AutismKB 2.0

Annotation Detail for MAPK12


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Basic Information Top
Gene Symbol:MAPK12 ( ERK3,ERK6,P38GAMMA,PRKM12,SAPK-3,SAPK3 )
Gene Full Name: mitogen-activated protein kinase 12
Band: 22q13.33
Quick LinksEntrez ID:6300; OMIM: 602399; Uniprot ID:MK12_HUMAN; ENSEMBL ID: ENSG00000188130; HGNC ID: 6874
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
hsa04912GnRH signaling pathway
hsa04010MAPK signaling pathway
hsa05142Chagas disease
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05131Shigellosis
hsa04722Neurotrophin signaling pathway
hsa04114Oocyte meiosis
hsa04370VEGF signaling pathway
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
Pathway IDPathway Name
Myogenesis
Signalling by NGF
Pathway IDPathway Name
200007RhoA signaling pathway
200143Signaling mediated by p38-gamma and p38-delta
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P00035Interferon-gamma signaling pathway
P00046Oxidative stress response
P04398p53 pathway feedback loops 2
P00018EGF receptor signaling pathway
P00052TGF-beta signaling pathway
P00049Parkinson disease
P00021FGF signaling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in decreased activity of MAPK12 proteindecreases activity 18389075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MAPK12 mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of MAPK12 mRNAincreases expression 14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MAPK12 mRNAincreases expression 11566570
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MAPK12 mRNAaffects expression 17484886
D000431 Ethanol Ethanol results in increased expression of MAPK12 mRNAincreases expression 17920746
C071834 glycidamide glycidamide results in increased expression of MAPK12 mRNAincreases expression 17822822
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAPK12 mRNAaffects binding|decreases expression|increases activity 19710929
C017947 sodium arsenite sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK12 proteinincreases activity|increases phosphorylation 15504454
D018038 Sodium Selenite Sodium Selenite results in decreased expression of MAPK12 mRNAdecreases expression 16705456
C402769 tipifarnib tipifarnib results in increased expression of MAPK12 mRNAincreases expression 16403772
D002762 Cholecalciferol Cholecalciferol results in increased expression of MAPK12 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 4.1117676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 11.1318287403
MESH:D000138 Acidosis Ethanol 11.1311192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1217306315 16712894
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.5415451040 15451039
MESH:D000853 Anophthalmos Ethanol 5.0015513904
MESH:D001008 Anxiety Disorders Ethanol 4.1211141031
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.2016142846
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D002056 Burns Ethanol 4.8316374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9515721981 16011737 16050911 18705752 15700767 10355542 16192424 16124888 16227642 16097048 15673190 3786805
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7918788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.7915763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.7915276417 16507464 17306315
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4118572023
MESH:D006332 Cardiomegaly Ethanol 3.5119332462
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0819524636 20056578
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D002971 Cleft Lip Ethanol 3.6515513904
MESH:D002972 Cleft Palate Ethanol 3.2215513904
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3319302082 15513904 15451039 11198716 10194807 15451040 11873399
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5819085960 7120509 16177239 10092053 2869522 19336974 16227642 6623471 17522070 15027814 9327722 15998439 10915739 3786805 7440962 21278145 4309450 6884620 15968718 3732212 11566570 7179309
MESH:D056486 Drug-Induced Liver Injury Ethanol 6.5811566570
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.5815131321
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004938 Esophageal Neoplasms Ethanol 2.7816704527
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.0016239168 15959796 17595544 12795759 19224547 12631006 16045604 61145
MESH:D005234 Fatty Liver Ethanol 14.0019236843 16409862 18620774
MESH:D005234 Fatty Liver pirinixic acid 14.0019236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4916946407 15451040 10194807 15513904
MESH:D005355 Fibrosis Carbon Tetrachloride 3.6318705752
MESH:D005756 Gastritis Ethanol 4.9115046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.1718467677 16221962 19772884 19176532
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006930 Hyperalgesia Ethanol 3.8318783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007248 Infertility, Male sodium arsenite 3.0815346721 12646999
MESH:D007333 Insulin Resistance pirinixic acid 7.6016306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6014714311
MESH:D007569 Jaw Abnormalities Ethanol 4.5515513904
MESH:D007674 Kidney Diseases sodium arsenite 2.8720008137
MESH:D007859 Learning Disorders Ethanol 4.3915451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9117676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0511408273 17174718 21278145 17157831 16943688 16221502 17334410 11903743 16239168
MESH:D008103 Liver Cirrhosis Ethanol 7.0515289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2918295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6117761835 12667390 17708605 17944888 12898905 15730626 12389079 18395095 18054572 18205269 15931870 16097048 17481882 18339082 17922224 15362042 17557913 11481614 14748882 15057751 17714472 12445421 16015684 18481824 12445418 16116963 18251166 18418968 14716833 17766677 18412020 16033810 18376398 17525996 12666154 18187930 18277467 17900296 17823541 17721639 14512876 18210741 15370692 17640975 17869086 15052691 15818738 12632512 15959796 13678700 18263696 12741479 14716496 18317297 16638106 10355542 14620537 12632514 16136751 16248980 18472094 15673190 12546737 12958196 18006644 15650968 15925388 16027843 18395914 16011737 12649538 18705752 18472332 17976157 17698563 15876570 12586293 17631135 18429990 18156304 18279442 18166357 15123356 15996030 14724832 17565644 17805973 15338365 16192424 18420326 12609069 15893842 20821823
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.6118166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6115474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1117285989 15720792 16246199 16964402 15830285
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.8317347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7019294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.7016377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 7.7015276417 16712894
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6912014681 15583823
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D008175 Lung Neoplasms sodium arsenite 3.1516712894 19931552 17306315 17077188 15276417
MESH:D008175 Lung Neoplasms tipifarnib 3.1516885199
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008325 Mammary Neoplasms, Experimental tipifarnib 4.4116648579
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008569 Memory Disorders Ethanol 4.3518411066 15451040
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009369 Neoplasms pirinixic acid 5.1517405874
MESH:D009369 Neoplasms sodium arsenite 5.1511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.2312854658
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4715276417 17306315
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0112384795
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.7117024972
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7116039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.7118760546
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012640 Seizures Ethanol 3.269754883
MESH:D012878 Skin Neoplasms sodium arsenite 6.0318572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.038532709
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9012854658
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.679562338 17918041 17189318 11906479 9211565 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.399754883
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5516452187 16712894 11723127 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9011813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
Pathway ID Pathway Name
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04912 GnRH signaling pathway
KEGG:05160 Hepatitis C
REACT:23853 Interactions of the immunoglobulin superfamily (IgSF) member proteins
KEGG:05140 Leishmaniasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:04010 MAPK signaling pathway
REACT:21303 Myogenesis
KEGG:04722 Neurotrophin signaling pathway
KEGG:04621 NOD-like receptor signaling pathway
KEGG:04114 Oocyte meiosis
KEGG:04380 Osteoclast differentiation
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04622 RIG-I-like receptor signaling pathway
KEGG:05131 Shigellosis
REACT:11061 Signalling by NGF
KEGG:04660 T cell receptor signaling pathway
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05145 Toxoplasmosis
KEGG:05152 Tuberculosis
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30619
  • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    Releated drug ID Related drug Name
    PA7000sorafenib
    PA449014cisplatin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02482 - Phosphonothreonine Indicators and Reagents
    DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018