AutismKB 2.0

Annotation Detail for BDNF


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Basic Information Top
Gene Symbol:BDNF ( MGC34632 )
Gene Full Name: brain-derived neurotrophic factor
Band: 11p14.1
Quick LinksEntrez ID:627; OMIM: 113505; Uniprot ID:BDNF_HUMAN; ENSEMBL ID: ENSG00000176697; HGNC ID: 1033
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa05016Huntington's disease
hsa04722Neurotrophin signaling pathway
No data
Pathway IDPathway Name
200128Neurotrophic factor-mediated Trk receptor signaling
200103p75(NTR)-mediated signaling
Pathway IDPathway Name
P00040Metabotropic glutamate receptor group II pathway
P00029Huntington disease
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1707Multiple myeloma
1745Huntington disease
1799Epilepsy
1856Obesity
1870Drug abuse
1877Multiple sclerosis
1904Diabetes mellitus
1907Depression
1909Migraine
1918Atherosclerosis
1954Stroke
1955Urogenital abnormalities
1997Dental plaque
2006Anorexia nervosa
2030Bronchiolitis
2045Bipolar disorder
2047Rett syndrome
2074Asthma
2081Pulmonary fibrosis
2124Autistic disorder
2134Amyotrophic lateral sclerosis
2144Fibromyalgia
2145Subarachnoid hemorrhage
2185Obsessive-compulsive disorder
2192Lung disease
2198Psychotic disorder
2220Dermatitis
2221Behavior disease
Desease Name
obsessive compulsive disorder
bipolar disorder
cognitive function
mood disorder
Parkinson's disease
depression stroke
personality traits
CARDIOVASCULAR
Coronary Artery Disease
reasoning skills
Parkinsons disease
CHEMDEPENDENCY
Fragile X Syndrome
ADHD
eating disorders mood disorders schizophrenia substance abuse
Alzheimer's disease
methamphetamine abuse
epilepsy
PSYCH
Body mass index
cognition
depressive disorder, major hippocampal volume
rumination
Angina, Unstable
PHARMACOGENOMIC
alcoholism
body mass
serotonin transporter availability
obsessive-compulsive disorder
introversion and neuroticism
attention-deficit hyperactivity disorder
anorexia nervosa
personality disorders
weight
NEUROLOGICAL
Multiple System Atrophy
eating disorders
schizophrenia
childhood-onset mood disorders
METABOLIC
brain activity
BDNF serum concentrations
smoking behavior
depression
bulimia
hippocampal volume
substance abuse
psychoses
cognitive function schizophrenia
cognitive ability
bulimia eating disorder
schizophrenia weight gain
affective psychoses
Desease Name
Body mass index
Smoking behavior
Weight
Desease Name
Bulimia nervosa, age of onset of weight loss in
Central hypoventilation syndrome, congenital
WAGRO syndrome
Anorexia nervosa, susceptibility to
Memory impairment, susceptibility to
Obsessive-compulsive disorder, protection against
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C118559 1-bromopropane 1-bromopropane inhibits the reaction [Bucladesine results in increased expression of BDNF mRNA]decreases reaction|increases expression 19189864
C118559 1-bromopropane 1-bromopropane inhibits the reaction [Forskolin results in increased expression of BDNF mRNA]decreases reaction|increases expression 19189864
C118559 1-bromopropane 1-bromopropane inhibits the reaction [Forskolin results in increased expression of BDNF protein]decreases reaction|increases expression 19189864
C118559 1-bromopropane 1-bromopropane results in decreased expression of BDNF mRNAdecreases expression 19189864
C118559 1-bromopropane 1-bromopropane inhibits the reaction [Forskolin results in increased expression of BDNF protein]decreases reaction|increases expression 19189864
C118559 1-bromopropane 1-bromopropane results in decreased expression of BDNF mRNAdecreases expression 19189864
C488185 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide BDNF gene mutant form results in increased susceptibility to 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamideincreases response to substance 16945347
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]decreases reaction|increases expression 17209049
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]decreases reaction|increases expression 17209049
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of BDNF mRNAdecreases expression 16337876
C027576 4-hydroxy-2-nonenal CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA]decreases expression|decreases reaction 16337876
D000082 Acetaminophen Acetaminophen affects the expression of BDNF mRNAaffects expression 17562736
D000171 Acrolein Acrolein results in decreased expression of BDNF mRNAdecreases expression 16337876
D000171 Acrolein CREBBP protein inhibits the reaction [Acrolein results in decreased expression of BDNF mRNA]decreases expression|decreases reaction 16337876
D018350 alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased expression of BDNF proteinincreases expression 11279263
C067527 aluminum maltolate aluminum maltolate results in decreased expression of BDNF mRNAdecreases expression 12606298
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BDNF mRNAaffects expression 16483693
D003913 Dextroamphetamine BDNF gene polymorphism affects the susceptibility to Dextroamphetamineaffects response to substance 16823800
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of BDNF mRNAincreases expression 18681898
D003913 Dextroamphetamine Dextroamphetamine affects the expression of BDNF mRNAaffects expression 19222557
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of BDNF mRNAincreases expression 12213320
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of BDNF proteinincreases expression 12213320
D000661 Amphetamine BDNF gene mutant form affects the susceptibility to Amphetamineaffects response to substance 11421589
D000728 Androgens Androgens affects the expression of BDNF proteinaffects expression 17463054
D016718 Arachidonic Acid Arachidonic Acid results in decreased expression of BDNF mRNAdecreases expression 16704987
D001151 Arsenic Arsenic results in decreased expression of BDNF mRNAdecreases expression 19654921
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of BDNF mRNAincreases expression 18687144
D001205 Ascorbic Acid Ascorbic Acid results in increased expression of BDNF mRNAincreases expression 15305145
D001280 Atrazine Atrazine results in increased expression of BDNF mRNAincreases expression 18585445
D001374 Azacitidine Azacitidine results in decreased methylation of BDNF promoterdecreases methylation 18184782
D001374 Azacitidine Azacitidine results in increased expression of BDNF mRNAincreases expression 18184782
D001374 Azacitidine Tetrodotoxin inhibits the reaction [Azacitidine results in decreased methylation of BDNF promoter]decreases methylation|decreases reaction 18184782
D001374 Azacitidine Tetrodotoxin inhibits the reaction [Azacitidine results in increased expression of BDNF mRNA]decreases reaction|increases expression 18184782
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BDNF mRNAdecreases expression 20018196
19150397
C006780 bisphenol A bisphenol A inhibits the reaction [Potassium results in increased expression of BDNF mRNA]decreases reaction|increases expression 15527870
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of BDNF mRNAincreases expression 15336504
D002220 Carbamazepine Carbamazepine results in increased expression of BDNF mRNAincreases expression 18719996
D002220 Carbamazepine Carbamazepine results in increased expression of BDNF proteinincreases expression 18719996
D004390 Chlorpyrifos Chlorpyrifos affects the expression of BDNF mRNAaffects expression 18502319
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of BDNF mRNAincreases expression 17893397
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of BDNF proteinincreases expression 17893397
D002809 Chondroitin Sulfates [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to BDNF proteinaffects binding 15385557
D003024 Clozapine Clozapine results in decreased expression of BDNF mRNAdecreases expression 11488957
D003024 Clozapine Clozapine results in increased expression of BDNF mRNAincreases expression 12478621
D003024 Clozapine Clozapine results in increased expression of BDNF proteinincreases expression 17442489
D003474 Curcumin Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]decreases reaction|increases expression 19033880
D003474 Curcumin Curcumin affects the expression of BDNF proteinaffects expression 17617388
D003474 Curcumin [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]affects cotreatment|decreases reaction|increases expression 17827730
D003474 Curcumin Curcumin results in increased expression of BDNF proteinincreases expression 17022948
C052570 cyfluthrin cyfluthrin results in increased expression of BDNF mRNAincreases expression 16166269
C017160 cypermethrin cypermethrin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]decreases reaction|increases expression 11082455
C017160 cypermethrin cypermethrin results in increased expression of BDNF mRNAincreases expression 16166269
D003634 DDT DDT inhibits the reaction [Potassium results in increased expression of BDNF mRNA]decreases reaction|increases expression 15527870
D003634 DDT [Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of BDNF mRNA]affects cotreatment|decreases reaction|increases expression 15527870
C010902 decabromobiphenyl ether decabromobiphenyl ether affects the expression of BDNF proteinaffects expression 18061678
C010902 decabromobiphenyl ether decabromobiphenyl ether results in increased expression of BDNF proteinincreases expression 18753049
C017180 decamethrin decamethrin results in increased expression of BDNF mRNAincreases expression 16166269
12760793
C017180 decamethrin decamethrin results in increased expression of BDNF proteinincreases expression 16166269
12760793
C017180 decamethrin Nicardipine inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]decreases reaction|increases expression 16166269
C017180 decamethrin Tetrodotoxin inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]decreases reaction|increases expression 16166269
C017180 decamethrin U 0126 inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]decreases reaction|increases expression 16166269
C014347 decitabine decitabine results in increased expression of BDNF mRNAincreases expression 16367923
C014347 decitabine decitabine results in increased expression of BDNF mRNAincreases expression 19476549
C107676 deguelin deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]decreases reaction|increases expression 17209049
D003871 Dermatan Sulfate [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to BDNF proteinaffects binding 15385557
C493686 diacetylcurcumin [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]affects cotreatment|decreases reaction|increases expression 17827730
D003975 Diazepam [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]affects cotreatment|increases expression|increases reaction 11259499
D003975 Diazepam Diazepam results in increased expression of BDNF proteinincreases expression 17442489
