Annotation Detail for SAT1
Basic Information Top
| Gene Symbol: | SAT1 ( DC21,KFSD,KFSDX,SAT,SSAT,SSAT-1 ) |
|---|---|
| Gene Full Name: | spermidine/spermine N1-acetyltransferase 1 |
| Band: | Xp22.11 |
| Quick Links | Entrez ID:6303; OMIM: 313020; Uniprot ID:SAT1_HUMAN; ENSEMBL ID: ENSG00000130066; HGNC ID: 10540 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Pathway ID | Pathway Name |
|---|---|
| PWY-0 | putrescine degradation III |
| PWY-6117 | spermine and spermidine degradation I |
| Pathway ID | Pathway Name |
|---|---|
| hsa00330 | Arginine and proline metabolism |
| hsa01100 | Metabolic pathways |
| Pathway ID | Pathway Name |
|---|---|
| Metabolism of amino acids and derivatives |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| 500788 | Interconversion of polyamines |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of SAT1 mRNA | affects expression | 17562736 |
| D017638 | Asbestos, Crocidolite | Asbestos, Crocidolite results in increased expression of SAT1 mRNA | increases expression | 18687144 |
| D001241 | Aspirin | Aspirin promotes the reaction [NFKB1 protein binds to SAT1 promoter] | affects binding|increases reaction | 16262603 |
| D001241 | Aspirin | Aspirin results in increased expression of and results in increased activity of SAT1 protein | increases activity|increases expression | 16262603 |
| D001241 | Aspirin | Aspirin results in increased expression of SAT1 mRNA | increases expression | 16262603 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SAT1 mRNA | increases expression | 20382639 19150397 |
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in increased expression of SAT1 mRNA | increases expression | 15336504 |
| D002104 | Cadmium | Cadmium results in increased expression of SAT1 mRNA | increases expression | 21172416 |
| C031662 | CB 3717 | CB 3717 results in increased activity of SAT1 protein | increases activity | 17371283 |
| C031662 | CB 3717 | CB 3717 results in increased expression of SAT1 mRNA | increases expression | 17371283 |
| D003513 | Cycloheximide | [Cycloheximide co-treated with N(1),N(11)-diethylnorspermine] promotes the reaction [RELA protein binds to SAT1 promoter] | affects binding|affects cotreatment|increases reaction | 16637064 |
| D003513 | Cycloheximide | Cycloheximide promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of SAT1 mRNA] | increases expression|increases reaction | 16637064 |
| D003513 | Cycloheximide | Cycloheximide promotes the reaction [RELA protein binds to SAT1 promoter] | affects binding|increases reaction | 16637064 |
| D003513 | Cycloheximide | NFKBIA protein affects the reaction [Cycloheximide promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of SAT1 mRNA]] | affects reaction|increases expression|increases reaction | 16637064 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of SAT1 mRNA | decreases expression | 20106945 |
| D003609 | Dactinomycin | Dactinomycin inhibits the reaction [N(1),N(11)-diethylnorspermine results in increased expression of SAT1 mRNA] | decreases reaction|increases expression | 16637064 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased activity of SAT1 protein | increases activity | 14695980 |
| D004054 | Diethylstilbestrol | Diethylstilbestrol results in increased expression of SAT1 mRNA | increases expression | 15289156 |
| D004178 | Diquat | Diquat results in increased expression of SAT1 mRNA | increases expression | 21172416 |
| D004317 | Doxorubicin | SAT1 mRNA results in decreased susceptibility to Doxorubicin | decreases response to substance | 16322897 |
| D004391 | Dust | Dust results in increased expression of SAT1 mRNA | increases expression | 17805423 |
| D004958 | Estradiol | Estradiol results in increased expression of SAT1 mRNA | increases expression | 15289156 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of SAT1 mRNA | increases expression | 17557909 |
| D005472 | Fluorouracil | [Fluorouracil co-treated with N(1),N(11)-diethylnorspermine] results in increased expression of SAT1 mRNA | affects cotreatment|increases expression | 17237273 |
| D005472 | Fluorouracil | [Fluorouracil co-treated with N(1),N(11)-diethylnorspermine] results in increased expression of SAT1 protein | affects cotreatment|increases expression | 17237273 16510598 |
| D005472 | Fluorouracil | Fluorouracil results in increased expression of SAT1 mRNA | increases expression | 16510598 15152939 17237273 |
| D005472 | Fluorouracil | [N(1),N(11)-diethylnorspermine co-treated with Fluorouracil] results in increased expression of SAT1 mRNA | affects cotreatment|increases expression | 16637064 |
| D005472 | Fluorouracil | SAT1 mRNA results in decreased susceptibility to Fluorouracil | decreases response to substance | 15152939 |
| D005472 | Fluorouracil | TP53 protein affects the reaction [Fluorouracil results in increased expression of SAT1 mRNA] | affects reaction|increases expression | 15152939 |
| D005492 | Folic Acid | Folic Acid results in increased expression of SAT1 mRNA | increases expression | 17868486 |
| D019833 | Genistein | Genistein results in increased expression of SAT1 mRNA | increases expression | 15289156 |
| D007052 | Ibuprofen | Ibuprofen results in increased expression of SAT1 mRNA | increases expression | 16262603 |
| D007213 | Indomethacin | Indomethacin results in increased expression of SAT1 mRNA | increases expression | 16262603 |
| C051890 | irinotecan | irinotecan results in increased expression of SAT1 mRNA | increases expression | 15152939 |
| C051890 | irinotecan | SAT1 mRNA results in decreased susceptibility to irinotecan | decreases response to substance | 15152939 |
| D007657 | Ketone Bodies | Ketone Bodies results in increased expression of SAT1 mRNA | increases expression | 16807920 |
| C054938 | methoctramine | methoctramine analog results in increased activity of SAT1 protein | increases activity | 19576191 |
| C054938 | methoctramine | methoctramine results in increased activity of SAT1 protein | increases activity | 19576191 |
| C008493 | methylselenic acid | methylselenic acid affects the expression of SAT1 mRNA | affects expression | 14617803 |
| D016685 | Mitomycin | SAT1 protein affects the susceptibility to Mitomycin | affects response to substance | 16217747 |
| C059685 | N(1),N(11)-diethylnorspermine | [Cycloheximide co-treated with N(1),N(11)-diethylnorspermine] promotes the reaction [RELA protein binds to SAT1 promoter] | affects binding|affects cotreatment|increases reaction | 16637064 |
| C059685 | N(1),N(11)-diethylnorspermine | Cycloheximide promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of SAT1 mRNA] | increases expression|increases reaction | 16637064 |
