AutismKB 2.0

Annotation Detail for RPS19


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Basic Information Top
Gene Symbol:RPS19 ( DBA,DBA1 )
Gene Full Name: ribosomal protein S19
Band: 19q13.2
Quick LinksEntrez ID:6223; OMIM: 603474; Uniprot ID:RS19_HUMAN; ENSEMBL ID: ENSG00000105372; HGNC ID: 10402
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03010Ribosome
Pathway IDPathway Name
Diabetes pathways
Metabolism of proteins
Regulation of beta-cell development
Influenza Infection
Gene Expression
3' -UTR-mediated translational regulation
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00237Diamond-Blackfan anemia
Desease IDDesease Name
1863Aplastic anemia
No data
No data
Desease Name
Diamond-Blackfan anemia 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RPS19 mRNAaffects expression 21346803
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of RPS19 mRNAincreases expression 15890375
14600272
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS19 mRNAincreases expression 14600272
15890375
D000082 Acetaminophen Acetaminophen affects the expression of RPS19 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of RPS19 mRNAincreases expression 15890375
14600272
D000638 Amiodarone Amiodarone affects the expression of RPS19 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RPS19 mRNAaffects expression 16483693
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of RPS19 mRNAaffects cotreatment|decreases expression 16532367
D001553 Benzbromarone Benzbromarone affects the expression of RPS19 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RPS19 mRNAdecreases expression 20504355
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of RPS19 mRNAdecreases expression 12419474
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of RPS19 mRNAincreases expression 12760830
D002713 Chlorine Chlorine results in increased expression of RPS19 mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of RPS19 mRNAaffects cotreatment|affects expression 18636392
D002994 Clofibrate Clofibrate affects the expression of RPS19 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in increased expression of RPS19 mRNAincreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RPS19 mRNAincreases expression 15766595
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RPS19 mRNAincreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of RPS19 mRNAincreases expression 14600272
15890375
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of RPS19 mRNAaffects cotreatment|decreases expression 16532367
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of RPS19 mRNAdecreases expression 17557909
D005001 Ethionine Ethionine affects the expression of RPS19 mRNAaffects expression 19483382
D019833 Genistein Genistein results in decreased expression of RPS19 mRNAdecreases expression 15256057
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of RPS19 mRNAaffects cotreatment|decreases expression 16532367
D007657 Ketone Bodies Ketone Bodies results in increased expression of RPS19 mRNAincreases expression 15469884
D008701 Methapyrilene Methapyrilene results in increased expression of RPS19 mRNAincreases expression 15890375
D009853 Omeprazole Omeprazole affects the expression of RPS19 mRNAaffects expression 19483382
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of RPS19 mRNAaffects cotreatment|affects expression 18636392
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of RPS19 mRNAincreases expression 15890375
C006253 pirinixic acid pirinixic acid affects the expression of RPS19 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in increased expression of RPS19 mRNAincreases expression 15890375
D011441 Propylthiouracil Propylthiouracil affects the expression of RPS19 mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPS19 mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RPS19 mRNAincreases expression 18796159
D013853 Thioacetamide Thioacetamide affects the expression of RPS19 mRNAaffects expression 19483382
D014303 Trinitrotoluene Trinitrotoluene affects the expression of RPS19 mRNAaffects expression 21346803
D014810 Vitamin E Vitamin E results in decreased expression of RPS19 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4915322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 7.497525203
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D055371 Acute Lung Injury Chlorine 8.1520601635
MESH:D055371 Acute Lung Injury pirinixic acid 8.1518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.4520127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 9.4516033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.4514692618
MESH:D000230 Adenocarcinoma Genistein 9.4511473722
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.2716176798
MESH:D000236 Adenoma Benzo(a)pyrene 10.276695378
MESH:D000236 Adenoma Dimethylnitrosamine 10.2719555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8216835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.9011874814
MESH:D000544 Alzheimer Disease Ozone 2.3715513908
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1715469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D029503 Anemia, Diamond-Blackfan marker/mechanism
MESH:D000799 Angioedema Acetaminophen 3.5110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7619183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5218218290 18057881 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4615885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4815570426
MESH:D001249 Asthma Ozone 2.5416373670 17854713
MESH:D001281 Atrial Fibrillation Amiodarone 3.6618651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 52.5419483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 52.5419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 52.5419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 52.5419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 52.5419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 52.5419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 52.5419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 52.5412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 52.5419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.2420146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2417474063 20146248
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.2415324884 17129689
MESH:D001943 Breast Neoplasms Genistein 2.2416541309 17200150 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2420435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4218417511 18315731 15516495 14754758 19059883 16777450 17626835
MESH:D002100 Cachexia Ozone 4.4116183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6116050911
MESH:D002277 Carcinoma Dimethylnitrosamine 7.5119555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5116835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.1816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.183084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.1812907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 13.181701930
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.1815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.1816924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.1817997003
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4720419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.4716033868
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1918670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7815710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 3.0816332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7618974383