D003975 Diazepam [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF proteinaffects cotreatment|increases expression 11259499
D003994 Bucladesine 1-bromopropane inhibits the reaction [Bucladesine results in increased expression of BDNF mRNA]decreases reaction|increases expression 19189864
D003994 Bucladesine Bucladesine results in increased expression of BDNF mRNAincreases expression 19189864
D004054 Diethylstilbestrol Diethylstilbestrol inhibits the reaction [Potassium results in increased expression of BDNF mRNA]decreases reaction|increases expression 15527870
D004054 Diethylstilbestrol [Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of BDNF mRNA]affects cotreatment|decreases reaction|increases expression 15527870
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of BDNF mRNAincreases expression 17292805
D002117 Calcitriol Calcitriol results in increased expression of BDNF mRNAincreases expression 16002434
D016291 Dizocilpine Maleate Dizocilpine Maleate affects the expression of BDNF mRNAaffects expression 8405262
D016291 Dizocilpine Maleate Dizocilpine Maleate results in decreased expression of BDNF mRNAdecreases expression 8247360
D016291 Dizocilpine Maleate Pentobarbital inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]affects expression|decreases reaction 8405262
D016291 Dizocilpine Maleate Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]affects expression|decreases reaction 8405262
D004298 Dopamine BDNF gene mutant form results in increased abundance of Dopamineincreases abundance 11421589
D004958 Estradiol Estradiol results in increased expression of BDNF proteinincreases expression 15570173
D004958 Estradiol Progesterone inhibits the reaction [Estradiol results in increased expression of BDNF protein]decreases reaction|increases expression 15570173
D004967 Estrogens Estrogens affects the expression of BDNF mRNAaffects expression 15893308
D000431 Ethanol Ethanol results in increased expression of BDNF mRNAincreases expression 18713641
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of BDNF geneincreases mutagenesis 16495775
D005054 Eugenol Eugenol results in increased expression of BDNF mRNAincreases expression 15157811
C017690 fenvalerate fenvalerate results in increased expression of BDNF mRNAincreases expression 16166269
D005473 Fluoxetine Fluoxetine results in increased expression of BDNF mRNAincreases expression 8601816
D005576 Forskolin 1-bromopropane inhibits the reaction [Forskolin results in increased expression of BDNF mRNA]decreases reaction|increases expression 19189864
D005576 Forskolin 1-bromopropane inhibits the reaction [Forskolin results in increased expression of BDNF protein]decreases reaction|increases expression 19189864
D005576 Forskolin Forskolin results in increased expression of BDNF mRNAincreases expression 19189864
D005576 Forskolin Forskolin results in increased expression of BDNF proteinincreases expression 19189864
D005576 Forskolin 1-bromopropane inhibits the reaction [Forskolin results in increased expression of BDNF protein]decreases reaction|increases expression 19189864
D005576 Forskolin Forskolin results in increased expression of BDNF proteinincreases expression 19189864
C063170 Ginkgo biloba extract 761 Ginkgo biloba extract 761 inhibits the reaction [APP protein results in decreased expression of BDNF protein]decreases expression|decreases reaction 18001288
D006220 Haloperidol Haloperidol inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]decreases expression|decreases reaction 17442543
D006220 Haloperidol Haloperidol results in decreased expression of BDNF mRNAdecreases expression 12478621
11488957
12393228
18208916
D006854 Hydrocortisone Hydrocortisone results in increased expression of BDNF proteinincreases expression 15531528
D007099 Imipramine Imipramine results in increased expression of BDNF mRNAincreases expression 15157811
D007099 Imipramine Imipramine affects the expression of BDNF proteinaffects expression 17617388
D007099 Imipramine Imipramine results in increased expression of BDNF mRNAincreases expression 8601816
17950272
D007099 Imipramine Rolipram promotes the reaction [Imipramine results in increased expression of BDNF mRNA]increases expression|increases reaction 8601816
D007608 Kainic Acid [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]affects cotreatment|decreases reaction|increases expression 17827730
D007608 Kainic Acid [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]affects cotreatment|decreases reaction|increases expression 17827730
D007608 Kainic Acid Kainic Acid results in increased expression of BDNF mRNAincreases expression 17827730
1641125
11279263
D007608 Kainic Acid Kainic Acid results in increased expression of BDNF proteinincreases expression 16166269
11279263
C047781 lamotrigine lamotrigine results in increased expression of BDNF mRNAincreases expression 18719996
C047781 lamotrigine lamotrigine results in increased expression of BDNF proteinincreases expression 18719996
D001556 Lindane Lindane results in increased expression of BDNF proteinincreases expression 11279263
D008094 Lithium BDNF gene polymorphism affects the susceptibility to Lithiumaffects response to substance 19018715
D008094 Lithium BDNF protein results in increased susceptibility to Lithiumincreases response to substance 19018715
D008094 Lithium Lithium results in increased expression of BDNF proteinincreases expression 17442489
D008345 Manganese [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]affects cotreatment|decreases reaction|increases expression 17827730
D008345 Manganese [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]affects cotreatment|decreases reaction|increases expression 17827730
D008694 Methamphetamine BDNF gene polymorphism affects the susceptibility to Methamphetamineaffects response to substance 19462300
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BDNF mRNAincreases expression 19285098
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of BDNF mRNAincreases expression 15120970
D008743 Methyl Parathion Methyl Parathion results in increased expression of BDNF mRNAincreases expression 17893397
D008743 Methyl Parathion Methyl Parathion results in increased expression of BDNF proteinincreases expression 17893397
D008774 Methylphenidate Methylphenidate affects the expression of BDNF mRNAaffects expression 19222557
D009020 Morphine Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]decreases reaction|increases expression 19033880
D009020 Morphine Morphine results in increased expression of BDNF mRNAincreases expression 19033880
D009151 Mustard Gas Mustard Gas results in increased expression of BDNF mRNAincreases expression 15674844
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FGF2 protein results in increased expression of BDNF mRNA]decreases reaction|increases expression 16269011
D009529 Nicardipine Nicardipine inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]decreases reaction|increases expression 16166269
D009538 Nicotine BDNF gene polymorphism affects the susceptibility to Nicotineaffects response to substance 17186223
D009543 Nifedipine Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF protein]decreases reaction|increases expression 11279263
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of BDNF mRNAdecreases expression 17616710
C076029 olanzapine olanzapine results in increased expression of BDNF mRNAincreases expression 12478621
C076029 olanzapine olanzapine results in increased expression of BDNF proteinincreases expression 17442489
D010126 Ozone Ozone results in increased expression of BDNF mRNAincreases expression 17095637
D010126 Ozone Ozone results in increased expression of BDNF mRNAincreases expression 16716893
D010208 Papaverine Papaverine results in increased expression of BDNF mRNAincreases expression 8601816
D010242 Paraldehyde Paraldehyde promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]increases expression|increases reaction 11259499
C093973 PD 98059 PD 98059 inhibits the reaction [FGF2 protein results in increased expression of BDNF mRNA]decreases reaction|increases expression 16269011
C093973 PD 98059 PD 98059 inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein]decreases reaction|increases phosphorylation 14622123
D010424 Pentobarbital [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]affects cotreatment|increases expression|increases reaction 11259499
D010424 Pentobarbital Pentobarbital inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]affects expression|decreases reaction 8405262
D010424 Pentobarbital Pentobarbital results in decreased expression of BDNF mRNAdecreases expression 8247360
D010424 Pentobarbital [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF proteinaffects cotreatment|increases expression 11259499
D010433 Pentylenetetrazole Pentylenetetrazole results in increased expression of BDNF mRNAincreases expression 11279263
D010433 Pentylenetetrazole Pentylenetetrazole results in increased expression of BDNF proteinincreases expression 11279263
D026023 Permethrin [Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of BDNF mRNA]affects cotreatment|decreases reaction|increases expression 15527870
D026023 Permethrin Permethrin inhibits the reaction [Potassium results in increased expression of BDNF mRNA]decreases reaction|increases expression 15527870
D026023 Permethrin Permethrin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]decreases reaction|increases expression 11082455
D026023 Permethrin Permethrin results in decreased expression of BDNF mRNAdecreases expression 12111003
D026023 Permethrin Permethrin results in increased expression of BDNF mRNAincreases expression 19017407
D010656 Phenylephrine Phenylephrine results in increased expression of BDNF mRNAincreases expression 18158353
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of BDNF mRNAaffects expression 17651324
D010852 Picrotoxin Picrotoxin results in decreased methylation of BDNF promoterdecreases methylation 18184782
D010852 Picrotoxin Picrotoxin results in increased expression of BDNF mRNAincreases expression 18184782
D010852 Picrotoxin Picrotoxin results in increased expression of BDNF proteinincreases expression 11279263
D010862 Pilocarpine [Diazepam co-treated with Pentobarbital] promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]affects cotreatment|increases expression|increases reaction 11259499
D010862 Pilocarpine Paraldehyde promotes the reaction [Pilocarpine results in increased expression of BDNF mRNA]increases expression|increases reaction 11259499
D010862 Pilocarpine [Pilocarpine co-treated with Diazepam co-treated with Pentobarbital] results in increased expression of BDNF proteinaffects cotreatment|increases expression 11259499
D010862 Pilocarpine Pilocarpine results in decreased expression of BDNF proteindecreases expression 11259499
D010862 Pilocarpine Pilocarpine results in increased expression of BDNF mRNAincreases expression 8405262