| C059685 | N(1),N(11)-diethylnorspermine | Dactinomycin inhibits the reaction [N(1),N(11)-diethylnorspermine results in increased expression of SAT1 mRNA] | decreases reaction|increases expression | 16637064 |
| C059685 | N(1),N(11)-diethylnorspermine | [Fluorouracil co-treated with N(1),N(11)-diethylnorspermine] results in increased expression of SAT1 mRNA | affects cotreatment|increases expression | 17237273 |
| C059685 | N(1),N(11)-diethylnorspermine | [Fluorouracil co-treated with N(1),N(11)-diethylnorspermine] results in increased expression of SAT1 protein | affects cotreatment|increases expression | 17237273 16510598 |
| C059685 | N(1),N(11)-diethylnorspermine | [N(1),N(11)-diethylnorspermine co-treated with Fluorouracil] results in increased expression of SAT1 mRNA | affects cotreatment|increases expression | 16637064 |
| C059685 | N(1),N(11)-diethylnorspermine | N(1),N(11)-diethylnorspermine results in increased activity of SAT1 protein | increases activity | 19576191 |
| C059685 | N(1),N(11)-diethylnorspermine | N(1),N(11)-diethylnorspermine results in increased expression of SAT1 mRNA | increases expression | 16637064 |
| C059685 | N(1),N(11)-diethylnorspermine | NFKBIA protein affects the reaction [Cycloheximide promotes the reaction [N(1),N(11)-diethylnorspermine results in increased expression of SAT1 mRNA]] | affects reaction|increases expression|increases reaction | 16637064 |
| C059685 | N(1),N(11)-diethylnorspermine | [oxaliplatin co-treated with N(1),N(11)-diethylnorspermine] results in increased expression of SAT1 mRNA | affects cotreatment|increases expression | 17237273 |
| C059685 | N(1),N(11)-diethylnorspermine | [oxaliplatin co-treated with N(1),N(11)-diethylnorspermine] results in increased expression of SAT1 protein | affects cotreatment|increases expression | 17237273 16510598 |
| C029938 | nickel sulfate | nickel sulfate results in increased expression of SAT1 mRNA | increases expression | 16780908 |
| C030110 | oxaliplatin | [oxaliplatin co-treated with N(1),N(11)-diethylnorspermine] results in increased expression of SAT1 mRNA | affects cotreatment|increases expression | 17237273 |
| C030110 | oxaliplatin | [oxaliplatin co-treated with N(1),N(11)-diethylnorspermine] results in increased expression of SAT1 protein | affects cotreatment|increases expression | 17237273 16510598 |
| C030110 | oxaliplatin | oxaliplatin results in increased expression of SAT1 mRNA | increases expression | 15152939 17237273 16510598 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of SAT1 mRNA | increases expression | 18445702 |
| D028321 | Plant Preparations | Plant Preparations affects the expression of SAT1 mRNA | affects expression | 16046712 |
| C068874 | raltitrexed | raltitrexed results in increased expression of SAT1 mRNA | increases expression | 15152939 |
| C068874 | raltitrexed | TYMS protein inhibits the reaction [raltitrexed results in increased expression of SAT1 mRNA] | decreases reaction|increases expression | 15152939 |
| D013467 | Sulindac | Sulindac results in increased expression of SAT1 mRNA | increases expression | 16262603 14506281 |
| D013467 | Sulindac | Sulindac results in increased expression of SAT1 mRNA | increases expression | 16262603 |
| C025463 | sulindac sulfone | PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA] | increases expression|increases reaction | 14506281 |
| C025463 | sulindac sulfone | [sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer] | affects binding|increases activity|increases reaction | 14506281 |
| C025463 | sulindac sulfone | sulindac sulfone results in increased expression of SAT1 mRNA | increases expression | 14506281 16262603 |
| D013739 | Testosterone | Testosterone results in decreased activity of SAT1 protein | decreases activity | 17371283 |
| D014212 | Tretinoin | Tretinoin results in increased expression of SAT1 mRNA | increases expression | 16129123 16249480 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000008 | Abdominal Neoplasms | Sulindac | 5.12 | 14745880 | |
| MESH:D000152 | Acne Vulgaris | Ethinyl Estradiol | 3.57 | 17505938 | |
| MESH:D058186 | Acute Kidney Injury | Folic Acid | 12.82 | 16595132 17003819 16316344 | |
| MESH:D058186 | Acute Kidney Injury | Ibuprofen | 12.82 | 6375363 | |
| MESH:D058186 | Acute Kidney Injury | Sulindac | 12.82 | 7897758 | |
| MESH:D055371 | Acute Lung Injury | nickel sulfate | 8.02 | 12718980 11954676 16100012 19131640 | |
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 8.02 | 18653653 | |
| MESH:D000230 | Adenocarcinoma | Doxorubicin | 22.95 | 17418594 | |
| MESH:D000230 | Adenocarcinoma | Estradiol | 22.95 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Ethinyl Estradiol | 22.95 | 14692618 | |
| MESH:D000230 | Adenocarcinoma | Fluorouracil | 22.95 | 17638652 | |
| MESH:D000230 | Adenocarcinoma | Genistein | 22.95 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Ibuprofen | 22.95 | 10697514 | |
| MESH:D000230 | Adenocarcinoma | Indomethacin | 22.95 | 16537180 | |
| MESH:D000230 | Adenocarcinoma | Sulindac | 22.95 | 11910360 | |
| MESH:D000236 | Adenoma | Folic Acid | 10.24 | 16963246 | |
| MESH:D000236 | Adenoma | Indomethacin | 10.24 | 11497255 | |
| MESH:D000236 | Adenoma | Sulindac | 10.24 | 10223192 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 3.11 | 16434500 | |
| MESH:D011125 | Adenomatous Polyposis Coli | Sulindac | 9.34 | 11535846 15623613 17611924 11874996 19003578 12394442 16460482 | |
| MESH:D011125 | Adenomatous Polyposis Coli | sulindac sulfone | 9.34 | 16150858 | |
| MESH:D000419 | Albuminuria | Doxorubicin | 4.19 | 21441931 | |
| MESH:D000505 | Alopecia | Tretinoin | 3.33 | 15955085 | |
| MESH:D016301 | Alveolar Bone Loss | Indomethacin | 5.00 | 17225004 | |
| MESH:D000544 | Alzheimer Disease | Folic Acid | 6.35 | 17116317 | |
| MESH:D000544 | Alzheimer Disease | Ibuprofen | 6.35 | 18351690 | |
| MESH:D000544 | Alzheimer Disease | Indomethacin | 6.35 | 17627676 15579461 | |
| MESH:D000686 | Amyloidosis | Diethylstilbestrol | 4.13 | 15469931 | |
| MESH:D000707 | Anaphylaxis | Ibuprofen | 4.89 | 9532969 | |
| MESH:D000740 | Anemia | Fluorouracil | 3.40 | 16511603 17963324 15504547 | |
| MESH:D000799 | Angioedema | Acetaminophen | 3.47 | 10982225 | |
| MESH:D000987 | Antisocial Personality Disorder | Testosterone | 5.48 | 7506515 | |
| MESH:D001014 | Aortic Aneurysm | Indomethacin | 4.50 | 10231640 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Indomethacin | 4.51 | 10388637 | |
| MESH:D001161 | Arteriosclerosis | Ethinyl Estradiol | 3.11 | 11256880 | |
| MESH:D018771 | Arthralgia | Indomethacin | 4.79 | 2160914 | |
