AutismKB 2.0

Annotation Detail for S100A1


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Basic Information Top
Gene Symbol:S100A1 ( S100,S100-alpha,S100A )
Gene Full Name: S100 calcium binding protein A1
Band: 1q21.3
Quick LinksEntrez ID:6271; OMIM: 176940; Uniprot ID:S10A1_HUMAN; ENSEMBL ID: ENSG00000160678; HGNC ID: 10486
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1766Renal Cell cancer
2075Heart failure
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of S100A1 mRNAaffects expression 18648102
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of S100A1 mRNAdecreases expression 15982314
D000082 Acetaminophen Acetaminophen affects the expression of S100A1 mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in decreased expression of S100A1 mRNAdecreases expression 15982314
D000643 Ammonium Chloride Ammonium Chloride affects the expression of S100A1 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A affects the expression of S100A1 mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of S100A1 mRNAaffects expression 17484886
D004280 Dobutamine S100A1 gene mutant form results in increased susceptibility to Dobutamineincreases response to substance 18645228
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of S100A1 mRNAaffects expression 20170705
D015474 Isotretinoin Isotretinoin results in decreased expression of S100A1 mRNAdecreases expression 15982314
D013629 Tamoxifen Tamoxifen results in decreased expression of S100A1 mRNAdecreases expression 17555576
D014212 Tretinoin Tretinoin metabolite results in decreased expression of S100A1 mRNAdecreases expression 15982314
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 4.6918769834
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.0918769834
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D017486 Acneiform Eruptions Isotretinoin 6.4616232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 12.5917505938
MESH:D000152 Acne Vulgaris Isotretinoin 12.5918769834 16185265
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3716456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.191440618 11289319
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7216197459 16206674
MESH:D001862 Bone Resorption bisphenol A 3.9711985600
MESH:D001943 Breast Neoplasms alitretinoin 2.0316344269
MESH:D001943 Breast Neoplasms bisphenol A 2.0317123778
MESH:D001943 Breast Neoplasms Tamoxifen 2.0319142967 19066611 18815881 16818667 19221464 17440819 15565566 20135344 15668708 18351453 19288272 17242785 19155303 18997820 18629630 19289846 18855134 17049068 20544844 20005174 19189212 19103187 20859285 11161223 20390343 18425577 16202921 19410462 19189210 21138602 21152245 20065188 19011961 18821012 19200415 18984771 19115204 16273361 17261762 19487384 19084267 16873071 17893378 19244106 19059307
MESH:D001943 Breast Neoplasms Tretinoin 2.0316443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9210355542 16011737 15700767 18705752 15721981 16097048 15673190 16050911 16227642 16192424 3786805 16124888
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.047296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.043084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0418788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.0416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.041917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.1417123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 5.1611237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.1616051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7217572228
MESH:D002386 Cataract Acetaminophen 7.4310977129
MESH:D002386 Cataract Tretinoin 7.4317460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.837505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.1319486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1317333356 17681005 17110522 16105132 15861022 11677210 16919318
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tretinoin 2.719407595
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.1018769834 9879862
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.1010589399 16925845 9125849 9142499 9211117 9664655 8800419 9224671 17551590 14991402
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.948156756 8970840 18759878 12868966 14531868 11298694 2524372 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5719279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.3611289319 18648102 18692083 7440962 18289764 8291058 6482804 9653073 1440618 9328219 6679447 16192314 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3616485898 19416960 19164858 11461765 16081117 18071297 16393943 14986274 12392966 11287661 19923254 15968718 16109766 11529661 11743745 10663392 11739529 14550746 19085960 19739265 17562736 12540782 15619225 11421492 16177239 17522070 19420014 12705907 18713872 12153990 2444490 16227642 19370779 11834606 12594235 10915739 10774834 16781746 12958197 17906064 14725611
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.366884620 10915739 15027814 7440962 10092053 6623471 7179309 7120509 16227642 15998439 21278145 2869522 3786805 19336974 4309450 17522070 3732212 11566570 9327722 15968718 19085960 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004489 Edema, Cardiac Tretinoin 4.6418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6719155303 16202921 20544844 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6716569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.133581430
MESH:D005124 Eye Abnormalities Tretinoin 3.669664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.7516045604 12795759 19224547 15959796 16239168 17595544 61145 12631006
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.7515345470
MESH:D005234 Fatty Liver Tamoxifen 13.7514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.2718705752
MESH:D005355 Fibrosis Tretinoin 9.2717994277
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.959664655 14991402
