AutismKB 2.0

Annotation Detail for RYK


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Basic Information Top
Gene Symbol:RYK ( D3S3195,JTK5,JTK5A,RYK1 )
Gene Full Name: RYK receptor-like tyrosine kinase
Band: 3q22.2
Quick LinksEntrez ID:6259; OMIM: 600524; Uniprot ID:RYK_HUMAN; ENSEMBL ID: ENSG00000163785; HGNC ID: 10481
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200055Wnt signaling network
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No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RYK mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RYK mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of RYK mRNAdecreases expression 15761015
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RYK mRNAdecreases expression 19150397
D019833 Genistein Genistein results in increased expression of RYK mRNAincreases expression 17341692
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000230 Adenocarcinoma arsenic trioxide 4.7711798837 19825857
MESH:D000230 Adenocarcinoma Genistein 4.7711473722
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0416206674
MESH:D001943 Breast Neoplasms Genistein 2.4917200150 16541309 16873071
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7311589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8916705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8915553829 11135700 14691202 15073043 16217749
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8916924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4712490120
MESH:D002318 Cardiovascular Diseases Genistein 3.5416332659
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.446135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4420889678
MESH:D002972 Cleft Palate marker/mechanism 10932185
MESH:D003110 Colonic Neoplasms Genistein 2.3317182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6312609071
MESH:D019465 Craniofacial Abnormalities marker/mechanism 10932185
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5018551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5015213294
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5516647724
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0421346803 18551238
MESH:D004714 Endometrial Hyperplasia Genistein 5.1316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5811473722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7012903497
MESH:D005234 Fatty Liver arsenic trioxide 3.6615073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7016904648
MESH:D005909 Glioblastoma Genistein 3.4716598420
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2816705839
MESH:D007938 Leukemia arsenic trioxide 6.9415070760
MESH:D007938 Leukemia Genistein 6.9417468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1820471514 16968895 17050201 16467208 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.439834237 11161223 12712474 17107899 16891316 16331271 15213294 12018890 17712046 17217047 17649720 19642359 19075265 16966277 17869043 19225113 11468182 15336539 16823087 15748426 19035177 16330433 16112521 15622746 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7916882451
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.977678174
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9714682389
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.656135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.6520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6215213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.1512929590 14578162
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3519549372 14977855 11468182 15949261 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3216882451 16105982
MESH:D009203 Myocardial Infarction Genistein 2.9817141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.9317141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.4018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4016624393
MESH:D009421 Nervous System Malformations Genistein 4.4716427766
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3310525206
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7816049721
MESH:D010024 Osteoporosis Genistein 3.4519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.4916169203
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.2712452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Genistein 5.2719005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6215580305
MESH:D010235 Paraganglioma arsenic trioxide 4.5719927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2819131511
MESH:D011471 Prostatic Neoplasms Genistein 3.2816925846 15378649 15256057
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4016646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7618551238
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3619014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5015213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4716049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4712973940 20435036 11780464 12845720
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.8610091137
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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