| MESH:D001169 | Arthritis, Experimental | Ethinyl Estradiol | 6.44 | 15885639 | |
| MESH:D001169 | Arthritis, Experimental | Tretinoin | 6.44 | 16412693 | |
| MESH:D001172 | Arthritis, Rheumatoid | Indomethacin | 4.44 | 11248219 | |
| MESH:D001172 | Arthritis, Rheumatoid | Tretinoin | 4.44 | 16292516 | |
| MESH:D001249 | Asthma | Tretinoin | 2.23 | 16456186 | |
| MESH:D055963 | Asthma, Aspirin-Induced | Aspirin | 4.40 | 20485159 12372130 | |
| MESH:D050197 | Atherosclerosis | Cadmium | 3.42 | 15687053 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 2.16 | 18445737 | |
| MESH:D001321 | Autistic Disorder | Folic Acid | 2.16 | 21388746 | |
| MESH:D001471 | Barrett Esophagus | Tretinoin | 4.05 | 16935849 | |
| MESH:D001477 | Bartter Syndrome | Indomethacin | 4.62 | 10684365 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 7.89 | 19483382 | |
| MESH:D001778 | Blood Coagulation Disorders | Tretinoin | 7.89 | 16206674 16197459 | |
| MESH:D019046 | Bone Marrow Neoplasms | Dactinomycin | 11.05 | 14601052 | |
| MESH:D019046 | Bone Marrow Neoplasms | Doxorubicin | 11.05 | 14601052 | |
| MESH:D001913 | Bowen's Disease | Sulindac | 4.98 | 11207687 | |
| MESH:D001929 | Brain Edema | Indomethacin | 4.65 | 11481608 | |
| MESH:D002545 | Brain Ischemia | Ibuprofen | 9.35 | 15837124 | |
| MESH:D002545 | Brain Ischemia | Indomethacin | 9.35 | 12524144 | |
| MESH:D001932 | Brain Neoplasms | Aspirin | 8.09 | 15481559 | |
| MESH:D001932 | Brain Neoplasms | Doxorubicin | 8.09 | 17150277 | |
| MESH:D001943 | Breast Neoplasms | Aspirin | 9.13 | 15161893 | |
| MESH:D001943 | Breast Neoplasms | Diethylstilbestrol | 9.13 | 15324884 17129689 | |
| MESH:D001943 | Breast Neoplasms | Doxorubicin | 9.13 | 17426702 16264153 16322301 15939500 15668708 15994142 16935488 15993339 15567936 18382427 15634643 16826403 16115903 16096432 11325840 15692762 18234424 15136595 17369602 16595493 19526202 18695136 17983394 18628466 | |
| MESH:D001943 | Breast Neoplasms | Estradiol | 9.13 | 17261762 17289903 19861407 12948864 18497071 16675129 17018787 14630087 | |
| MESH:D001943 | Breast Neoplasms | Fluorouracil | 9.13 | 18608205 16110121 19217205 18357371 16557594 16595493 15136595 | |
| MESH:D001943 | Breast Neoplasms | Folic Acid | 9.13 | 16777985 | |
| MESH:D001943 | Breast Neoplasms | Genistein | 9.13 | 16873071 16541309 17200150 | |
| MESH:D001943 | Breast Neoplasms | Indomethacin | 9.13 | 17401462 | |
| MESH:D001943 | Breast Neoplasms | Plant Preparations | 9.13 | 17398067 | |
| MESH:D001943 | Breast Neoplasms | Sulindac | 9.13 | 16642371 | |
| MESH:D001943 | Breast Neoplasms | Testosterone | 9.13 | 17261762 | |
| MESH:D001943 | Breast Neoplasms | Tretinoin | 9.13 | 16873071 16443354 16166294 | |
| MESH:D001997 | Bronchopulmonary Dysplasia | Tretinoin | 4.22 | 16813970 | |
| MESH:D002056 | Burns | Indomethacin | 4.35 | 10459503 | |
| MESH:D002100 | Cachexia | Ibuprofen | 11.44 | 15141370 | |
| MESH:D002100 | Cachexia | Indomethacin | 11.44 | 11239499 15141370 16537180 15625704 | |
| MESH:D002181 | Candidiasis, Vulvovaginal | Estradiol | 4.09 | 16111702 | |
| MESH:D002276 | Carcinoid Tumor | Doxorubicin | 11.10 | 16051944 | |
| MESH:D002276 | Carcinoid Tumor | Fluorouracil | 11.10 | 16051944 | |
| MESH:D002277 | Carcinoma | Fluorouracil | 3.28 | 17121937 | |
| MESH:D018236 | Carcinoma, Embryonal | Tretinoin | 4.78 | 16168501 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 15.72 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylstilbestrol | 15.72 | 15948411 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Doxorubicin | 15.72 | 16023760 16234567 17876044 18059187 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Estradiol | 15.72 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Fluorouracil | 15.72 | 18930000 16332177 17971768 17045692 17088986 16799960 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Genistein | 15.72 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Indomethacin | 15.72 | 16391822 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Tretinoin | 15.72 | 1917145 | |
| MESH:D018827 | Carcinoma, Lewis Lung | Indomethacin | 4.36 | 11053908 | |
| MESH:D018276 | Carcinoma, Medullary | Indomethacin | 4.98 | 18791128 14736730 11352223 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | sulindac sulfone | 3.95 | 18758305 | |
| MESH:D002292 | Carcinoma, Renal Cell | Doxorubicin | 9.84 | 16201981 1485588 | |
| MESH:D002292 | Carcinoma, Renal Cell | Fluorouracil | 9.84 | 18695887 | |
| MESH:D002292 | Carcinoma, Renal Cell | Indomethacin | 9.84 | 17341418 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Doxorubicin | 13.11 | 6189445 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Fluorouracil | 13.11 | 18986760 17066447 16280240 16757204 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Indomethacin | 13.11 | 15482327 12636206 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Plant Preparations | 13.11 | 17418620 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Tretinoin | 13.11 | 16051514 16096774 | |
| MESH:D009202 | Cardiomyopathies | Doxorubicin | 3.29 | 16269455 17007740 17382496 16612575 16731534 16278810 16651473 16455267 15811867 17131338 18627295 15476868 15792986 17924179 17351982 17928571 16109756 16952015 17308081 17519947 15505089 17329180 16242529 17974986 16364871 | |
| MESH:D002311 | Cardiomyopathy, Dilated | Doxorubicin | 2.81 | 16243910 17334414 | |
| MESH:D002318 | Cardiovascular Diseases | Folic Acid | 10.97 | 16755160 | |
| MESH:D002318 | Cardiovascular Diseases | Genistein | 10.97 | 16332659 | |
| MESH:D002318 | Cardiovascular Diseases | Plant Preparations | 10.97 | 16862667 | |
| MESH:D016893 | Carotid Stenosis | Plant Preparations | 5.77 | 15158307 | |
| MESH:D002386 | Cataract | Acetaminophen | 6.50 | 10977129 | |
| MESH:D002386 | Cataract | Tretinoin | 6.50 | 17460283 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 13.96 | 20889678 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cadmium | 13.96 | 17332340 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 13.96 | 12371664 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Estradiol | 13.96 | 18566989 | |
| MESH:D018290 | Cervical Intraepithelial Neoplasia | Tretinoin | 4.22 | 16129372 | |
| MESH:D002659 | Child Development Disorders, Pervasive | Testosterone | 3.54 | 20678186 | |
| MESH:D002764 | Cholecystitis | Indomethacin | 4.79 | 11181007 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 11.77 | 19486331 | |
| MESH:D002779 | Cholestasis | Ethinyl Estradiol | 11.77 | 17681005 17333356 16105132 15861022 16919318 11677210 17110522 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 11.77 | 19176532 | |