MESH:D002386 Cataract Acetaminophen 6.8710977129
MESH:D002386 Cataract Trinitrotoluene 6.8714694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.956135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 9.951399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.9512371664
MESH:D002637 Chest Pain Omeprazole 4.7815447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6416835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.6418291259
MESH:D002779 Cholestasis Cyclosporine 11.9619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.9616919318 15861022 16105132 17333356 11677210 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 11.9619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.978697196 16354765 15340226 12621046 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.2317182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.3717141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.3715095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3710048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.3719769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2512952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.1718551238
MESH:D003490 Cyanosis Trinitrotoluene 10.1718551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.0416647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0417107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.0812392966 11461765 18713872 12705907 16177239 14725611 12958197 19416960 12594235 19085960 12153990 15968718 11834606 16781746 14986274 17906064 19923254 11529661 16227642 11287661 15619225 18071297 14550746 11739529 2444490 19739265 10663392 16109766 16485898 11743745 11421492 10915739 10774834 16081117 19420014 19370779 17562736 19164858 16393943 17522070 12540782
MESH:D056486 Drug-Induced Liver Injury Amiodarone 17.0815265979 18218290
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 17.088172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.0820420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 17.0812963478
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 17.0818551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.0221218061 15991576 17151854 16613094
MESH:D050171 Dyslipidemias Clofibrate 3.8316707586
MESH:D004417 Dyspnea Chlorine 4.3020016425
MESH:C538011 Eales disease Vitamin E 4.379068938
MESH:D004487 Edema pirinixic acid 5.5912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.5911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8812538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.8116402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.8116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 6.9816804899 15700306
MESH:D016889 Endometrial Neoplasms Genistein 6.9811473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.749294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3516530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.3517016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3916456712
MESH:D005234 Fatty Liver Amiodarone 21.5714986274
MESH:D005234 Fatty Liver Clofibrate 21.5719224547
MESH:D005234 Fatty Liver Cyclosporine 21.5719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.5715345470
MESH:D005234 Fatty Liver pirinixic acid 21.5720131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4616534752 16611131 16002989 16513791 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005355 Fibrosis Cyclosporine 7.4312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.4320067830
MESH:D005739 Gas Poisoning Chlorine 4.6820016425
MESH:D005756 Gastritis Acetaminophen 3.3416983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.898708960
MESH:D005909 Glioblastoma Genistein 3.0516598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.0920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.0911294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 10.0916080930
MESH:D006333 Heart Failure pirinixic acid 2.3420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2817276928 15929193 18665440
MESH:D006505 Hepatitis Thioacetamide 3.9116456712
MESH:D006529 Hepatomegaly Amiodarone 18.1015265979
MESH:D006529 Hepatomegaly pirinixic acid 18.1019176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.1016120746 15340226 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 18.1015817613
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.6414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7116354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.4516870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.588137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1214722030 12960047
MESH:D006973 Hypertension Cyclosporine 4.5210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5218670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 10.1816002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.1816569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.5517991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.5518031379 8137927
MESH:D007246 Infertility Diethylstilbestrol 4.0515036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Atrazine 10.1312948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.1317937319
MESH:D007248 Infertility, Male Trinitrotoluene 10.1312150543
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7012878042 12200463
MESH:D007251 Influenza, Human Vitamin E 3.8816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1115604871
MESH:D007674 Kidney Diseases Acetaminophen 12.9012587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 12.9016962696
MESH:D007674 Kidney Diseases Cyclosporine 12.9010903974 8314463 18776723
MESH:D007674 Kidney Diseases Vitamin E 12.9012488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.9216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 10.9212371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 10.9215003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7517184923
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8419248655
MESH:D007938 Leukemia Genistein 2.8617468513 18980019
MESH:D008064 Lipidoses Amiodarone 3.2815342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 8.1517724770 16544323 14568256 15298665 17198567 15366600 15383259 17534399 15369754 15842777 15577212 18629640 18239293 18210741 16627068 15081153 16603200 18364076 15571005 15744066 17719030 17196135 15099470 15864749 17201889 18371158 14726149 16042886 15591649 15793283 16009107 15504291 17465448 16270385 16169303 18567088 17203207 17432682 14643895 18637143 16570917 15067225 15723089 15763062 15161499 15086199 15942678 12925901 17348192 18095165 18672772 17036385 15339415 14709902 17640959 12918455 15798949 17881167 15492853 15138612 14659978 17666798 15479170 18237412 15733078
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.1517823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.1515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.1512878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 8.1512557150 18395095 18615449 18032466 16511523 17050028 16343077 17629604 18606216 18458672 12175628 15075984 16097051 11682029 14739098 16126171 15465738 15716488 12085344 15288473 15158331 15474484 18416461 18295389 16489207 17127702 12679928 15316131 15334695 15095483 15362042 17355460 11481614 12531686 12891558 18031379 10677585 17292413 16098781 18380797 15288472 15078482 18263696 11172339 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.1516169303
MESH:D008107 Liver Diseases Acetaminophen 3.8319784758 16610002 19014921 12587719 19460945 12969438 11587558 16611625