MESH:D006333 Heart Failure Dobutamine 4.5117440445
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.656705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.6519900420 19110552
MESH:D006930 Hyperalgesia Acetaminophen 7.9216870215
MESH:D006930 Hyperalgesia Tretinoin 7.9216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Tamoxifen 2.4119457130
MESH:D007333 Insulin Resistance bisphenol A 3.3616393666
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007569 Jaw Abnormalities Tretinoin 4.0115992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.7916144296
MESH:D007674 Kidney Diseases Acetaminophen 2.2615629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.696582329
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6918625569
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8119285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0917596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2219029980 19075265 15748426 12679006 17217047 16788101 19035177 16891316 16140955 17361223 9834237 16823087 17301526 17294898 16331271 17506722 16766008 19225113 16935935 17107899 17368321 17712046 19642359 17649720 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8611408273 17174718 21278145 11903743 16239168 17334410 16221502 16943688 17157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5818205269 15338365 18317297 15673190 16027843 17481882 17640975 18395914 12445421 14716496 14716833 16015684 12586293 18054572 16011737 12445418 16116963 18006644 15876570 15730626 18263696 18472332 18251166 16136751 15996030 18395095 18418968 12666154 12667390 12546737 17761835 17922224 17976157 16033810 17525996 18210741 15123356 12649538 15818738 14512876 18156304 20821823 17714472 15931870 18429990 14724832 12632512 12609069 17766677 12389079 17708605 15370692 15959796 17869086 16192424 16097048 12741479 17823541 18339082 16638106 17631135 18705752 15052691 18412020 17557913 17900296 17721639 16248980 12898905 18481824 10355542 17805973 17565644 18277467 18187930 18166357 15362042 15057751 12958196 14748882 18279442 14620537 15893842 17698563 15650968 15925388 18376398 17944888 12632514 11481614 18420326 18472094 13678700
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5818564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5818397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.9819014921 12587719 12969438 16610002 19784758 16611625 19460945 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9816246199 16964402 15720792 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.7616899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.7019294768
MESH:D008113 Liver Neoplasms Tamoxifen 4.7016684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.136587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1315583823 12014681
MESH:D008133 Long QT Syndrome Dobutamine 4.8219353679
MESH:D008171 Lung Diseases Dobutamine 4.6016638327
MESH:D008175 Lung Neoplasms alitretinoin 3.7816413115
MESH:D008175 Lung Neoplasms Isotretinoin 3.7815899809
MESH:D008175 Lung Neoplasms Tamoxifen 3.7818625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6914580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.7219453300
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Isotretinoin 5.3417237267
MESH:D008545 Melanoma Tamoxifen 5.3412393984 19393235
MESH:D008545 Melanoma Tretinoin 5.3416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D017202 Myocardial Ischemia Dobutamine 5.1212447174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.833581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms alitretinoin 5.5616946489
MESH:D009369 Neoplasms Tretinoin 5.5616594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719200415 19189210 19196722
MESH:D009421 Nervous System Malformations bisphenol A 10.2211399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.229125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.466679447
MESH:D009436 Neural Tube Defects Tretinoin 7.469142499
MESH:D009447 Neuroblastoma Isotretinoin 4.0917368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.526482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010049 Ovarian Diseases bisphenol A 5.1411985600
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3716936753
MESH:D010146 Pain Acetaminophen 6.8916870215
MESH:D010146 Pain Tretinoin 6.8916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D017499 Porokeratosis alitretinoin 6.1816144296
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.6510548101
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 10.6518769834
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2616740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2615067354
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011596 Psychomotor Disorders Isotretinoin 6.0718769834
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D011629 Puberty, Precocious bisphenol A 4.9410548101
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.6516467112
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1516709447
MESH:D013088 Spermatocele Tamoxifen 12.1516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.1416684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.411399818 3712494 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.4117045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D016171 Torsades de Pointes Dobutamine 5.5019353679
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.168074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1617572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7816129372
MESH:D014591 Uterine Diseases bisphenol A 5.1814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00768 antagonist Olopatadine Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamines;Histamine H1 Antagonists, Non-Sedating
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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