| MESH:D002822 | Choriocarcinoma | Tretinoin | 4.78 | 16461808 | |
| MESH:D002971 | Cleft Lip | Folic Acid | 3.78 | 21254359 | |
| MESH:D002972 | Cleft Palate | Folic Acid | 5.77 | 8946559 21254359 | |
| MESH:D002972 | Cleft Palate | Tretinoin | 5.77 | 9407595 | |
| MESH:D003092 | Colitis | Tretinoin | 3.35 | 17035595 | |
| MESH:D003110 | Colonic Neoplasms | Aspirin | 16.08 | 12411196 | |
| MESH:D003110 | Colonic Neoplasms | Fluorouracil | 16.08 | 17018589 16340194 17725105 15001691 17172411 16510598 18772588 17016597 17287894 17169374 | |
| MESH:D003110 | Colonic Neoplasms | Genistein | 16.08 | 17182828 | |
| MESH:D003110 | Colonic Neoplasms | Indomethacin | 16.08 | 15786552 11260862 15625704 15936596 15963497 15637740 | |
| MESH:D003110 | Colonic Neoplasms | irinotecan | 16.08 | 17725105 17287894 | |
| MESH:D003110 | Colonic Neoplasms | oxaliplatin | 16.08 | 16024531 16510598 16004971 | |
| MESH:D003110 | Colonic Neoplasms | Sulindac | 16.08 | 12458338 12902858 | |
| MESH:D015179 | Colorectal Neoplasms | Aspirin | 14.30 | 17047198 | |
| MESH:D015179 | Colorectal Neoplasms | Doxorubicin | 14.30 | 18259882 18802399 | |
| MESH:D015179 | Colorectal Neoplasms | Fluorouracil | 14.30 | 17016601 18509181 18802399 18949393 16391804 14970324 17594712 17255274 15289873 16524972 18448328 17454858 16282729 15148649 17401013 16331619 18383874 17695437 17094418 16303861 20501625 18288408 | |
| MESH:D015179 | Colorectal Neoplasms | Folic Acid | 14.30 | 16985020 17087956 16963246 17245555 17116713 | |
| MESH:D015179 | Colorectal Neoplasms | Indomethacin | 14.30 | 12606626 17054584 18059344 11197048 | |
| MESH:D015179 | Colorectal Neoplasms | irinotecan | 14.30 | 15273666 16391804 17159606 16303861 18259882 17454858 18509181 | |
| MESH:D015179 | Colorectal Neoplasms | oxaliplatin | 14.30 | 17594712 17255274 18509181 18448328 17401013 17695437 | |
| MESH:D015179 | Colorectal Neoplasms | Sulindac | 14.30 | 10666051 11076880 11197048 18059344 | |
| MESH:D015179 | Colorectal Neoplasms | sulindac sulfone | 14.30 | 10416599 18059344 10666051 11197048 | |
| MESH:D003324 | Coronary Artery Disease | Plant Preparations | 3.85 | 15158307 | |
| MESH:D018352 | Coronavirus Infections | Indomethacin | 5.34 | 17302372 | |
| MESH:D019465 | Craniofacial Abnormalities | Tretinoin | 1.80 | 17551590 8800419 10589399 9142499 16925845 9664655 9211117 9224671 9125849 14991402 | |
| MESH:D003456 | Cryptorchidism | Diethylstilbestrol | 4.21 | 16002989 12952375 | |
| MESH:D007644 | Darier Disease | Fluorouracil | 4.42 | 16733453 | |
| MESH:D017449 | Dermatitis, Allergic Contact | nickel sulfate | 3.33 | 11298694 16780908 16823706 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.25 | 18249437 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Folic Acid | 4.53 | 16886840 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Genistein | 4.53 | 16647724 | |
| MESH:D003928 | Diabetic Nephropathies | Estradiol | 3.11 | 19279558 | |
| MESH:D003930 | Diabetic Retinopathy | Sulindac | 4.83 | 12861449 17621415 | |
| MESH:D003967 | Diarrhea | Indomethacin | 3.45 | 7907874 7237001 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 5.75 | 19739265 11529661 14550746 14986274 10915739 16227642 17906064 12392966 16781746 16393943 19416960 19420014 16177239 10663392 11287661 19164858 12540782 19370779 16109766 11421492 15968718 12594235 11461765 17562736 18071297 2444490 19085960 19923254 12705907 18713872 14725611 17522070 11743745 12958197 11739529 11834606 12153990 10774834 16081117 15619225 16485898 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diquat | 5.75 | 18164269 18445702 | |
| MESH:D056486 | Drug-Induced Liver Injury | Doxorubicin | 5.75 | 17416283 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 3.72 | 19426721 | |
| MESH:D004362 | Drug Toxicity | Doxorubicin | 7.91 | 18602426 | |
| MESH:D004362 | Drug Toxicity | Plant Preparations | 7.91 | 11033412 | |
| MESH:D004374 | Ductus Arteriosus, Patent | Ibuprofen | 12.00 | 16133044 18446180 18450898 | |
| MESH:D004374 | Ductus Arteriosus, Patent | Indomethacin | 12.00 | 16326151 18446180 16133044 17190690 12774134 18043480 | |
| MESH:D004381 | Duodenal Ulcer | Indomethacin | 3.79 | 16699067 17329845 11991626 10671773 11595415 17045617 11535926 17151854 17351913 11595431 17202747 | |
| MESH:D004487 | Edema | Aspirin | 9.78 | 17259670 | |
| MESH:D004487 | Edema | Indomethacin | 9.78 | 19703484 7907874 8985016 8273558 10653021 7990266 16100529 | |
| MESH:D004487 | Edema | pirinixic acid | 9.78 | 12083418 | |
| MESH:D004489 | Edema, Cardiac | Tretinoin | 4.09 | 18230668 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Ethinyl Estradiol | 2.84 | 12538720 | |
| MESH:D004714 | Endometrial Hyperplasia | Diethylstilbestrol | 10.67 | 16402032 | |
| MESH:D004714 | Endometrial Hyperplasia | Genistein | 10.67 | 16402032 | |
| MESH:D016889 | Endometrial Neoplasms | Diethylstilbestrol | 25.97 | 16804899 15700306 | |
| MESH:D016889 | Endometrial Neoplasms | Doxorubicin | 25.97 | 17359293 | |
| MESH:D016889 | Endometrial Neoplasms | Estradiol | 25.97 | 19148513 11473722 18566989 | |
| MESH:D016889 | Endometrial Neoplasms | Folic Acid | 25.97 | 17301261 | |
| MESH:D016889 | Endometrial Neoplasms | Genistein | 25.97 | 11473722 | |
| MESH:D016889 | Endometrial Neoplasms | Tretinoin | 25.97 | 16569247 | |
| MESH:D004715 | Endometriosis | Ibuprofen | 13.77 | 15652904 | |
| MESH:D004715 | Endometriosis | Indomethacin | 13.77 | 15652904 | |
| MESH:D004715 | Endometriosis | Sulindac | 13.77 | 15652904 | |
| MESH:D004719 | Endomyocardial Fibrosis | Doxorubicin | 4.78 | 18037988 | |
| MESH:D019446 | Endotoxemia | Ibuprofen | 9.64 | 11545620 | |
| MESH:D019446 | Endotoxemia | Indomethacin | 9.64 | 18509659 | |
| MESH:D004751 | Enteritis | Indomethacin | 4.37 | 10567023 17763956 16328016 | |
| MESH:D020345 | Enterocolitis, Necrotizing | Indomethacin | 4.62 | 17980183 | |
| MESH:D004802 | Eosinophilia | Indomethacin | 3.70 | 11298111 | |
| MESH:D004938 | Esophageal Neoplasms | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 12.74 | 20426865 | |
| MESH:D004938 | Esophageal Neoplasms | Fluorouracil | 12.74 | 16337965 16481741 17638652 15173087 16785472 | |
| MESH:D004938 | Esophageal Neoplasms | Indomethacin | 12.74 | 11005569 | |
| MESH:D004938 | Esophageal Neoplasms | Plant Preparations | 12.74 | 16510608 | |
| MESH:D004938 | Esophageal Neoplasms | Sulindac | 12.74 | 12235107 | |
| MESH:D017889 | Exfoliation Syndrome | Folic Acid | 5.12 | 16504073 | |
| MESH:D005124 | Eye Abnormalities | Tretinoin | 3.30 | 9664655 16938888 | |
| MESH:D005234 | Fatty Liver | Cyclosporine | 11.11 | 19224547 | |
