AutismKB 2.0

Annotation Detail for SERPINB4


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Basic Information Top
Gene Symbol:SERPINB4 ( LEUPIN,PI11,SCCA-2,SCCA1,SCCA2 )
Gene Full Name: serpin peptidase inhibitor, clade B (ovalbumin), member 4
Band: 18q21.33
Quick LinksEntrez ID:6318; OMIM: 600518; Uniprot ID:SPB4_HUMAN; ENSEMBL ID: ENSG00000206073; HGNC ID: 10570
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1759Skin cancer
1934Cancer
1950Parasitic disease
2074Asthma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002945 Cisplatin Cisplatin results in decreased expression of SERPINB4 proteindecreases expression 16803524
D005472 Fluorouracil Fluorouracil results in decreased expression of SERPINB4 proteindecreases expression 16803524
C009277 sodium arsenate sodium arsenate results in decreased expression of SERPINB4 mRNAdecreases expression 12727804
C017947 sodium arsenite sodium arsenite results in decreased expression of SERPINB4 mRNAdecreases expression 12727804
D014212 Tretinoin Tretinoin results in increased expression of SERPINB4 mRNAincreases expression 16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.3312690470 17670903 15814532
MESH:D000230 Adenocarcinoma Cisplatin 4.9217638652 11798837
MESH:D000230 Adenocarcinoma Fluorouracil 4.9217638652
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5117306315 16712894
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000740 Anemia Fluorouracil 4.0616511603 15504547 17963324
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.5014601052
MESH:D001943 Breast Neoplasms Cisplatin 2.0119526202 18382427
MESH:D001943 Breast Neoplasms Fluorouracil 2.0115136595 16595493 19217205 16110121 18357371 16557594 18608205
MESH:D001943 Breast Neoplasms Tretinoin 2.0116166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002276 Carcinoid Tumor Fluorouracil 5.2816051944
MESH:D002277 Carcinoma Fluorouracil 3.8517121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 7.0017982673
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 7.0016332177 18930000 17088986 17971768 17045692 16799960
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 7.0017306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 7.001917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1316685392 12023789
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1518695887
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 11.546189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 11.5416757204 18986760 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 11.5418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 11.5416096774 16051514
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.2219524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2816340194 18772588 17016597 17725105 17172411 15001691 17287894 16510598 17169374 17018589
MESH:D015179 Colorectal Neoplasms Cisplatin 2.7815273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7818448328 17094418 17401013 16391804 16524972 16303861 16282729 18949393 17695437 18383874 16331619 17255274 18802399 17016601 15148649 14970324 20501625 18288408 15289873 17454858 18509181 17594712
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.0710525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.0716925845 9211117 14991402 8800419 10589399 9142499 17551590 9224671 9664655 9125849
MESH:D007644 Darier Disease Fluorouracil 5.3316733453
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 3.0818186108
MESH:D004362 Drug Toxicity Cisplatin 4.1112231392 12649298 19839026 15033597
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D004938 Esophageal Neoplasms Cisplatin 5.0116481741 15464296 17638652 15173087 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 5.0116481741 17638652 16785472 16337965 15173087
MESH:D005124 Eye Abnormalities Tretinoin 3.8416938888 9664655
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D005910 Glioma Fluorouracil 2.9816145905
MESH:D018149 Glucose Intolerance sodium arsenate 5.4819446573
MESH:D006258 Head and Neck Neoplasms Cisplatin 14.3515464296 15102660
MESH:D006258 Head and Neck Neoplasms Fluorouracil 14.3518337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 14.3516096774
MESH:D034381 Hearing Loss Cisplatin 4.6219898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.7315464296
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0514991402 9664655
MESH:D006689 Hodgkin Disease Cisplatin 8.6416200630 16170182
MESH:D006689 Hodgkin Disease sodium arsenite 8.6412676792
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D007248 Infertility, Male sodium arsenite 3.2112646999 15346721
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2715992940 17551590
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.7515464296
MESH:D007674 Kidney Diseases Cisplatin 6.9619839026 12649298 15190930 12231392 18289764
MESH:D007674 Kidney Diseases sodium arsenite 6.9620008137
MESH:D007680 Kidney Neoplasms Fluorouracil 3.6116985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.4111231351
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3716140955 16766008 17217047 17294898 19035177 15748426 17368321 12679006 17712046 19029980 17649720 19225113 16891316 16331271 19642359 17506722 17339181 16788101 9834237 16935935 17107899 17301526 17361223 16823087 19075265
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008113 Liver Neoplasms Fluorouracil 5.1016603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms sodium arsenite 5.1016712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.4019095001
MESH:D008175 Lung Neoplasms Cisplatin 3.7411798837 6189445 17225452
MESH:D008175 Lung Neoplasms Fluorouracil 3.7415246190
MESH:D008175 Lung Neoplasms sodium arsenite 3.7419931552 17077188 16712894 15276417 17306315
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.3315086387
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Cisplatin 5.4617023156 12374674 18505091 16809738 16432458 18176117 11135225 12393984 12883367 15577323 16248763 18332650 17761969
MESH:D008545 Melanoma sodium arsenite 5.4619082730 16487513
MESH:D008545 Melanoma Tretinoin 5.4616752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.3115990972
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D008654 Mesothelioma Cisplatin 3.3617638057
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9016757204 18986760
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 5.2318186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009369 Neoplasms Cisplatin 13.2116773208
MESH:D009369 Neoplasms Fluorouracil 13.2116928823 18239605 18600527
MESH:D009369 Neoplasms sodium arsenite 13.2111559025
MESH:D009369 Neoplasms Tretinoin 13.2116946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009395 Nephritis, Interstitial Cisplatin 5.1015464296
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects sodium arsenate 13.5519446573 11749123 18186108 10525206
MESH:D009436 Neural Tube Defects sodium arsenite 13.5512854658
MESH:D009436 Neural Tube Defects Tretinoin 13.559142499
MESH:D009447 Neuroblastoma Cisplatin 3.608761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.248761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6616436463
MESH:D010051 Ovarian Neoplasms Cisplatin 8.4917225452 19769630 15464296 6897625
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.4917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 8.4916936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 9.3219003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 9.3215113037 16929163 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 9.3215976015
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.7515464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.9517638057
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2719082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2716039940
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3418722050 18286688 16160472 15538739
MESH:D051437 Renal Insufficiency Cisplatin 4.8915464296
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.8714601052
MESH:D012878 Skin Neoplasms sodium arsenite 6.2819524636 18572023
MESH:D012878 Skin Neoplasms Tretinoin 6.2816467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.9515464296
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0712854658
MESH:D013274 Stomach Neoplasms Cisplatin 3.6117522103 15958060 18396642
MESH:D013274 Stomach Neoplasms Fluorouracil 3.6118396642 17522103 19015929 19084572 16951190 17172411 18567086 17498489 15786421 16424979
MESH:D013274 Stomach Neoplasms Tretinoin 3.6117261132
MESH:D013736 Testicular Neoplasms Cisplatin 5.0315464296 17225452
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 11.0116280240
MESH:D014062 Tongue Neoplasms Tretinoin 11.0116051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.7215464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.7211723127 16452187 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 25.7016803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 25.7016803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 25.7011813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 25.7016129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014625 Vaginal Neoplasms Cisplatin 5.0915577323
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D014839 Vomiting Cisplatin 5.3311897121
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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