AutismKB 2.0

Annotation Detail for RTN1


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Basic Information Top
Gene Symbol:RTN1 ( MGC133250,NSP )
Gene Full Name: reticulon 1
Band: 14q23.1
Quick LinksEntrez ID:6252; OMIM: 600865; Uniprot ID:RTN1_HUMAN; ENSEMBL ID: ENSG00000139970; HGNC ID: 10467
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of RTN1 mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RTN1 mRNAaffects expression 21346803
C058317 arsenic disulfide arsenic disulfide results in decreased expression of RTN1 mRNAdecreases expression 12890387
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RTN1 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of RTN1 mRNAincreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RTN1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of RTN1 mRNAdecreases expression 20106945
D005419 Flavonoids Flavonoids results in increased expression of RTN1 mRNAincreases expression 18035473
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RTN1 mRNAaffects binding|decreases expression|increases activity 19710929
C024746 tobacco tar tobacco tar results in increased expression of RTN1 mRNAincreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816124888 18705752 16227642 16097048 10355542 15700767 15673190 3786805 16011737 16050911 16192424 15721981
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0816705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0818788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.256135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.2512371664
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 12.2519559774
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.0816177239 3732212 10915739 7179309 2869522 11566570 19085960 9327722 6884620 6623471 15968718 19336974 21278145 17522070 16227642 4309450 15998439 10092053 7440962 7120509 15027814 3786805
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.5015959796 17595544 12631006 16239168 12795759 19224547 16045604 61145
MESH:D005234 Fatty Liver Cyclosporine 14.5019224547
MESH:D005234 Fatty Liver pirinixic acid 14.5020131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 9.7118705752
MESH:D005355 Fibrosis Cyclosporine 9.7112168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.3019772884 16221962 18467677 19176532
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Flavonoids 2.7517296493
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 5.0812421474
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9211903743 16943688 21278145 11408273 16239168 17334410 17174718 16221502 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3816116963 18277467 15959796 15362042 18705752 18472094 14724832 17640975 18429990 18187930 18205269 12741479 18420326 12667390 15052691 17708605 16027843 14620537 18395095 17557913 17721639 16136751 17900296 12632514 16015684 12898905 18317297 14748882 16011737 18418968 16033810 15996030 15650968 18054572 17565644 14512876 18263696 15370692 18156304 15730626 10355542 18339082 16097048 17714472 17976157 18006644 12666154 12632512 17944888 17525996 14716833 12958196 15057751 18251166 18279442 17698563 17823541 15673190 18166357 12649538 14716496 15931870 15893842 12546737 13678700 16192424 20821823 18210741 12609069 12445418 18481824 18376398 11481614 17631135 16248980 15123356 12586293 15876570 18395914 16638106 17922224 12389079 15818738 17481882 15338365 18412020 12445421 17805973 17766677 15925388 17761835 17869086 18472332
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1317285989 15720792 16246199 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9216899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.347678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.3421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.3419294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.3415890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.392876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3912014681 15583823
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5617053015 6695378 20464547 20135361 18816296 20869020 18569708 18520028 20064080
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4610029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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