11259499
D011188 Potassium bisphenol A inhibits the reaction [Potassium results in increased expression of BDNF mRNA]decreases reaction|increases expression 15527870
D011188 Potassium DDT inhibits the reaction [Potassium results in increased expression of BDNF mRNA]decreases reaction|increases expression 15527870
D011188 Potassium Diethylstilbestrol inhibits the reaction [Potassium results in increased expression of BDNF mRNA]decreases reaction|increases expression 15527870
D011188 Potassium [Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of BDNF mRNA]affects cotreatment|decreases reaction|increases expression 15527870
D011188 Potassium Permethrin inhibits the reaction [Potassium results in increased expression of BDNF mRNA]decreases reaction|increases expression 15527870
D011188 Potassium Pyrethrins inhibits the reaction [Potassium results in increased expression of BDNF mRNA]decreases reaction|increases expression 15527870
D011374 Progesterone Progesterone results in decreased expression of BDNF mRNAdecreases expression 18070364
D011374 Progesterone Progesterone affects the localization of BDNF proteinaffects localization 17052708
D011374 Progesterone Progesterone inhibits the reaction [VPS54 gene mutant form results in decreased expression of BDNF mRNA]decreases expression|decreases reaction 17052708
D011374 Progesterone Progesterone results in increased expression of BDNF mRNAincreases expression 17549730
D011374 Progesterone Progesterone results in increased expression of BDNF proteinincreases expression 17549730
D011374 Progesterone Progesterone inhibits the reaction [Estradiol results in increased expression of BDNF protein]decreases reaction|increases expression 15570173
D011722 Pyrethrins Pyrethrins inhibits the reaction [Potassium results in increased expression of BDNF mRNA]decreases reaction|increases expression 15527870
D001498 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF mRNAincreases expression 11279263
D001498 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF proteinincreases expression 11279263
D001498 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BDNF protein]decreases reaction|increases expression 11279263
C069541 quetiapine quetiapine results in increased expression of BDNF proteinincreases expression 17442489
D017378 Quinolinic Acid Quinolinic Acid results in increased expression of BDNF mRNAincreases expression 15698628
D018967 Risperidone Risperidone inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]decreases expression|decreases reaction 17442543
D018967 Risperidone Risperidone results in decreased expression of BDNF mRNAdecreases expression 12393228
D016713 Ritanserin Ritanserin results in increased expression of BDNF mRNAincreases expression 12393228
D020889 Rolipram Rolipram promotes the reaction [Imipramine results in increased expression of BDNF mRNA]increases expression|increases reaction 8601816
D020889 Rolipram Rolipram results in increased expression of BDNF mRNAincreases expression 8601816
C104586 roscovitine roscovitine inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]decreases reaction|increases expression 17209049
C104586 roscovitine roscovitine inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]decreases reaction|increases expression 17209049
D012402 Rotenone BDNF protein affects the reaction [PITX3 protein results in decreased susceptibility to Rotenone]affects reaction|decreases response to substance 18646205
D012402 Rotenone Haloperidol inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]decreases expression|decreases reaction 17442543
D012402 Rotenone Risperidone inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]decreases expression|decreases reaction 17442543
D012402 Rotenone Rotenone results in decreased expression of BDNF mRNAdecreases expression 17442543
D012402 Rotenone BDNF protein results in decreased susceptibility to Rotenonedecreases response to substance 18646205
D012601 Scopolamine Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]affects expression|decreases reaction 8405262
D020280 Sertraline Sertraline results in increased expression of BDNF proteinincreases expression 18403212
D020123 Sirolimus Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]decreases reaction|increases expression 17209049
D020123 Sirolimus Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]decreases reaction|increases expression 17209049
C424127 SL 327 BDNF gene mutant form results in increased susceptibility to SL 327increases response to substance 16945347
C017947 sodium arsenite sodium arsenite results in increased expression of BDNF mRNAincreases expression 12760830
D013629 Tamoxifen Tamoxifen affects the expression of BDNF mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BDNF mRNAincreases expression 16443690
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BDNF mRNAincreases expression 15328365
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of BDNF mRNAaffects expression 12606293
D013779 Tetrodotoxin Tetrodotoxin inhibits the reaction [Azacitidine results in decreased methylation of BDNF promoter]decreases methylation|decreases reaction 18184782
D013779 Tetrodotoxin Tetrodotoxin inhibits the reaction [Azacitidine results in increased expression of BDNF mRNA]decreases reaction|increases expression 18184782
D013779 Tetrodotoxin Tetrodotoxin inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]decreases reaction|increases expression 16166269
D013779 Tetrodotoxin Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]decreases reaction|increases expression 16166269
D014050 Toluene Toluene results in decreased expression of BDNF mRNAdecreases expression 17481687
D014050 Toluene Toluene results in increased expression of BDNF mRNAincreases expression 17870172
D014191 Tranylcypromine Tranylcypromine results in increased expression of BDNF mRNAincreases expression 8601816
D014212 Tretinoin [BDNF protein co-treated with Tretinoin] results in increased expression of APP proteinaffects cotreatment|increases expression 16150056
D014212 Tretinoin BDNF protein inhibits the reaction [Tretinoin results in increased N-linked glycosylation of APLP1 protein]decreases reaction|increases N-linked glycosylation 16150056
D014212 Tretinoin [Tretinoin co-treated with BDNF protein co-treated with NTF3 protein] results in decreased expression of MAP2 proteinaffects cotreatment|decreases expression 16646665
D014212 Tretinoin Tretinoin results in decreased expression of BDNF proteindecreases expression 17026715
C034613 triacsin C triacsin C results in decreased expression of BDNF mRNAdecreases expression 16704987
C012589 trichostatin A trichostatin A results in increased expression of BDNF mRNAincreases expression 19476549
C068051 tripchlorolide tripchlorolide results in increased expression of BDNF mRNAincreases expression 12504865
C113580 U 0126 U 0126 inhibits the reaction [FGF2 protein results in increased expression of BDNF mRNA]decreases reaction|increases expression 16269011
C113580 U 0126 U 0126 inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein]decreases reaction|increases phosphorylation 14622123
C113580 U 0126 U 0126 inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]decreases reaction|increases expression 16166269
D014635 Valproic Acid Valproic Acid results in decreased expression of BDNF mRNAdecreases expression 20603192
D014635 Valproic Acid Valproic Acid results in increased expression of BDNF proteinincreases expression 17442489
C047426 venlafaxine venlafaxine results in increased expression of BDNF mRNAincreases expression 17950272
D014701 Veratridine cypermethrin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]decreases reaction|increases expression 11082455
D014701 Veratridine Permethrin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]decreases reaction|increases expression 11082455
D014701 Veratridine Veratridine results in increased expression of BDNF mRNAincreases expression 11082455
D014701 Veratridine Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]decreases reaction|increases expression 16166269
D014701 Veratridine Veratridine results in increased expression of BDNF mRNAincreases expression 16166269
C025643 vinclozolin vinclozolin affects the expression of BDNF mRNAaffects expression 19015723
C009687 wortmannin wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]decreases reaction|increases expression 17209049
D014978 Xenon Xenon results in increased expression of BDNF proteinincreases expression 16034370
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of BDNF mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.5914745880
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 12.878986270
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.8718926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.8711752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.878875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.0719490988
MESH:D000138 Acidosis Ammonium Chloride 12.4818287403
MESH:D000138 Acidosis Ethanol 12.4811192467
MESH:D000138 Acidosis Zinc Sulfate 12.487265320
MESH:D000168 Acrocephalosyndactylia U 0126 4.5617694057
MESH:D055371 Acute Lung Injury Acrolein 3.8521297076 20525806
MESH:D000230 Adenocarcinoma Estradiol 1.8011473722
MESH:D000236 Adenoma Ethylnitrosourea 3.116695378
MESH:D018248 Adenoma, Liver Cell DDT 7.4512597452
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 7.4516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 3.7515276417
MESH:D018246 Adrenocortical Adenoma Arsenic 10.6317306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 10.6316712894 17306315
MESH:D000380 Agranulocytosis Clozapine 4.1414617031 12649775 16160616
MESH:D000382 Agricultural Workers' Diseases Atrazine 17.0511874814
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 17.0516611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases cypermethrin 17.0516487989
MESH:D000382 Agricultural Workers' Diseases DDT 17.0516487989 12584743
MESH:D000382 Agricultural Workers' Diseases Lindane 17.0512661182
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.3615451040 15451039
MESH:D019973 Alcohol-Related Disorders Curcumin 4.1317887948
MESH:D000505 Alopecia Tretinoin 2.8315955085
MESH:D000544 Alzheimer Disease marker/mechanism 17344400
MESH:D000544 Alzheimer Disease Acrolein 11.3815207723 14715435 17570602
MESH:D000544 Alzheimer Disease Androgens 11.3817182789 17917157
MESH:D000544 Alzheimer Disease Curcumin 11.3815590663
MESH:D000544 Alzheimer Disease Lithium 11.3819621015
MESH:D000544 Alzheimer Disease Nicotine 11.3816627626
MESH:D000544 Alzheimer Disease Ozone 11.3815513908
MESH:D000550 Amblyopia Valproic Acid 4.2817688650
MESH:D000647 Amnesia Scopolamine 5.9316946593
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.1215010207 16916582 18475255 16459022
MESH:D000686 Amyloidosis Diethylstilbestrol 3.5815469931
