AutismKB 2.0

Annotation Detail for RYR3


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Basic Information Top
Gene Symbol:RYR3 ( - )
Gene Full Name: ryanodine receptor 3
Band: 15q13.3-q14
Quick LinksEntrez ID:6263; OMIM: 180903; Uniprot ID:RYR3_HUMAN; ENSEMBL ID: ENSG00000198838; HGNC ID: 10485
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa04970Salivary secretion
hsa05010Alzheimer's disease
No data
No data
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P04377Beta1 adrenergic receptor signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2124Autistic disorder
Desease Name
CARDIOVASCULAR
Carotid atherosclerosis in HIV infection
CHEMDEPENDENCY
smoking cessation
Desease Name
Carotid atherosclerosis in HIV infection
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of RYR3 mRNAdecreases expression 20406850
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RYR3 mRNAaffects expression 12734012
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.5415721981 16097048 3786805 18705752 15700767 10355542 16227642 16124888 15673190 16050911 16011737 16192424
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1516705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1518788625
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.096135515
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.7818551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.253732212 7440962 3786805 17522070 2869522 9327722 6884620 11566570 15027814 15998439 7179309 4309450 19336974 16177239 10092053 16227642 7120509 21278145 15968718 19085960 6623471 10915739
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.7216045604 15959796 19224547 12795759 17595544 61145 12631006 16239168
MESH:D005355 Fibrosis Carbon Tetrachloride 4.2218705752
MESH:D006505 Hepatitis Carbon Tetrachloride 4.2719110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.4216899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.8515338365
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.4116705839
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0416943688 11408273 17334410 16239168 17174718 21278145 17157831 11903743 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7618187930 16136751 18205269 14748882 17761835 15925388 17631135 15057751 15362042 17714472 16192424 15818738 15052691 12445418 15673190 16033810 16027843 11481614 17708605 15893842 18263696 16638106 18420326 17922224 16011737 16248980 15876570 15650968 17976157 18210741 17525996 18317297 18429990 17698563 12609069 16097048 12445421 14716496 18339082 12389079 15123356 16116963 12586293 12666154 18395095 16015684 18418968 20821823 18279442 18395914 17721639 18006644 10355542 18705752 12632512 17823541 12958196 14620537 12667390 18472094 14716833 18277467 15959796 18054572 17640975 17565644 15730626 14512876 13678700 17900296 18156304 12546737 17766677 17557913 15996030 12898905 12632514 18251166 12741479 12649538 17944888 14724832 18166357 17481882 15931870 18472332 18481824 17869086 18376398 18412020 15338365 17805973 15370692
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1716246199 16964402 15830285 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.9315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.2016899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 5.047678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 5.0419294768
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.862876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.8615583823 12014681
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.7518551238 7678174
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.9416049721
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8518551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4316049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.2010091137
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:04020 Calcium signaling pathway
KEGG:04970 Salivary secretion
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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