AutismKB 2.0

Annotation Detail for SAFB


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Basic Information Top
Gene Symbol:SAFB ( DKFZp779C1727,HAP,HET,SAF-B1,SAFB1 )
Gene Full Name: scaffold attachment factor B
Band: 19p13.3
Quick LinksEntrez ID:6294; OMIM: 602895; Uniprot ID:SAFB1_HUMAN; ENSEMBL ID: ENSG00000160633; HGNC ID: 10520
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1737Cholangiocarcinoma
1976Squamous cell cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SAFB mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SAFB mRNAdecreases expression 20127859
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SAFB mRNAdecreases expression 19150397
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of SAFB mRNAdecreases expression 17616710
D020849 Raloxifene Raloxifene results in increased expression of SAFB mRNAincreases expression 19429434
D012643 Selenium Selenium results in increased expression of SAFB mRNAincreases expression 19244175
D013629 Tamoxifen Tamoxifen results in increased expression of SAFB mRNAincreases expression 19429434
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000419 Albuminuria Raloxifene 4.9217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms Raloxifene 1.9216912660 16837676 17595753 17893378 17261762 17242785 15775269 15572757 17952589 17440819 17049068 15758505
MESH:D001943 Breast Neoplasms Tamoxifen 1.9220005174 21152245 18997820 20390343 19244106 19115204 17440819 20135344 16273361 19011961 19155303 19189210 19289846 19084267 18351453 19200415 19059307 19410462 17242785 17261762 19066611 19221464 16818667 17893378 19487384 11161223 18984771 16202921 17049068 20544844 18821012 18629630 18425577 19288272 20065188 16873071 19103187 19189212 15668708 21138602 20859285 18855134 18815881 15565566 19142967
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.4017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.4017572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6315775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.7220423518
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D003928 Diabetic Nephropathies Raloxifene 9.8717308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.8719279558
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2315131321
MESH:D004487 Edema Raloxifene 3.6115860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.3615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.3619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2117893378 16202921 20544844 19155303
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5416530937
MESH:D005234 Fatty Liver Raloxifene 8.9417473493
MESH:D005234 Fatty Liver Tamoxifen 8.9414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006331 Heart Diseases Raloxifene 3.7211110106
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006973 Hypertension Raloxifene 2.9517577099 15787275
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007251 Influenza, Human Selenium 4.6416624496
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8120195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 4.8116684651
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4320064080 18520028 20869020 17053015 18569708 6695378 18816296 20135361 20464547
MESH:D008175 Lung Neoplasms Tamoxifen 2.4318625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6019196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009101 Multiple Myeloma Raloxifene 3.6316497877
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19189210 19200415
MESH:D010024 Osteoporosis Raloxifene 3.5519059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5317823083 15579764 15758505 17893378
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5217292933
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5216220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5215067354
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4819755658 10029692
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.3415864552
MESH:D013978 Tibial Fractures Raloxifene 5.6519048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8917053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.8917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.8917572228 16712894 8653321
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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