AutismKB 2.0

Annotation Detail for RSU1


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Basic Information Top
Gene Symbol:RSU1 ( FLJ31034,RSP-1 )
Gene Full Name: Ras suppressor protein 1
Band: 10p13
Quick LinksEntrez ID:6251; OMIM: 179555; Uniprot ID:RSU1_HUMAN; ENSEMBL ID: ENSG00000148484; HGNC ID: 10464
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Cell junction organization
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Pathway IDPathway Name
500125Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RSU1 mRNAincreases expression 18648102
D016572 Cyclosporine Cyclosporine results in increased expression of RSU1 mRNAincreases expression 20106945
D003634 DDT DDT results in increased expression of RSU1 proteinincreases expression 15619295
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RSU1 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of RSU1 mRNAaffects expression 17555576
C025643 vinclozolin vinclozolin affects the expression of RSU1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D018248 Adenoma, Liver Cell DDT 5.6812597452
MESH:D000382 Agricultural Workers' Diseases DDT 5.1512584743 16487989
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001943 Breast Neoplasms DDT 2.6112709520 16792888
MESH:D001943 Breast Neoplasms Tamoxifen 2.6120065188 20859285 20135344 18984771 19155303 21138602 18425577 20005174 18855134 19288272 18629630 19289846 18997820 17049068 19244106 19103187 19059307 19487384 17893378 20390343 18815881 21152245 19221464 16873071 19084267 20544844 16273361 17261762 19066611 15565566 18821012 17440819 15668708 19115204 19142967 19200415 17242785 19189212 16818667 19189210 11161223 19410462 19011961 16202921 18351453
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.983581430 7296757
MESH:D006528 Carcinoma, Hepatocellular DDT 4.9812597452
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.9816924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.277505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.759022650 19486331
MESH:D002779 Cholestasis Cyclosporine 14.7519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.7516105132 16919318 17681005 17110522 15861022 11677210 17333356
MESH:D000013 Congenital Abnormalities DDT 5.1915095906
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.218156756 8970840 18759878 11298694 2524372 11906362 12868966 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.039328219 16192314 1440618 6679447 9653073 9022650 18692083 11289319 18648102 6482804 18289764 7440962 8291058
MESH:D004417 Dyspnea DDT 5.6816487989
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2417893378 20544844 19155303 16202921
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Cyclosporine 15.0219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.0215345470
MESH:D005234 Fatty Liver Tamoxifen 15.0219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Cyclosporine 3.5612168785 12639820
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 11.026705139
MESH:D006505 Hepatitis DDT 11.0216487989
MESH:D006529 Hepatomegaly DDT 5.152387028
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male DDT 12.5517192596 17157474
MESH:D007248 Infertility, Male Ethinyl Estradiol 12.5517937319
MESH:D007248 Infertility, Male vinclozolin 12.5516467254
MESH:D007249 Inflammation Tamoxifen 2.4919457130
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.508314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.986582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.9818625569
MESH:D007859 Learning Disorders DDT 5.407589230
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008064 Lipidoses Tamoxifen 3.3715342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008107 Liver Diseases DDT 3.4815729006
MESH:D008113 Liver Neoplasms DDT 5.4015975961 11948501
MESH:D008113 Liver Neoplasms Tamoxifen 5.4016684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.711399818 3712494 6587162 598648
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8116827153 11731420 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.053581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.0519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms DDT 3.828820588
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219196722 19189210 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.3618042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms DDT 3.6212584743
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.6215067354
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.123712494 6582329 1399818 6587162 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.388074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3817572228 16712894 8653321
MESH:D014570 Urologic Diseases DDT 6.1616487989
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
REACT:20676 Cell junction organization
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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