| MESH:D005234 | Fatty Liver | Ethinyl Estradiol | 11.11 | 15345470 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 11.11 | 20131406 19236843 | |
| MESH:D052776 | Female Urogenital Diseases | Diethylstilbestrol | 3.43 | 16534752 16513791 15751030 16002989 16611131 | |
| MESH:D005334 | Fever | Ibuprofen | 8.51 | 16997862 | |
| MESH:D005334 | Fever | Indomethacin | 8.51 | 11852909 10431976 17627676 | |
| MESH:D018221 | Fibromatosis, Abdominal | Sulindac | 5.11 | 14745880 | |
| MESH:D018222 | Fibromatosis, Aggressive | Doxorubicin | 10.56 | 19069698 | |
| MESH:D018222 | Fibromatosis, Aggressive | Sulindac | 10.56 | 19069698 | |
| MESH:D005354 | Fibrosarcoma | Indomethacin | 4.53 | 10962813 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 12.79 | 12639820 12168785 | |
| MESH:D005355 | Fibrosis | Indomethacin | 12.79 | 17994277 | |
| MESH:D005355 | Fibrosis | Tretinoin | 12.79 | 17994277 | |
| MESH:D005391 | Firesetting Behavior | Testosterone | 5.48 | 7506515 | |
| MESH:D005499 | Folliculitis | Indomethacin | 4.79 | 11298111 | |
| MESH:D005756 | Gastritis | Acetaminophen | 24.29 | 16983495 | |
| MESH:D005756 | Gastritis | Diquat | 24.29 | 15046732 | |
| MESH:D005756 | Gastritis | Folic Acid | 24.29 | 17171786 | |
| MESH:D005756 | Gastritis | Indomethacin | 24.29 | 15046732 | |
| MESH:D005764 | Gastroesophageal Reflux | Sulindac | 4.66 | 11910360 | |
| MESH:D005833 | Genital Neoplasms, Female | Diethylstilbestrol | 4.58 | 16452187 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 3.85 | 8708960 | |
| MESH:D005901 | Glaucoma | Folic Acid | 4.74 | 16504073 | |
| MESH:D005909 | Glioblastoma | Aspirin | 24.64 | 12870263 | |
| MESH:D005909 | Glioblastoma | Doxorubicin | 24.64 | 17150277 | |
| MESH:D005909 | Glioblastoma | Genistein | 24.64 | 16598420 | |
| MESH:D005909 | Glioblastoma | Indomethacin | 24.64 | 12870263 | |
| MESH:D005909 | Glioblastoma | Testosterone | 24.64 | 17162496 | |
| MESH:D005909 | Glioblastoma | Tretinoin | 24.64 | 17312396 | |
| MESH:D005910 | Glioma | Fluorouracil | 5.74 | 16145905 | |
| MESH:D005910 | Glioma | Indomethacin | 5.74 | 18371953 16487511 | |
| MESH:D005923 | Glomerulosclerosis, Focal Segmental | Indomethacin | 3.99 | 11849393 | |
| MESH:D006073 | Gout | Indomethacin | 4.98 | 11248219 | |
| MESH:D006261 | Headache | Aspirin | 4.59 | 15240983 | |
| MESH:D006258 | Head and Neck Neoplasms | Doxorubicin | 16.43 | 15692506 | |
| MESH:D006258 | Head and Neck Neoplasms | Fluorouracil | 16.43 | 15102660 18337622 15162350 | |
| MESH:D006258 | Head and Neck Neoplasms | Indomethacin | 16.43 | 15482327 | |
| MESH:D006258 | Head and Neck Neoplasms | Tretinoin | 16.43 | 16096774 | |
| MESH:D006317 | Hearing Loss, Noise-Induced | Tretinoin | 4.78 | 16084493 | |
| MESH:D006330 | Heart Defects, Congenital | Folic Acid | 6.41 | 17286298 16524890 | |
| MESH:D006330 | Heart Defects, Congenital | Tretinoin | 6.41 | 9664655 14991402 | |
| MESH:D006331 | Heart Diseases | Doxorubicin | 3.23 | 18006777 12587719 16244372 16330681 17875725 18674790 16495754 16244371 16879835 16707910 14766674 16144979 17888722 | |
| MESH:D006333 | Heart Failure | Doxorubicin | 6.29 | 17481944 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 6.29 | 20558911 | |
| MESH:D006394 | Hemangiosarcoma | Doxorubicin | 3.57 | 15692506 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 4.05 | 15720958 | |
| MESH:D006501 | Hepatic Encephalopathy | Indomethacin | 4.24 | 15633222 | |
| MESH:D019698 | Hepatitis C, Chronic | Indomethacin | 4.33 | 15135802 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 2.64 | 16221962 19176532 19772884 18467677 | |
| MESH:D006558 | Herpes Genitalis | Estradiol | 4.66 | 15709030 | |
| MESH:D006628 | Hirsutism | Testosterone | 5.28 | 17019078 | |
| MESH:D006679 | HIV Seropositivity | Folic Acid | 5.12 | 17209195 | |
| MESH:D006689 | Hodgkin Disease | Doxorubicin | 3.11 | 18501091 15147373 17606976 | |
| MESH:D019584 | Hot Flashes | Estradiol | 3.38 | 17088409 | |
| MESH:D012001 | Hyperacusis | Aspirin | 5.39 | 15240983 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 16.35 | 16870215 | |
| MESH:D006930 | Hyperalgesia | Indomethacin | 16.35 | 12727271 | |
| MESH:D006930 | Hyperalgesia | oxaliplatin | 16.35 | 17418472 | |
| MESH:D006930 | Hyperalgesia | Tretinoin | 16.35 | 16870215 | |
| MESH:D034321 | Hyperamylasemia | Indomethacin | 5.34 | 17883296 | |
| MESH:D017588 | Hyperandrogenism | Testosterone | 4.93 | 17019078 | |
| MESH:D006940 | Hyperemia | Indomethacin | 4.64 | 12524144 | |
| MESH:D017681 | Hypereosinophilic Syndrome | Tretinoin | 4.21 | 16778211 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 2.87 | 20558911 | |
| MESH:D020138 | Hyperhomocysteinemia | Folic Acid | 4.19 | 16755160 16395265 16397167 16433478 16865747 | |
| MESH:D006949 | Hyperlipidemias | Indomethacin | 3.83 | 17546600 | |
| MESH:D006965 | Hyperplasia | Diethylstilbestrol | 4.08 | 12960047 14722030 | |
| MESH:D006973 | Hypertension | Cyclosporine | 1.96 | 10903974 | |
| MESH:D006984 | Hypertrophy | Ibuprofen | 4.65 | 16672835 | |
| MESH:D007006 | Hypogonadism | Testosterone | 4.33 | 12002444 | |
| MESH:D007018 | Hypopituitarism | Testosterone | 5.83 | 17426086 | |
| MESH:D007021 | Hypospadias | Diethylstilbestrol | 10.05 | 16002989 | |
| MESH:D007021 | Hypospadias | Ethinyl Estradiol | 10.05 | 16945680 16569931 | |
| MESH:D007077 | Ileal Diseases | Indomethacin | 4.65 | 18306037 10574470 | |
| MESH:D007079 | Ileitis | Indomethacin | 4.98 | 10651667 16133968 10647630 | |
| MESH:D007174 | Impulse Control Disorders | Testosterone | 5.48 | 7506515 | |
| MESH:D007235 | Infant, Premature, Diseases | Ibuprofen | 12.95 | 16133044 | |
| MESH:D007235 | Infant, Premature, Diseases | Indomethacin | 12.95 | 16133044 | |
| MESH:D007246 | Infertility | Diethylstilbestrol | 4.01 | 15036965 | |
| MESH:D007247 | Infertility, Female | Ethinyl Estradiol | 3.12 | 12013081 | |
| MESH:D007248 | Infertility, Male | Diquat | 6.30 | 4850670 | |
| MESH:D007248 | Infertility, Male | Ethinyl Estradiol | 6.30 | 17937319 | |
| MESH:D007249 | Inflammation | Ibuprofen | 7.55 | 3291741 | |
| MESH:D007249 | Inflammation | Indomethacin | 7.55 | 3291741 12568917 7812673 | |
| MESH:D007249 | Inflammation | Sulindac | 7.55 | 3291741 | |
| MESH:D007333 | Insulin Resistance | Estradiol | 6.39 | 16627594 16393666 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 6.39 | 16306350 | |
| MESH:D007410 | Intestinal Diseases | Indomethacin | 8.69 | 17994277 15831440 17329856 11686837 11713966 11855677 18236018 10210152 15610444 | |
| MESH:D007410 | Intestinal Diseases | Tretinoin | 8.69 | 17994277 | |