MESH:D008107 Liver Diseases Thioacetamide 3.8316337175 15158337 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 14.7216871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 14.7217457977
MESH:D017114 Liver Failure, Acute Thioacetamide 14.7215633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 35.817678174
MESH:D008113 Liver Neoplasms 2-nitrofluorene 35.8115890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 35.8115890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 35.8115890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 35.8121137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 35.8116712894 15890375
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 35.813113478 15890375
MESH:D008113 Liver Neoplasms Methapyrilene 35.8115890375
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 35.8120101389 19690152 15890375 18648771
MESH:D008113 Liver Neoplasms pirinixic acid 35.8116377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 35.8116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.472876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.478603461
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 12.476150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.4712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3317391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 11.1312587719
MESH:D008171 Lung Diseases Ozone 11.138266340 19066396
MESH:D008171 Lung Diseases Vitamin E 11.1316863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1518516814
MESH:D055370 Lung Injury Ozone 3.5320417186
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.0112438228 19931552 15172992 16061637 18508827 16401635 15893417 17139156 14755239 9255578 18813816
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.0114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.0118816296 17053015 20464547 6695378 18569708 20064080 18520028 20135361 20869020
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 10.0119555203 16061637 11884234
MESH:D008175 Lung Neoplasms Ozone 10.018597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0111884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 10.0111062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8215166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.2415700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1816002989
MESH:D008325 Mammary Neoplasms, Experimental Genistein 2.7412929590 14578162
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2519513568
MESH:D008654 Mesothelioma Atrazine 3.401916698
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4616801185
MESH:D008679 Metaplasia Ozone 4.7710496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9416381670
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009181 Mycoses Amiodarone 4.5717974566 12754197
MESH:D009203 Myocardial Infarction Genistein 5.2117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.5717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5716411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.6018551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 9.6018551238
MESH:D009369 Neoplasms Benzo(a)pyrene 7.2811141357
MESH:D009369 Neoplasms Diethylstilbestrol 7.2815313581
MESH:D009369 Neoplasms pirinixic acid 7.2817405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0119348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 14.6411399458
MESH:D009421 Nervous System Malformations Genistein 14.6416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.6414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6118514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.629802331
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.2916049721
MESH:D009784 Occupational Diseases Trinitrotoluene 8.2917852074 12819281 14694615
MESH:D010024 Osteoporosis Genistein 3.0519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7916169203
MESH:D010051 Ovarian Neoplasms Genistein 2.5019005980
MESH:D010146 Pain Acetaminophen 2.1416870215
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 3.3212384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010300 Parkinson Disease Atrazine 3.1517218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010538 Peritonitis Ozone 3.8116369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3516977796 15687265
MESH:D011014 Pneumonia Ozone 4.0718381685 18007984 18929643
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9512371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.4817184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4811222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms marker/mechanism 17199135
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1617292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1615846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Genistein 2.1615256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1615084515
MESH:D011537 Pruritus Ethinyl Estradiol 2.9916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7311597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D012120 Respiration Disorders Chlorine 4.8818579056
MESH:D012135 Respiratory Sounds Atrazine 4.2011874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012640 Seizures 2,6-dinitrotoluene 5.4718551238
MESH:D012640 Seizures Trinitrotoluene 5.4718551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7618724381
MESH:D012871 Skin Diseases Vitamin E 2.3618709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.4810029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.488532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.4816192470
MESH:D013088 Spermatocele Diethylstilbestrol 10.6116709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.6116709447
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.9412587719
MESH:D013163 Splenomegaly Trinitrotoluene 4.8815817613
MESH:D013272 Stomach Diseases Omeprazole 4.2918545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5020155912 2093021
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.5016033868
MESH:D013276 Stomach Ulcer Amiodarone 6.6318087811
MESH:D013276 Stomach Ulcer Omeprazole 6.6315991576 18237397 11906479 16755016 10750652 17977527
MESH:D020521 Stroke Vitamin E 3.2716517955
MESH:D013610 Tachycardia Amiodarone 3.9811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8819225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D013959 Thyroid Diseases Amiodarone 10.9519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9512697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.4415710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.5418020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 3.8711989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.5516049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.5517053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.5516712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9910091137
MESH:D014581 Urticaria Acetaminophen 2.6810982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.7516175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.4515809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.4514692618
MESH:D014605 Uveitis Cyclosporine 3.651336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1216002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1117120751
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
REACT:6167 Influenza Infection
REACT:17015 Metabolism of proteins
REACT:13698 Regulation of beta-cell development
KEGG:03010 Ribosome
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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