AutismKB 2.0

Annotation Detail for SBF1


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Basic Information Top
Gene Symbol:SBF1 ( DKFZp761D0422,MGC99700,MTMR5 )
Gene Full Name: SET binding factor 1
Band: 22q13.33
Quick LinksEntrez ID:6305; OMIM: 603560; Uniprot ID:MTMR5_HUMAN; ENSEMBL ID: ENSG00000100241; HGNC ID: 10542
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SBF1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SBF1 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of SBF1 mRNAaffects expression 18414638
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SBF1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SBF1 mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of SBF1 mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in decreased expression of SBF1 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.7317306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D020261 Arsenic Poisoning Arsenic 2.9318414634 16251483 16835338 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D050197 Atherosclerosis Arsenic 3.4219371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.803084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8017306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7617687452 18922899 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3818640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.6615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.6016973168 18022660
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1017681005 16105132 11677210 17110522 16919318 15861022 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 8697196 15340226 16354765 12621046
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5711834606 18071297 19420014 12153990 17522070 16781746 17906064 19164858 16109766 12392966 10774834 11287661 16081117 11529661 16227642 12705907 15619225 16485898 11421492 11739529 19085960 11743745 16177239 19739265 14986274 19370779 12958197 17562736 15968718 12594235 14550746 11461765 19416960 14725611 12540782 16393943 10663392 10915739 2444490 18713872 19923254
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005534 Foot Diseases Arsenic 6.086392382
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5715340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7617050553
MESH:D006973 Hypertension Arsenic 5.5611953799 9931084 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.5618670907 18850075
MESH:D006987 Hypesthesia Arsenic 6.0816093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3317937319
MESH:D007248 Infertility, Male vinclozolin 7.3316467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007642 Keratosis Arsenic 5.4516930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2416705839
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7417339181
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 4.2919460945 19784758 19014921 12969438 16611625 12587719 16610002 11587558
MESH:D008107 Liver Diseases Arsenic 4.2911134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.037678174
MESH:D008113 Liver Neoplasms Arsenic 8.0316368122
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.346135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3412151625
MESH:D008175 Lung Neoplasms Arsenic 2.4917306315 19168569 17976673
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4911884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D017202 Myocardial Ischemia Arsenic 9.8615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.8612213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.3218551238 7678174
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects Arsenic 3.6416620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.7317056641
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010051 Ovarian Neoplasms Arsenic 2.8217306315
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.456392382 15371236 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.0811896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.0818042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms Arsenic 3.5616140617
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D011507 Proteinuria Arsenic 4.3521343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D012871 Skin Diseases Arsenic 2.8119834688 17548696 18709164 15952646 6392382 17938729 17050553 16702368 16759981 16353154 17453740
MESH:D012878 Skin Neoplasms Arsenic 6.1317976673 19538983 17029826 15504454 17050553 16251483
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.5516049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.5519322015 17976673 11144890 15987713 17306315 18640142 19429237
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014652 Vascular Diseases Arsenic 5.2017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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