AutismKB 2.0

Annotation Detail for ACSM3


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Basic Information Top
Gene Symbol:ACSM3 ( SA,SAH )
Gene Full Name: acyl-CoA synthetase medium-chain family member 3
Band: 16p12.3
Quick LinksEntrez ID:6296; OMIM: 145505; Uniprot ID:ACSM3_HUMAN; ENSEMBL ID: ENSG00000005187; HGNC ID: 10522
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5143fatty acid activation
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00650Butanoate metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
2091Hypertension
2083IGA glomerulonephritis
Desease Name
cholesterol
CARDIOVASCULAR
blood pressure
body mass
hypertension
METABOLIC
triglycerides
obesity
insulin
hypertension, pregnancy induced
No data
Desease Name
Hypertension, essential
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ACSM3 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ACSM3 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACSM3 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of ACSM3 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of ACSM3 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol results in decreased expression of ACSM3 mRNAdecreases expression 20106945
C041786 palm oil palm oil results in decreased expression of ACSM3 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital results in increased expression of ACSM3 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ACSM3 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ACSM3 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0916434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.1320435547
MESH:D001943 Breast Neoplasms Estradiol 2.1316675129 17289903 17261762 12948864 14630087 19861407 17018787 18497071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.793084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7921507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7916924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.7920935162 1701930 6705139 17173139 20007298
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.0318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6311421492 16781746 19085960 18713872 16081117 11461765 12958197 16109766 16227642 11743745 14986274 18071297 11834606 11739529 10774834 10915739 17522070 19739265 15968718 19416960 19420014 12705907 16177239 17906064 15619225 14725611 17562736 11287661 19164858 10663392 16485898 11529661 12392966 16393943 19923254 12153990 12540782 12594235 2444490 14550746 19370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.1118566989 11473722 19148513
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.193922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D005234 Fatty Liver Cyclosporine 14.2919224547
MESH:D005234 Fatty Liver Dietary Fats 14.2917967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 14.2920131406 19236843
MESH:D005355 Fibrosis Cyclosporine 9.5712168785 12639820
MESH:D005355 Fibrosis Dietary Fats 9.5718296743
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006529 Hepatomegaly Phenobarbital 9.3616109766
MESH:D006529 Hepatomegaly pirinixic acid 9.3619772884 16221962 19176532 18467677
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007249 Inflammation Dietary Fats 2.5220412841
MESH:D007333 Insulin Resistance Dietary Fats 13.0411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 13.0416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 13.0416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.6212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.628314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.6215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.8515610895
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0118296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0121047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.0816611625 12969438 11587558 19460945 16610002 12587719 19014921 19784758
MESH:D008107 Liver Diseases Phenobarbital 4.0819363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.8315890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Phenobarbital 7.8321047994 8742319 19812893 15975961 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 7.8316377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.438603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.4317172636 1399818 6150874 2563599 18308698
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8714755239
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6811807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 3.8916427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Dietary Fats 4.5816723640 21332399 11836018 18674790 20518802 19632207 18457598 20132043 17217161
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2719401270
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5516965848
MESH:D011230 Precancerous Conditions Cyclosporine 9.5912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.592563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures Phenobarbital 2.824039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.211399818
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
KEGG:00650 Butanoate metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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