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.4410965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.1211748828
MESH:D000756 Anemia, Sideroblastic Manganese 4.0116910769
MESH:D000799 Angioedema Acetaminophen 2.8910982225
MESH:D000853 Anophthalmos Ethanol 3.9015513904
MESH:D000855 Anorexia Amphetamine 7.8816084549 16101753 12005258 12183048
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 7.8815146954
MESH:D000856 Anorexia Nervosa marker/mechanism
MESH:D000860 Anoxia Zinc Sulfate 4.097265320
MESH:D001008 Anxiety Disorders Diazepam 29.5718313124 16284244
MESH:D001008 Anxiety Disorders Ethanol 29.5711141031
MESH:D001008 Anxiety Disorders Fluoxetine 29.5718083778
MESH:D001008 Anxiety Disorders Pentobarbital 29.5718313124 11141031
MESH:D001008 Anxiety Disorders Sertraline 29.5718822694
MESH:D001008 Anxiety Disorders Valproic Acid 29.5717497229
MESH:D001008 Anxiety Disorders vinclozolin 29.5719015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.2917460149
MESH:D020261 Arsenic Poisoning Arsenic 2.5116251483 18414634 16835338 12569548
MESH:D001161 Arteriosclerosis Acrolein 4.1015014928
MESH:D001169 Arthritis, Experimental Tretinoin 2.4316412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 5.4116807698
MESH:D001172 Arthritis, Rheumatoid Ozone 5.4115570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 5.4116292516
MESH:D020817 Asperger Syndrome Risperidone 4.6716401163
MESH:D001249 Asthma Mustard Gas 5.5210378619
MESH:D001249 Asthma Ozone 5.5216373670 17854713
MESH:D001249 Asthma Tretinoin 5.5216456186
MESH:D050197 Atherosclerosis Acrolein 7.4516126721 17363696 16037261
MESH:D050197 Atherosclerosis Arsenic 7.4519371607 12928151
MESH:D050197 Atherosclerosis Curcumin 7.4518704882
MESH:D001289 Attention Deficit Disorder with Hyperactivity Methylphenidate 7.0217276750 16919137 10490706
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 7.0218349709
MESH:D001321 Autistic Disorder marker/mechanism 17349978 20662941
MESH:D001321 Autistic Disorder Acetaminophen 9.4618445737
MESH:D001321 Autistic Disorder Arachidonic Acid 9.4618582451
MESH:D001321 Autistic Disorder Fluoxetine 9.4619232924 18775368
MESH:D001321 Autistic Disorder Haloperidol 9.4618080171 19368416
MESH:D001321 Autistic Disorder Methylphenidate 9.4616919137 19232924 18752063
MESH:D001321 Autistic Disorder olanzapine 9.4618685284 17069543
MESH:D001321 Autistic Disorder Quinolinic Acid 9.4616139734
MESH:D001321 Autistic Disorder Risperidone 9.4617019624 16239862 18278980 16948927 15492353 16379507 18349709 19368416 19232924 15994720 17929164 19013209 15930063 17069546 15543515 18775368 16730335 18026891 19154706 18080171 16601648
MESH:D001321 Autistic Disorder Sertraline 9.4618775368
MESH:D001321 Autistic Disorder Sirolimus 9.4621115397
MESH:D001321 Autistic Disorder Valproic Acid 9.4618985861 17157402 20603192 16609825 19232924 17688650 15238991 18775368 18940202 18177632 18558336 18316065 19460635 17507914 18396377
MESH:D001327 Autoimmune Diseases Curcumin 3.5819761891
MESH:D001471 Barrett Esophagus Tretinoin 3.5016935849
MESH:D001714 Bipolar Disorder marker/mechanism 14708030 19018715
MESH:D001714 Bipolar Disorder Carbamazepine 12.2817594078 20046352
MESH:D001714 Bipolar Disorder Lithium 12.2820046352 20338123 17594078 19153942
MESH:D001714 Bipolar Disorder Risperidone 12.2819154706 18278980
MESH:D001714 Bipolar Disorder Valproic Acid 12.2820046352 17594078
MESH:D001768 Blister Mustard Gas 4.2219167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 6.1112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 6.1116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.8415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 5.7515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 5.758888407
MESH:D001851 Bone Diseases, Metabolic Ginkgo biloba extract 761 5.4019356626
MESH:D001862 Bone Resorption bisphenol A 3.0111985600
MESH:D001919 Bradycardia Phenylephrine 3.6215306635
MESH:D001927 Brain Diseases Ethylnitrosourea 4.0414991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.3817868700
MESH:D001930 Brain Injuries Progesterone 3.3415845082 15665606 15380490
MESH:D002545 Brain Ischemia Curcumin 7.5516770732
MESH:D002545 Brain Ischemia Morphine 7.5519211983
MESH:D001932 Brain Neoplasms Curcumin 6.3817596214
MESH:D001932 Brain Neoplasms Ethylnitrosourea 6.3818412241 16357521 16651633 16436596 15144691
MESH:D001943 Breast Neoplasms Androgens 10.8117018787
MESH:D001943 Breast Neoplasms Ascorbic Acid 10.8116443354
MESH:D001943 Breast Neoplasms bisphenol A 10.8117123778
MESH:D001943 Breast Neoplasms Calcitriol 10.8111237771
MESH:D001943 Breast Neoplasms Curcumin 10.8116243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms DDT 10.8112709520 16792888
MESH:D001943 Breast Neoplasms decitabine 10.8119208741 18320071
MESH:D001943 Breast Neoplasms deguelin 10.8118593368 17035597
MESH:D001943 Breast Neoplasms Diethylstilbestrol 10.8117129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 10.8112948864 19861407 16675129 18497071 17289903 17018787 17261762 14630087
MESH:D001943 Breast Neoplasms Lindane 10.8114688026
MESH:D001943 Breast Neoplasms Progesterone 10.8115562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 10.8119189210 20390343 17049068 19066611 18855134 16818667 18351453 18425577 21138602 20859285 20544844 19288272 19084267 19289846 15668708 17242785 18815881 18821012 19410462 18997820 17440819 20065188 19142967 17261762 16873071 21152245 19011961 19200415 19221464 18984771 17893378 20005174 15565566 19059307 19487384 18629630 19189212 20135344 19115204 16273361 11161223 16202921 19103187 19155303 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.8120435547
MESH:D001943 Breast Neoplasms Tretinoin 10.8116873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 2.9118417511 14754758 15516495 18315731 17626835 19059883 16777450
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.2215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.0210378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.6516813970
MESH:D052018 Bulimia Nervosa marker/mechanism
MESH:D002056 Burns Ethanol 3.7416374292
MESH:D002100 Cachexia Ozone 3.8016183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.5316111702
MESH:D002277 Carcinoma Curcumin 5.7018593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 5.7016835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 2.9717687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.5919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.2016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 22.193084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 22.1916507464 17306315
MESH:D006528 Carcinoma, Hepatocellular DDT 22.1912597452
MESH:D006528 Carcinoma, Hepatocellular deguelin 22.1918575727
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 22.1916924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 22.1916924424
MESH:D006528 Carcinoma, Hepatocellular Estrogens 22.1915341023
MESH:D006528 Carcinoma, Hepatocellular Ethanol 22.1915289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 22.1919335982
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 22.1916507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 22.1916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 22.191917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.0517123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.5618414057
MESH:D002294 Carcinoma, Squamous Cell Arsenic 15.7417687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 15.7411237771
MESH:D002294 Carcinoma, Squamous Cell Curcumin 15.7418462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 15.7419215824
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 15.7419435901
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 15.7418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 15.7416051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 6.7318640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 6.7317572228
MESH:D006332 Cardiomegaly Ethanol 7.8919332462
MESH:D006332 Cardiomegaly Phenylephrine 7.8917124262 11754973 16170337 17287366 11179087 15728586
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.8918670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 2.7619152805 15738583 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 3.4916973168 18022660
MESH:D002375 Catalepsy Haloperidol 3.9815215559 1977408
MESH:D002386 Cataract Acetaminophen 5.0810977129
MESH:D002386 Cataract Tretinoin 5.0817460283
MESH:D002389 Catatonia olanzapine 5.2918071103 16772815
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13.6520889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.6518566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 13.6516003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 13.652727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 13.6519524636 20056578
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.0317160924
MESH:D002547 Cerebral Palsy Toluene 4.919294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.6516129372
MESH:D002659 Child Development Disorders, Pervasive Methylphenidate 5.1318752063 15319018
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 5.1320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.3516835633
MESH:D002822 Choriocarcinoma Tretinoin 4.2016461808
MESH:D002971 Cleft Lip Ethanol 3.0015513904
MESH:D002972 Cleft Palate Diazepam 13.163629520
MESH:D002972 Cleft Palate Ethanol 13.1615513904
MESH:D002972 Cleft Palate Hydrocortisone 13.1615826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 13.1615668235 16354765 12621046 8697196 15340226
MESH:D002972 Cleft Palate Tretinoin 13.169407595
MESH:D019970 Cocaine-Related Disorders Methylphenidate 5.5619462300
MESH:D003072 Cognition Disorders Clozapine 9.2617123785
MESH:D003072 Cognition Disorders Scopolamine 9.2619527754
MESH:D003092 Colitis Curcumin 6.6216782535 16804969 18200517
MESH:D003092 Colitis Tretinoin 6.6217035595
MESH:D003103 Coloboma Curcumin 3.6918809619
MESH:D003110 Colonic Neoplasms Curcumin 3.0719359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 3.0717616700
MESH:D015179 Colorectal Neoplasms Acrolein 2.9017597105
MESH:D015179 Colorectal Neoplasms Azacitidine 2.9019934284
MESH:D015179 Colorectal Neoplasms decitabine 2.9018981723
MESH:D003128 Coma Ginkgo biloba extract 761 5.2710836866
MESH:D003139 Common Cold Ascorbic Acid 4.5217323712
MESH:D000013 Congenital Abnormalities DDT 6.7515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 6.7514669216 17141729
MESH:C536209 Congenital central hypoventilation syndrome marker/mechanism
MESH:D016510 Corneal Neovascularization Curcumin 3.9818497527
MESH:D019465 Craniofacial Abnormalities Carbamazepine 15.069014606
MESH:D019465 Craniofacial Abnormalities decamethrin 15.0619861644
MESH:D019465 Craniofacial Abnormalities Ethanol 15.0615451039 10194807 19302082 15513904 11198716 11873399 15451040
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 15.0617728286
