Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
C090942 |
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole |
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in decreased activity of MAPK12 protein | decreases activity | 18389075
|
D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of MAPK12 mRNA | affects expression | 16483693
|
D020122 |
tert-Butylhydroperoxide |
tert-Butylhydroperoxide results in increased expression of MAPK12 mRNA | increases expression | 14729362
|
D002251 |
Carbon Tetrachloride |
Carbon Tetrachloride results in increased expression of MAPK12 mRNA | increases expression | 11566570
|
D002251 |
Carbon Tetrachloride |
Carbon Tetrachloride affects the expression of MAPK12 mRNA | affects expression | 17484886
|
D000431 |
Ethanol |
Ethanol results in increased expression of MAPK12 mRNA | increases expression | 17920746
|
C071834 |
glycidamide |
glycidamide results in increased expression of MAPK12 mRNA | increases expression | 17822822
|
C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAPK12 mRNA | affects binding|decreases expression|increases activity | 19710929
|
C017947 |
sodium arsenite |
sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK12 protein | increases activity|increases phosphorylation | 15504454
|
D018038 |
Sodium Selenite |
Sodium Selenite results in decreased expression of MAPK12 mRNA | decreases expression | 16705456
|
C402769 |
tipifarnib |
tipifarnib results in increased expression of MAPK12 mRNA | increases expression | 16403772
|
D002762 |
Cholecalciferol |
Cholecalciferol results in increased expression of MAPK12 mRNA | increases expression | 17170073
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000014 |
Abnormalities, Drug-Induced |
|
Ethanol |
4.11 | 17676605 18926900 |
MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
11.13 | 18287403 |
MESH:D000138 |
Acidosis |
|
Ethanol |
11.13 | 11192467 |
MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.27 | 18653653 |
MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
3.67 | 16434500 |
MESH:D000310 |
Adrenal Gland Neoplasms |
|
sodium arsenite |
4.92 | 15276417 |
MESH:D018246 |
Adrenocortical Adenoma |
|
sodium arsenite |
5.12 | 17306315 16712894 |
MESH:D020268 |
Alcohol-Induced Disorders, Nervous System |
|
Ethanol |
5.54 | 15451040 15451039 |
MESH:D000853 |
Anophthalmos |
|
Ethanol |
5.00 | 15513904 |
MESH:D001008 |
Anxiety Disorders |
|
Ethanol |
4.12 | 11141031 |
MESH:D001327 |
Autoimmune Diseases |
|
Cholecalciferol |
5.20 | 16142846 |
MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.29 | 19483382 |
MESH:D002056 |
Burns |
|
Ethanol |
4.83 | 16374292 |
MESH:D002252 |
Carbon Tetrachloride Poisoning |
|
Carbon Tetrachloride |
3.95 | 15721981 16011737 16050911 18705752 15700767 10355542 16192424 16124888 16227642 16097048 15673190 3786805 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Carbon Tetrachloride |
4.79 | 18788625 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Ethanol |
4.79 | 15763234 18788625 15289165 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
sodium arsenite |
4.79 | 15276417 16507464 17306315 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
sodium arsenite |
2.41 | 18572023 |
MESH:D006332 |
Cardiomegaly |
|
Ethanol |
3.51 | 19332462 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
sodium arsenite |
3.08 | 19524636 20056578 |
MESH:D002779 |
Cholestasis |
|
pirinixic acid |
2.93 | 19176532 |
MESH:D019457 |
Chromosome Breakage |
|
Sodium Selenite |
4.93 | 15894690 |
MESH:D002971 |
Cleft Lip |
|
Ethanol |