| MESH:D007414 | Intestinal Neoplasms | Sulindac | 4.32 | 10213222 12584176 12628509 12351151 12663524 10223192 | |
| MESH:D007417 | Intestinal Polyps | Sulindac | 4.65 | 11245490 12394442 | |
| MESH:D019586 | Intracranial Hypertension | Indomethacin | 5.00 | 15241188 | |
| MESH:D007569 | Jaw Abnormalities | Tretinoin | 3.57 | 17551590 15992940 | |
| MESH:D007579 | Jejunal Diseases | Indomethacin | 4.65 | 18306037 10574470 16133968 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 4.07 | 15604871 | |
| OMIM:308800 | KERATOSIS FOLLICULARIS SPINULOSA DECALVANS, X-LINKED | marker/mechanism | |||
| MESH:D007674 | Kidney Diseases | Acetaminophen | 21.07 | 15629191 12587719 | |
| MESH:D007674 | Kidney Diseases | Cadmium | 21.07 | 16962696 16226777 16322080 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 21.07 | 18776723 8314463 10903974 | |
| MESH:D007674 | Kidney Diseases | Doxorubicin | 21.07 | 15369732 16775033 15699352 | |
| MESH:D007674 | Kidney Diseases | Estradiol | 21.07 | 15618244 | |
| MESH:D007674 | Kidney Diseases | Indomethacin | 21.07 | 17190690 | |
| MESH:D007676 | Kidney Failure, Chronic | Doxorubicin | 3.83 | 16707910 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 15.34 | 12371664 | |
| MESH:D007680 | Kidney Neoplasms | Diethylstilbestrol | 15.34 | 14681315 15003126 16762066 | |
| MESH:D007680 | Kidney Neoplasms | Estradiol | 15.34 | 15610895 | |
| MESH:D007680 | Kidney Neoplasms | Fluorouracil | 15.34 | 16985049 | |
| MESH:D007859 | Learning Disorders | Diethylstilbestrol | 3.70 | 17184923 | |
| MESH:D016773 | Leishmaniasis, Cutaneous | Indomethacin | 3.61 | 12228301 10320625 11703811 | |
| MESH:D007938 | Leukemia | Genistein | 5.78 | 18980019 17468513 | |
| MESH:D007938 | Leukemia | Tretinoin | 5.78 | 17143497 | |
| MESH:D004915 | Leukemia, Erythroblastic, Acute | Doxorubicin | 4.78 | 16085563 | |
| MESH:D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Indomethacin | 3.65 | 16572323 10785260 15631656 | |
| MESH:D007951 | Leukemia, Myeloid | Tretinoin | 3.37 | 16932348 16482212 19285840 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | Indomethacin | 3.81 | 18360721 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | Tretinoin | 3.81 | 17596541 16294345 19850784 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Tretinoin | 2.91 | 17506722 17712046 19075265 17368321 17649720 16331271 17107899 15748426 17294898 9834237 12679006 17217047 17361223 16935935 16823087 16140955 19225113 17339181 19029980 16766008 16891316 17301526 16788101 19035177 19642359 | |
| MESH:D007964 | Leukocytosis | Indomethacin | 5.00 | 16537180 | |
| MESH:D007969 | Leukomalacia, Periventricular | Indomethacin | 5.34 | 17980183 | |
| MESH:D017880 | Limb Deformities, Congenital | Tretinoin | 3.05 | 9224671 | |
| MESH:D008101 | Liver Abscess, Amebic | Indomethacin | 5.34 | 11479899 | |
| MESH:D008105 | Liver Cirrhosis, Biliary | Sulindac | 3.99 | 12468960 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Doxorubicin | 10.10 | 16439617 16595196 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Estradiol | 10.10 | 14716833 14659978 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Genistein | 10.10 | 17823541 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Indomethacin | 10.10 | 18194892 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 10.10 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Plant Preparations | 10.10 | 17724770 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tretinoin | 10.10 | 16248980 18397230 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 6.11 | 19784758 12587719 19460945 16611625 19014921 12969438 16610002 11587558 | |
| MESH:D008107 | Liver Diseases | Folic Acid | 6.11 | 16877991 | |
| MESH:D008107 | Liver Diseases | Sulindac | 6.11 | 16867024 14986274 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 2.92 | 16871587 17185352 | |
| MESH:D008113 | Liver Neoplasms | Diethylstilbestrol | 9.55 | 16712894 15890375 | |
| MESH:D008113 | Liver Neoplasms | Fluorouracil | 9.55 | 16603448 17045692 18383874 15113037 | |
| MESH:D008113 | Liver Neoplasms | Mitomycin | 9.55 | 15113037 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 9.55 | 15890375 16377806 20007298 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Doxorubicin | 2.79 | 16842330 17085340 | |
| MESH:D055370 | Lung Injury | Asbestos, Crocidolite | 3.67 | 17365036 | |
| MESH:D008175 | Lung Neoplasms | Doxorubicin | 4.55 | 6189445 17418594 | |
| MESH:D008175 | Lung Neoplasms | Fluorouracil | 4.55 | 15246190 | |
| MESH:D008175 | Lung Neoplasms | Indomethacin | 4.55 | 11497255 11053908 16537180 | |
| MESH:D008175 | Lung Neoplasms | Sulindac | 4.55 | 19359593 15713900 | |
| MESH:D008178 | Lupus Erythematosus, Cutaneous | Fluorouracil | 4.42 | 15086387 | |
| MESH:D008180 | Lupus Erythematosus, Systemic | Folic Acid | 3.23 | 17718048 | |
| MESH:D008181 | Lupus Nephritis | Diethylstilbestrol | 4.78 | 15166399 | |
| MESH:D008223 | Lymphoma | Diethylstilbestrol | 6.87 | 15700306 | |
| MESH:D008223 | Lymphoma | Doxorubicin | 6.87 | 16098063 | |
| MESH:D008228 | Lymphoma, Non-Hodgkin | Doxorubicin | 3.49 | 17654614 | |
| MESH:D016399 | Lymphoma, T-Cell | Doxorubicin | 4.21 | 15621674 | |
| MESH:D052801 | Male Urogenital Diseases | Diethylstilbestrol | 5.14 | 16002989 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Doxorubicin | 12.38 | 15458769 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Estradiol | 12.38 | 11408345 11807958 17203775 16891317 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Genistein | 12.38 | 14578162 12929590 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Ibuprofen | 12.38 | 10697514 | |
| MESH:D020149 | Manganese Poisoning | Estradiol | 4.11 | 19453300 | |
| MESH:D019767 | Maxillofacial Abnormalities | Folic Acid | 5.33 | 16832597 | |
| MESH:D008527 | Medulloblastoma | Tretinoin | 2.63 | 17453147 | |
| MESH:D008545 | Melanoma | Doxorubicin | 4.83 | 16827129 | |
| MESH:D008545 | Melanoma | Sulindac | 4.83 | 16642371 | |
| MESH:D008545 | Melanoma | Tretinoin | 4.83 | 16752155 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 3.21 | 19513568 | |
| MESH:D008591 | Meningomyelocele | Tretinoin | 4.06 | 16940565 | |
| MESH:D008654 | Mesothelioma | Asbestos, Crocidolite | 5.92 | 18303189 16166281 16966607 | |
| MESH:D008654 | Mesothelioma | Doxorubicin | 5.92 | 17638057 | |
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 4.41 | 16801185 | |
| MESH:D008881 | Migraine Disorders | Aspirin | 7.17 | 15240983 | |
| MESH:D008881 | Migraine Disorders | Indomethacin | 7.17 | 11903285 | |
| MESH:D028361 | Mitochondrial Diseases | Doxorubicin | 4.17 | 15792986 | |
| MESH:D009062 | Mouth Neoplasms | Fluorouracil | 13.01 | 16757204 18986760 | |
| MESH:D009062 | Mouth Neoplasms | Indomethacin | 13.01 | 12636206 | |
| MESH:D009062 | Mouth Neoplasms | Plant Preparations | 13.01 | 17418620 | |
| MESH:D052016 | Mucositis | Doxorubicin | 11.19 | 17415656 | |
| MESH:D052016 | Mucositis | irinotecan | 11.19 | 17159606 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 3.15 | 16239165 | |
| MESH:D009190 | Myelodysplastic Syndromes | Tretinoin | 2.87 | 17596541 | |
| MESH:D009203 | Myocardial Infarction | Aspirin | 12.27 | 12692751 | |
| MESH:D009203 | Myocardial Infarction | Doxorubicin | 12.27 | 15857846 19429709 | |
| MESH:D009203 | Myocardial Infarction | Genistein | 12.27 | 17141266 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 12.27 | 19151258 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Estradiol | 12.55 | 16810080 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Genistein | 12.55 | 17141266 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 12.55 | 16411023 | |
| MESH:D009325 | Nausea | Aspirin | 4.84 | 15240983 | |
| MESH:D009362 | Neoplasm Metastasis | Doxorubicin | 8.78 | 18259882 | |
| MESH:D009362 | Neoplasm Metastasis | Indomethacin | 8.78 | 11053908 11239499 16537180 | |
| MESH:D009362 | Neoplasm Metastasis | irinotecan | 8.78 | 18259882 | |
| MESH:D009369 | Neoplasms | Diethylstilbestrol | 10.32 | 15313581 | |
| MESH:D009369 | Neoplasms | Fluorouracil | 10.32 | 16928823 18600527 18239605 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 10.32 | 17405874 | |
| MESH:D009369 | Neoplasms | Tretinoin | 10.32 | 16946489 16594593 | |
| MESH:D009374 | Neoplasms, Experimental | Indomethacin | 3.78 | 10663608 15625704 | |
| MESH:D009389 | Neovascularization, Pathologic | Estradiol | 3.37 | 17289903 | |
| MESH:D009395 | Nephritis, Interstitial | Ibuprofen | 4.61 | 6375363 | |
| MESH:D009401 | Nephrosis | Doxorubicin | 4.41 | 16636307 16899518 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 4.07 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 8.27 | 18481113 19348381 | |
| MESH:D009404 | Nephrotic Syndrome | Doxorubicin | 8.27 | 16889571 15640375 | |
| MESH:D009410 | Nerve Degeneration | Ibuprofen | 4.11 | 10961664 | |
| MESH:D009421 | Nervous System Malformations | Diethylstilbestrol | 20.61 | 11399458 | |
| MESH:D009421 | Nervous System Malformations | Estradiol | 20.61 | 11399458 16427766 | |
| MESH:D009421 | Nervous System Malformations | Genistein | 20.61 | 16427766 | |
| MESH:D009421 | Nervous System Malformations | Tretinoin | 20.61 | 9125849 | |
| MESH:D009436 | Neural Tube Defects | Folic Acid | 6.81 | 17438019 | |
| MESH:D009436 | Neural Tube Defects | Tretinoin | 6.81 | 9142499 | |
| MESH:D009447 | Neuroblastoma | Doxorubicin | 6.51 | 15555623 | |
| MESH:D009447 | Neuroblastoma | irinotecan | 6.51 | 8761367 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 12.48 | 18514411 | |
| MESH:D019636 | Neurodegenerative Diseases | Indomethacin | 12.48 | 12349958 | |
| MESH:D019636 | Neurodegenerative Diseases | Sulindac | 12.48 | 16850258 17266991 | |
| MESH:D017599 | Neuroectodermal Tumors | irinotecan | 4.36 | 8761367 | |
| MESH:D020258 | Neurotoxicity Syndromes | Fluorouracil | 3.19 | 16436463 | |
| MESH:D009503 | Neutropenia | Folic Acid | 4.17 | 16322990 | |
| MESH:D009765 | Obesity | pirinixic acid | 1.72 | 20558911 | |
| MESH:D007752 | Obstetric Labor, Premature | Indomethacin | 4.79 | 6374098 | |
| MESH:D010003 | Osteoarthritis | Aspirin | 11.49 | 7009135 | |
| MESH:D010003 | Osteoarthritis | Ibuprofen | 11.49 | 7009135 | |
| MESH:D010003 | Osteoarthritis | Indomethacin | 11.49 | 7009135 | |
| MESH:D010024 | Osteoporosis | Genistein | 3.03 | 19401787 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Genistein | 3.75 | 16169203 | |
| MESH:D012516 | Osteosarcoma | Doxorubicin | 3.82 | 15930896 | |
| MESH:D010051 | Ovarian Neoplasms | Estradiol | 7.16 | 19401270 | |
| MESH:D010051 | Ovarian Neoplasms | Genistein | 7.16 | 19005980 | |
| MESH:D010051 | Ovarian Neoplasms | Tretinoin | 7.16 | 16936753 | |
| MESH:D010146 | Pain | Acetaminophen | 22.65 | 16870215 | |
| MESH:D010146 | Pain | Aspirin | 22.65 | 6995502 6363464 | |
| MESH:D010146 | Pain | Ibuprofen | 22.65 | 3291741 | |
| MESH:D010146 | Pain | Indomethacin | 22.65 | 13679232 3291741 17440234 17627676 | |
| MESH:D010146 | Pain | Sulindac | 22.65 | 3291741 | |
| MESH:D010146 | Pain | Tretinoin | 22.65 | 16870215 | |
| MESH:D010149 | Pain, Postoperative | Ibuprofen | 10.23 | 16678543 | |
| MESH:D010149 | Pain, Postoperative | Indomethacin | 10.23 | 12538197 18702446 | |
| MESH:D010190 | Pancreatic Neoplasms | Fluorouracil | 14.86 | 16500647 16929163 19003803 15113037 | |
| MESH:D010190 | Pancreatic Neoplasms | Ibuprofen | 14.86 | 12384795 | |
| MESH:D010190 | Pancreatic Neoplasms | Mitomycin | 14.86 | 15113037 | |
| MESH:D010190 | Pancreatic Neoplasms | Sulindac | 14.86 | 11504793 16820089 | |
| MESH:D010190 | Pancreatic Neoplasms | Tretinoin | 14.86 | 15976015 | |
| MESH:D010195 | Pancreatitis | Indomethacin | 3.59 | 15028970 17883296 | |
| MESH:D016584 | Panic Disorder | Ethinyl Estradiol | 3.35 | 11578682 | |
| MESH:D010257 | Paraneoplastic Syndromes | Indomethacin | 5.34 | 16537180 | |
| MESH:D020734 | Parkinsonian Disorders | Indomethacin | 3.80 | 12349958 | |
| MESH:D051302 | Paroxysmal Hemicrania | Indomethacin | 5.34 | 11903285 | |
| MESH:D010437 | Peptic Ulcer | Indomethacin | 4.78 | 11148446 | |
| MESH:D010438 | Peptic Ulcer Hemorrhage | Aspirin | 5.17 | 11156591 | |
| MESH:D010518 | Periodontitis | Indomethacin | 4.54 | 17225004 | |
| MESH:D016491 | Peripheral Vascular Diseases | Cadmium | 5.01 | 15687053 | |
| MESH:D020795 | Photophobia | Aspirin | 5.39 | 15240983 | |
| MESH:D003557 | Phyllodes Tumor | Doxorubicin | 4.78 | 17983394 | |
| MESH:D010900 | Pituitary Diseases | Diethylstilbestrol | 4.79 | 14722030 | |
| MESH:D010911 | Pituitary Neoplasms | Diethylstilbestrol | 4.31 | 15687265 16977796 | |
| MESH:D010995 | Pleural Diseases | Asbestos, Crocidolite | 4.53 | 10923243 | |
| MESH:D010997 | Pleural Neoplasms | Doxorubicin | 4.78 | 17638057 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 2.92 | 12371664 | |
| MESH:D047928 | Premature Birth | Indomethacin | 4.77 | 17000239 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Diethylstilbestrol | 3.75 | 17184923 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | Estradiol | 9.77 | 20887781 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | Testosterone | 9.77 | 20887781 | |
| MESH:D011471 | Prostatic Neoplasms | Cadmium | 2.81 | 17075824 | |
| MESH:D011471 | Prostatic Neoplasms | Diethylstilbestrol | 2.81 | 17136230 15046698 15846301 | |
| MESH:D011471 | Prostatic Neoplasms | Doxorubicin | 2.81 | 16888761 16729912 16868541 18437689 15897917 15749863 | |
| MESH:D011471 | Prostatic Neoplasms | Estradiol | 2.81 | 16740699 | |
| MESH:D011471 | Prostatic Neoplasms | Fluorouracil | 2.81 | 18626508 19082440 | |
| MESH:D011471 | Prostatic Neoplasms | Genistein | 2.81 | 15256057 16925846 15378649 | |
| MESH:D011471 | Prostatic Neoplasms | Ibuprofen | 2.81 | 17409433 | |
| MESH:D011471 | Prostatic Neoplasms | methylselenic acid | 2.81 | 16205645 | |
| MESH:D011471 | Prostatic Neoplasms | sulindac sulfone | 2.81 | 17908994 15570007 | |
| MESH:D011507 | Proteinuria | Ibuprofen | 13.63 | 6375363 | |
| MESH:D011507 | Proteinuria | Indomethacin | 13.63 | 11849393 | |
| MESH:D011507 | Proteinuria | Tretinoin | 13.63 | 16636307 | |
| MESH:D011537 | Pruritus | Ethinyl Estradiol | 2.95 | 15861022 16919318 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 2.10 | 16882103 | |
| MESH:D011625 | Pterygium | Tretinoin | 4.42 | 16723453 | |
| MESH:D011658 | Pulmonary Fibrosis | Asbestos, Crocidolite | 2.88 | 17365031 15814490 17322281 17975199 | |
| MESH:D012004 | Rectal Neoplasms | Fluorouracil | 3.70 | 18286688 15538739 18722050 16160472 | |
| MESH:D051437 | Renal Insufficiency | Doxorubicin | 9.32 | 17922066 | |
| MESH:D051437 | Renal Insufficiency | Folic Acid | 9.32 | 15728788 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 2.20 | 19058328 | |
| MESH:D012208 | Rhabdomyosarcoma | Tretinoin | 3.76 | 16116481 16283617 | |
| MESH:D012220 | Rhinitis | Aspirin | 4.06 | 12372130 | |
| MESH:D012509 | Sarcoma | Doxorubicin | 3.67 | 16767912 17710206 15675481 15625365 18313854 17203757 | |
| MESH:D012512 | Sarcoma, Ewing's | Dactinomycin | 9.53 | 14601052 | |
| MESH:D012512 | Sarcoma, Ewing's | Doxorubicin | 9.53 | 14601052 16326096 | |
| MESH:D012514 | Sarcoma, Kaposi | Doxorubicin | 4.42 | 17846226 | |
| MESH:D012559 | Schizophrenia | Folic Acid | 2.85 | 16641680 | |
| MESH:D012735 | Sexual Dysfunction, Physiological | Testosterone | 5.83 | 16631401 | |
| MESH:D012851 | Sinus Thrombosis, Intracranial | Aspirin | 4.90 | 12269725 | |
| MESH:D012871 | Skin Diseases | Folic Acid | 3.15 | 18709164 | |
| MESH:D012878 | Skin Neoplasms | Doxorubicin | 8.50 | 15692506 | |
| MESH:D012878 | Skin Neoplasms | tert-Butylhydroperoxide | 8.50 | 8532709 | |
| MESH:D012878 | Skin Neoplasms | Tretinoin | 8.50 | 16467112 | |
| MESH:D012983 | Soft Tissue Neoplasms | Doxorubicin | 4.21 | 16767912 17203757 15625365 | |
| MESH:D013088 | Spermatocele | Diethylstilbestrol | 10.47 | 16002989 16709447 | |
| MESH:D013088 | Spermatocele | Ethinyl Estradiol | 10.47 | 16709447 | |
| MESH:D013118 | Spinal Cord Diseases | Folic Acid | 5.12 | 16361298 | |
| MESH:D013272 | Stomach Diseases | Indomethacin | 4.05 | 17160473 18545984 15038085 15472012 10486359 10192188 10215738 17638125 16113693 17207306 16280098 18209964 16184426 | |
| MESH:D013274 | Stomach Neoplasms | Fluorouracil | 5.97 | 15786421 17498489 19015929 17522103 16951190 18396642 19084572 17172411 18567086 16424979 | |
| MESH:D013274 | Stomach Neoplasms | Folic Acid | 5.97 | 17171786 | |
| MESH:D013274 | Stomach Neoplasms | Indomethacin | 5.97 | 15609394 | |
| MESH:D013274 | Stomach Neoplasms | irinotecan | 5.97 | 15723263 | |
| MESH:D013274 | Stomach Neoplasms | Tretinoin | 5.97 | 17261132 | |
| MESH:D013276 | Stomach Ulcer | Indomethacin | 3.27 | 12077510 18726076 18087811 18181030 11906479 17654042 10750652 18209962 18543354 17657623 15104355 16252198 11523592 11595431 18431645 12787963 1323529 17895592 17627676 15255614 18299717 12500499 16631530 18237397 16150113 16169175 17977527 10423059 12467913 16934674 11595415 11145282 17918041 18193104 16755016 10878458 14567935 12498302 11729361 16397915 17135157 15138204 | |
| MESH:D020521 | Stroke | Aspirin | 8.25 | 16403987 | |
| MESH:D020521 | Stroke | Folic Acid | 8.25 | 16517955 | |
| MESH:D019851 | Thrombophilia | Ethinyl Estradiol | 3.28 | 11994571 | |
| MESH:D013927 | Thrombosis | Aspirin | 8.18 | 17672075 | |
| MESH:D013927 | Thrombosis | Ethinyl Estradiol | 8.18 | 15669648 | |
| MESH:D013964 | Thyroid Neoplasms | Doxorubicin | 10.49 | 17909728 16010429 | |
| MESH:D013964 | Thyroid Neoplasms | Indomethacin | 10.49 | 18791128 14736730 11352223 | |
| MESH:D013964 | Thyroid Neoplasms | Tretinoin | 10.49 | 17045167 16026305 | |
| MESH:D013978 | Tibial Fractures | Estradiol | 4.31 | 19048282 | |
| MESH:D014062 | Tongue Neoplasms | Fluorouracil | 8.77 | 16280240 | |
| MESH:D014062 | Tongue Neoplasms | Tretinoin | 8.77 | 16051514 | |
| MESH:D014376 | Tuberculosis | Tretinoin | 3.00 | 16040207 | |
| MESH:D014456 | Ulcer | Indomethacin | 4.53 | 17380554 10574470 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Diethylstilbestrol | 7.72 | 16452187 16712894 17306315 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Doxorubicin | 7.72 | 17653716 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Plant Preparations | 7.72 | 11251952 | |
| MESH:D014581 | Urticaria | Acetaminophen | 7.78 | 10982225 | |
| MESH:D014581 | Urticaria | Aspirin | 7.78 | 20485159 10982225 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Diethylstilbestrol | 14.06 | 16175088 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Fluorouracil | 14.06 | 16803524 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Tretinoin | 14.06 | 16129372 | |
| MESH:D014591 | Uterine Diseases | Diethylstilbestrol | 4.79 | 14652134 | |
| MESH:D014594 | Uterine Neoplasms | Diethylstilbestrol | 14.11 | 16690809 15809267 | |
| MESH:D014594 | Uterine Neoplasms | Ethinyl Estradiol | 14.11 | 14692618 | |
| MESH:D014594 | Uterine Neoplasms | Sulindac | 14.11 | 18645019 | |
| MESH:D014604 | Uveal Neoplasms | Tretinoin | 4.24 | 16752155 | |
| MESH:D014605 | Uveitis | Cyclosporine | 3.61 | 1336536 | |
| MESH:D014625 | Vaginal Neoplasms | Diethylstilbestrol | 4.08 | 16002989 16513791 | |
| MESH:D020301 | Vasospasm, Intracranial | Ibuprofen | 4.82 | 19057314 | |
| MESH:D020246 | Venous Thrombosis | Ethinyl Estradiol | 3.21 | 15869587 14671159 | |
| MESH:D018487 | Ventricular Dysfunction, Left | Doxorubicin | 3.86 | 17334414 16364871 17678736 17638931 | |
| MESH:D014820 | Vitiligo | Tretinoin | 3.71 | 16761959 | |
| MESH:D014839 | Vomiting | Indomethacin | 4.37 | 11897121 | |
| MESH:D009396 | Wilms Tumor | Tretinoin | 3.66 | 16287080 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 4.07 | 17120751 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:00330 | Arginine and proline metabolism |
| KEGG:01100 | Metabolic pathways |
| REACT:13 | Metabolism of amino acids and derivatives |
Pharmacogenomics Knowledge Base