MESH:D019465 Craniofacial Abnormalities Permethrin 15.0619861644
MESH:D019465 Craniofacial Abnormalities Ritanserin 15.0614991402 10978843
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 15.0615322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Toluene 15.069294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 15.069142499 17551590 9125849 10589399 8800419 16925845 9224671 9664655 14991402 9211117
MESH:D019465 Craniofacial Abnormalities Valproic Acid 15.0616575769 17688650 8888407
MESH:D016638 Critical Illness Androgens 10.5816670151
MESH:D016638 Critical Illness Estrogens 10.5816670151
MESH:D003456 Cryptorchidism Diethylstilbestrol 8.3916002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 8.3914966744
MESH:D003556 Cystitis Acrolein 9.3812161096
MESH:D003556 Cystitis Rolipram 9.3818710439
MESH:D007644 Darier Disease Lithium 4.9720338123
MESH:D003643 Death Pentylenetetrazole 10.736431079
MESH:D003643 Death Toluene 10.736431079
MESH:D016757 Death, Sudden, Cardiac Haloperidol 8.5520210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 8.5520210726
MESH:D003704 Dementia Haloperidol 7.7111575062
MESH:D003704 Dementia Risperidone 7.7111575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.4419031437
MESH:D003866 Depressive Disorder Fluoxetine 12.6515014590
MESH:D003866 Depressive Disorder Imipramine 12.6520305041
MESH:D003866 Depressive Disorder Sertraline 12.6515014590 20305041 18822694
MESH:D003866 Depressive Disorder venlafaxine 12.6520305041
MESH:D003865 Depressive Disorder, Major Sertraline 4.5416968574
MESH:D003872 Dermatitis Rolipram 5.1716442096
MESH:D003877 Dermatitis, Contact Permethrin 4.1314617103
MESH:D002658 Developmental Disabilities olanzapine 3.9917069543
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 4.8319244398
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 7.3216506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 7.3216402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 7.3218403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3217107852
MESH:D003928 Diabetic Nephropathies Curcumin 10.3218204486
MESH:D003928 Diabetic Nephropathies Estradiol 10.3219279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 10.3219279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.5717187935
MESH:D003967 Diarrhea Hydrocortisone 6.017237001
MESH:D003967 Diarrhea Morphine 6.012540324
MESH:D006970 Disorders of Excessive Somnolence Clozapine 11.2815331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 11.2816379507
MESH:D053207 Diurnal Enuresis Risperidone 5.7217822346
MESH:D004314 Down Syndrome Risperidone 4.3418349709
OMIM:607208 DRAVET SYNDROME Carbamazepine 4.5311748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 3.7515057820 20216337 16538176 16538175
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.7116393943 19739265 2444490 11461765 16227642 12705907 19923254 15968718 16485898 19416960 12958197 19085960 19164858 16781746 14986274 14725611 17522070 17906064 19370779 11287661 11834606 18713872 12594235 11739529 16081117 10915739 17562736 11743745 11421492 16109766 11529661 16177239 12540782 18071297 15619225 12153990 14550746 10774834 10663392 12392966 19420014
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 7.7117465707
MESH:D056486 Drug-Induced Liver Injury Ethanol 7.7111566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.7120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 7.711733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.1419426721
MESH:D004362 Drug Toxicity Carbamazepine 5.9220216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 5.9211462148
MESH:D004381 Duodenal Ulcer Curcumin 3.1717351913
MESH:D050171 Dyslipidemias Clozapine 3.4516402076
MESH:D004417 Dyspnea cypermethrin 7.9516487989
MESH:D004417 Dyspnea DDT 7.9516487989
MESH:D004421 Dystonia Diazepam 8.141851702
MESH:D004421 Dystonia Valproic Acid 8.141851702
MESH:D020821 Dystonic Disorders Nicotine 4.9917881519
MESH:C538011 Eales disease Ascorbic Acid 4.529068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.0318357618
MESH:D004487 Edema Arachidonic Acid 12.917990266 9599246 9831321 16716910 11698051 15177302
MESH:D004487 Edema Fluoxetine 12.9112798668
MESH:D004487 Edema Imipramine 12.9112798668
MESH:D004487 Edema Mustard Gas 12.9111428631 9260866 11428647 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.9111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 8.7918230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 8.7918230668
MESH:D020803 Encephalitis, Herpes Simplex Quinolinic Acid 5.8817174341
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.7415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 14.7417654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.7417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.7419031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 10.8719294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 10.8719294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 3.7616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.1416804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 12.1419148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.1417893378 19155303 20544844 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 12.1416569247
MESH:D004715 Endometriosis Progesterone 6.1616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 6.169294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 9.1016538176 19915237 18855540 16415921 20485159
MESH:D004816 Epidermal Necrolysis, Toxic lamotrigine 9.1020235791
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 13.4717275665
MESH:D004831 Epilepsies, Myoclonic lamotrigine 13.4717275665
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 13.473659116 17275665
MESH:D004828 Epilepsies, Partial Carbamazepine 16.5316628512 15008574 17116037
MESH:D004828 Epilepsies, Partial Diazepam 16.533922381
MESH:D004828 Epilepsies, Partial lamotrigine 16.5317116037
MESH:D004828 Epilepsies, Partial Valproic Acid 16.533922381 16628512
MESH:D004827 Epilepsy Carbamazepine 14.5519439326 7988514 19620853 17178248 19700373 18234410 9014606 821787 20417680 17465707
MESH:D004827 Epilepsy Diazepam 14.55821787
MESH:D004827 Epilepsy lamotrigine 14.5519668019
MESH:D004827 Epilepsy Pilocarpine 14.5511162239 19700373 19439326
MESH:D004827 Epilepsy Valproic Acid 14.5518234410 20417680
MESH:D004832 Epilepsy, Absence Diazepam 10.666426943 6401628
MESH:D004832 Epilepsy, Absence Pentylenetetrazole 10.666426943
MESH:D004832 Epilepsy, Absence Valproic Acid 10.667562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 8.677750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 8.677750514
MESH:D004833 Epilepsy, Temporal Lobe lamotrigine 5.8816499746
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 7.793659116 15276670
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 7.793659116
MESH:D004890 Erythema Mustard Gas 4.229357497
MESH:D004916 Erythromelalgia Carbamazepine 4.7819549232
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 5.2220426865
MESH:D004938 Esophageal Neoplasms Ethanol 5.2216704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 5.2216704527 16805852 15547721 15547733 15623463 15150132 16510608 15878914 15264214
MESH:D005076 Exanthema Carbamazepine 4.5320485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 6.3311564622
MESH:D005124 Eye Abnormalities Tretinoin 6.3316938888 9664655
MESH:D005221 Fatigue Amphetamine 4.6619890266
MESH:D005234 Fatty Liver Curcumin 11.9419297423
MESH:D005234 Fatty Liver Ethanol 11.9419236843 16409862 18620774
MESH:D005234 Fatty Liver Tamoxifen 11.9414986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 11.9419224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 4.7117920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 6.0116002989 16611131 16513791 16534752 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 6.0116709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.3616946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.5411858732
MESH:D005315 Fetal Diseases Valproic Acid 3.9316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.2418558336 8888407
MESH:D005334 Fever Arachidonic Acid 3.8311852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.5914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.2519069698
MESH:D005355 Fibrosis Curcumin 9.6018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6020067830
MESH:D005355 Fibrosis Tretinoin 9.6017994277
MESH:D005534 Foot Diseases Arsenic 4.606392382
MESH:D005756 Gastritis Acetaminophen 7.9816983495
MESH:D005756 Gastritis Ethanol 7.9815046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 3.7818462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.0016973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.3416417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 9.7116452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 9.7116452187
MESH:D005909 Glioblastoma Curcumin 15.0517596214
MESH:D005909 Glioblastoma Ethylnitrosourea 15.0516436596
MESH:D005909 Glioblastoma Manganese 15.0517043766
MESH:D005909 Glioblastoma Tretinoin 15.0517312396
MESH:D005909 Glioblastoma trichostatin A 15.0518801729
MESH:D005910 Glioma Ethylnitrosourea 3.0218412241 16651633 16357521
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.6410696789
MESH:D006258 Head and Neck Neoplasms Curcumin 12.7618462866 18829502
MESH:D006258 Head and Neck Neoplasms decitabine 12.7619215824
MESH:D006258 Head and Neck Neoplasms Sirolimus 12.7619435901
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.7616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.2016084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 14.7716080930
MESH:D006330 Heart Defects, Congenital Lithium 14.7719638421
MESH:D006330 Heart Defects, Congenital Ritanserin 14.7714991402
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.7711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 14.7714991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.4811000095
MESH:D006505 Hepatitis cypermethrin 7.3716487989
MESH:D006505 Hepatitis DDT 7.3716487989
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 4.0817063115
MESH:D006529 Hepatomegaly DDT 9.602387028
MESH:D006529 Hepatomegaly fenvalerate 9.6015602828
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.6016120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.1217701891
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.0516863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.0815709030
MESH:D006628 Hirsutism Androgens 5.1316914592 17019078
MESH:D006689 Hodgkin Disease sodium arsenite 2.3812676792
MESH:D019584 Hot Flashes Estradiol 11.9717088409
MESH:D019584 Hot Flashes Fluoxetine 11.9714716179
MESH:D019584 Hot Flashes venlafaxine 11.9714716179
MESH:D006816 Huntington Disease Sertraline 5.1018403212