3.65 | 15513904 |
MESH:D002972 |
Cleft Palate |
|
Ethanol |
3.22 | 15513904 |
MESH:D019465 |
Craniofacial Abnormalities |
|
Ethanol |
2.33 | 19302082 15513904 15451039 11198716 10194807 15451040 11873399 |
MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.48 | 18249437 |
MESH:D003920 |
Diabetes Mellitus |
|
Sodium Selenite |
3.90 | 16285004 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Carbon Tetrachloride |
6.58 | 19085960 7120509 16177239 10092053 2869522 19336974 16227642 6623471 17522070 15027814 9327722 15998439 10915739 3786805 7440962 21278145 4309450 6884620 15968718 3732212 11566570 7179309 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Ethanol |
6.58 | 11566570 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Sodium Selenite |
6.58 | 15131321 |
MESH:D004487 |
Edema |
|
pirinixic acid |
2.62 | 12083418 |
MESH:D004938 |
Esophageal Neoplasms |
|
Ethanol |
2.78 | 16704527 |
MESH:D005234 |
Fatty Liver |
|
Carbon Tetrachloride |
14.00 | 16239168 15959796 17595544 12795759 19224547 12631006 16045604 61145 |
MESH:D005234 |
Fatty Liver |
|
Ethanol |
14.00 | 19236843 16409862 18620774 |
MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
14.00 | 19236843 20131406 |
MESH:D005235 |
Fatty Liver, Alcoholic |
|
Ethanol |
5.88 | 17920746 |
MESH:D005310 |
Fetal Alcohol Syndrome |
|
Ethanol |
5.49 | 16946407 15451040 10194807 15513904 |
MESH:D005355 |
Fibrosis |
|
Carbon Tetrachloride |
3.63 | 18705752 |
MESH:D005756 |
Gastritis |
|
Ethanol |
4.91 | 15046732 |
MESH:D005833 |
Genital Neoplasms, Female |
|
sodium arsenite |
4.87 | 16452187 |
MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.62 | 20558911 |
MESH:D006505 |
Hepatitis |
|
Carbon Tetrachloride |
3.76 | 19110552 19900420 |
MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.17 | 18467677 16221962 19772884 19176532 |
MESH:D006689 |
Hodgkin Disease |
|
sodium arsenite |
3.27 | 12676792 |
MESH:D006930 |
Hyperalgesia |
|
Ethanol |
3.83 | 18783367 |
MESH:D006932 |
Hyperbilirubinemia |
|
Carbon Tetrachloride |
4.73 | 16899240 |
MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.31 | 20558911 |
MESH:D006975 |
Hypertension, Portal |
|
Carbon Tetrachloride |
4.26 | 15338365 |
MESH:D007248 |
Infertility, Male |
|
sodium arsenite |
3.08 | 15346721 12646999 |
MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
7.60 | 16306350 |
MESH:D007333 |
Insulin Resistance |
|
Sodium Selenite |
7.60 | 14714311 |
MESH:D007569 |
Jaw Abnormalities |
|
Ethanol |
4.55 | 15513904 |
MESH:D007674 |
Kidney Diseases |
|
sodium arsenite |
2.87 | 20008137 |
MESH:D007859 |
Learning Disorders |
|
Ethanol |
4.39 | 15451040 |
MESH:D017880 |
Limb Deformities, Congenital |
|
Ethanol |
3.91 | 17676605 |
MESH:D008103 |
Liver Cirrhosis |
|
Carbon Tetrachloride |
7.05 | 11408273 17174718 21278145 17157831 16943688 16221502 17334410 11903743 16239168 |
MESH:D008103 |
Liver Cirrhosis |
|
Ethanol |
7.05 | 15289165 |
MESH:D008104 |
Liver Cirrhosis, Alcoholic |
|
Ethanol |
5.29 | 18295389 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Carbon Tetrachloride |
3.61 | 17761835 12667390 17708605 17944888 12898905 15730626 12389079 18395095 18054572 18205269 15931870 16097048 17481882 18339082 17922224 15362042 17557913 11481614 14748882 15057751 17714472 12445421 16015684 18481824 12445418 16116963 18251166 18418968 14716833 17766677 18412020 16033810 18376398 17525996 12666154 18187930 18277467 17900296 17823541 17721639 14512876 18210741 15370692 17640975 17869086 15052691 15818738 12632512 15959796 13678700 18263696 12741479 14716496 18317297 16638106 10355542 14620537 12632514 16136751 16248980 18472094 15673190 12546737 12958196 18006644 15650968 15925388 16027843 18395914 16011737 12649538 18705752 18472332 17976157 17698563 15876570 12586293 17631135 18429990 18156304 18279442 18166357 15123356 15996030 14724832 17565644 17805973 15338365 16192424 18420326 12609069 15893842 20821823 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Ethanol |
