AutismKB 2.0

Annotation Detail for SLC22A23


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Basic Information Top
Gene Symbol:SLC22A23 ( C6orf85,DKFZp434F011,FLJ22174 )
Gene Full Name: solute carrier family 22, member 23
Band: 6p25.2
Quick LinksEntrez ID:63027; OMIM: 611697; Uniprot ID:S22AN_HUMAN; ENSEMBL ID: ENSG00000137266; HGNC ID: 21106
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SLC22A23 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC22A23 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC22A23 mRNAdecreases expression 20064835
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC22A23 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.399612607
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9920146248 17474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6716485898 12958197 11739529 11287661 11834606 14550746 12392966 12705907 2444490 17522070 15619225 12540782 16109766 16781746 17562736 19739265 19923254 10663392 10774834 11421492 16081117 15968718 19164858 19416960 19420014 11461765 14986274 18071297 16227642 17906064 19370779 14725611 12594235 12153990 19085960 11529661 16393943 10915739 11743745 18713872 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004362 Drug Toxicity Zidovudine 4.3015040536
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005234 Fatty Liver Zidovudine 4.3318299183
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006402 Hematologic Diseases Zidovudine 5.1812579204
MESH:D015658 HIV Infections Zidovudine 3.6720032539 17358032 11698656 11363243 11141242
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D007680 Kidney Neoplasms Zidovudine 4.1312579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.8420370541
MESH:D008107 Liver Diseases Acetaminophen 1.7019460945 12969438 12587719 16611625 19014921 11587558 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1521137059 20195826
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.7317053015 20064080 20135361 18816296 6695378 18569708 20464547 20869020 18520028
MESH:D008175 Lung Neoplasms Zidovudine 2.7318800350
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.5617358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5210029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6720155912 2093021
MESH:D013274 Stomach Neoplasms Zidovudine 2.6717696246
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D014625 Vaginal Neoplasms Zidovudine 5.3212579204
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018