.093581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Diethylnitrosamine 7.4920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.4915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8920067830
MESH:D005739 Gas Poisoning Chlorine 4.9520016425
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3011294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.376705139
MESH:D006505 Hepatitis Diazinon 9.3716487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8316120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9918606429 16959395 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Atrazine 11.1512948887
MESH:D007248 Infertility, Male Diazinon 11.1516466525 12948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.1517937319
MESH:D007249 Inflammation Diethylnitrosamine 8.1118785209
MESH:D007249 Inflammation Flavonoids 8.1117296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1112200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.9216627594 16393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.969022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007674 Kidney Diseases Acetaminophen 5.7615629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.7615618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.0716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.076582329
MESH:D007680 Kidney Neoplasms Estradiol 12.0715610895
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7920032147 18522880 18665156 19638242 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1515034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2412878042
MESH:D008107 Liver Diseases Acetaminophen 3.8519784758 16610002 19014921 12969438 19460945 11587558 12587719 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1817185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.537678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.5320583210 10737359 21167192 18648771 21071580 18754104 16942905 18644402 2862719 20137499 19551842 12771043 18978307 15175105 19294768 20492335 19996281 12112319 20501860 9163691 19850985 19812893 19427195 19256749 15885732 19690152 20434301 21047994 2422723 20405173 19090486 21278145 19255062 18977376 20118626 20101389 19642983 19426721 20452335 19833225 19073162 19638242 19254457 19499222
MESH:D008113 Liver Neoplasms Methapyrilene 10.5315890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.5316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.762876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.76598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.7619519916 18775883 18253720 18093689 16842330 3124819 17854601 17942915 17174075 18079962 18308698 18544905 19004024 21159647 19009564 19539802 9362446 18164116 16267830 2563599 18282651 19126423
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.7612151625
MESH:D008171 Lung Diseases Ozone 3.3319066396 8266340
MESH:D055370 Lung Injury Ozone 3.7820417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.3721163286 6695378 20512841 20970405
MESH:D008175 Lung Neoplasms Ozone 3.377614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3711884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5216891317 11408345 11807958 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008654 Mesothelioma Atrazine 3.501916698
MESH:D008679 Metaplasia Ozone 5.0510496685
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2316810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8018551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.613581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.613581430 9029167
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009421 Nervous System Malformations Estradiol 9.2516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.876679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.9920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0620387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D010051 Ovarian Neoplasms CD 437 5.0917474084
MESH:D010051 Ovarian Neoplasms Estradiol 5.0919401270
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4016540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010300 Parkinson Disease Atrazine 3.2517218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010538 Peritonitis Ozone 4.0716369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D011014 Pneumonia Ozone 4.3318007984 18381685 18929643
MESH:D011041 Poisoning Diazinon 4.2917603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.492563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.2515861022 16919318
MESH:D012120 Respiration Disorders Chlorine 5.1618579056
MESH:D012135 Respiratory Sounds Atrazine 4.4511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.951399818 6582329 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.957505956
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.2816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.288074119
MESH:D001749 Urinary Bladder Neoplasms CD 437 8.2816720286
MESH:D014570 Urologic Diseases Diazinon 5.2216487989
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2610091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34797
    • No data
    Releated disease ID Related disease Name
    PA447182Anemia, Diamond-Blackfan
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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