3.61 | 18166357 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
3.61 | 15474484 |
MESH:D008107 |
Liver Diseases |
|
Carbon Tetrachloride |
2.11 | 17285989 15720792 16246199 16964402 15830285 |
MESH:D008108 |
Liver Diseases, Alcoholic |
|
Ethanol |
4.83 | 17347304 17207112 |
MESH:D017093 |
Liver Failure |
|
Carbon Tetrachloride |
4.34 | 15123358 |
MESH:D017114 |
Liver Failure, Acute |
|
Carbon Tetrachloride |
3.82 | 14706259 16899240 |
MESH:D008113 |
Liver Neoplasms |
|
Carbon Tetrachloride |
7.70 | 19294768 |
MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
7.70 | 16377806 20007298 15890375 |
MESH:D008113 |
Liver Neoplasms |
|
sodium arsenite |
7.70 | 15276417 16712894 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
Carbon Tetrachloride |
2.69 | 12014681 15583823 |
MESH:D008171 |
Lung Diseases |
|
sodium arsenite |
3.26 | 19095001 |
MESH:D008175 |
Lung Neoplasms |
|
sodium arsenite |
3.15 | 16712894 19931552 17306315 17077188 15276417 |
MESH:D008175 |
Lung Neoplasms |
|
tipifarnib |
3.15 | 16885199 |
MESH:D016393 |
Lymphoma, B-Cell |
|
Sodium Selenite |
4.21 | 14737004 |
MESH:D008325 |
Mammary Neoplasms, Experimental |
|
tipifarnib |
4.41 | 16648579 |
MESH:D008545 |
Melanoma |
|
sodium arsenite |
2.05 | 19082730 16487513 |
MESH:D008569 |
Memory Disorders |
|
Ethanol |
4.35 | 18411066 15451040 |
MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.68 | 16239165 |
MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.19 | 19151258 |
MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.05 | 16411023 |
MESH:D009369 |
Neoplasms |
|
pirinixic acid |
5.15 | 17405874 |
MESH:D009369 |
Neoplasms |
|
sodium arsenite |
5.15 | 11559025 |
MESH:D009374 |
Neoplasms, Experimental |
|
sodium arsenite |
3.84 | 20056578 |
MESH:D009436 |
Neural Tube Defects |
|
sodium arsenite |
3.23 | 12854658 |
MESH:D009765 |
Obesity |
|
pirinixic acid |
1.84 | 20558911 |
MESH:D010051 |
Ovarian Neoplasms |
|
sodium arsenite |
2.47 | 15276417 17306315 |
MESH:D010190 |
Pancreatic Neoplasms |
|
Ethanol |
3.01 | 12384795 |
MESH:D011471 |
Prostatic Neoplasms |
|
Cholecalciferol |
2.71 | 17024972 |
MESH:D011471 |
Prostatic Neoplasms |
|
sodium arsenite |
2.71 | 16039940 |
MESH:D011471 |
Prostatic Neoplasms |
|
Sodium Selenite |
2.71 | 18760546 |
MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.45 | 19058328 |
MESH:D012640 |
Seizures |
|
Ethanol |
3.26 | 9754883 |
MESH:D012878 |
Skin Neoplasms |
|
sodium arsenite |
6.03 | 18572023 19524636 |
MESH:D012878 |
Skin Neoplasms |
|
tert-Butylhydroperoxide |
6.03 | 8532709 |
MESH:D016135 |
Spinal Dysraphism |
|
sodium arsenite |
3.90 | 12854658 |
MESH:D013274 |
Stomach Neoplasms |
|
Ethanol |
2.30 | 18456281 |
MESH:D013276 |
Stomach Ulcer |
|
Ethanol |
3.67 | 9562338 17918041 17189318 11906479 9211565 16755016 |
MESH:D013375 |
Substance Withdrawal Syndrome |
|
Ethanol |
4.39 | 9754883 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
sodium arsenite |
2.55 | 16452187 16712894 11723127 17306315 |
MESH:D002583 |
Uterine Cervical Neoplasms |
|
sodium arsenite |
3.90 | 11813266 |
MESH:D014652 |
Vascular Diseases |
|
sodium arsenite |
4.62 | 17056641 |