MESH:D006849 Hydrocephalus Valproic Acid 3.9317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.098697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 12.4516870215
MESH:D006930 Hyperalgesia alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 12.4515706230
MESH:D006930 Hyperalgesia Ethanol 12.4518783367
MESH:D006930 Hyperalgesia Tretinoin 12.4516870215
MESH:D017588 Hyperandrogenism Androgens 4.7817019078
MESH:D006937 Hypercholesterolemia Curcumin 3.2118704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.6516778211
MESH:D006943 Hyperglycemia Risperidone 4.3318278980
MESH:D020138 Hyperhomocysteinemia Carbamazepine 3.9110459572
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.6117050553
MESH:D006948 Hyperkinesis Amphetamine 13.9414960337 1977408
MESH:D006948 Hyperkinesis Clozapine 13.9416046005
MESH:D006948 Hyperkinesis Methamphetamine 13.9417658665
MESH:D006963 Hyperphagia olanzapine 5.2917933447
MESH:D006965 Hyperplasia Carbamazepine 8.2718773962
MESH:D006965 Hyperplasia Diethylstilbestrol 8.2712960047 14722030
MESH:D006973 Hypertension Arsenic 8.5116076760 9931084 11953799
MESH:D006973 Hypertension Nifedipine 8.5120102058
MESH:D006973 Hypertension Phenylephrine 8.5112717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5118670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 8.1712791704 18502941
MESH:D006984 Hypertrophy Sirolimus 8.1719211884
MESH:D006987 Hypesthesia Arsenic 4.6016093927
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 4.9219822448
MESH:D007021 Hypospadias Diethylstilbestrol 3.6616002989
MESH:D007022 Hypotension Dopamine 6.956740701
MESH:D007022 Hypotension Zinc Sulfate 6.957265320
MESH:D007077 Ileal Diseases Rolipram 5.4518306037
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.4815869954
MESH:D007246 Infertility Diethylstilbestrol 3.4615036965
MESH:D007248 Infertility, Male Atrazine 13.8112948887
MESH:D007248 Infertility, Male DDT 13.8117157474 17192596
MESH:D007248 Infertility, Male decitabine 13.8117581917
MESH:D007248 Infertility, Male sodium arsenite 13.8115346721 12646999
MESH:D007248 Infertility, Male vinclozolin 13.8116467254
MESH:D007249 Inflammation Arachidonic Acid 18.2617371808 15177302 9831321
MESH:D007249 Inflammation Curcumin 18.2617151092 18403477 16956363
MESH:D007249 Inflammation Fluoxetine 18.2612798668
MESH:D007249 Inflammation Imipramine 18.2612798668
MESH:D007249 Inflammation Mustard Gas 18.2611428620 8975870 9260866 17524151 11428631 9357497 11402378 16001271 11428647
MESH:D007249 Inflammation Progesterone 18.2615869954
MESH:D007249 Inflammation Tamoxifen 18.2619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.2612878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.7318596194 18200517
MESH:D007299 Insect Bites and Stings cypermethrin 16.1015189238
MESH:D007299 Insect Bites and Stings decamethrin 16.1015189238
MESH:D007299 Insect Bites and Stings Permethrin 16.1012971516 15189238 12749493
MESH:D007333 Insulin Resistance bisphenol A 5.1516393666
MESH:D007333 Insulin Resistance Estradiol 5.1516393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 2.8617994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.3910783313
MESH:D007569 Jaw Abnormalities Ethanol 12.2415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 12.2416580747
MESH:D007569 Jaw Abnormalities Tretinoin 12.2415992940 17551590
MESH:D007579 Jejunal Diseases Rolipram 5.4518306037
MESH:D007638 Keratoconjunctivitis Sicca Scopolamine 5.9315604871
MESH:D007642 Keratosis Arsenic 4.0512749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.3015629191 12587719
MESH:D007674 Kidney Diseases Acrolein 9.3012488133
MESH:D007674 Kidney Diseases Estradiol 9.3015618244
MESH:D007674 Kidney Diseases sodium arsenite 9.3020008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.3715003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 11.3715610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 11.3717379185
MESH:D007680 Kidney Neoplasms Tamoxifen 11.3718625569
MESH:D007859 Learning Disorders DDT 15.597589230
MESH:D007859 Learning Disorders Diethylstilbestrol 15.5917184923
MESH:D007859 Learning Disorders Ethanol 15.5915451040
MESH:D007859 Learning Disorders Scopolamine 15.5919426756 19182383
MESH:D007889 Leiomyoma Curcumin 3.6918555241
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.4815237267
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20.9412970779
MESH:D007938 Leukemia Azacitidine 20.9419148494
MESH:D007938 Leukemia Curcumin 20.9418462866
MESH:D007938 Leukemia decitabine 20.9418980019 19235587
MESH:D007938 Leukemia Permethrin 20.9412937054
MESH:D007938 Leukemia roscovitine 20.9416275999
MESH:D007938 Leukemia Tretinoin 20.9417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.3516106398
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 8.9916972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 8.9916972261
MESH:D007951 Leukemia, Myeloid Azacitidine 11.1919077051
MESH:D007951 Leukemia, Myeloid decitabine 11.1919117987 18454857 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 11.1919285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 8.5418720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.5418704418 17679729 19387464 18460780 19010910 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.5419850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 8.5418206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 8.5417596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.5118055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.3119299654
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 5.4617339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 5.4617361223 17506722 19642359 16140955 17294898 12679006 16823087 17217047 19225113 17712046 19029980 15748426 19075265 9834237 16935935 17339181 17649720 16766008 19035177 16331271 17301526 17107899 16788101 17368321 16891316
MESH:D015458 Leukemia, T-Cell Curcumin 3.8616106398
MESH:D007984 Leydig Cell Tumor vinclozolin 3.7916417039
MESH:D017880 Limb Deformities, Congenital Ethanol 5.8817676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 5.889224671
MESH:D008064 Lipidoses Clozapine 16.9317567588
MESH:D008064 Lipidoses Fluoxetine 16.9317567588 15342952
MESH:D008064 Lipidoses Imipramine 16.9317567588 15342952
MESH:D008064 Lipidoses Sertraline 16.9317567588
MESH:D008064 Lipidoses Tamoxifen 16.9317567588 15342952
MESH:D008103 Liver Cirrhosis Ethanol 2.7815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.1618295389
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 7.6717355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.6714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 7.6718166357
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 7.6717050028
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 7.6718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.6712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.6718397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 13.6012969438 16610002 16611625 19460945 11587558 19784758 19014921 12587719
MESH:D008107 Liver Diseases Arsenic 13.6011134558
MESH:D008107 Liver Diseases Chlorpyrifos 13.6015991261
MESH:D008107 Liver Diseases Curcumin 13.6016956363
MESH:D008107 Liver Diseases cypermethrin 13.6015991261
MESH:D008107 Liver Diseases DDT 13.6015729006
MESH:D008107 Liver Diseases Lindane 13.601715830
MESH:D008108 Liver Diseases, Alcoholic Ethanol 3.7417347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 7.2617185352 16871587
MESH:D017114 Liver Failure, Acute venlafaxine 7.2619857765
MESH:D008113 Liver Neoplasms Arsenic 11.7516368122
MESH:D008113 Liver Neoplasms DDT 11.7511948501 15975961
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.7515890375 16712894
MESH:D008113 Liver Neoplasms sodium arsenite 11.7515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 11.7516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.7516984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 3.9518544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 3.9512151625
MESH:D008133 Long QT Syndrome olanzapine 3.9820210726
MESH:D008171 Lung Diseases Acrolein 15.7311504702
MESH:D008171 Lung Diseases Ascorbic Acid 15.7316863852
MESH:D008171 Lung Diseases Mustard Gas 15.7318161513 18702808
MESH:D008171 Lung Diseases Ozone 15.738266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 15.7319095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.3117228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 6.2417365036
MESH:D055370 Lung Injury Ozone 6.2420417186
MESH:D008175 Lung Neoplasms Arsenic 15.2217976673 19168569 17306315
MESH:D008175 Lung Neoplasms Ascorbic Acid 15.2216401635
MESH:D008175 Lung Neoplasms Azacitidine 15.2221224363
MESH:D008175 Lung Neoplasms Curcumin 15.2219359593 16243823 18462866
MESH:D008175 Lung Neoplasms deguelin 15.2219336726 16288123
MESH:D008175 Lung Neoplasms Ethylnitrosourea 15.226695378 16271038 16019985 17703301
MESH:D008175 Lung Neoplasms Mustard Gas 15.228781369 3148597
MESH:D008175 Lung Neoplasms Ozone 15.227614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 15.2215276417 16712894 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 15.2218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.2211884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.2116628512
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.2115166399
MESH:D008223 Lymphoma Curcumin 11.9818462866
MESH:D008223 Lymphoma decitabine 11.9819470736
MESH:D008223 Lymphoma Diethylstilbestrol 11.9815700306
MESH:D008223 Lymphoma Ethylnitrosourea 11.9815790496
MESH:D016399 Lymphoma, T-Cell Curcumin 8.7016173963
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 8.7015375218
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.5616002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 2.8419428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.7811408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 8.7810767621 10838139 18041768
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.7811408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.7819196722 14580682 19196723 11731420 16827153
MESH:D020149 Manganese Poisoning Estradiol 16.9119453300
MESH:D020149 Manganese Poisoning Manganese 16.9119453300 16568477 16551646
MESH:D020149 Manganese Poisoning Tamoxifen 16.9119453300
MESH:D008527 Medulloblastoma Tretinoin 2.3117453147
MESH:D008545 Melanoma Curcumin 10.9818462866 17885582
MESH:D008545 Melanoma decitabine 10.9816505122 17785578
MESH:D008545 Melanoma Sirolimus 10.9819282848
MESH:D008545 Melanoma sodium arsenite 10.9819082730 16487513
MESH:D008545 Melanoma Tamoxifen 10.9819393235 12393984
MESH:D008545 Melanoma Tretinoin 10.9816752155
MESH:D008545 Melanoma trichostatin A 10.9816505122
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.2515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 7.9519513568
MESH:D008546 Melanoma, Experimental Acrolein 7.9510803710
MESH:D008569 Memory Disorders Curcumin 11.1217263510
