AutismKB 2.0

Annotation Detail for RREB1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RREB1 ( FINB,HNT,LZ321,RREB-1,Zep-1 )
Gene Full Name: ras responsive element binding protein 1
Band: 6p24.3
Quick LinksEntrez ID:6239; OMIM: 602209; Uniprot ID:RREB1_HUMAN; ENSEMBL ID: ENSG00000124782; HGNC ID: 10449
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of RREB1 mRNAaffects expression 17331233
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RREB1 mRNAdecreases expression 19150397
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA]decreases expression|decreases reaction 18200517
D003907 Dexamethasone Dexamethasone results in increased expression of RREB1 mRNAincreases expression 16144937
D006851 Hydrochloric Acid Hydrochloric Acid results in decreased expression of RREB1 mRNAdecreases expression 15046208
C006253 pirinixic acid pirinixic acid results in increased expression of RREB1 mRNAincreases expression 18301758
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA]decreases expression|decreases reaction 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNAdecreases expression 18200517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Hydrochloric Acid 5.5916144966 19262391 15920416 12771618 20872349 11574821
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 6.1317183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 6.2620597076
MESH:D055371 Acute Lung Injury Hydrochloric Acid 10.3519760209 11850527 19094174 15970105 16759491 11953099 19060228
MESH:D055371 Acute Lung Injury pirinixic acid 10.3518653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D019973 Alcohol-Related Disorders Curcumin 5.5217887948
MESH:D000544 Alzheimer Disease Curcumin 2.6615590663
MESH:D000860 Anoxia Hydrochloric Acid 5.7015090967
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6917659584
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7916807698
MESH:D050197 Atherosclerosis Curcumin 3.4718704882
MESH:D001327 Autoimmune Diseases Curcumin 4.8519761891
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 10.3815920416
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.3819483382
MESH:D002545 Brain Ischemia Curcumin 4.7316770732
MESH:D001932 Brain Neoplasms Curcumin 4.2017596214
MESH:D001943 Breast Neoplasms Curcumin 2.7116243823 19250217 18593918 18462866
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 4.8112378975
MESH:D001986 Bronchial Spasm Hydrochloric Acid 5.9115578804
MESH:D002277 Carcinoma Curcumin 4.0618593918
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0518414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8218462866
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D003092 Colitis Curcumin 11.1718200517 16804969 16782535
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 11.1718200517 18023891 16804969 17991707 16474422 16867261 16782535 17936198 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5217276891
MESH:D003103 Coloboma Curcumin 4.8318809619
MESH:D003110 Colonic Neoplasms Curcumin 4.1716340194 19359593
MESH:D003110 Colonic Neoplasms Dexamethasone 4.1715824018
MESH:D016510 Corneal Neovascularization Curcumin 5.2618497527
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2917728286
MESH:D003556 Cystitis Hydrochloric Acid 5.9112599022 19279288 12853844 20719367
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 6.2617714534
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.7612438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7518403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.2618204486
MESH:D003967 Diarrhea Dexamethasone 4.027237001
MESH:D004381 Duodenal Ulcer Curcumin 4.3817351913
MESH:D004485 Eczema Dexamethasone 4.7912438553
MESH:D004487 Edema Dexamethasone 7.8619703484
MESH:D004487 Edema pirinixic acid 7.8612083418
MESH:D004935 Esophageal Diseases Hydrochloric Acid 6.1919566590
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D004941 Esophagitis Hydrochloric Acid 6.3912928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 6.4614621274 11346197 20516732
MESH:D005234 Fatty Liver Curcumin 8.8219297423
MESH:D005234 Fatty Liver pirinixic acid 8.8219236843 20131406
MESH:D005355 Fibrosis Curcumin 17.3918705752
MESH:D005355 Fibrosis Hydrochloric Acid 17.3918497604
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 17.3917994277
MESH:D005739 Gas Poisoning Hydrochloric Acid 5.9112378975
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 5.6620545468 19957777 20616304 19951613 12212954 20516732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0518462866
MESH:D005909 Glioblastoma Curcumin 3.6417596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8318829502 18462866
MESH:D006356 Heartburn Hydrochloric Acid 6.1919566590
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3519176532 18467677 19772884 16221962
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.4017701891
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.157520565
