AutismKB 2.0

Annotation Detail for RRM1


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Basic Information Top
Gene Symbol:RRM1 ( R1,RIR1,RR1 )
Gene Full Name: ribonucleotide reductase M1
Band: 11p15.4
Quick LinksEntrez ID:6240; OMIM: 180410; Uniprot ID:RIR1_HUMAN; ENSEMBL ID: ENSG00000167325; HGNC ID: 10451
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY0-166pyrimidine deoxyribonucleotides de novo biosynthesis
Pathway IDPathway Name
hsa00480Glutathione metabolism
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
Pathway IDPathway Name
200027E2F transcription factor network
Pathway IDPathway Name
P02739De novo pyrimidine deoxyribonucleotide biosynthesis
P02738De novo purine biosynthesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
Desease Name
PHARMACOGENOMIC
breast cancer neutropenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RRM1 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of RRM1 mRNAdecreases expression 16514628
D000082 Acetaminophen Acetaminophen affects the expression of RRM1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of RRM1 mRNAdecreases expression 17942131
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RRM1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RRM1 mRNAdecreases expression 17942131
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RRM1 mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RRM1 mRNAdecreases expression 20382639
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of RRM1 mRNAdecreases expression 17942131
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of RRM1 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RRM1 mRNAaffects expression 17484886
D003345 Corticosterone Corticosterone results in decreased expression of RRM1 mRNAdecreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of RRM1 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of RRM1 mRNAdecreases expression 17942131
D003976 Diazinon Diazinon results in decreased expression of RRM1 mRNAdecreases expression 16539210
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RRM1 mRNAincreases expression 17854601
D004958 Estradiol Estradiol results in increased expression of RRM1 mRNAincreases expression 16514628
D004958 Estradiol Estradiol affects the expression of RRM1 mRNAaffects expression 16684588
15598610
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of RRM1 mRNAincreases expression 17317680
D005472 Fluorouracil Fluorouracil results in increased expression of RRM1 proteinincreases expression 15331170
C070081 fulvestrant fulvestrant results in decreased expression of RRM1 mRNAdecreases expression 16514628
C008493 methylselenic acid methylselenic acid affects the expression of RRM1 mRNAaffects expression 14617803
D010126 Ozone Ozone results in increased expression of RRM1 mRNAincreases expression 12763052
19555225
D010634 Phenobarbital Phenobarbital affects the expression of RRM1 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of RRM1 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in increased expression of RRM1 mRNAincreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of RRM1 mRNA]increases expression|increases reaction 17950772
D028321 Plant Preparations Plant Preparations affects the expression of RRM1 mRNAaffects expression 16046712
D011374 Progesterone Progesterone affects the expression of RRM1 mRNAaffects expression 17251523
D011374 Progesterone Progesterone results in increased expression of RRM1increases expression 17510236
C037219 quinoline quinoline analog results in decreased expression of RRM1 proteindecreases expression 18645022
D020849 Raloxifene Raloxifene results in decreased expression of RRM1 mRNAdecreases expression 16514628
D024505 Tocopherols Tocopherols results in increased expression of RRM1 mRNAincreases expression 17056531
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.236195326
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7620127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.7611473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.7617638652
MESH:D000236 Adenoma 2-Acetylaminofluorene 10.5610737359
MESH:D000236 Adenoma Benzo(a)pyrene 10.566695378
MESH:D000236 Adenoma Diethylnitrosamine 10.566695378 10737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.806705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.1319052882 17620307 19061943 18056438 16434500 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.1317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.1316434500
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.1316487989
MESH:D000419 Albuminuria Raloxifene 4.3917451421 17308373
MESH:D000544 Alzheimer Disease Ozone 4.2115513908
MESH:D000544 Alzheimer Disease Raloxifene 4.2115800139
MESH:D000740 Anemia Fluorouracil 3.5315504547 17963324 16511603
MESH:D000799 Angioedema Acetaminophen 3.6310982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Ozone 2.5817854713 16373670
MESH:D001284 Atrophy fulvestrant 4.6511514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.9619483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1317868700
MESH:D001930 Brain Injuries Progesterone 10.2815665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 10.2816580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.5617474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.5617474063
MESH:D001943 Breast Neoplasms Estradiol 4.5617289903 17261762 12948864 16675129 18497071 19861407 14630087 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 4.5616110121 18357371 16557594 15136595 19217205 16595493 18608205
MESH:D001943 Breast Neoplasms fulvestrant 4.5618984771
MESH:D001943 Breast Neoplasms Plant Preparations 4.5617398067
MESH:D001943 Breast Neoplasms Progesterone 4.5617614352 16175315 15562024
MESH:D001943 Breast Neoplasms Raloxifene 4.5616837676 15572757 17595753 17049068 17242785 17893378 17440819 17952589 15775269 17261762 16912660 15758505
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5114754758 16777450 17626835 18315731 19059883 15516495 18417511
MESH:D002100 Cachexia Ozone 4.5316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5716050911 16097048 15721981 18705752 16011737 16124888 15700767 3786805 16192424 15673190 10355542 16227642
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4616051944
MESH:D002277 Carcinoma Fluorouracil 3.4017121937
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 18230555
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 22.2616705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 22.263084413 6705139 10737359 17761372 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 22.263084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 22.2621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 22.2618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 22.2620935162 16878318 19383236 10672840 16807293 16698587 19701751 16328049 17428255 20514400 19107877 17761372 16779866 16502159 19418558 18971187 3581430 17055752 3084413 20727157 20524982 17978847 19394651 19539802 21159647 16540662 10737359 19208518 11831363 17138121 18056438 18506893 20512989 20214788 18494052 18978308 19335982 16569478 20432363 19919837 20007298 19171122 19822196 16288022 18785209 18788625 19052882 17173139 18691550 16935385 20101231 16830150 18210153 18665156 20084675 18393292 19519916 16681979 17162532
MESH:D006528 Carcinoma, Hepatocellular Estradiol 22.2616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 22.2617971768 17045692 16332177 18930000 16799960 17088986
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 22.2620007298 1701930 6705139 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular quinoline 22.26598648
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9218695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3420419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.3416280240 16757204 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 7.3417418620
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8917572228
MESH:D002318 Cardiovascular Diseases Plant Preparations 7.4316862667
MESH:D002318 Cardiovascular Diseases Raloxifene 7.4315775269
MESH:D016893 Carotid Stenosis Plant Preparations 5.9315158307
MESH:D002386 Cataract Acetaminophen 2.4610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 19.566135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.5620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.5612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.5617174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.5618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5119052882
MESH:D002779 Cholestasis Cyclosporine 7.2519486331
MESH:D002779 Cholestasis pirinixic acid 7.2519176532
MESH:D003072 Cognition Disorders Raloxifene 4.4115800139
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2016510598 17172411 15001691 17016597 17725105 17287894 17018589 18772588 16340194 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017255274 17454858 15289873 17401013 14970324 15148649 17016601 18509181 18288408 16331619 18949393 16391804 17594712 17695437 17094418 18802399 18383874 18448328 16524972 16282729 16303861 20501625
MESH:D003324 Coronary Artery Disease Plant Preparations 3.9215158307
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8118551238
MESH:D007644 Darier Disease Fluorouracil 4.5816733453
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9817474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.1420387270
MESH:D003928 Diabetic Nephropathies Estradiol 8.4219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.4217451421 17308373 15920148
MESH:D003929 Diabetic Neuropathies Progesterone 4.2817187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.4419370779 10663392 17562736 12594235 19416960 18713872 16109766 11743745 11834606 12392966 11461765 14550746 11421492 11739529 19923254 11287661 16393943 11529661 19085960 12540782 14986274 19164858 17522070 15619225 15968718 10774834 14725611 19739265 16485898 10915739 16081117 19420014 18071297 17906064 12705907 12153990 12958197 16781746 16227642 16177239 2444490
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.447120509 10915739 16227642 15968718 3786805 19085960 4309450 2869522 15027814 16177239 11566570 21278145 3732212 7440962 9327722 6884620 19336974 6623471 10092053 15998439 17522070 7179309
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.4419107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8919426721
MESH:D004362 Drug Toxicity Plant Preparations 4.5211033412
MESH:D004417 Dyspnea Diazinon 4.5916487989
MESH:D004421 Dystonia Phenobarbital 3.811851702
MESH:D004487 Edema pirinixic acid 6.2712083418
MESH:D004487 Edema Raloxifene 6.2715860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.6617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.6615845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.3319148513
MESH:D016889 Endometrial Neoplasms Estradiol 7.3311473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 3.5816134523
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.903659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.663922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.376401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.813659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.9920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.9916530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.9915173087 16785472 16337965 16481741 17638652
MESH:D004938 Esophageal Neoplasms Plant Preparations 9.9916510608
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.6319224547 15959796 61145 12631006 17595544 16045604 16239168 12795759
MESH:D005234 Fatty Liver Cyclosporine 22.6319224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.6320387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 22.6320131406 19236843
MESH:D005234 Fatty Liver Raloxifene 22.6317473493
MESH:D005355 Fibrosis Carbon Tetrachloride 7.9818705752
MESH:D005355 Fibrosis Cyclosporine 7.9812168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.4616983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005910 Glioma Fluorouracil 2.7916145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.2515102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.5520471113
MESH:D006331 Heart Diseases Raloxifene 3.3911110106
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 12.286705139
MESH:D006390 Hemangioendothelioma quinoline 12.28598648
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 9.186705139
MESH:D006394 Hemangiosarcoma quinoline 9.18598648
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006505 Hepatitis Carbon Tetrachloride 8.9419900420 19110552
MESH:D006505 Hepatitis Diazinon 8.9416487989
MESH:D006529 Hepatomegaly Phenobarbital 7.7916109766
MESH:D006529 Hepatomegaly pirinixic acid 7.7919176532 19772884 18467677 16221962
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006930 Hyperalgesia Acetaminophen 2.5416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006973 Hypertension Cyclosporine 5.0310903974
MESH:D006973 Hypertension Raloxifene 5.0317577099 15787275
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8815338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1915869954
MESH:D007248 Infertility, Male Diazinon 6.9512948887 16466525
MESH:D007248 Infertility, Male fulvestrant 6.9511514358
MESH:D007249 Inflammation Diethylnitrosamine 4.8118785209
MESH:D007249 Inflammation Progesterone 4.8115869954
MESH:D007333 Insulin Resistance Estradiol 6.7516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.7516306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Acetaminophen 9.2812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.288314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.2815618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.3616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 16.3612371664
MESH:D007680 Kidney Neoplasms Estradiol 16.3615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 16.3616985049
MESH:D007889 Leiomyoma Raloxifene 4.3016973256
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3516943688 16239168 21278145 11903743 17157831 16221502 17174718 17334410 11408273
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3518665156 19638242 18522880 18407596 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3521047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7915925388 20821823 17869086 12609069 18277467 17823541 12445418 11481614 15123356 10355542 12546737 17565644 18156304 16116963 17708605 14716833 15730626 17721639 18376398 17525996 15673190 18279442 12649538 18420326 17761835 17640975 18006644 15052691 14620537 18705752 17631135 17944888 18429990 15893842 15996030 18166357 15818738 18263696 12632514 18418968 17481882 16011737 12741479 15650968 17557913 12666154 15370692 15876570 16136751 14716496 14512876 18317297 16638106 12667390 12898905 15057751 15362042 12445421 18472332 17900296 14748882 15959796 12389079 17976157 17922224 16033810 15338365 16015684 18412020 16097048 17805973 13678700 17766677 18481824 17714472 18395095 16192424 14724832 15931870 18205269 17698563 18339082 12632512 18210741 18054572 18187930 12586293 18251166 12958196 16248980 16027843 18472094 18395914
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7915474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 4.7917724770
MESH:D008107 Liver Diseases Acetaminophen 8.9016611625 12587719 19460945 16610002 12969438 19784758 11587558 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.9015720792 16246199 15830285 17285989 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 8.9017034775
MESH:D008107 Liver Diseases Phenobarbital 8.9019363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8017185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8016899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 28.617678174
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 28.6110672840 18001218 11376686 14678523 16273603 10737359
MESH:D008113 Liver Neoplasms Aflatoxin B1 28.619163691 18177683 15890375 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 28.6120195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.6119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 28.6110737359 19690152 18754104 12771043 20405173 20137499 20118626 19812893 18644402 18977376 20501860 2862719 15885732 20101389 19256749 15175105 19551842 21071580 16942905 19090486 9163691 19255062 20434301 20583210 21047994 19996281 19833225 18648771 19850985 21278145 19427195 12112319 19426721 19294768 19073162 19254457 20492335 2422723 18978307 19499222 20452335 19638242 21167192 19642983
MESH:D008113 Liver Neoplasms Fluorouracil 28.6116603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 28.6119812893 8742319 19073162 19482888 15975961 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 28.6120007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 21.696135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 21.69534488 6150874 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 21.698603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 21.6915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.6918544905 19004024 18775883 2563599 9362446 17942915 18079962 21159647 18308698 18093689 19009564 19126423 18282651 3124819 16842330 18253720 16267830 17854601 19539802 18164116 19519916 17174075
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.6918308698 1399818 2563599 17172636 6150874
MESH:D008171 Lung Diseases Ozone 3.248266340 19066396
MESH:D055370 Lung Injury Ozone 3.6420417186
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 8.2111376686
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.2114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2120869020 17053015 18520028 20464547 6695378 18569708 18816296 20135361 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.2120970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 8.2115246190
MESH:D008175 Lung Neoplasms Ozone 8.217614698 8597069
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5815086387
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 13.2912807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.2911408345 17203775 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.2917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 13.2917927505
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3619513568
MESH:D008654 Mesothelioma Tocopherols 4.0215878867
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D008679 Metaplasia Ozone 4.8910496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3415863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 13.6116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 13.6116757204 18986760
MESH:D009062 Mouth Neoplasms Plant Preparations 13.6117418620
MESH:D009101 Multiple Myeloma Raloxifene 3.2916497877
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0619151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009232 Myxoma Raloxifene 5.3416343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.657678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.009029167 3581430
MESH:D009362 Neoplasm Metastasis quinoline 6.00598648
MESH:D009369 Neoplasms Benzo(a)pyrene 7.6211141357
MESH:D009369 Neoplasms Fluorouracil 7.6218239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 7.6217405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.4511399458 16427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3016436463
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2516049721
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010024 Osteoporosis Raloxifene 3.2715775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0315758505 15579764 17823083 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 4.6519401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.6516525653 17393432
MESH:D010146 Pain Acetaminophen 2.2316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.1916540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.1916500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.1916965848
MESH:D010538 Peritonitis Ozone 3.9216369182
MESH:D011014 Pneumonia Ozone 4.1818007984 18381685 18929643
MESH:D011041 Poisoning Diazinon 4.1617603234
MESH:D011230 Precancerous Conditions Cyclosporine 14.2512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.252563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.252563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8919082440 18626508
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.8916205645
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8915731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tocopherols 1.8912504091
MESH:D019310 Pseudolymphoma Phenobarbital 4.2812752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011693 Purpura Raloxifene 5.3415770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8315538739 18722050 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012640 Seizures 2,6-dinitrotoluene 5.4618551238
MESH:D012640 Seizures Phenobarbital 5.463137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3810029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.388532709
MESH:D013119 Spinal Cord Injuries Progesterone 4.0715862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.242093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2418456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.2417522103 19084572 19015929 18567086 16424979 17172411 16951190 15786421 18396642 17498489
MESH:D020521 Stroke Raloxifene 3.6616837676
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.667505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.661399818
MESH:D013978 Tibial Fractures Estradiol 13.0019048282
MESH:D013978 Tibial Fractures Raloxifene 13.0019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8116280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.9616049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 14.961399818 15867355 15289314
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.9617053015
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 14.9611251952
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.9617572228
MESH:D014570 Urologic Diseases Diazinon 5.0616487989
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1110091137
MESH:D014581 Urticaria Acetaminophen 2.7810982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.7016803524
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D054556 Venous Thromboembolism Raloxifene 5.0016837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3416343187
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:00480 Glutathione metabolism
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA298
    • No data
    Releated disease ID Related disease Name
    PA444760Leukemia, Myeloid, Acute
    PA446108Colorectal Neoplasms
    PA443560Breast Neoplasms
    PA443622Carcinoma, Non-Small-Cell Lung
    PA444814Lung Diseases
    PA444818Lung Neoplasms
    PA446512Lung Diseases, Interstitial
    PA445062Neoplasms
    PA445218Pancreatic Neoplasms
    Releated drug ID Related drug Name
    PA449177cytarabine
    PA448771capecitabine
    PA128406956fluorouracil
    PA10090l-glutamine
    PA449014cisplatin
    PA449748gemcitabine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00242 antagonist Cladribine Antineoplastic Agents;Immunosuppressive Agents
    DB00441 antagonist Gemcitabine Antineoplastic Agents;Antiviral Agents;Radiation-Sensitizing Agents;Antimetabolites;Enzyme Inhibitors;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    DB00631 antagonist Clofarabine Antineoplastic Agents;Antimetabolites;Purine analogues
    DB01005 antagonist Hydroxyurea Antineoplastic Agents;Enzyme Inhibitors;Nucleic Acid Synthesis Inhibitors;Antisickling Agents
    DB01073 antagonist Fludarabine Antineoplastic Agents;Antimetabolites;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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