AutismKB 2.0

Annotation Detail for RRM2


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Basic Information Top
Gene Symbol:RRM2 ( R2,RR2,RR2M )
Gene Full Name: ribonucleotide reductase M2
Band: 2p25.1
Quick LinksEntrez ID:6241; OMIM: 180390; Uniprot ID:RIR2_HUMAN; ENSEMBL ID: ENSG00000171848; HGNC ID: 10452
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY0-166pyrimidine deoxyribonucleotides de novo biosynthesis
Pathway IDPathway Name
hsa00480Glutathione metabolism
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa04115p53 signaling pathway
hsa01100Metabolic pathways
Pathway IDPathway Name
Cell Cycle, Mitotic
Metabolism of nucleotides
Pathway IDPathway Name
200027E2F transcription factor network
Pathway IDPathway Name
P02739De novo pyrimidine deoxyribonucleotide biosynthesis
P00059p53 pathway
P02738De novo purine biosynthesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of RRM2 mRNAincreases expression 20713471
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RRM2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen results in decreased expression of RRM2 mRNAdecreases expression 17942131
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RRM2 proteinaffects expression 20106945
D000968 Antimycin A Antimycin A results in decreased expression of RRM2 mRNAdecreases expression 19304788
D001374 Azacitidine [Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNAaffects cotreatment|affects expression 18720364
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RRM2 mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RRM2 mRNAdecreases expression 17942131
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RRM2 mRNAdecreases expression 20382639
C053541 bicalutamide bicalutamide results in decreased expression of RRM2 mRNAdecreases expression 15638997
C006780 bisphenol A bisphenol A results in increased expression of RRM2 mRNAincreases expression 16474171
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of RRM2 mRNAdecreases expression 17942131
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of RRM2 mRNAdecreases expression 17961207
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RRM2 mRNAaffects expression 17484886
D003520 Cyclophosphamide RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D016572 Cyclosporine Cyclosporine results in decreased expression of RRM2 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of RRM2 mRNAdecreases expression 17942131
D003561 Cytarabine Cytarabine results in increased expression of RRM2 mRNAincreases expression 19194470
C020735 dibutyldichlorotin dibutyldichlorotin results in increased expression of RRM2 mRNAincreases expression 10722888
D004041 Dietary Fats Dietary Fats results in increased expression of RRM2 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RRM2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RRM2 mRNAincreases expression 19638242
D004317 Doxorubicin Doxorubicin affects the expression of RRM2 mRNAaffects expression 15205334
D004317 Doxorubicin RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D004958 Estradiol Estradiol results in decreased expression of RRM2 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of RRM2 mRNAincreases expression 16474171
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of RRM2 mRNAaffects cotreatment|decreases expression 17404688
D004958 Estradiol Estradiol affects the expression of RRM2 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RRM2 mRNAaffects expression 17351261
D005472 Fluorouracil Fluorouracil affects the expression of RRM2 mRNAaffects expression 15205334
16584549
D005472 Fluorouracil Fluorouracil results in decreased expression of RRM2 mRNAdecreases expression 17039268
16557594
D005472 Fluorouracil Fluorouracil results in increased expression of RRM2 mRNAincreases expression 16709241
D005472 Fluorouracil RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
D005472 Fluorouracil RRM2 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
C106014 gedunin gedunin results in decreased expression of RRM2 mRNAdecreases expression 17010675
D019833 Genistein Genistein results in increased expression of RRM2 mRNAincreases expression 16474171
D007501 Iron [Iron co-treated with Oxygen] binds to RRM2 proteinaffects binding|affects cotreatment 16829694
C015329 lycopene lycopene results in increased expression of RRM2 mRNAincreases expression 16886892
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of RRM2 mRNAincreases expression 20713471
C008493 methylselenic acid methylselenic acid affects the expression of RRM2 mRNAaffects expression 14617803
D010100 Oxygen [Iron co-treated with Oxygen] binds to RRM2 proteinaffects binding|affects cotreatment 16829694
D010126 Ozone Ozone results in increased expression of RRM2 mRNAincreases expression 19555225
D017239 Paclitaxel RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]affects cotreatment|affects response to substance 16896004
C041786 palm oil palm oil results in increased expression of RRM2 mRNAincreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of RRM2 mRNAincreases expression 17560707
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of RRM2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of RRM2 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of RRM2 mRNAincreases expression 18445702
18301758
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of RRM2 mRNAincreases expression 16474171
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of RRM2 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone Progesterone results in increased expression of RRM2 mRNAincreases expression 18070364
C059514 resveratrol resveratrol results in decreased expression of RRM2 mRNAdecreases expression 15767336
D012402 Rotenone Rotenone results in decreased expression of RRM2 mRNAdecreases expression 19304788
D012402 Rotenone Rotenone results in increased expression of RRM2 mRNAincreases expression 19013527
C025462 sulindac sulfide sulindac sulfide results in decreased expression of RRM2 mRNAdecreases expression 12734198
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RRM2 mRNAdecreases expression 16714409
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RRM2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RRM2 mRNAincreases expression 15667827
19465110
D013792 Thalidomide [Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNAaffects cotreatment|affects expression 18720364
D024505 Tocopherols Tocopherols results in increased expression of RRM2 mRNAincreases expression 17056531
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of RRM2 mRNAdecreases expression 17951470
C050414 tripterine tripterine results in decreased expression of RRM2 mRNAdecreases expression 17010675
D014635 Valproic Acid Valproic Acid results in decreased expression of RRM2 mRNAdecreases expression 19101580
D014747 Vinblastine RRM2 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 16.236195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.2315322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 16.238333272
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 16.238875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.4719490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4217505938
MESH:D058186 Acute Kidney Injury resveratrol 3.4016538975
MESH:D055371 Acute Lung Injury Oxygen 7.6716759491
MESH:D055371 Acute Lung Injury pirinixic acid 7.6718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 15.0720127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 15.0717418594
MESH:D000230 Adenocarcinoma Estradiol 15.0711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.0714692618
MESH:D000230 Adenocarcinoma Fluorouracil 15.0717638652
MESH:D000230 Adenocarcinoma Genistein 15.0711473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 17.723712494
MESH:D000236 Adenoma Benzo(a)pyrene 17.726695378
MESH:D000236 Adenoma Diethylnitrosamine 17.726695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 17.726695378 10545420
MESH:D000236 Adenoma resveratrol 17.7215688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.6918056438 19061943 17162532 17620307 16434500 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.6917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.6916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.6916835633
MESH:D000419 Albuminuria Doxorubicin 4.0621441931
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.1416640825
MESH:D000544 Alzheimer Disease Iron 8.3316563566 16640825
MESH:D000544 Alzheimer Disease Ozone 8.3315513908
MESH:D000544 Alzheimer Disease resveratrol 8.3316162502 16183991
MESH:D000544 Alzheimer Disease sulindac sulfide 8.3318759972
MESH:D000550 Amblyopia Valproic Acid 4.7117688650
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.0316510725
MESH:D000740 Anemia Fluorouracil 12.3415504547 16511603 17963324
MESH:D000740 Anemia Iron 12.3416566752 16434484
MESH:D000740 Anemia Tetrachlorodibenzodioxin 12.3411748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.2116569441 17163184 17375513 17162259 17147795
MESH:D000756 Anemia, Sideroblastic Iron 4.3616910769
MESH:D000799 Angioedema Acetaminophen 3.3310982225
MESH:D000860 Anoxia Oxygen 4.5520872349
MESH:D001008 Anxiety Disorders Valproic Acid 3.1717497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5819183758
MESH:D001145 Arrhythmias, Cardiac Iron 3.9316604332
MESH:D001161 Arteriosclerosis Cyclophosphamide 14.2015014928
MESH:D001161 Arteriosclerosis Dietary Fats 14.2015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 14.2011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.5315885639
MESH:D001169 Arthritis, Experimental resveratrol 10.5317115116
MESH:D001169 Arthritis, Experimental Thalidomide 10.539598899
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4215570426
MESH:D001249 Asthma Ozone 2.4717854713 16373670
MESH:D001260 Ataxia Telangiectasia Iron 4.9415336622
MESH:D050197 Atherosclerosis Iron 13.1416640825 16632123
MESH:D050197 Atherosclerosis Methylcholanthrene 13.1411922910
MESH:D050197 Atherosclerosis Oxygen 13.1416391483
MESH:D050197 Atherosclerosis resveratrol 13.1416873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 2.1018445737
MESH:D001321 Autistic Disorder Iron 2.1017352947
MESH:D001321 Autistic Disorder Valproic Acid 2.1017688650 20603192 19460635 15238991 18985861 18316065 18177632 17507914 18775368 18558336 17157402 18396377 18940202 16609825 19232924
MESH:D001424 Bacterial Infections Iron 4.6916640825
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.501440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 2.8020046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.2619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.2612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.9015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.908888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.1814601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.1015867366
MESH:D001862 Bone Resorption bisphenol A 3.4111985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8217868700
MESH:D001930 Brain Injuries Progesterone 3.7615665606 15380490 15845082
MESH:D002545 Brain Ischemia resveratrol 3.7817600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.3717150277
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 14.7411921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 14.7420146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 14.7417123778
MESH:D001943 Breast Neoplasms Cyclophosphamide 14.7411325840 15136595 17388661 15093573 18234424 12006526 16978400 17020986 18323546
MESH:D001943 Breast Neoplasms Dietary Fats 14.7420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 14.7417474063
MESH:D001943 Breast Neoplasms Doxorubicin 14.7416096432 15634643 18234424 15692762 16264153 16826403 18628466 18382427 18695136 16595493 17369602 15993339 19526202 16935488 15939500 15994142 15567936 16115903 17426702 16322301 11325840 17983394 15136595 15668708
MESH:D001943 Breast Neoplasms Estradiol 14.7417289903 16675129 17261762 17018787 12948864 14630087 19861407 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 14.7419217205 16595493 16110121 16557594 18357371 15136595 18608205
MESH:D001943 Breast Neoplasms Genistein 14.7416541309 17200150 16873071
MESH:D001943 Breast Neoplasms Methylcholanthrene 14.7417474063
MESH:D001943 Breast Neoplasms Oxygen 14.7417263869
MESH:D001943 Breast Neoplasms Paclitaxel 14.7418223236 16273361 11325840 16244791 18234424 15136595 16115903 18323546
MESH:D001943 Breast Neoplasms Progesterone 14.7415562024 17614352 16175315
MESH:D001943 Breast Neoplasms resveratrol 14.7417651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 14.7420435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2816777450 17626835 15516495 18315731 19059883 18417511 14754758
MESH:D002100 Cachexia Ozone 4.2316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.293786805 16227642 16097048 15700767 16192424 16011737 16050911 15673190 10355542 18705752 15721981 16124888
MESH:D002276 Carcinoid Tumor Doxorubicin 10.6316051944
MESH:D002276 Carcinoid Tumor Fluorouracil 10.6316051944
MESH:D002277 Carcinoma Fluorouracil 11.6517121937
MESH:D002277 Carcinoma Methylcholanthrene 11.6510545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.6516835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 18230555
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 33.043581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 33.043084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 33.0421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 33.0418788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 33.0419701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 33.0416681979 20007298 20514400 19822196 20101231 19171122 10737359 11831363 19208518 3581430 19919837 20935162 17162532 16807293 19701751 17138121 19418558 16288022 20512989 17173139 19107877 16779866 18691550 16698587 10672840 19335982 18393292 19519916 19052882 17428255 19383236 16830150 18665156 17978847 16328049 20524982 18978308 18785209 18788625 18506893 18056438 20084675 18210153 16540662 20727157 21159647 16569478 19394651 19539802 16878318 18971187 16502159 3084413 20432363 18494052 20214788 16935385 17055752 17761372
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 33.0416234567 16023760 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 33.0416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 33.0416332177 17088986 17045692 16799960 18930000 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 33.0416924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 33.0416313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 33.0417173139 1701930 20007298 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular resveratrol 33.0419321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 33.0416313753
MESH:D002278 Carcinoma in Situ bisphenol A 4.4817123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 9.8016152834
MESH:D018827 Carcinoma, Lewis Lung resveratrol 9.8016675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.2512391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 17.457296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 17.4516201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 17.4516201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 17.4518695887
MESH:D002292 Carcinoma, Renal Cell Vinblastine 17.451485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.3620419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 9.366189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.3616280240 16757204 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 9.3616227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0716120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 7.0215792986 16651473 16109756 16364871 17928571 15476868 17351982 16731534 17382496 17308081 16952015 17519947 16278810 17131338 16612575 17329180 15811867 16269455 17007740 17924179 15505089 18627295 16242529 17974986 16455267
MESH:D009202 Cardiomyopathies Iron 7.0216640825
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.5216243910 17334414
MESH:D002311 Cardiomyopathy, Dilated Iron 5.5216604332
MESH:D002318 Cardiovascular Diseases Genistein 6.3216332659
MESH:D002318 Cardiovascular Diseases resveratrol 6.3215458977
MESH:D002386 Cataract Acetaminophen 2.2710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 26.307505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 26.3020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 26.3012371664
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 26.308243401
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 26.307505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 26.3018566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 26.3016192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.764080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5120734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.7219052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.7216835633
MESH:D018281 Cholangiocarcinoma Thalidomide 13.7218291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.089022650 19486331
MESH:D002779 Cholestasis Cyclosporine 16.0819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.0815861022 16919318 16105132 17333356 17110522 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 16.0819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8716354765 15668235 8697196 12621046 15340226
MESH:D003092 Colitis resveratrol 8.4016474422
MESH:D003092 Colitis Thalidomide 8.4016680017
MESH:D003110 Colonic Neoplasms Fluorouracil 7.3516510598 17018589 17725105 17172411 15001691 18772588 16340194 17287894 17169374 17016597
MESH:D003110 Colonic Neoplasms Genistein 7.3517182828
MESH:D003110 Colonic Neoplasms Iron 7.3516640825
MESH:D003110 Colonic Neoplasms resveratrol 7.3516338953
MESH:D015179 Colorectal Neoplasms marker/mechanism 15814641
MESH:D015179 Colorectal Neoplasms Azacitidine 9.4819934284
MESH:D015179 Colorectal Neoplasms Doxorubicin 9.4818802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 9.4818509181 18949393 20501625 17255274 16282729 17016601 18448328 15148649 16524972 17401013 17454858 15289873 16303861 14970324 18802399 18383874 16331619 17094418 17695437 18288408 16391804 17594712
MESH:D015179 Colorectal Neoplasms Paclitaxel 9.4818802399
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 9.4815531428
MESH:D015179 Colorectal Neoplasms resveratrol 9.4816550006
MESH:D015179 Colorectal Neoplasms Vinblastine 9.4818802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6317141729 14669216
MESH:D016510 Corneal Neovascularization Thalidomide 5.079301478
MESH:D003327 Coronary Disease resveratrol 3.4116507316
MESH:D003389 Cranial Nerve Diseases Thalidomide 5.799200351
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Thalidomide 3.529200351
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.5217688650 16575769 8888407
MESH:D003424 Crohn Disease Thalidomide 3.9016078585
MESH:D003556 Cystitis Cyclophosphamide 4.4718093676 15276878 15643279 16413132 16614059 16651033 18433785 18483878 12913760 16989017 17979934 17010015 10498854 12388444 18710439 18295254 11948286 10700343 18372110 12161096
MESH:D007644 Darier Disease Fluorouracil 4.2816733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.2516140633
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.348970840 8156756 11298694 12868966 14531868 2524372 11906362 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.033621924 2952479
MESH:D003920 Diabetes Mellitus Iron 4.0316604332 16640825
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 7.3010990075 11751995 15331540
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.3016873680
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 5.3618772604
MESH:D003922 Diabetes Mellitus, Type 1 Iron 5.3616506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.0020387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.0016647724
MESH:D003924 Diabetes Mellitus, Type 2 Iron 9.0016506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.0017107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.6019279558
MESH:D003928 Diabetic Nephropathies resveratrol 7.6016286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.0017187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.909022650 16192314 8291058 7440962 11289319 18289764 6482804 1440618 6679447 9653073 9328219 18692083 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.9014725611 12958197 19739265 14986274 16393943 17906064 12594235 19085960 11461765 15968718 11529661 17522070 16781746 15619225 2444490 19420014 19923254 10774834 18713872 16177239 12705907 16109766 19416960 16081117 19370779 16227642 17562736 11421492 10915739 11834606 16485898 11743745 14550746 18071297 19164858 11739529 12153990 11287661 10663392 12392966 12540782
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.904309450 19336974 15027814 7179309 9327722 6884620 17522070 11566570 2869522 3732212 10092053 19085960 21278145 16227642 10915739 7120509 15968718 6623471 3786805 15998439 16177239 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.9019107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 15.9017416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.9020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.901733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5819426721
MESH:D004362 Drug Toxicity Doxorubicin 6.8418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.0818367378
MESH:D004417 Dyspnea Oxygen 4.3220016425
MESH:D004421 Dystonia Phenobarbital 8.881851702
MESH:D004421 Dystonia Valproic Acid 8.881851702
MESH:D004487 Edema perfluorooctanoic acid 12.7712083418 17259670
MESH:D004487 Edema pirinixic acid 12.7712083418
MESH:D004487 Edema resveratrol 12.778985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.7711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.6112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.6117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 12.6117872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.0816402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 10.5217359293
MESH:D016889 Endometrial Neoplasms Estradiol 10.5211473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 10.5211473722
MESH:D004715 Endometriosis Progesterone 7.4616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.4610568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6418037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3517923197
MESH:D004802 Eosinophilia Cyclophosphamide 3.7311006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.153659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.1517275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.263922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 8.263922381 16628512
MESH:D004827 Epilepsy Phenobarbital 5.7320417680
MESH:D004827 Epilepsy Valproic Acid 5.7318234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 7.446401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.446254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.657750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.657750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.793659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.793659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6016302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 12.123581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.1220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.1216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.1216785472 16481741 15173087 16337965 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 12.1216481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 35.3716239168 12631006 16045604 19224547 17595544 61145 15959796 12795759
MESH:D005234 Fatty Liver Cyclosporine 35.3719224547
MESH:D005234 Fatty Liver Dietary Fats 35.3717967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 35.3720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 35.3715345470
MESH:D005234 Fatty Liver Iron 35.3716640825
MESH:D005234 Fatty Liver pirinixic acid 35.3720131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 35.3714986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9611858732
MESH:D005315 Fetal Diseases Valproic Acid 4.3716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.658888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.506705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.0819069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.4314633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 17.0818705752
MESH:D005355 Fibrosis Cyclosporine 17.0812639820 12168785
MESH:D005355 Fibrosis Dietary Fats 17.0818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.0820067830
MESH:D005621 Friedreich Ataxia Iron 4.9316640825 16604332
MESH:D005739 Gas Poisoning Oxygen 4.7020016425
MESH:D005756 Gastritis Acetaminophen 3.1616983495
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 5.7912701121
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.718708960
MESH:D005909 Glioblastoma Doxorubicin 6.2017150277
MESH:D005909 Glioblastoma Genistein 6.2016598420
MESH:D005910 Glioma Fluorouracil 5.7116145905
MESH:D005910 Glioma Thalidomide 5.7116327979
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0011389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.577505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0810696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.5411014644 16376943 15172196
MESH:D006258 Head and Neck Neoplasms Doxorubicin 6.7415692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.7418337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.4911294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.1318674790 16707910 16879835 18006777 14766674 17888722 17875725 16244371 16244372 16495754 16144979 16330681 12587719
MESH:D006333 Heart Failure Doxorubicin 5.9617481944
MESH:D006333 Heart Failure pirinixic acid 5.9620558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4515692506
MESH:D006432 Hemochromatosis Iron 4.1117236123 16640825 17255318 17053826 16604332 16574947
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9115720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.7911918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8811000095
MESH:D006486 Hemosiderosis Iron 4.7016604332
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.0214986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 7.636705139
MESH:D006505 Hepatitis Carbon Tetrachloride 7.6319110552 19900420
MESH:D006525 Hepatitis, Viral, Human Iron 4.9516640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.4417182432
MESH:D006529 Hepatomegaly Iron 21.9116890145
MESH:D006529 Hepatomegaly perfluorooctanoic acid 21.913609246
MESH:D006529 Hepatomegaly Phenobarbital 21.9116109766
MESH:D006529 Hepatomegaly pirinixic acid 21.9118467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 21.9115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.5115709030
MESH:D006561 Herpes Simplex resveratrol 3.6816876885
MESH:D015658 HIV Infections Iron 3.3916597321
MESH:D006689 Hodgkin Disease Cyclophosphamide 14.1216135485 17606976
MESH:D006689 Hodgkin Disease Cytarabine 14.1216200630
MESH:D006689 Hodgkin Disease Doxorubicin 14.1218501091 15147373 17606976
MESH:D006689 Hodgkin Disease Vinblastine 14.1218501091 18180244
MESH:D019584 Hot Flashes Estradiol 3.2417088409
MESH:D006849 Hydrocephalus Valproic Acid 4.3617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5316354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.5216870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.5212083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 7.7121332399
MESH:D006937 Hypercholesterolemia resveratrol 7.7117188708
MESH:D006943 Hyperglycemia pirinixic acid 2.7420558911
MESH:D006949 Hyperlipidemias Dietary Fats 7.7421332399
MESH:D006949 Hyperlipidemias resveratrol 7.7416873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4415034207
MESH:D006973 Hypertension Cyclosporine 4.2210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.2218850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5915338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8617488730
MESH:D007006 Hypogonadism Iron 4.0416640825
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3116569931 16945680
MESH:D007037 Hypothyroidism Iron 4.5916640825
MESH:D007154 Immune System Diseases Cyclophosphamide 4.8116076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.8415869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.8417600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9912013081
MESH:D007248 Infertility, Male Cyclophosphamide 5.727193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.7217937319
MESH:D007249 Inflammation Dietary Fats 19.8720412841
MESH:D007249 Inflammation Diethylnitrosamine 19.8718785209
MESH:D007249 Inflammation perfluorooctanoic acid 19.8712083418
MESH:D007249 Inflammation Progesterone 19.8715869954
MESH:D007249 Inflammation resveratrol 19.8716366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.8712878042 12200463
MESH:D007249 Inflammation Thalidomide 19.8716134734
MESH:D007251 Influenza, Human resveratrol 4.0316624496
MESH:D007333 Insulin Resistance bisphenol A 14.8216393666
MESH:D007333 Insulin Resistance Dietary Fats 14.8211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 14.8216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 14.8216306350
MESH:D019189 Iron Metabolism Disorders Iron 4.5717163184
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.509022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9215604871
MESH:D007674 Kidney Diseases Acetaminophen 15.7812587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 15.7816962696
MESH:D007674 Kidney Diseases Cyclosporine 15.788314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 15.7815369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 15.7815618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.7016707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.366582329
MESH:D007680 Kidney Neoplasms Cyclosporine 14.3612371664
MESH:D007680 Kidney Neoplasms Estradiol 14.3615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 14.3616985049
MESH:D007898 Leishmaniasis, Visceral Thalidomide 3.9516514283
MESH:D007938 Leukemia Azacitidine 9.1219148494
MESH:D007938 Leukemia Cyclophosphamide 9.1210602166
MESH:D007938 Leukemia Genistein 9.1218980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6416085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.2617008537 17802794 18172266 17658394 17296974 18587576
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.7110373061
MESH:D007951 Leukemia, Myeloid Azacitidine 4.1719077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 5.6917596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 5.6918720364
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 5.6917596541 16294345
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.7219299654
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.2416087638
MESH:D007970 Leukopenia Cyclophosphamide 4.4610052129 11830472
MESH:D020961 Lewy Body Disease Iron 4.9316563566
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.728812269
MESH:D017880 Limb Deformities, Congenital Thalidomide 4.0810473037
MESH:D008080 Liposarcoma Paclitaxel 4.3517353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 22.0517157831 16221502 16943688 16239168 11408273 17174718 21278145 11903743 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 22.0518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 22.0518407596 19638242 18522880 20032147 18665156
MESH:D008103 Liver Cirrhosis Iron 22.0516640825
MESH:D008103 Liver Cirrhosis Phenobarbital 22.0521047994
MESH:D008103 Liver Cirrhosis Thalidomide 22.0517174718 16943688
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.8715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.6418705752 18376398 18317297 12666154 16097048 15338365 17565644 17823541 18166357 14512876 14716833 18251166 18472094 15370692 14724832 14620537 15123356 15730626 18187930 17557913 17766677 18395914 15893842 17708605 20821823 14716496 12586293 18006644 17481882 15673190 17976157 13678700 18395095 18418968 15650968 12667390 12649538 15925388 12445418 17721639 15959796 18156304 18339082 18205269 15362042 12546737 18263696 17761835 18054572 15876570 12958196 18210741 15052691 16248980 17869086 17640975 12741479 12389079 18481824 18277467 15057751 12632514 18420326 12445421 17922224 17698563 16033810 18472332 15931870 18429990 16136751 16192424 12609069 12898905 16116963 17805973 16011737 15818738 16638106 16015684 17900296 10355542 15996030 17631135 11481614 18279442 17944888 12632512 18412020 17714472 14748882 17525996 16027843
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 9.6416595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.6414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 9.6417823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.6415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.6412878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 9.6415465738
MESH:D008107 Liver Diseases Acetaminophen 8.0419784758 19460945 12969438 12587719 19014921 16611625 11587558 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.0416964402 15830285 16246199 15720792 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 8.0417034775
MESH:D008107 Liver Diseases Phenobarbital 8.0419363144
MESH:D008108 Liver Diseases, Alcoholic Iron 4.5116737972 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.9416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.9414706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 33.5415890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 33.5420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 33.5419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 33.5419499222 2422723 19996281 15175105 19638242 2862719 19073162 19690152 20492335 19850985 19427195 19254457 20137499 18978307 12771043 15885732 19833225 18754104 9163691 19551842 21047994 20452335 21278145 18648771 20405173 20118626 21167192 19090486 10737359 18644402 21071580 20501860 19255062 20434301 19256749 18977376 19642983 20101389 12112319 19426721 16942905 19294768 20583210 19812893
MESH:D008113 Liver Neoplasms Fluorouracil 33.5415113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Iron 33.5420302851 16640825
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 33.5418709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 33.5419482888 8742319 19812893 15975961 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 33.5415890375 16377806 20007298
MESH:D008113 Liver Neoplasms resveratrol 33.5420405173 19073162 19321006 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 33.5416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 31.903712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 31.908603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 31.9012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 31.9017854601 19126423 21159647 18775883 16267830 19519916 19539802 18308698 18079962 3124819 19009564 17942915 19004024 18253720 2563599 18164116 9362446 18093689 17174075 18282651 18544905 16842330
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 31.9017085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 31.901399818 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 31.9017172636 2563599 6150874 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 31.901423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 31.9012151625
MESH:D008171 Lung Diseases Ozone 3.038266340 19066396
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.7417228818
MESH:D055370 Lung Injury Oxygen 7.7918339021
MESH:D055370 Lung Injury Ozone 7.7920417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 16.1014755239
MESH:D008175 Lung Neoplasms Azacitidine 16.1021224363
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 16.1020464547 18520028 17053015 18816296 6695378 18569708 20064080 20135361 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 16.1020970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 16.1017418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 16.1015246190
MESH:D008175 Lung Neoplasms Iron 16.1016640825
MESH:D008175 Lung Neoplasms Methylcholanthrene 16.109230183 20970405 10545420 16337739 11893704 16271038 20512841 15390079 1399818 6695378 21163286 17909032 7750092
MESH:D008175 Lung Neoplasms Ozone 16.107614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 16.1019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2815086387
MESH:D008223 Lymphoma Cyclophosphamide 6.6512854902
MESH:D008223 Lymphoma Doxorubicin 6.6516098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 8.9216675587
MESH:D016393 Lymphoma, B-Cell resveratrol 8.9217088997
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 17.3111911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 17.3117654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 17.3114749477
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 17.3114749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.0715621674
MESH:D008268 Macular Degeneration Iron 3.6916640825
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7415688416
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 23.3211921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 23.3215458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 23.3217203775 11408345 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 23.3214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 23.3211408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 23.3211606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 23.3217927505
MESH:D020149 Manganese Poisoning Estradiol 3.9619453300
MESH:D008545 Melanoma Doxorubicin 8.6116827129
MESH:D008545 Melanoma Paclitaxel 8.6112025231 16342250 12040289
MESH:D008545 Melanoma resveratrol 8.6117992120
MESH:D008545 Melanoma Thalidomide 8.6116098027 12829675 17089043
MESH:D008545 Melanoma Vinblastine 8.6115577323 16809738 18332650 16432458 17761969 15577320 16248763 18176117 12374674 18505091
MESH:D008546 Melanoma, Experimental Acetaminophen 9.1819513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.1816388313
MESH:D008654 Mesothelioma Doxorubicin 6.0217638057
MESH:D008654 Mesothelioma Tocopherols 6.0215878867
MESH:D008659 Metabolic Diseases resveratrol 3.9217112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2716801185
MESH:D008679 Metaplasia Ozone 4.5910496685
MESH:D008881 Migraine Disorders Valproic Acid 2.8218803445 18765137
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0415792986
MESH:D009006 Monosomy Azacitidine 5.5619299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.2216381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.2218986760 16757204
MESH:D052016 Mucositis Doxorubicin 4.2817415656
MESH:D009101 Multiple Myeloma Azacitidine 14.3619549372 18443271
MESH:D009101 Multiple Myeloma Paclitaxel 14.3614749477
MESH:D009101 Multiple Myeloma resveratrol 14.3616490592 16267019 17164350 17049120 17935668 14749477
MESH:D009101 Multiple Myeloma Thalidomide 14.3615744524 15867202 16445831 19112201 15939924 17168659 19372569 19112817 15741222 15920492
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.1517086897
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.3617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.578888407
MESH:D009181 Mycoses Iron 4.9516640825
MESH:D009190 Myelodysplastic Syndromes Azacitidine 10.8017596541 19805378 17611569 18720364
MESH:D009190 Myelodysplastic Syndromes Thalidomide 10.8018720364
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 10.8017596541
MESH:D009203 Myocardial Infarction Doxorubicin 11.6219429709 15857846
MESH:D009203 Myocardial Infarction Genistein 11.6217141266
MESH:D009203 Myocardial Infarction pirinixic acid 11.6219151258
MESH:D009203 Myocardial Infarction resveratrol 11.6217125593 17188708 16456233 16525036 17015251 16317513
MESH:D017202 Myocardial Ischemia Iron 13.0216604332
MESH:D017202 Myocardial Ischemia resveratrol 13.0217015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 13.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 17.0916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 17.0917141266
MESH:D015428 Myocardial Reperfusion Injury Iron 17.0916604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 17.0916411023
MESH:D009205 Myocarditis resveratrol 4.2517322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9717484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 11.733581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.739029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 11.7318259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 11.7315867366
MESH:D009369 Neoplasms Benzo(a)pyrene 12.8511141357
MESH:D009369 Neoplasms Cyclophosphamide 12.8518854779
MESH:D009369 Neoplasms Fluorouracil 12.8516928823 18239605 18600527
MESH:D009369 Neoplasms lycopene 12.8517051425
MESH:D009369 Neoplasms pirinixic acid 12.8517405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.518985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2317289903
MESH:D009401 Nephrosis Doxorubicin 4.2716899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 13.3319348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 13.3315640375 16889571
MESH:D009404 Nephrotic Syndrome Iron 13.3317178036
MESH:D009410 Nerve Degeneration Rotenone 3.4917356569 15790535 18619942
MESH:D009421 Nervous System Malformations bisphenol A 25.6516427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 25.6511399458 16427766
MESH:D009421 Nervous System Malformations Genistein 25.6516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.6514600291
MESH:D009421 Nervous System Malformations Thalidomide 25.6516859833
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.116679447
MESH:D009436 Neural Tube Defects Valproic Acid 6.1116359493 8888407
MESH:D009447 Neuroblastoma Cyclophosphamide 6.2715176712 8761367 16115947
MESH:D009447 Neuroblastoma Doxorubicin 6.2715555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 16.7118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 16.7120387270
MESH:D019636 Neurodegenerative Diseases Iron 16.7117296847 16604332
MESH:D019636 Neurodegenerative Diseases resveratrol 16.7117652729
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.388761367 12837982
MESH:D020078 Neurogenic Inflammation resveratrol 3.9317929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6020387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0916436463
MESH:D009503 Neutropenia Cyclophosphamide 8.208291058
MESH:D009503 Neutropenia Vinblastine 8.2017378895
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.469802331
MESH:D009765 Obesity Dietary Fats 3.9318674790 16723640 19632207 20518802 21332399 20132043 11836018 17217161 18457598
MESH:D009765 Obesity pirinixic acid 3.9320558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.986482804 4026338
MESH:D009845 Oligospermia Cyclophosphamide 4.2116517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.503988306
MESH:D010003 Osteoarthritis Iron 3.6516640825
MESH:D010014 Osteolysis Paclitaxel 4.4715867366
MESH:D010018 Osteomalacia Phenobarbital 3.8617016548
MESH:D010024 Osteoporosis Genistein 6.4119401787
MESH:D010024 Osteoporosis Iron 6.4116640825 16648989
MESH:D015663 Osteoporosis, Postmenopausal Genistein 8.6016169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.6017513867
MESH:D012516 Osteosarcoma Doxorubicin 3.7115930896
MESH:D010049 Ovarian Diseases bisphenol A 4.4811985600
MESH:D010051 Ovarian Neoplasms Estradiol 13.0019401270
MESH:D010051 Ovarian Neoplasms Genistein 13.0019005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 13.0011161223
MESH:D010051 Ovarian Neoplasms Progesterone 13.0016525653 17393432
MESH:D010051 Ovarian Neoplasms Thalidomide 13.0016288038
MESH:D010146 Pain Acetaminophen 5.5016870215
MESH:D010146 Pain Cyclophosphamide 5.5012161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 10.6411332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.6416540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 10.6416500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.6416965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 7.827296757
MESH:D010212 Papilloma Iron 7.8212065085
MESH:D020447 Parasomnias Iron 5.5017352947
MESH:D010291 Paresis Thalidomide 5.799200351
MESH:D010300 Parkinson Disease Iron 7.6616640825 16563566
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 7.6616702228
MESH:D010300 Parkinson Disease Rotenone 7.6611445065 19232380 15451049 18619942 19114014 18191903 11535288 16412576 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 3.6418197244 15927086 15574749 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7312520081
MESH:D010538 Peritonitis Ozone 3.6416369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.956228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6417983394
MESH:D010900 Pituitary Diseases Iron 5.1516604332
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6417638057
MESH:D011014 Pneumonia Ozone 3.8918381685 18929643 18007984
MESH:D011041 Poisoning Iron 3.8316604332
MESH:D017119 Porphyria Cutanea Tarda Iron 9.4216640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.4218163543
MESH:D011230 Precancerous Conditions Cyclosporine 12.7912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 12.792563599
MESH:D011230 Precancerous Conditions Phenobarbital 12.792563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 11.0021297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 11.0021297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 11.0017031469
MESH:D011225 Pre-Eclampsia Iron 4.0316640825
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 25.0910548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 25.0917132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 25.0916679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 25.0911118676 11399792 11222880 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 25.0920603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.0420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.0420887781
MESH:D011471 Prostatic Neoplasms Azacitidine 8.3118324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 8.3117292933
MESH:D011471 Prostatic Neoplasms bicalutamide 8.3118487222 17914592 19011039 19240160 15638997
MESH:D011471 Prostatic Neoplasms bisphenol A 8.3116740699
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 8.3117136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 8.3115897917 15749863 18437689 16888761 16729912 16868541
MESH:D011471 Prostatic Neoplasms Estradiol 8.3116740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 8.3119082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 8.3115256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms lycopene 8.3117337101 15084515
MESH:D011471 Prostatic Neoplasms methylselenic acid 8.3116205645
MESH:D011471 Prostatic Neoplasms Paclitaxel 8.3116356831 17172428 16729912 17136230
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 8.3115721890
MESH:D011471 Prostatic Neoplasms resveratrol 8.3117675339 17636462 17718901 17804756 16731767 15767336
MESH:D011471 Prostatic Neoplasms Thalidomide 8.3116729912
MESH:D011471 Prostatic Neoplasms Tocopherols 8.3112504091
MESH:D011528 Protozoan Infections Iron 5.5016640825
MESH:D011536 Prurigo Thalidomide 5.7912755975
MESH:D011537 Pruritus Ethinyl Estradiol 2.8116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 10.4712752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.4711422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.0316882103
MESH:D011629 Puberty, Precocious bisphenol A 4.2810548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.0716636934
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5818722050 16160472 18286688 15538739
MESH:D051437 Renal Insufficiency Doxorubicin 3.7317922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0616325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.6719058328
MESH:D015427 Reperfusion Injury resveratrol 5.6716317513 16314181 17520802 15827377 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.0418339021 17627322
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3518990726
MESH:D012148 Restless Legs Syndrome Iron 4.1616930377
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.993692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.7119155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6618045962
MESH:D012509 Sarcoma Doxorubicin 3.5518313854 15675481 17710206 17203757 16767912 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.7616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.2817846226
MESH:D012559 Schizophrenia Valproic Acid 1.9915737665 19110320
MESH:D019873 Schnitzler Syndrome Thalidomide 5.4316096327
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.3516636934
MESH:D012640 Seizures Phenobarbital 4.844039156 3137016 16876388 11442880
MESH:D012640 Seizures Valproic Acid 4.8411044598 16876388 17978042 14763951 3137016 15475178 1511512 11738929
MESH:D003294 Seizures, Febrile Phenobarbital 4.316407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.1619755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 15.1615692506
MESH:D012878 Skin Neoplasms Iron 15.1612065085
MESH:D012878 Skin Neoplasms resveratrol 15.168985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.1616192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0715625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4216709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0016517039
MESH:D013119 Spinal Cord Injuries Progesterone 3.7715862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.3919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.0212833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.212093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.2118456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.2119084572 18396642 16951190 19015929 15786421 18567086 17498489 17522103 17172411 16424979
MESH:D013274 Stomach Neoplasms Paclitaxel 4.2118396642 18506536
MESH:D013276 Stomach Ulcer Thalidomide 3.7415138204
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0416321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.4816045194 16684133
MESH:D013398 Sudden Infant Death Iron 11.6316640825
MESH:D013398 Sudden Infant Death Oxygen 11.6312563064
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.5512837982
MESH:D024801 Tauopathies Paclitaxel 4.3016930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 13.913712494 1399818 6582329 6587162 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 13.917505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 13.9116010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 13.911399818
MESH:D013978 Tibial Fractures Estradiol 4.1719048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.5216280240
MESH:D014062 Tongue Neoplasms resveratrol 8.5216227395
MESH:D014178 Translocation, Genetic Valproic Acid 4.7117262798
MESH:D014376 Tuberculosis Iron 3.7616597321
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.013119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 10.108074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.1017053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 10.1014692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 10.1017653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.158888407
MESH:D014581 Urticaria Acetaminophen 2.5110982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.1416803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.1417473185
MESH:D014591 Uterine Diseases bisphenol A 4.4914652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.3714692618
MESH:D014594 Uterine Neoplasms resveratrol 13.3717044934
MESH:D014594 Uterine Neoplasms sulindac sulfide 13.3718645019
MESH:D014605 Uveitis Cyclosporine 3.471336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.5515577323
MESH:D014652 Vascular Diseases Thalidomide 4.9715741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.6917678736 16364871 17334414 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.6917488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7315886252
MESH:D015430 Weight Gain Dietary Fats 3.3116723640
MESH:D014985 Xerophthalmia Cyclosporine 3.9217120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
KEGG:00480 Glutathione metabolism
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:04115 p53 signaling pathway
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA299
    • No data
    Releated disease ID Related disease Name
    PA444760Leukemia, Myeloid, Acute
    PA446108Colorectal Neoplasms
    PA445742Stomach Neoplasms
    PA444283Glioblastoma
    PA443622Carcinoma, Non-Small-Cell Lung
    Releated drug ID Related drug Name
    PA449177cytarabine
    PA448771capecitabine
    PA128406956fluorouracil
    PA10090l-glutamine
    PA449748gemcitabine
    PA449014cisplatin
    PA449957ibuprofen
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00242 antagonist Cladribine Antineoplastic Agents;Immunosuppressive Agents
    DB05260 antagonist Gallium nitrate Antineoplastic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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