MESH:D008569 Memory Disorders Ethanol 11.1218411066 15451040
MESH:D008569 Memory Disorders Scopolamine 11.1219426756 19182383 15957009 19527754
MESH:D008579 Meningioma Ethylnitrosourea 5.0317943659
MESH:D008591 Meningomyelocele Tretinoin 3.5116940565
MESH:D001523 Mental Disorders Clozapine 31.2516856516
MESH:D001523 Mental Disorders Fluoxetine 31.2516856516
MESH:D001523 Mental Disorders Haloperidol 31.2516856516
MESH:D001523 Mental Disorders Imipramine 31.2516856516
MESH:D001523 Mental Disorders olanzapine 31.2516856516
MESH:D001523 Mental Disorders quetiapine 31.2516856516
MESH:D001523 Mental Disorders Risperidone 31.2516596465 16856516
MESH:D001523 Mental Disorders Sertraline 31.2516856516
MESH:D001523 Mental Disorders venlafaxine 31.2516856516
MESH:D008607 Mental Retardation marker/mechanism 11357950
MESH:D008607 Mental Retardation Carbamazepine 7.309014606
MESH:D008607 Mental Retardation Risperidone 7.3018349709
MESH:D008607 Mental Retardation Toluene 7.309294310
MESH:D008654 Mesothelioma Asbestos, Crocidolite 4.9516966607 16166281 18303189
MESH:D008654 Mesothelioma Atrazine 4.951916698
MESH:D008659 Metabolic Diseases olanzapine 4.5319142110
MESH:D024821 Metabolic Syndrome X Clozapine 7.5219142101
MESH:D024821 Metabolic Syndrome X Risperidone 7.5219142101
MESH:D008679 Metaplasia Ozone 4.1510496685
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 4.9517671175
MESH:D008881 Migraine Disorders Valproic Acid 5.7118765137 18803445
MESH:D008881 Migraine Disorders venlafaxine 5.7118803445
MESH:D009006 Monosomy Azacitidine 5.1319299654
MESH:D019964 Mood Disorders Risperidone 4.9117019624
MESH:D009041 Motion Sickness Dextroamphetamine 10.151613127
MESH:D009041 Motion Sickness Scopolamine 10.151613127
MESH:D019957 Motor Skills Disorders Toluene 4.359294310
MESH:D009062 Mouth Neoplasms Sirolimus 3.9519435901
MESH:D009069 Movement Disorders Manganese 4.1316551646
MESH:D009101 Multiple Myeloma Azacitidine 11.4218443271 19549372
MESH:D009101 Multiple Myeloma Curcumin 11.4219372569
MESH:D009101 Multiple Myeloma decitabine 11.4218172295
MESH:D009101 Multiple Myeloma trichostatin A 11.4218172295
MESH:D009134 Muscular Atrophy, Spinal Curcumin 3.9817962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.178888407
MESH:D009190 Myelodysplastic Syndromes Azacitidine 12.4219805378 17596541 17611569 18720364
MESH:D009190 Myelodysplastic Syndromes decitabine 12.4216882708 19010910 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 12.4217596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 12.4217596541
MESH:D009203 Myocardial Infarction Lithium 3.4516288908
MESH:D017202 Myocardial Ischemia Arsenic 6.4015371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 6.4012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.5216810080
MESH:D009207 Myoclonus Fluoxetine 4.948041377
MESH:D009224 Myotonia Congenita Carbamazepine 4.5320399394
MESH:D009361 Neoplasm Invasiveness Curcumin 3.4818495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.0819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1119410462
MESH:D009369 Neoplasms Acrolein 24.8317329238
MESH:D009369 Neoplasms DDT 24.838820588
MESH:D009369 Neoplasms decitabine 24.8317925555 19116145 19470736
MESH:D009369 Neoplasms deguelin 24.8317764071
MESH:D009369 Neoplasms Diethylstilbestrol 24.8315313581
MESH:D009369 Neoplasms fenvalerate 24.832895627
MESH:D009369 Neoplasms Lindane 24.8316818664 12807735
MESH:D009369 Neoplasms Nicotine 24.8316365874
MESH:D009369 Neoplasms sodium arsenite 24.8311559025
MESH:D009369 Neoplasms Tretinoin 24.8316594593 16946489
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 6.3716707424
MESH:D009374 Neoplasms, Experimental sodium arsenite 6.3720056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 7.6912497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 7.6919189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 7.2817289903
MESH:D009389 Neovascularization, Pathologic Nicotine 7.2816365874
MESH:D009393 Nephritis Acrolein 5.3312653641
MESH:D009410 Nerve Degeneration Manganese 6.3116551646
MESH:D009410 Nerve Degeneration Rotenone 6.3118619942 17356569 15790535
MESH:D009421 Nervous System Malformations bisphenol A 32.5816427766 11399458
MESH:D009421 Nervous System Malformations Carbamazepine 32.5816990009
MESH:D009421 Nervous System Malformations Diethylstilbestrol 32.5811399458
MESH:D009421 Nervous System Malformations Estradiol 32.5816427766 11399458
MESH:D009421 Nervous System Malformations Pilocarpine 32.5815987249
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 32.5814600291
MESH:D009421 Nervous System Malformations Tretinoin 32.589125849
MESH:D009423 Nervous System Neoplasms Curcumin 4.6718462866
MESH:D009436 Neural Tube Defects Arsenic 11.7116620997
MESH:D009436 Neural Tube Defects sodium arsenite 11.7112854658
MESH:D009436 Neural Tube Defects Tretinoin 11.719142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.7116359493 8888407
MESH:D009442 Neurilemmoma Ethylnitrosourea 4.4816003739 17160924 16651423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.7318514411
MESH:D019636 Neurodegenerative Diseases Acrolein 9.7311342003
MESH:D019636 Neurodegenerative Diseases Amphetamine 9.7315183010
MESH:D020078 Neurogenic Inflammation Arsenic 3.5017056641
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 9.8115081274
MESH:D020258 Neurotoxicity Syndromes Methyl Parathion 9.8119784758
MESH:D020258 Neurotoxicity Syndromes Pyrethrins 9.8119861644
MESH:D009503 Neutropenia Mustard Gas 3.117688884 16761898
MESH:D053206 Nocturnal Enuresis Risperidone 5.3717822346
MESH:D009765 Obesity Ascorbic Acid 7.7917217161
MESH:D009765 Obesity Clozapine 7.7918515891 19142110
MESH:D009765 Obesity Curcumin 7.7919297423
MESH:D009765 Obesity olanzapine 7.7918515891
MESH:D009771 Obsessive-Compulsive Disorder marker/mechanism
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 8.8120418887
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 8.8117503984
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.0317160924
MESH:D010018 Osteomalacia Carbamazepine 4.5317016548
MESH:D010024 Osteoporosis Curcumin 2.8318719352
MESH:D010049 Ovarian Diseases bisphenol A 4.0511985600
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 26.4216211241
MESH:D010051 Ovarian Neoplasms Arsenic 26.4217306315
MESH:D010051 Ovarian Neoplasms Curcumin 26.4218462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 26.4219331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 26.4219401270
MESH:D010051 Ovarian Neoplasms Progesterone 26.4216525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 26.4215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 26.4216936753
MESH:D010051 Ovarian Neoplasms trichostatin A 26.4219331143
MESH:D010051 Ovarian Neoplasms U 0126 26.4216211241
MESH:D010146 Pain Acetaminophen 16.4116870215
MESH:D010146 Pain Carbamazepine 16.4115215642
MESH:D010146 Pain Fluoxetine 16.4112798668
MESH:D010146 Pain Imipramine 16.4112798668
MESH:D010146 Pain Morphine 16.4115275824 6776300 16273134 15215642 18699797 20225289
MESH:D010146 Pain Tretinoin 16.4116870215
MESH:D010190 Pancreatic Neoplasms Curcumin 11.3819401701 19196508 17440100
MESH:D010190 Pancreatic Neoplasms decitabine 11.3819294695
MESH:D010190 Pancreatic Neoplasms Ethanol 11.3812384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.3815976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 11.3819294695
MESH:D010243 Paralysis fenvalerate 5.068952708
MESH:D010267 Parapsoriasis Carbamazepine 4.7816538176
MESH:D010300 Parkinson Disease Acrolein 14.3217690948
MESH:D010300 Parkinson Disease Atrazine 14.3217218051
MESH:D010300 Parkinson Disease Eugenol 14.3217329831
MESH:D010300 Parkinson Disease Manganese 14.3211181820
MESH:D010300 Parkinson Disease Rotenone 14.3211535288 19114014 11445065 19232380 15451049 16140633 16412576 18191903 18619942
MESH:D010300 Parkinson Disease Sirolimus 14.3219682553
MESH:D020734 Parkinsonian Disorders Manganese 6.7416140633
MESH:D020734 Parkinsonian Disorders Rotenone 6.7415927086 15795934 15574749 18197244
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 4.9817145499 17679678
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.2912520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.2916093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.0515371236 6392382 16905509
MESH:D010538 Peritonitis Ozone 3.2216369182
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 10.3011550810
MESH:D010787 Photosensitivity Disorders Acrolein 10.3011550810
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.088041377
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.2114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 3.7515687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 3.9710923243
MESH:D011014 Pneumonia Ozone 3.4618381685 18007984 18929643
MESH:D011041 Poisoning Methyl Parathion 6.4017603234
MESH:D011041 Poisoning Mustard Gas 6.4015727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.6618163543
MESH:D011248 Pregnancy Complications Carbamazepine 4.249014606
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 25.9910548101
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 25.999014606
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 25.9917184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 25.9911222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 25.9920603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 25.9918220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 9.3817616702
MESH:D055728 Primary Myelofibrosis trichostatin A 9.3817616702
MESH:D011469 Prostatic Diseases vinclozolin 4.0018220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 3.8415572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 7.7020887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 7.7020887781
MESH:D011471 Prostatic Neoplasms Androgens 5.2115389811 17909013 16998812
MESH:D011471 Prostatic Neoplasms Arsenic 5.2116140617
MESH:D011471 Prostatic Neoplasms Azacitidine 5.2118324645
MESH:D011471 Prostatic Neoplasms bisphenol A 5.2116740699
MESH:D011471 Prostatic Neoplasms Calcitriol 5.2118247401 12479363 16644109 15754350 16289102
MESH:D011471 Prostatic Neoplasms Curcumin 5.2112497104 15129424 18769126 10851300 18156803 18226269 11398177
MESH:D011471 Prostatic Neoplasms DDT 5.2112584743
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 5.2117136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 5.2116740699
MESH:D011471 Prostatic Neoplasms Lindane 5.2112661182 14688026
MESH:D011471 Prostatic Neoplasms roscovitine 5.2116140939
MESH:D011471 Prostatic Neoplasms sodium arsenite 5.2116039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 5.2115067354
MESH:D011471 Prostatic Neoplasms trichostatin A 5.2119789329 18798265
MESH:D011472 Prostatitis vinclozolin 4.0018629315
MESH:D011507 Proteinuria Arsenic 6.3921343184
MESH:D011507 Proteinuria Tretinoin 6.3916636307
MESH:D011537 Pruritus Mustard Gas 3.1718058305