MESH:D006937 Hypercholesterolemia Curcumin 4.3318704882
MESH:D006940 Hyperemia Hydrochloric Acid 6.0512646421
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Dexamethasone 3.0217042910
MESH:D006975 Hypertension, Portal Hydrochloric Acid 5.7116984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.6519262391
MESH:D007022 Hypotension Hydrochloric Acid 5.0611574821
MESH:D007249 Inflammation Curcumin 9.4116956363 17151092 18403477
MESH:D007249 Inflammation Dexamethasone 9.418960868 11099482
MESH:D007249 Inflammation Hydrochloric Acid 9.4111574821
MESH:D015212 Inflammatory Bowel Diseases Curcumin 7.0018596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 7.0018200517
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007410 Intestinal Diseases Hydrochloric Acid 11.6511574821
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 11.6517994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.4810783313
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 6.8116498863
MESH:D007826 Laryngismus Hydrochloric Acid 6.8111510729
MESH:D007889 Leiomyoma Curcumin 4.8818555241
MESH:D007938 Leukemia Curcumin 3.3618462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4916106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.0916106398
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 4.2016984587
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.7417355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 3.7416718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.7415474484
MESH:D008107 Liver Diseases Curcumin 2.6616956363
MESH:D008113 Liver Neoplasms pirinixic acid 1.9016377806 20007298 15890375
MESH:D008171 Lung Diseases Hydrochloric Acid 4.4616784557
MESH:D055370 Lung Injury Asbestos, Crocidolite 10.8017365036
MESH:D055370 Lung Injury Hydrochloric Acid 10.8017627322 18573544 18497604 15607125 20597076 21311175 19262391 11395602 21114838 16129981 15090967 18339021 19644408 15044056
MESH:D008175 Lung Neoplasms Curcumin 2.8918462866 19359593 16243823
MESH:D008175 Lung Neoplasms Dexamethasone 2.8911195469 15824018
MESH:D008223 Lymphoma Curcumin 3.7818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0516173963
MESH:D008545 Melanoma Curcumin 2.4417885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.4817263510
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2718303189 16966607 16166281
MESH:D009101 Multiple Myeloma Curcumin 8.2319372569
MESH:D009101 Multiple Myeloma Dexamethasone 8.2316118317 15867202 15744524
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.3117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.689809623
MESH:D009203 Myocardial Infarction Hydrochloric Acid 6.3518534312
MESH:D009203 Myocardial Infarction pirinixic acid 6.3519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.7018495463
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.9812497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.0718462866
MESH:D009765 Obesity Curcumin 4.7919297423
MESH:D009765 Obesity pirinixic acid 4.7920558911
MESH:D009784 Occupational Diseases Hydrochloric Acid 5.0312378975
MESH:D010024 Osteoporosis Curcumin 3.6218719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8819020741 18462866
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0119401701 17440100 19196508
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.5017698068
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2510923243
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 5.7718497604 18573544 15607125 15970105
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6821297632
MESH:D011471 Prostatic Neoplasms Curcumin 3.6415129424 18226269 18156803 11398177 12497104 10851300 18769126
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 6.4620597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 5.6615090967
MESH:D011656 Pulmonary Emphysema Curcumin 4.7919168576
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1117322281 15814490 17365031 17975199
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 17.2210666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 17.2218379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 17.2217627322 18549715 18339021 16784557 16129981
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 6.8111510729
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 5.6120516732
MESH:D012509 Sarcoma Curcumin 4.3818462866
MESH:D018805 Sepsis Curcumin 4.3118389075
MESH:D013272 Stomach Diseases Dexamethasone 4.7215472012
MESH:D013276 Stomach Ulcer Curcumin 13.9816631530 19188055
MESH:D013276 Stomach Ulcer Dexamethasone 13.9815138204
MESH:D013276 Stomach Ulcer Hydrochloric Acid 13.9816755016 15309881 17189318
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.9818593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.6618462866
MESH:D014605 Uveitis Dexamethasone 5.261336536
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved