AutismKB 2.0

Annotation Detail for RXRB


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Basic Information Top
Gene Symbol:RXRB ( DAUDI6,H-2RIIBP,MGC1831,NR2B2,RCoR-1 )
Gene Full Name: retinoid X receptor, beta
Band: 6p21.32
Quick LinksEntrez ID:6257; OMIM: 180246; Uniprot ID:RXRB_HUMAN; ENSEMBL ID: ENSG00000204231; HGNC ID: 10478
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa03320PPAR signaling pathway
hsa05216Thyroid cancer
hsa05223Non-small cell lung cancer
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Gene Expression
Pathway IDPathway Name
200142Retinoic acid receptors-mediated signaling
200112RXR and RAR heterodimerization with other nuclear receptor
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1761Respiratory tract disease
1831Prostate cancer
1870Drug abuse
2069Schizophrenia
Desease Name
PSYCH
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C004762 2,4-dichlorophenol 2,4-dichlorophenol results in increased activity of RXRB proteinincreases activity 18207673
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RXRB mRNAaffects expression 21346803
C091238 2-isopropylphenol 2-isopropylphenol results in increased activity of RXRB proteinincreases activity 18207673
C035406 2-tert-butylphenol 2-tert-butylphenol results in increased activity of RXRB proteinincreases activity 18207673
C043374 3,4-dichlorophenol 3,4-dichlorophenol results in increased activity of RXRB proteinincreases activity 18207673
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of RXRB mRNAdecreases expression 12419474
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased activity of RXRB proteinincreases activity 18207673
C430898 AGN 194204 AGN 194204 binds to and results in increased activity of RXRB proteinaffects binding|increases activity 16178010
C103303 alitretinoin alitretinoin binds to and results in increased activity of RXRB proteinaffects binding|increases activity 7565671
C103303 alitretinoin alitretinoin binds to and affects the activity of RXRB proteinaffects activity|affects binding 15941851
C103303 alitretinoin alitretinoin binds to RXRB proteinaffects binding 11939783
C103303 alitretinoin alitretinoin promotes the reaction [RXRB protein binds to BGLAP gene]affects binding|increases reaction 12898515
C103303 alitretinoin alitretinoin results in increased activity of RXRB proteinincreases activity 18207673
C103303 alitretinoin alitretinoin results in increased degradation of RXRB proteinincreases degradation 12898515
C103303 alitretinoin alitretinoin results in increased expression of RXRB proteinincreases expression 16043492
C053541 bicalutamide bicalutamide results in decreased expression of RXRBdecreases expression 11845989
C006780 bisphenol A bisphenol A results in increased activity of RXRB proteinincreases activity 18207673
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of RXRB mRNAdecreases expression 12419474
D002211 Capsaicin Capsaicin results in decreased expression of RXRB mRNAdecreases expression 18769453
D002784 Cholesterol [RXRB protein binds to NR1H2 protein] which affects the metabolism of Cholesterolaffects binding|affects metabolic processing 14993927
D003634 DDT DDT analog results in increased activity of RXRB proteinincreases activity 18207673
C014347 decitabine decitabine results in increased expression of RXRB mRNAincreases expression 17908484
C438269 diazepinylbenzoic acid diazepinylbenzoic acid binds to and results in decreased activity of RXRB proteinaffects binding|decreases activity 19095448
D002945 Cisplatin RXRB protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004281 Docosahexaenoic Acids Docosahexaenoic Acids binds to RXRB proteinaffects binding 11939783
D000431 Ethanol Ethanol results in increased expression of RXRB mRNAincreases expression 11696672
D006581 Hexachlorobenzene Hexachlorobenzene results in increased activity of RXRB proteinincreases activity 18207673
D017313 Fenretinide Fenretinide results in increased expression of RXRB mRNAincreases expression 16570282
D001556 Lindane Lindane results in increased activity of RXRB proteinincreases activity 18207673
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased activity of RXRB proteindecreases activity 12388159
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of RXRB mRNAdecreases expression 16847310
12388159
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of RXRB proteindecreases expression 12388159
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of RXRB mRNAincreases expression 12057914
D008095 Lithocholic Acid Lithocholic Acid binds to RXRB proteinaffects binding 11939783
D008726 Methoprene Methoprene binds to and results in increased activity of RXRB proteinaffects binding|increases activity 12970175
D010831 Phytanic Acid Phytanic Acid binds to RXRB proteinaffects binding 11939783
D020849 Raloxifene Raloxifene results in increased expression of RXRB mRNAincreases expression 16497877
D012176 Retinoids Retinoids analog binds to and results in increased activity of RXRB proteinaffects binding|increases activity 16364638
D013449 Sulfonamides Sulfonamides analog binds to and results in decreased activity of RXRB proteinaffects binding|decreases activity 19095448
D013449 Sulfonamides Sulfonamides analog binds to and results in increased activity of RXRB proteinaffects binding|increases activity 19095448
D014284 Triiodothyronine Triiodothyronine results in increased expression of RXRB mRNAincreases expression 15708448
C004648 testosterone enanthate testosterone enanthate affects the expression of RXRB mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RXRB mRNAdecreases expression 17586704
D014212 Tretinoin Tretinoin binds to RXRB proteinaffects binding 15958702
D014212 Tretinoin Tretinoin results in increased expression of and results in increased activity of RXRB proteinincreases activity|increases expression 16158052
D014212 Tretinoin [Tretinoin binds to RXRB protein] which binds to COL11A2 enhanceraffects binding 15206905
D014212 Tretinoin Tretinoin results in increased expression of RXRB mRNAincreases expression 16392701
D014212 Tretinoin IL1B protein promotes the reaction [Tretinoin affects the localization of RXRB protein]affects localization|increases reaction 17078027
D014212 Tretinoin IL1B protein promotes the reaction [Tretinoin results in increased expression of RXRB protein]increases expression|increases reaction 11171635
D014212 Tretinoin Tretinoin affects the localization of RXRB proteinaffects localization 17078027
D014212 Tretinoin Tretinoin results in increased expression of RXRB mRNAincreases expression 15708448
D014212 Tretinoin Tretinoin results in increased expression of RXRB proteinincreases expression 11171635
C007567 triphenyltin hydroxide triphenyltin hydroxide binds to and affects the activity of RXRB proteinaffects activity|affects binding 15941851
D014801 Vitamin A Vitamin A affects the expression of RXRB mRNAaffects expression 14529804
D002762 Cholecalciferol Cholecalciferol promotes the reaction [[RXRB protein binds to VDR protein] which binds to TNFSF11 promoter]affects binding|increases reaction 17008384
D015054 Zymosan Zymosan results in decreased expression of RXRB mRNAdecreases expression 16847310
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 17.2718926900
MESH:D000014 Abnormalities, Drug-Induced Ethanol 17.2717676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.2715322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced triphenyltin hydroxide 17.2717619067
MESH:D000015 Abnormalities, Multiple Vitamin A 4.5110992263
MESH:D000138 Acidosis Ethanol 4.1011192467
MESH:D058186 Acute Kidney Injury Capsaicin 7.9818460982
MESH:D058186 Acute Kidney Injury Cisplatin 7.9812690470 17670903 15814532
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.6711850527 18653653
MESH:D000230 Adenocarcinoma Cisplatin 4.5711798837 17638652
MESH:D000230 Adenocarcinoma Fenretinide 4.5710697514
MESH:D018248 Adenoma, Liver Cell DDT 9.2312597452
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2316835633
MESH:D000382 Agricultural Workers' Diseases DDT 8.0112584743 16487989
MESH:D000382 Agricultural Workers' Diseases Lindane 8.0112661182
MESH:D000419 Albuminuria Raloxifene 4.2217451421 17308373
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9215451040 15451039
MESH:D000505 Alopecia Capsaicin 8.5517569567
MESH:D000505 Alopecia Tretinoin 8.5515955085
MESH:D000544 Alzheimer Disease Raloxifene 2.4515800139
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.8510965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 13.0611748828
MESH:D000740 Anemia Vitamin A 13.0616960172
MESH:D000740 Anemia Zymosan 13.0618664788
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.4616960172
MESH:D000853 Anophthalmos Ethanol 4.4315513904
MESH:D001008 Anxiety Disorders Ethanol 3.7011141031
MESH:D001169 Arthritis, Experimental Tretinoin 6.9216412693
MESH:D001169 Arthritis, Experimental Zymosan 6.9216872482 17659584 15944321 15142272 15188379
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1716292516
MESH:D001249 Asthma Tretinoin 4.7716456186
MESH:D001249 Asthma Vitamin A 4.7716732791
MESH:D050197 Atherosclerosis Cholesterol 4.0116632123
MESH:D001321 Autistic Disorder Docosahexaenoic Acids 3.2418582451
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.6516142846
MESH:D001471 Barrett Esophagus Tretinoin 4.0316935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.7712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.7716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.4814601052
MESH:D001862 Bone Resorption bisphenol A 3.5111985600
MESH:D001919 Bradycardia Capsaicin 4.6618207255
MESH:D001930 Brain Injuries Raloxifene 4.0916580743
MESH:D002545 Brain Ischemia Capsaicin 4.5819211983
MESH:D001932 Brain Neoplasms Fenretinide 4.0116187019
MESH:D001943 Breast Neoplasms alitretinoin 9.0716344269
MESH:D001943 Breast Neoplasms bisphenol A 9.0717123778
MESH:D001943 Breast Neoplasms Cisplatin 9.0718382427 19526202
MESH:D001943 Breast Neoplasms DDT 9.0716792888 12709520
MESH:D001943 Breast Neoplasms decitabine 9.0719208741 18320071
MESH:D001943 Breast Neoplasms Fenretinide 9.0716601279
MESH:D001943 Breast Neoplasms Hexachlorobenzene 9.0712709520 15061365
MESH:D001943 Breast Neoplasms Lindane 9.0714688026
MESH:D001943 Breast Neoplasms Raloxifene 9.0717952589 17242785 16912660 16837676 15572757 15775269 15758505 17595753 17049068 17261762 17440819 17893378
MESH:D001943 Breast Neoplasms Retinoids 9.0717368321 17491551 19340624
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.0720435547
MESH:D001943 Breast Neoplasms Tretinoin 9.0716166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 11.7116813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 11.7117426644 17377406
MESH:D002056 Burns Ethanol 4.2716374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7616168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 10.4316705839
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 10.4317982673
MESH:D006528 Carcinoma, Hepatocellular DDT 10.4312597452
MESH:D006528 Carcinoma, Hepatocellular Ethanol 10.4315763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 10.4316270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.431917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.5917123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.8912023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 9.816189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell decitabine 9.8119215824
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 9.8116274795
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.8116051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.7317572228
MESH:D006332 Cardiomegaly Ethanol 6.1019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1018850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.1715775269
MESH:D002386 Cataract Tretinoin 2.8617460283
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 11.6616154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 11.6616129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.0716153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8316835633
MESH:D002779 Cholestasis Lithocholic Acid 8.1719965603
MESH:D002779 Cholestasis Vitamin A 8.1716175620
MESH:D002822 Choriocarcinoma Tretinoin 4.7616461808
MESH:D002869 Chromosome Aberrations triphenyltin hydroxide 6.6110477351
MESH:D002971 Cleft Lip Ethanol 3.3715513904
MESH:D002972 Cleft Palate Ethanol 16.7715513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 16.7715340226 15668235 8697196 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 16.779407595
MESH:D002972 Cleft Palate triphenyltin hydroxide 16.7717619067
MESH:D002972 Cleft Palate Vitamin A 16.7716054864
MESH:D003072 Cognition Disorders Raloxifene 4.2315800139
MESH:D003092 Colitis Tretinoin 3.3217035595
MESH:D003110 Colonic Neoplasms decitabine 3.8917616700
MESH:D003110 Colonic Neoplasms Vitamin A 3.8916267017 17219422
MESH:D015179 Colorectal Neoplasms Cisplatin 3.3915273666
MESH:D015179 Colorectal Neoplasms decitabine 3.3918981723
MESH:D015179 Colorectal Neoplasms Fenretinide 3.3917273769
MESH:D000013 Congenital Abnormalities DDT 8.3615095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.3617141729 14669216
MESH:D003371 Cough Capsaicin 4.7810350223
MESH:D019465 Craniofacial Abnormalities Ethanol 5.0411198716 15513904 11873399 10194807 15451040 15451039 19302082
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.049224671 9664655 9142499 10589399 9211117 17551590 16925845 9125849 8800419 14991402
MESH:D019465 Craniofacial Abnormalities Vitamin A 5.0410992263
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6318551238
MESH:D003550 Cystic Fibrosis Docosahexaenoic Acids 4.3419747007
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8317474826
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.3816506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5717107852
MESH:D003928 Diabetic Nephropathies Raloxifene 3.6117451421 17308373 15920148
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 5.5018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.5011566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5020420201
MESH:D004362 Drug Toxicity Cisplatin 7.2115033597 19839026 12649298 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.2111462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.4116146918
MESH:D004381 Duodenal Ulcer Capsaicin 4.3211535926 10671773
MESH:D004417 Dyspnea DDT 4.7616487989
MESH:C538011 Eales disease Vitamin A 5.229068938
MESH:D004480 Ectromelia Vitamin A 5.4216054864
MESH:D004487 Edema Raloxifene 9.6215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.6211000095 12711302
MESH:D004487 Edema Zymosan 9.627907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6116714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.6118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 3.6315845917
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7119294695
MESH:D016889 Endometrial Neoplasms Tretinoin 2.8516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.689294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.0017637181 15821434 15328337
MESH:D004935 Esophageal Diseases Capsaicin 5.3119566590
MESH:D004938 Esophageal Neoplasms Cisplatin 4.5015173087 17638652 16481741 16785472 15464296
MESH:D004938 Esophageal Neoplasms Ethanol 4.5016704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.8611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.869664655 16938888
MESH:D015785 Eye Diseases, Hereditary Retinoids 5.5916968212
MESH:D005234 Fatty Liver Ethanol 7.0419236843 18620774 16409862
MESH:D005234 Fatty Liver Raloxifene 7.0417473493
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9016946407 10194807 15451040 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 9.8711858732
MESH:D005313 Fetal Death triphenyltin hydroxide 9.872087686
MESH:D005327 Fetal Resorption Vitamin A 4.9616054864
MESH:D005334 Fever Lipopolysaccharides 3.679205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.3520067830
MESH:D005355 Fibrosis Tretinoin 7.3517994277
MESH:D005756 Gastritis Ethanol 4.2915046732
MESH:D005909 Glioblastoma Capsaicin 10.6118405923
MESH:D005909 Glioblastoma Fenretinide 10.6116187019
MESH:D005909 Glioblastoma Tretinoin 10.6117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 16.3515102660 15464296
MESH:D006258 Head and Neck Neoplasms decitabine 16.3519215824
MESH:D006258 Head and Neck Neoplasms Retinoids 16.3517368321
MESH:D006258 Head and Neck Neoplasms Tretinoin 16.3516096774
MESH:D034381 Hearing Loss Cisplatin 3.9719898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7616084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1015464296
MESH:D006356 Heartburn Capsaicin 5.3119566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.0111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.019664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin A 10.0110992263 16080930
MESH:D006331 Heart Diseases Raloxifene 3.2611110106
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0416366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006505 Hepatitis DDT 8.9116487989
MESH:D006505 Hepatitis Zymosan 8.9119110552
MESH:D006529 Hepatomegaly DDT 7.632387028
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.6315340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.4716490937 16863852 16292552 16877224 17436238 15707848
MESH:D015658 HIV Infections Vitamin A 3.6116960176
MESH:D006679 HIV Seropositivity Vitamin A 5.2017209195
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3417440010
MESH:D006689 Hodgkin Disease Cisplatin 3.2716200630 16170182
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6415340226 18606429 16354765 16959395 8697196
MESH:D006930 Hyperalgesia Capsaicin 11.5017434803 17043245
MESH:D006930 Hyperalgesia Ethanol 11.5018783367
MESH:D006930 Hyperalgesia Tretinoin 11.5016870215
MESH:D006937 Hypercholesterolemia Cholesterol 4.6216933029
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1816778211
MESH:D006943 Hyperglycemia triphenyltin hydroxide 5.506714370
MESH:D006973 Hypertension Raloxifene 4.6915787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6918670907 18850075
MESH:D006986 Hypervitaminosis A Vitamin A 5.7716054864
MESH:D007248 Infertility, Male DDT 6.4617157474 17192596
MESH:D007248 Infertility, Male decitabine 6.4617581917
MESH:D007249 Inflammation Capsaicin 10.3216956363
MESH:D007249 Inflammation Lipopolysaccharides 10.3217237260 12878042 9205823 17963957 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.3212200463 12878042
MESH:D007249 Inflammation Zymosan 10.3211289658 8014878
MESH:D007333 Insulin Resistance bisphenol A 3.0316393666
MESH:D007410 Intestinal Diseases Tretinoin 3.3817994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.4215955940
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.2717255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.4417553498
MESH:D007569 Jaw Abnormalities Ethanol 15.1515513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 15.1516580747
MESH:D007569 Jaw Abnormalities Tretinoin 15.1515992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.2416144296
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7415464296
MESH:D007674 Kidney Diseases Cisplatin 3.0212231392 18289764 12649298 15190930 19839026
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.6616705839
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.3911231351
MESH:D007859 Learning Disorders Cholesterol 14.1817134702
MESH:D007859 Learning Disorders DDT 14.187589230
MESH:D007859 Learning Disorders Ethanol 14.1815451040
MESH:D007889 Leiomyoma Raloxifene 4.1316973256
MESH:D007938 Leukemia decitabine 5.7519235587 18980019
MESH:D007938 Leukemia Tretinoin 5.7517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Docosahexaenoic Acids 4.6517077332
MESH:D007951 Leukemia, Myeloid decitabine 14.2019117987 17236224 18454857
MESH:D007951 Leukemia, Myeloid Retinoids 14.2016482212
MESH:D007951 Leukemia, Myeloid Tretinoin 14.2016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.6918704418 19387464 17679729 18206229 18460780 19010910
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6919850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.0618055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8917107899 16935935 17217047 19029980 17339181 16823087 16788101 17361223 15748426 19225113 19035177 16891316 17368321 17301526 9834237 17649720 19642359 17294898 17712046 16140955 16766008 12679006 16331271 19075265 17506722
MESH:D007970 Leukopenia Lipopolysaccharides 4.3015821434
MESH:D007972 Leukoplakia, Oral Fenretinide 5.6416707609
MESH:D017880 Limb Deformities, Congenital Ethanol 12.1917676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 12.199224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 12.1916054864
MESH:D008103 Liver Cirrhosis Ethanol 6.4615289165
MESH:D008103 Liver Cirrhosis Vitamin A 6.4616256175
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7018295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.1518166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.1512878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.1518397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 6.1516248980
MESH:D008107 Liver Diseases Capsaicin 14.4116956363
MESH:D008107 Liver Diseases DDT 14.4115729006
MESH:D008107 Liver Diseases Docosahexaenoic Acids 14.4117056761
MESH:D008107 Liver Diseases Lindane 14.411715830
MESH:D008107 Liver Diseases Sulfonamides 14.4114986274
MESH:D008107 Liver Diseases Vitamin A 14.4116175620
MESH:D008108 Liver Diseases, Alcoholic Ethanol 10.2717347304 17207112
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 10.2716762690
MESH:D008113 Liver Neoplasms DDT 4.3715975961 11948501
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3716984957
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 8.641423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.6412151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 8.6417113696
MESH:D008171 Lung Diseases Vitamin A 3.8316863852
MESH:D055370 Lung Injury Lipopolysaccharides 3.6321114838
MESH:D008175 Lung Neoplasms alitretinoin 3.2816413115
MESH:D008175 Lung Neoplasms Cisplatin 3.2811798837 17225452 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2819555203 11884234
MESH:D008223 Lymphoma decitabine 3.1419470736
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.3310697514
MESH:D008415 Mastocytosis Retinoids 6.1916953078
MESH:D008527 Medulloblastoma Tretinoin 2.6217453147
MESH:D008545 Melanoma Cisplatin 6.6917023156 18176117 16248763 11135225 16432458 15577323 17761969 18505091 18332650 12393984 16809738 12883367 12374674
MESH:D008545 Melanoma decitabine 6.6916505122 17785578
MESH:D008545 Melanoma Fenretinide 6.6916270382
MESH:D008545 Melanoma Tretinoin 6.6916752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.3815990972
MESH:D008569 Memory Disorders Ethanol 3.8215451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.0416940565
MESH:D008654 Mesothelioma Cisplatin 3.0817638057
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1515863610
MESH:D009062 Mouth Neoplasms Fenretinide 4.0216274795
MESH:D009101 Multiple Myeloma Capsaicin 15.0617505005
MESH:D009101 Multiple Myeloma decitabine 15.0618172295
MESH:D009101 Multiple Myeloma Raloxifene 15.0616497877
MESH:D009101 Multiple Myeloma Vitamin A 15.0616374440
MESH:D009102 Multiple Organ Failure Zymosan 4.8518160304 15259001 12130978 15834315 15241586 15213630 12879239 10479408 17724436 10890648
MESH:D009139 Musculoskeletal Abnormalities triphenyltin hydroxide 5.8017619067
MESH:D009190 Myelodysplastic Syndromes decitabine 6.7118608210 19157545 19010910 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.7117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7112213967
MESH:D009232 Myxoma Raloxifene 5.1516343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.4718551238
MESH:D009369 Neoplasms alitretinoin 20.9216946489
MESH:D009369 Neoplasms Cisplatin 20.9216773208
MESH:D009369 Neoplasms DDT 20.928820588
MESH:D009369 Neoplasms decitabine 20.9219470736 19116145 17925555
MESH:D009369 Neoplasms Fenretinide 20.9217353921 15958647
MESH:D009369 Neoplasms Lindane 20.9216818664 12807735
MESH:D009369 Neoplasms Tretinoin 20.9216946489 16594593
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0915464296
MESH:D009421 Nervous System Malformations bisphenol A 14.2116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.2114600291
MESH:D009421 Nervous System Malformations Tretinoin 14.219125849
MESH:D009436 Neural Tube Defects Tretinoin 6.799142499
MESH:D009436 Neural Tube Defects Vitamin A 6.7917400914
MESH:D009447 Neuroblastoma Cisplatin 3.248761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.308761367
MESH:D020078 Neurogenic Inflammation Capsaicin 4.7317961222
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.2816303764
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 5.3220557099 9802331
MESH:D009765 Obesity Capsaicin 3.2919056576
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.0912819281 16049721
MESH:D009845 Oligospermia triphenyltin hydroxide 5.7916806747
MESH:D010024 Osteoporosis Raloxifene 3.1519059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8717823083 15579764 17893378 15758505
MESH:D010049 Ovarian Diseases bisphenol A 4.5911985600
MESH:D010051 Ovarian Neoplasms Cisplatin 10.246897625 19769630 17225452 15464296
MESH:D010051 Ovarian Neoplasms decitabine 10.2419331143 19259094
MESH:D010051 Ovarian Neoplasms Fenretinide 10.2416133793
MESH:D010051 Ovarian Neoplasms Tretinoin 10.2416936753
MESH:D010146 Pain Capsaicin 6.1417434803 17084039 17043245 18987195 16996476 19081190
MESH:D010146 Pain Tretinoin 6.1416870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 14.7119003803
MESH:D010190 Pancreatic Neoplasms decitabine 14.7119294695
MESH:D010190 Pancreatic Neoplasms Ethanol 14.7112384795
MESH:D010190 Pancreatic Neoplasms Fenretinide 14.7115580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.7115976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9415464296
MESH:D010538 Peritonitis Zymosan 4.5011985352 15259001 19088179 17826846 18557954 19641140 18760300 15979727 14761945 18977430 17371808
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.1011550810
MESH:D010997 Pleural Neoplasms Cisplatin 4.9417638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.1611605937 12224865
MESH:D017499 Porokeratosis alitretinoin 5.6016144296
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 9.869918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.8618163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.2010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2011399792 11118676 11222880 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.3417616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.8520887781
MESH:D011471 Prostatic Neoplasms AGN 194204 2.7916000583
MESH:D011471 Prostatic Neoplasms bicalutamide 2.7919240160 15638997 17914592 18487222 19011039
MESH:D011471 Prostatic Neoplasms bisphenol A 2.7916740699
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.7917024972
MESH:D011471 Prostatic Neoplasms DDT 2.7912584743
MESH:D011471 Prostatic Neoplasms Fenretinide 2.7917024972
MESH:D011471 Prostatic Neoplasms Lindane 2.7912661182 14688026
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7916220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Retinoids 2.7916724957 16166285
MESH:D011507 Proteinuria Tretinoin 3.2416636307
MESH:D011625 Pterygium Tretinoin 4.4016723453
MESH:D011629 Puberty, Precocious bisphenol A 4.3910548101
MESH:D011693 Purpura Raloxifene 5.1515770314
MESH:D012035 Refsum Disease Phytanic Acid 7.3420871815
MESH:D051437 Renal Insufficiency Cisplatin 4.0215464296
MESH:D015427 Reperfusion Injury Capsaicin 3.7619211983 18460982
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.4116877224
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.4710835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012162 Retinal Degeneration Fenretinide 4.1116303925
MESH:D012208 Rhabdomyosarcoma decitabine 9.7419155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.7416116481 16283617
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.0614601052
MESH:D012640 Seizures 2,4-dinitrotoluene 12.0418551238
MESH:D012640 Seizures Ethanol 12.049754883
MESH:D012640 Seizures Lindane 12.0415475178 7539098 12842176
MESH:D012640 Seizures Sulfonamides 12.0420420384
MESH:D018805 Sepsis Zymosan 4.3311441115
MESH:D012871 Skin Diseases Vitamin A 3.2518709164
MESH:D012878 Skin Neoplasms Fenretinide 15.8916467112
MESH:D012878 Skin Neoplasms Retinoids 15.8917538947
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.898532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.8916192470
MESH:D012878 Skin Neoplasms Tretinoin 15.8916467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.9415464296
MESH:D013274 Stomach Neoplasms Cisplatin 5.9318396642 17522103 15958060
MESH:D013274 Stomach Neoplasms decitabine 5.9319037991
MESH:D013274 Stomach Neoplasms Docosahexaenoic Acids 5.9319015929
MESH:D013274 Stomach Neoplasms Ethanol 5.9318456281
MESH:D013274 Stomach Neoplasms Tretinoin 5.9317261132
MESH:D013276 Stomach Ulcer Ethanol 3.1917918041 9211565 16755016 17189318 11906479 9562338
MESH:D020521 Stroke Raloxifene 3.5116837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.5916045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.919754883
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.3217997062
MESH:D013736 Testicular Neoplasms Cisplatin 4.2715464296 17225452
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8215821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5012697716
MESH:D013964 Thyroid Neoplasms decitabine 10.5317967635
MESH:D013964 Thyroid Neoplasms Retinoids 10.5316940797
MESH:D013964 Thyroid Neoplasms Tretinoin 10.5316026305 17045167
MESH:D013978 Tibial Fractures Raloxifene 4.8119048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4516051514
MESH:D014376 Tuberculosis Tretinoin 2.9816040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.0716049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 14.0712973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms decitabine 14.0719087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 14.0716720286
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 14.0717572228
MESH:D014570 Urologic Diseases DDT 5.2316487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9210091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 14.0416803524
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 14.0416154183
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.0416129372
MESH:D014591 Uterine Diseases bisphenol A 4.6114652134
MESH:D014604 Uveal Neoplasms decitabine 11.4917785578
MESH:D014604 Uveal Neoplasms Tretinoin 11.4916752155
MESH:D014605 Uveitis Zymosan 5.0011006244
MESH:D014625 Vaginal Neoplasms Cisplatin 4.2315577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8116837676
MESH:D014802 Vitamin A Deficiency Vitamin A 4.9116175781 16960172 16146918
MESH:D014820 Vitiligo Tretinoin 3.6816761959
MESH:D014839 Vomiting Cisplatin 4.3211897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
MESH:D009396 Wilms Tumor Tretinoin 3.6416287080
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
REACT:71 Gene Expression
KEGG:05223 Non-small cell lung cancer
KEGG:05200 Pathways in cancer
KEGG:03320 PPAR signaling pathway
KEGG:05222 Small cell lung cancer
KEGG:05216 Thyroid cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34891
    • No data
    No data
    Releated drug ID Related drug Name
    PA451746tretinoin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00210 agonist Adapalene Dermatologic Agents
    DB00307 agonist Bexarotene Anticarcinogenic Agents
    DB00459 agonist Acitretin Keratolytic Agents
    DB00523 agonist Alitretinoin Antineoplastic Agents;Keratolytic Agents
    DB00755 agonist Tretinoin Antineoplastic Agents;Keratolytic Agents;Cell Stimulants and Proliferants
    DB00799 agonist Tazarotene Keratolytic Agents;Dermatologic Agents;Prodrugs;Teratogens
    DB00926 agonist Etretinate Keratolytic Agents
    DB01941 - 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid
    DB07080 - N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE
    DB07929 - N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE
    DB08175 - (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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