MESH:D019310 Pseudolymphoma Carbamazepine 9.4412752131 9591791
MESH:D019310 Pseudolymphoma Valproic Acid 9.4411422049 12752131
MESH:D011595 Psychomotor Agitation Haloperidol 14.0611575062
MESH:D011595 Psychomotor Agitation Methylphenidate 14.0618752063
MESH:D011595 Psychomotor Agitation olanzapine 14.0618685284
MESH:D011618 Psychotic Disorders marker/mechanism 14708030
MESH:D011618 Psychotic Disorders Clozapine 6.7115331141
MESH:D011618 Psychotic Disorders Haloperidol 6.7111575062
MESH:D011625 Pterygium Tretinoin 3.8516723453
MESH:D011629 Puberty, Precocious bisphenol A 3.8510548101
MESH:D011656 Pulmonary Emphysema Curcumin 3.6919168576
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.3814606601
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 4.3117322281 17365031 15814490 17975199
MESH:D011658 Pulmonary Fibrosis Mustard Gas 4.3117266442 10334151 17620002 17894541 17720292
MESH:D012021 Reflex, Abnormal Pentobarbital 5.0810930210
MESH:D051437 Renal Insufficiency Acrolein 4.1012732208
MESH:D015427 Reperfusion Injury Morphine 3.5819211983
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.1710666014 18379247
MESH:D012135 Respiratory Sounds Atrazine 7.0911874814
MESH:D012135 Respiratory Sounds Chlorpyrifos 7.0916611668 17119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 2.9418990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 3.9517119214 16611668
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 2.9516849425
MESH:D012208 Rhabdomyosarcoma decitabine 13.4719155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 13.4716116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 13.4719155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.4218045962
MESH:D012509 Sarcoma Curcumin 3.2918462866
MESH:D012512 Sarcoma, Ewing's roscovitine 4.8916230394
MESH:D012559 Schizophrenia marker/mechanism 12951204 17442489 14708030
MESH:D012559 Schizophrenia Clozapine 7.8617667964 17123785 20452607 16141801 17726453 18806925 20580759 19369910 20168265 11763009 20107430 20521320 18855531 11151749 20521326
MESH:D012559 Schizophrenia Haloperidol 7.861830565 20107430 19369910 18513383
MESH:D012559 Schizophrenia olanzapine 7.8617726453 20521326 20107430
MESH:D012559 Schizophrenia Risperidone 7.8618278980 19154706 20107430
MESH:D012559 Schizophrenia Valproic Acid 7.8615737665 19110320
MESH:D012640 Seizures Carbamazepine 47.9816876388 9844417 15946322 16938433 19414003 9046859 16180713
MESH:D012640 Seizures Diazepam 47.989754883 15946322 10087439
MESH:D012640 Seizures Dizocilpine Maleate 47.9811218047 17157343 12660363
MESH:D012640 Seizures Ethanol 47.989754883
MESH:D012640 Seizures Kainic Acid 47.981641125 15686955 16336964 17827730 14637104 10686065 19414003 19186208 18657176
MESH:D012640 Seizures lamotrigine 47.9816499746 9844417
MESH:D012640 Seizures Lindane 47.987539098 15475178 12842176
MESH:D012640 Seizures Lithium 47.9819660546
MESH:D012640 Seizures Nicotine 47.9817873105
MESH:D012640 Seizures Pentobarbital 47.9810087439 9754883
MESH:D012640 Seizures Pentylenetetrazole 47.9816054440 19660546 3037702 8954991 15475178 18657176 6431079 18164287 2616065 3352866
MESH:D012640 Seizures Picrotoxin 47.988635557 8954991
MESH:D012640 Seizures Pilocarpine 47.9819660546 7750514
MESH:D012640 Seizures Toluene 47.989294310 6431079
MESH:D012640 Seizures Valproic Acid 47.981511512 15475178 3137016 17978042 11044598 16876388 14763951 11738929
MESH:D018805 Sepsis Curcumin 3.2818389075
MESH:D020230 Serotonin Syndrome Fluoxetine 10.328704074
MESH:D020230 Serotonin Syndrome Methylphenidate 10.327854515
OMIM:608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO lamotrigine 5.6719668019 20485159
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.136418539
MESH:D012852 Sinusitis Phenylephrine 3.777327846
MESH:D012871 Skin Diseases Arsenic 5.9316353154 17548696 16759981 15952646 16702368 17050553 17938729 19834688 17453740 18709164 6392382
MESH:D012871 Skin Diseases Ascorbic Acid 5.9318709164
MESH:D012871 Skin Diseases Mustard Gas 5.9315451306 12880345 16961503
MESH:D012878 Skin Neoplasms Arsenic 15.2816251483 17976673 19538983 17029826 15504454 17050553
MESH:D012878 Skin Neoplasms deguelin 15.2816041863
MESH:D012878 Skin Neoplasms sodium arsenite 15.2818572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 15.288532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.2816192470
MESH:D012878 Skin Neoplasms Tretinoin 15.2816467112
MESH:D012892 Sleep Deprivation Imipramine 5.2619798453
MESH:D012893 Sleep Disorders Carbamazepine 12.9419414003
MESH:D012893 Sleep Disorders Kainic Acid 12.9419414003
MESH:D012893 Sleep Disorders Risperidone 12.9418278980
MESH:D013088 Spermatocele Diethylstilbestrol 8.6916002989 16709447
MESH:D013088 Spermatocele Tamoxifen 8.6916709447
MESH:D013119 Spinal Cord Injuries Progesterone 7.7815862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 7.7819457130
MESH:D016135 Spinal Dysraphism sodium arsenite 6.9812854658
MESH:D016135 Spinal Dysraphism Valproic Acid 6.9819490988
MESH:D013226 Status Epilepticus Lithium 15.9619430551 19570321 19951488
MESH:D013226 Status Epilepticus Pilocarpine 15.9611259499 15857427 19951488 15987249 19055492 19570321 19430551
MESH:D013226 Status Epilepticus Valproic Acid 15.9612833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.471977408
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 8.8819915237 20485159 18855540 16415921 16538176 15057820 19694795
MESH:D013262 Stevens-Johnson Syndrome lamotrigine 8.8820235791
MESH:D013272 Stomach Diseases Rolipram 4.8715038085
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms decitabine 3.4419037991
MESH:D013274 Stomach Neoplasms Ethanol 3.4418456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.4412958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 3.4417261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 17.3418726076
MESH:D013276 Stomach Ulcer Curcumin 17.3416631530 19188055
MESH:D013276 Stomach Ulcer Ethanol 17.349562338 16755016 17189318 9211565 17918041 11906479
MESH:D013276 Stomach Ulcer Eugenol 17.3418543354
MESH:D013276 Stomach Ulcer Nifedipine 17.3414653237
MESH:D013276 Stomach Ulcer Rolipram 17.3414567935
MESH:D020521 Stroke Acrolein 6.6716269634
MESH:D020521 Stroke Ascorbic Acid 6.6716403987 16517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.0616684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Diazepam 11.899754883
MESH:D013375 Substance Withdrawal Syndrome Ethanol 11.899754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 11.8911529278 9754883
MESH:D017180 Tachycardia, Ventricular Haloperidol 12.5220210726
MESH:D017180 Tachycardia, Ventricular olanzapine 12.5220210726
MESH:D017180 Tachycardia, Ventricular Risperidone 12.5220210726
MESH:D013733 Testicular Diseases Toluene 4.0310048760 10514026
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.2315790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 2.9512697716
MESH:D013964 Thyroid Neoplasms decitabine 4.8117967635
MESH:D013964 Thyroid Neoplasms Tretinoin 4.8117045167 16026305
MESH:D013978 Tibial Fractures Estradiol 3.7319048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO marker/mechanism 20418890
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 3.9916720336 11259349 16785264
MESH:D014029 Tobacco Use Disorder marker/mechanism 17186223
MESH:D014029 Tobacco Use Disorder Nicotine 4.5317979512 18305452 15735609 18041664
MESH:D014062 Tongue Neoplasms Tretinoin 2.9516051514
MESH:D005879 Tourette Syndrome Risperidone 5.0219154706
MESH:D014178 Translocation, Genetic Valproic Acid 4.2817262798
MESH:D014202 Tremor fenvalerate 8.608952708
MESH:D014202 Tremor Pilocarpine 8.6017594079
MESH:D014376 Tuberculosis Tretinoin 2.5716040207
MESH:D014402 Tuberous Sclerosis Sirolimus 4.6718495876 21115397
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.583119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 13.4818640142 17306315 15987713 19322015 19429237 11144890 17976673
MESH:D001749 Urinary Bladder Neoplasms Curcumin 13.4818593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 13.4819087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 13.4817306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.4811723127 17306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 13.4817572228 16712894 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.728888407
MESH:D014565 Urogenital Neoplasms Curcumin 4.3218462866
MESH:D014570 Urologic Diseases cypermethrin 9.6116487989
MESH:D014570 Urologic Diseases DDT 9.6116487989
MESH:D014581 Urticaria Acetaminophen 2.1210982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 11.0616175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 11.0611813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 11.0616129372
MESH:D014591 Uterine Diseases bisphenol A 10.6614652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 10.6614652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.1816690809 15809267
MESH:D014604 Uveal Neoplasms decitabine 9.6717785578
MESH:D014604 Uveal Neoplasms Tretinoin 9.6716752155
MESH:D014605 Uveitis Sirolimus 4.681336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.5216513791 16002989
MESH:D014652 Vascular Diseases Arsenic 8.7517056641
MESH:D014652 Vascular Diseases sodium arsenite 8.7517056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.6412125929
MESH:D020301 Vasospasm, Intracranial Nicardipine 9.6219057314
MESH:D020301 Vasospasm, Intracranial Papaverine 9.6219057314
MESH:D014820 Vitiligo Tretinoin 3.1616761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.2915886252
MESH:D015430 Weight Gain Clozapine 11.9117502770 16141801 20521320 20107430 20564506 16402076
MESH:D015430 Weight Gain olanzapine 11.9117933447 20107430 19434072
MESH:D015430 Weight Gain Risperidone 11.9116379507 20564506
MESH:D015431 Weight Loss Clozapine 4.1417933447
MESH:D009396 Wilms Tumor Tretinoin 3.1416287080
OMIM:612469 WILMS TUMOR, ANIRIDIA, GENITOURINARY ANOMALIES, MENTAL RETARDATION, AND OBESITY SYNDROME marker/mechanism
MESH:D014947 Wounds and Injuries Estrogens 3.9511172683
MESH:D014985 Xerophthalmia Scopolamine 5.9317120751
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
KEGG:04010 MAPK signaling pathway
KEGG:04722 Neurotrophin signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25335
    • Releated gene ID Related gene Name
    PA25335BDNF
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    PA445131Obesity
    PA446525WAGR Syndrome
    PA447199Bipolar Disorder
    PA443320Amblyopia
    PA447216Schizophrenia
    PA447196Anxiety Disorders
    PA447207Depressive Disorder
    PA447278Depression
    Releated drug ID Related drug Name
    PA451257risperidone
    PA452229antidepressants
    PA450243lithium
    PA452233antipsychotics
    PA448964chlorpromazine
    PA449673fluoxetine
    PA448932chlordiazepoxide
    PA449969imipramine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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